ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Blood

• Publication date

  1994-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V84.6.1747.BLOODJOURNAL8461747PMID 8080983
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper
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  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.

  1993cited by this paper
• Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

  1993cited by this paper
• The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

  1993cited by this paper
• Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

  1993cited by this paper
• HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.

  1993cited by this paper
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  1992cited by this paper
• A trithorax–like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

  1992cited by this paper
• The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.

  1992cited by this paper
• Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.

  1992cited by this paper
• Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper
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  1989cited by this paper
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  1987cited by this paper
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  1985cited by this paper
• Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

  1982cited by this paper

• MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter

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  2023cites this paper
• Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

  2021cites this paper
• Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro

  2020cites this paper
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• Identification and Characterization of Transcriptional Regulators as Therapeutic Vulnerabilities in Hematologic Malignancies

  2017influential citation
• Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity

  2016cites this paper
• Epigenetic balance of gene expression by Polycomb and COMPASS families

  2016influential citation
• The upstreams and downstreams of H3K79 methylation by DOT1L

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• Transcription control by the ENL YEATS domain in acute leukemia

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• Drosophila oncogene Gas41 is an RNA interference modulator that intersects heterochromatin and the small interfering RNA pathway

  2015cites this paper
• ENL and the DNA Binding Motifs of HRX the Transcriptional Transactivation Activity of The Oncogenic Capacity of HRX-ENL Requires

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• progenitors by MLL-AF10 The AF10 leucine zipper is required for leukemic transformation of myeloid

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• and Localizes to Nuclear Structures The HRX Proto-oncogene Product Is Widely Expressed in Human Tissues

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• Thermodynamic and structural characterization of the interaction between WD-40 repeat protein 5 (WDR5) and human SET1 family methyltransferases

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• MicroRNA-297b-5p/3p target Mllt3/Af9 to suppress lymphoma cell proliferation, migration and invasion in vitro and tumor growth in nude mice

  2012cites this paper
• Human ALKBH4 Interacts with Proteins Associated with Transcription

  2012cites this paper
• 11q23 rearrangements in childhood acute lymphoblastic leukemia

  2011cites this paper
• Characterization of specific roles for AF4 and Dot1 in transformation mediated by MLL-AF9 leukemic oncoprotein

  2011cites this paper
• Biochemistry of the Mixed Lineage Leukemia 1 (MLL1) Protein and Targeted Therapies for Associated Leukemia

  2011cites this paper
• Precursor B-Cell Acute Lymphoblastic Leukemia

  2010cites this paper
• Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development

  2010cites this paper
• Types Localizes to Subnuclear Compartments AF4 Encodes a Ubiquitous Protein That in Both Native and MLL-AF4 Fusion

  2010cites this paper
• Mechanisms of MLL Fusion Protein-Mediated Leukemic Transformation

  2010cites this paper
• 24B-Cell Acute Lymphoblastic Leukemia

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• Acute Leukemia : Update of Clinical Aspects

  2010cites this paper
• A model to investigate the oncogenic activity of MLL-fusions in Acute Myeloid Leukaemia

  2009cites this paper
• The Robotic Mouse: Understanding the Role of AF4, a Cofactor of Transcriptional Elongation and Chromatin Remodelling, in Purkinje Cell Function

  2009cites this paper
• Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

  2009cites this paper
• AF17 Competes with AF9 for Binding to Dot1a to Up-regulate Transcription of Epithelial Na+ Channel α*

  2009cites this paper
• Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization.

  2008cites this paper
• MLLT3 regulates early human erythroid and megakaryocytic cell fate.

  2008cites this paper
• Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study

  2008cites this paper
• The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.

  2007cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2007cites this paper
• Investigation of the role of MLL-ENL in leukaemogenesis.

  2007cites this paper
• Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia

  2007cites this paper
• Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement

  2006cites this paper
• A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology

  2006cites this paper
• Lentiviral-based RNA interference of genes in leukaemic cells

  2006cites this paper
• A COMPASS in the voyage of defining the role of trithorax/MLL‐containing complexes: Linking leukemogensis to covalent modifications of chromatin

  2005cites this paper
• Quantitative Analysis of Chromosome/Gene Spatial Distribution

  2005cites this paper
• The robotic mouse: Unravelling the function of AF4 in the cerebellum

  2005cites this paper
• New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes

  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
• The leukemia-associated gene Mllt1/ENL: characterization of a murine homolog and demonstration of an essential role in embryonic development.

  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
• In Acute Myeloid Leukemia M1 and M5 Incidence and Characterization of Mll Gene (11q23) Rearrangements

  2002cites this paper
• MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function

  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
• MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.

  2001cites this paper
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  2001cites this paper
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• Functional Analysis of the Leukemia Protein ELL: Evidence for a Role in the Regulation of Cell Growth and Survival

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  2001cites this paper
• Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies

  2001cites this paper
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  2001cites this paper
• The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis

  2001cites this paper
• Biological and therapeutic aspects of infant leukemia.

  2000cites this paper
• ENL, the MLL fusion partner in t(11;19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t(10;11)+

  2000cites this paper
• DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.

  2000influential citation
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
• Comparison of cytogenetics, Southern blotting, and fluorescence in situ hybridization as methods for detecting MLL gene rearrangements in children with acute leukemia and with 11q23 abnormalities

  1999cites this paper
• Childhood acute lymphoblastic leukemia with the MLL-ENL fusion and t(11;19)(q23;p13.3) translocation.

  1999cites this paper