Neuroprotective effects of brimonidine treatment in a rodent model of ischemic optic neuropathy.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Experimental Eye Research

• Publication date

  2007-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.EXER.2006.10.002PMID 17113077
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of a topical alpha2 adrenergic agonist on ciliary blood flow and aqueous production in rabbits.

  2006cited by this paper
• Intranasal Delivery of Insulin–Like Growth Factor–1 Distributes to the Optic Nerve and Retina in the Rat

  2006cited by this paper
• Histological and morphometric evaluation of transient retinal and optic nerve ischemia in rat.

  2006influential reference
• Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small.

  2006cited by this paper
• Efficacy and tolerability of 0.2% brimonidine tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a 3-month, double-masked, randomised, placebo-controlled trial

  2006cited by this paper
• Characterization of brimonidine transport in retinal pigment epithelium.

  2006cited by this paper
• Comparison of the Effects of Brimonidine 0.2% and Timolol 0.5% on Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive Patients: A Prospective, Unmasked Study

  2005cited by this paper
• Topical brimonidine reduces collateral damage caused by laser photocoagulation for choroidal neovascularization

  2005cited by this paper
• Age related optic nerve axonal loss in adult Brown Norway rats.

  2005cited by this paper
• Oligodendrocyte dysfunction after induction of experimental anterior optic nerve ischemia.

  2005cited by this paper
• Side-effect profile of brimonidine tartrate in children.

  2005cited by this paper
• Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat.

  2004cited by this paper
• Efficacy of brimonidine 0.2% in controlling acute postoperative intraocular pressure elevation after phacoemulsification.

  2004cited by this paper
• The efficacy of topical administration of brimonidine to reduce ischaemia in the very early stage of diabetic retinopathy in good controlled type-2 diabetes mellitus.

  2004cited by this paper
• Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine.

  2003cited by this paper
• Effect of Brimonidine on Intraocular Pressure in Normal Tension Glaucoma: A Short Term Clinical Trial

  2003cited by this paper
• Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy.

  2003cited by this paper
• Efficacy of brimonidine 0.2% in controlling acute postoperative intraocular pressure elevation after phacoemulsification

  2003cited by this paper
• Ocular myasthenia gravis and inflammatory bowel disease: a case report and literature review

  2003cited by this paper
• Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection

  2003cited by this paper
• Transient ischemia of the retina results in altered retrograde axoplasmic transport: neuroprotection with brimonidine.

  2002cited by this paper
• Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes.

  2002cited by this paper
• Alpha-2 adrenoceptor agonist protects retinal function after acute retinal ischemic injury in the rat

  2002influential reference
• NMDA-evoked [Ca2+]i increase in salamander retinal ganglion cells: modulation by PKA and adrenergic receptors.

  2002cited by this paper
• Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells.

  2002cited by this paper
• Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy.

  2001cited by this paper
• Brimonidines neuroprotective effects against transient ischaemia-induced retinal ganglion cell death.

  2001cited by this paper
• Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension.

  2001cited by this paper
• Neuroprotective effects of alpha(2)-selective adrenergic agonists against ischemia-induced retinal ganglion cell death.

  2001cited by this paper
• Hypoxic-ischaemic brain damage in immature rats: effects of adrenoceptor modulation.

  2001cited by this paper
• α2-Adrenoceptor Agonists Inhibit Vitreal Glutamate and Aspartate Accumulation and Preserve Retinal Function after Transient Ischemia

  2001cited by this paper
• Alpha-2 Adrenergic Receptor Agonists are Neuroprotective in Experimental Models of Glaucoma

  2001cited by this paper
• Vitreous concentration of topically applied brimonidine tartrate 0.2%.

  2001cited by this paper
• Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?

  2001cited by this paper
• Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma.

  2001cited by this paper
• The effect of brimonidine tartrate on retinal blood flow in patients with ocular hypertension.

  2000cited by this paper
• [Apoptosis in ischemic optic neuropathy].

  2000cited by this paper
• Optic nerve and peripapillary choroidal microvasculature of the rat eye.

  1999cited by this paper
• Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration.

  1999cited by this paper
• Effect of brimonidine on optic nerve blood flow in rabbits.

  1999cited by this paper
• Microvasculature of the rat optic nerve head.

  1999cited by this paper
• From the Lab to the Clinic: Activation of an Alpha-2 agonist Pathway is Neuroprotective in Models of Retinal and Optic Nerve Injury

  1999cited by this paper
• Effect of brimonidine tartrate on ocular hemodynamic measurements.

  1998cited by this paper
• Brimonidine: A New Alpha2-Adrenoreceptor Agonist for Glaucoma Treatment

  1997cited by this paper
• Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy.

  1996cited by this paper
• α2-Adrenergic Agonists Induce Basic Fibroblast Growth Factor Expression in Photoreceptors In Vivo and Ameliorate Light Damage

  1996cited by this paper
• Microvasculature of the human optic nerve.

  1995cited by this paper
• Structural, genetic and pharmacological identity of the rat α2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina

  1995cited by this paper
• Effects of brimonidine on aqueous humor dynamics in human eyes.

  1995cited by this paper
• Localization of alpha 2-adrenergic receptor subtypes in the anterior segment of the human eye with selective antibodies.

  1995cited by this paper
• Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits.

  1995cited by this paper
• Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats

  1994cited by this paper
• Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia.

  1993cited by this paper
• Localization of alpha-2 adrenergic receptors in the human eye.

  1992cited by this paper
• Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat

  1992cited by this paper
• MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.

  1992cited by this paper
• Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism.

  1991cited by this paper
• Inhibition of cAMP production by alpha 2-adrenoceptor stimulation in rabbit retina.

  1991cited by this paper
• Inhibition of cAMP production by α2-adrenoceptor stimulation in rabbit retina

  1991cited by this paper
• Effect of reduced blood flow on alpha 1- and alpha 2-adrenoceptor constriction of rat skeletal muscle microvessels.

  1991cited by this paper
• Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor

  1990cited by this paper
• Selective interaction of alpha-adrenoceptors with myogenic regulation of microvascular smooth muscle.

  1990cited by this paper
• Alpha2-adrenergic receptors in rat and rabbit eye: a tritium-sensitive film autoradiography.

  1989cited by this paper
• Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve.

  1987cited by this paper
• Autoradiographic localization of high affinity GABA, benzodiazepine, dopaminergic, adrenergic and muscarinic cholinergic receptors in the rat, monkey and human retina.

  1986cited by this paper
• Inter-individual variation in blood supply of the optic nerve head

  1985cited by this paper
• Angioarchitecture of the ciliary artery circulation of the posterior pole.

  1981cited by this paper
• Inhibition of adenylate cyclase by hormones and neurotransmitters.

  1979cited by this paper
• ß Federation of European Neuroscience Societies

  year unknowncited by this paper

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  2022cites this paper
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  2020cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Recent advances in cellular and molecular aspects of mammalian retinal ischemia

  2012cites this paper
• Multi‐Component, 1,3‐Dipolar Cycloaddition Reactions for the Chemo‐, Regio‐ and Stereoselective Synthesis of Novel Hybrid Spiroheterocycles in Ionic Liquid.

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