Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Nature

• Publication date

  1996-11-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/384080A0
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• MinK residues line a potassium channel pore.

  1996cited by this paper
• Fast inactivation causes rectification of the IKr channel

  1996cited by this paper
• Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

  1996cited by this paper
• Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.

  1996cited by this paper
• The inward rectification mechanism of the HERG cardiac potassium channel

  1996cited by this paper
• Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.

  1996cited by this paper
• Subunit composition of minK potassium channels.

  1995cited by this paper
• A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.

  1995cited by this paper
• Mutations in the K+ channel signature sequence.

  1994cited by this paper
• Gating of IsK expressed in Xenopus oocytes depends on the amount of mRNA injected

  1994cited by this paper
• The protein IsK is a dual activator of K+ and CI− channels

  1993cited by this paper
• Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression?

  1993cited by this paper
• An amino acid mutation in a potassium channel that prevents inhibition by protein kinase C.

  1992cited by this paper
• Site-specific mutations in a minimal voltage-dependent K+ channel alter ion selectivity and open-channel block.

  1991cited by this paper
• Alteration of channel activities and gating by mutations of slow ISK potassium channel.

  1991cited by this paper
• Functional characterization of a minimal K+ channel expressed from a synthetic gene.

  1991cited by this paper
• Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone.

  1991cited by this paper
• Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier

  1990cited by this paper
• Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

  1990cited by this paper
• Cloning of a membrane protein that induces a slow voltage-gated potassium current.

  1988cited by this paper

• Voltage-dependent potassium channel regulatory subunits in the immune system

  2026cites this paper
• Transmembrane channel-like 4 (TMC4) could act as a negative regulator of KCNQ1 (Kv7.1) potassium channel.

  2025cites this paper
• Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome

  2025cites this paper
• Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent

  2025cites this paper
• A novel role of the antidepressant paroxetine in inhibiting neuronal Kv7/M channels to enhance neuronal excitability

  2025cites this paper
• Involvement of CaMKII in the modulation of IKs under oxidative stress in guinea pig sinoatrial node cells.

  2025cites this paper
• Decoding polyubiquitin regulation of KV7. 1 (KCNQ1) surface expression with engineered linkage-selective deubiquitinases

  2025cites this paper
• The m6A Demethylase Fto Enhances Susceptibility to Atrial Fibrillation by Demethylating Kcne1 in Aging Mice

  2025cites this paper
• A physiologically-relevant intermediate state structure of a voltage-gated potassium channel

  2025cites this paper
• Functional Profiling of KCNE1 Variants Informs Population Carrier Frequency of Jervell and Lange-Nielsen Syndrome Type 2

  2025cites this paper
• Nanomachine‐Based Flexible Bubbles for Alleviating Long QT Syndrome

  2025cites this paper
• Visualizing Kv7 channels in living cells using a novel fluorescent probe.

  2025cites this paper
• Targeting Kv7 Potassium Channels for Epilepsy

  2025cites this paper
• Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5

  2025cites this paper
• Functions of the KCNE Gene Family in Ion Channels.

  2025cites this paper
• KCNE gene family: From basic functions to diseases

  2025cites this paper
• Long QT syndrome type 1: clinical and functional characterization of KCNQ1 variant c.1111G > C

  2025cites this paper
• Calmodulin D133H Disrupts Cav1.2 and Kv7.1 Regulation to Prolong Cardiac Action Potentials in Long QT Syndrome

  2025cites this paper
• Ca2+-calmodulin regulates Kv7.1 channel gating by allosterically interfering with its inactivation path

  2025cites this paper
• PIP2 activation of the cardiac IKs potassium channel

  2025cites this paper
• Molecular mechanisms of function deficiencies in KCNQ1 variants associated with Jervell and Lange–Nielsen syndrome

  2025cites this paper
• A Systematic Review on the Role of the Stria Vascularis in Menière’s Disease Pathogenesis

  2025cites this paper
• Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function

  2025cites this paper
• Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

  2025cites this paper
• Elucidation of the zinc binding site in KCNQ channels

  2025cites this paper
• Dual effects of mefenamic acid on the IKs molecular complex

  2024cites this paper
• Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

  2024cites this paper
• Identification of KCNE6, a new member of the KCNE family of potassium channel auxiliary subunits

  2024cites this paper
• PUFA stabilizes a conductive state of the selectivity filter in IKs channels

  2024cites this paper
• Further exploration of cardiac channelopathy and cardiomyopathy genes in stillbirth

  2024influential citation
• KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures

  2024cites this paper
• Detection of distant relatedness in biobanks to identify undiagnosed cases of Mendelian disease as applied to Long QT syndrome

  2024cites this paper
• Routing of Kv7.1 to endoplasmic reticulum plasma membrane junctions

  2024cites this paper
• Novel KCNQ1 Q234K variant, identified in patients with long QT syndrome and epileptiform activity, induces both gain- and loss-of-function of slowly activating delayed rectifier potassium currents

  2024cites this paper
• Modulation of potassium channels by transmembrane auxiliary subunits via voltage‐sensing domains

  2024cites this paper
• Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency

  2024cites this paper
• Neurocardiac pathologies associated with potassium channelopathies

  2024cites this paper
• Development of automated patch clamp assays to overcome the burden of variants of uncertain significance in inheritable arrhythmia syndromes

  2023cites this paper
• Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier K+ Current, IKs

  2023cites this paper
• Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue

  2023cites this paper
• Ligand activation mechanisms of human KCNQ2 channel

  2023cites this paper
• Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs

  2023cites this paper
• Chinese herbal medicine for the treatment of cardiovascular diseases ─ targeting cardiac ion channels.

  2023cites this paper
• The potassium channels: Neurobiology and pharmacology of tinnitus

  2023cites this paper
• Cardiomyopathy related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing

  2023cites this paper
• Sensing its own permeant ion: KCNQ1 channel inhibition by external K+

  2023cites this paper
• Long QT syndrome‐associated calmodulin variants disrupt the activity of the slowly activating delayed rectifier potassium channel

  2023cites this paper
• A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

  2023cites this paper
• Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1

  2023cites this paper
• Mechanism of external K+ sensitivity of KCNQ1 channels

  2023cites this paper
• KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule

  2023cites this paper
• Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population

  2023cites this paper
• Pancreatic Beta-cell Dysfunction in Type 2 Diabetes

  2023cites this paper
• The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition

  2023cites this paper
• The cellular pathways that maintain the quality control and transport of diverse potassium channels.

  2023cites this paper
• Apo state pore opening as functional basis of increased EAAT anion channel activity in episodic ataxia 6

  2023cites this paper
• Voltage-gated potassium channels KCNQs: Structures, mechanisms, and modulations.

  2023cites this paper
• Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants

  2023cites this paper
• Emerging mechanisms involving brain Kv7 channel in the pathogenesis of Hypertension.

  2022cites this paper
• Clinically Relevant KCNQ1 Variants Causing KCNQ1-KCNE2 Gain-of-Function Affect the Ca2+ Sensitivity of the Channel

  2022cites this paper
• Gene mutations in comorbidity of epilepsy and arrhythmia

  2022cites this paper
• Induction of potassium channel regulator KCNE4 in a submandibular lymph node metastasis model

  2022cites this paper
• Purification and membrane interactions of human KCNQ1100-370 potassium ion channel.

  2022cites this paper
• Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine

  2022cites this paper
• Regulation of cardiac ion channels by transcription factors: looking for new opportunities of druggable targets for the treatment of arrhythmias.

  2022cites this paper
• KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation

  2022cites this paper
• Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements

  2022cites this paper
• Mutation-Specific Differences in Kv7.1 (KCNQ1) and Kv11.1 (KCNH2) Channel Dysfunction and Long QT Syndrome Phenotypes

  2022cites this paper
• Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

  2022cites this paper
• Polymodal Control of TMEM16x Channels and Scramblases

  2022cites this paper
• Ionic currents underlying different patterns of electrical activity in working cardiac myocytes of mammals and non-mammalian vertebrates.

  2022cites this paper
• Effects of Vitamin D Deficiency on the Function of the Cardiac Autonomic Nervous System in Rats

  2022cites this paper
• A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling

  2022cites this paper
• Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

  2022cites this paper
• KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain

  2022cites this paper
• Kv Channel Ancillary Subunits: Where Do We Go from Here?

  2022cites this paper
• Effect of Channel Assembly (KCNQ1 or KCNQ1 + KCNE1) on the Response of Zebrafish IKs Current to IKs Inhibitors and Activators

  2022cites this paper
• The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease

  2022cites this paper
• An In-Silico Study on Effect of KCNQI P535T Mutation in Cardiac Ventricular Cells

  2022cites this paper
• Contribution of the Slow Delayed Rectifier K+Current to Pacemaker Activity of the Human Sinoatrial Node

  2022cites this paper
• Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells

  2022cites this paper
• Pacemaker activity and ion channels in the sinoatrial node cells: MicroRNAs and arrhythmia.

  2022cites this paper
• Functional evaluation of human ion channel variants using automated electrophysiology.

  2021cites this paper
• Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

  2021cites this paper
• Long QT syndrome – Bench to bedside

  2021cites this paper
• Delayed KCNQ1/KCNE1 assembly on the cell surface helps IKs fulfil its function as a repolarization reserve in the heart

  2021cites this paper
• Chemical modulation of Kv7 potassium channels.

  2021cites this paper
• Functional Hyperactivity in Long QT Syndrome Type 1 Pluripotent Stem Cell-Derived Sympathetic Neurons.

  2021cites this paper
• Physiological Functions, Biophysical Properties, and Regulation of KCNQ1 (KV7.1) Potassium Channels.

  2021cites this paper
• Targeting of Potassium Channels in Cardiac Arrhythmias.

  2021cites this paper
• Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology

  2021cites this paper
• Elevation of propofol sensitivity of cardiac IKs channel by KCNE1 polymorphism D85N

  2021influential citation
• Triad interaction stabilizes the voltage sensor domains in a constitutively open KCNQ1-KCNE3 channel

  2021cites this paper
• Kv7 Channels and Excitability Disorders.

  2021cites this paper
• Predicting the functional impact of KCNQ1 variants with artificial neural networks

  2021cites this paper
• Effect of channel assembly (KCNQ1 or KCNQ1 + KCNE1) on the response of zebrafish IKs to IKs inhibitors and activators

  2021cites this paper
• Disease-linked supertrafficking of a potassium channel

  2021cites this paper
• Hydrocotyle bonariensis Comm ex Lamm (Araliaceae) leaves extract inhibits IKs not IKr potassium currents: Potential implications for anti-arrhythmic therapy

  2021cites this paper
• The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation

  2021cites this paper
• COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

  2021influential citation