Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Endocrinology

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ENDO.142.8.8293PMID 11459807
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1

  2004cited by this paper
• Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.

  2001cited by this paper
• Sphingolipid Regulation of Female Gonadal Cell Apoptosis

  2000cited by this paper
• Regulation of Nitric Oxide Synthase to Promote Cytostasis in Ovarian Follicular Development1

  2000cited by this paper
• Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis

  2000cited by this paper
• Involvement of membrane surface charge in thermal stability of the rat ovarian LH/hCG receptor.

  2000cited by this paper
• Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling

  2000cited by this paper
• Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides.

  2000cited by this paper
• Crosstalk Among Multiple Signaling Pathways Controlling Ovarian Cell Death.

  1999cited by this paper
• Thiazolidinedione Induces Apoptosis and Monocytic Differentiation in the Promyelocytic Leukemia Cell Line HL60

  1999cited by this paper
• Insulin Signaling and Action in Fat Cells: Associations with Insulin Resistance and Type 2 Diabetes

  1999cited by this paper
• Peroxisome proliferator-activated receptors: nuclear control of metabolism.

  1999cited by this paper
• Cellular uptake and intracellular trafficking of long chain fatty acids.

  1999cited by this paper
• Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

  1998cited by this paper
• Role of plasmalemmal caveolae in signal transduction.

  1998cited by this paper
• Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary

  1998cited by this paper
• Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.

  1998influential reference
• Evidence for an inverse relationship between apoptosis and inducible nitric oxide synthase expression in rat granulosa cells: a possible role of nitric oxide in ovarian follicle atresia.

  1998cited by this paper
• Apoptosis in human primary brain tumours: actions of arachidonic acid.

  1998cited by this paper
• Insulin resistance in obesity: metabolic mechanisms and measurement methods.

  1998cited by this paper
• Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

  1998influential reference
• Pathophysiologic implications of membrane phospholipid asymmetry in blood cells.

  1997cited by this paper
• Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids

  1997cited by this paper
• Engineering of Glycerol-stimulated Insulin Secretion in Islet Beta Cells

  1997cited by this paper
• Suppression of W256 carcinosarcoma cell apoptosis by arachidonic acid and other polyunsaturated fatty acids.

  1997cited by this paper
• The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function.

  1997cited by this paper
• Randomized placebo-controlled study of the effects of simvastatin on haemostatic variables, lipoproteins and free fatty acids. The Oxford Cholesterol Study Group.

  1997influential reference
• Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

  1997cited by this paper
• Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with Escherichia coli hemolysin: critical dependence on exogenous free fatty acid supply.

  1997cited by this paper
• Hypertriglyceridemia and its metabolic consequences as a risk factor for atherosclerotic cardiovascular disease in non-insulin-dependent diabetes mellitus.

  1996cited by this paper
• Immunological evidence for the expression of the Fas antigen in the infant and adult human ovary during follicular regression and atresia.

  1996cited by this paper
• Does Leptin Contribute to Diabetes Caused by Obesity?

  1996cited by this paper
• Selective inhibition of inducible nitric oxide synthase by aminoguanidine.

  1996cited by this paper
• Modulation of Insulin Activities by Leptin

  1996cited by this paper
• Acylglycerol Recycling from Triacylglycerol to Phospholipid, Not Lipase Activity, Is Defective in Neutral Lipid Storage Disease Fibroblasts*

  1996cited by this paper
• Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals.

  1995cited by this paper
• Fas antigen-mediated apoptosis in human granulosa/luteal cells.

  1995cited by this paper
• Skeletal muscle membrane lipid composition is related to adiposity and insulin action.

  1995cited by this paper
• Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.

  1995cited by this paper
• Physiological Modulation of Plasma Free Fatty Acid Concentrations by Diet: Metabolic implications in nondiabetic subjects

  1995cited by this paper
• Comparison of the Reactivity of Tetradecenoic Acids, a Triacsin, and Unsaturated Oximes with Four Purified Saccharomyces cerevisiae Fatty Acid Activation Proteins (*)

  1995cited by this paper
• Postprandial lipid and hormone responses to meals of varying fat contents: modulatory role of lipoprotein lipase?

  1995cited by this paper
• Involvement of p53 expression in cAMP-mediated apoptosis in immortalized granulosa cells.

  1995cited by this paper
• Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes

  1995cited by this paper
• Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT).

  1994cited by this paper
• Modulation of Human Granulosa Cell Steroid Production In Vitro by Tumor Necrosis Factor Alpha: Implications of White Blood Cells in Culture

  1994cited by this paper
• Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

  1994cited by this paper
• Kinetics of free fatty acids in hypertriglyceridemia. Evidence for different types of insulin resistance.

  1993cited by this paper
• Kinetics of Free Fatty Acids in Hypertriglyceridemia

  1993cited by this paper
• Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

  1993cited by this paper
• Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

  1993cited by this paper
• Selective inhibition of the inducible nitric oxide synthase by aminoguanidine.

  1993cited by this paper
• pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids.

  1992cited by this paper
• Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.

  1989cited by this paper
• Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

  1988influential reference
• Postprandial hyperinsulinemia in patients with mild essential hypertension.

  1985cited by this paper
• Altered androstenedione and estrone dynamics associated with abnormal hormonal profiles in amenorrheic subjects with weight loss or obesity.

  1985cited by this paper
• Endocrine comparison of obese menstruating and amenorrheic women.

  1984cited by this paper
• Effect of fatty acids on glucose production and utilization in man.

  1983cited by this paper
• Glucose and free fatty acid turnover in normal subjects and in diabetic patients before and after insulin treatment

  1979cited by this paper
• Secondary amenorrhea in obesity: etiologic role of weight-related androgen excess.

  1978cited by this paper
• Prostaglandins: members of a new hormonal system. These physiologically very potent compounds of ubiquitous occurrence are formed from essential fatty acids.

  1967cited by this paper

• Unsaturated Fatty Acids Are Required for Germline Proliferation and Membrane Structural Integrity in Caenorhabditis elegans

  2025cites this paper
• Acanthus spinosus L.: In Vitro Antimicrobial Activity, Fixed Oil Amount, Mineral Element Analysis, and Fatty Acid Composition (Kireç Plateau/ Kahramanmaraş)

  2025cites this paper
• Review of Biological Activities of Some Rare Oils from Amazonian Plants

  2025cites this paper
• Comparative Transcriptomic and Metabolomic Profiling of Ovaries from Two Pig Breeds with Contrasting Reproductive Phenotype

  2025cites this paper
• Metabolic and endocrinologic interplay in the peri-ovulatory follicle to support the cumulus-oocyte-complex towards full competence

  2025cites this paper
• Increased palmitic acid levels in the folicular fluid of PCOS patients might lead to GSDMD palmitoylation-mediated pyroptotic death of granulosa cells, possibly contributing to low grade chronic inflammation in the ovary.

  2025cites this paper
• Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women

  2025cites this paper
• Unraveling the mechanisms of ovulatory failure in dairy cows: The role of lipid metabolism.

  2025cites this paper
• Functional MTTP and apoB for VLDL secretion in chicken ovaries support small follicle development under heat stress.

  2025cites this paper
• PDK4 is critical for metabolic regulation and progesterone production in bovine granulosa cells.

  2025cites this paper
• Follicular Biochemical Characterization and Fatty Acid Metabolic Signatures of Follicles During Ovulation Process Reveal the Potential Mechanism for Ovarian Cyst Formation in Sows

  2025cites this paper
• Mouse serum facilitates the expansion of the follicular cavity regardless of the estrous cycle phase

  2025cites this paper
• Acute and long-term transcriptomic responses of granulosa cells to obesogenic diet and concomitant effects on oocyte quality: insight from an outbred mouse model

  2025cites this paper
• Palmitic acid-induced insulin resistance triggers granulosa cell senescence by disruption of the UPRmt/mitophagy/lysosome axis.

  2025cites this paper
• Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome.

  2025cites this paper
• Follicular fluid lipid profile assessment using MALDI mass spectrometry

  2025cites this paper
• Unsaturated Fatty Acids Are Required for Germline Proliferation and Membrane Structural Integrity in Caenorhabditis elegans.

  2025cites this paper
• Rhein attenuates oxidative stress-induced injury in human ovarian granulosa cells by inhibiting the NF-κB-TNF-α/IL-6/PTGS2 inflammatory axis.

  2025cites this paper
• AMPKα alleviates the inhibitory effect of NEFA on the function of bovine follicular granulosa cells cultured in vitro.

  2025cites this paper
• The predictive value of the metabolic score for insulin resistance for metabolism-related disorders and fertility outcomes in Chinese women with polycystic ovary syndrome

  2025cites this paper
• 6-Gingerol and Astaxanthin Mitigate the Effects of Stearic Acid in Pig Oocyte Maturation.

  2024cites this paper
• The Effects of Oleic Acid and Palmitic Acid on Porcine Muscle Satellite Cells

  2024cites this paper
• Anticancer Activity of Rice Callus Suspension Cultures from Aromatic Varieties and Metabolite Regulated in Treated Cancer Cell Lines

  2024cites this paper
• Fumonisin B1 protects against long-chained polyunsaturated fatty acid-induced cell death in HepG2 cells - implications for cancer promotion.

  2024cites this paper
• Disturbed Follicular Microenvironment in Polycystic Ovary Syndrome: Relationship to Oocyte Quality and Infertility.

  2024cites this paper
• Bridging lipid metabolism and mitochondrial genome maintenance

  2024cites this paper
• Death and the desaturase: implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis.

  2024cites this paper
• Obesity-Related Hypogonadism in Women

  2023cites this paper
• NLRP3 Inflammasome-dependent Pathway is Involved in the Pathogenesis of Polycystic Ovary Syndrome

  2023cites this paper
• Mechanism of Guilu Erxian ointment based on targeted metabolomics in intervening in vitro fertilization and embryo transfer outcome in older patients with poor ovarian response of kidney-qi deficiency type

  2023cites this paper
• Effect of High Fat Diet on Disease Development of Polycystic Ovary Syndrome and Lifestyle Intervention Strategies

  2023cites this paper
• The Imitation of the Ovarian Fatty Acid Profile of Superfertile Dummerstorf Mouse Lines during IVM of Control Line Oocytes Could Influence Their Maturation Rates

  2023cites this paper
• Seasonal Variations in the Lipid Profile of the Ovarian Follicle in Italian Mediterranean Buffaloes

  2022cites this paper
• High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

  2022cites this paper
• Metabolism of fatty acids in follicular cells, oocytes, and blastocysts

  2022cites this paper
• Integrated Transcriptome and Metabolome Analysis Reveals the Regulatory Mechanisms of FASN in Geese Granulosa Cells

  2022cites this paper
• Lipid metabolism and endometrial receptivity.

  2022cites this paper
• Follicular fluid lipidomic profiling reveals potential biomarkers of polycystic ovary syndrome: A pilot study

  2022cites this paper
• Fatty Acid Supplementation During in vitro Embryo Production Determines Cryosurvival Characteristics of Bovine Blastocysts

  2022cites this paper
• Changes in intracapsular fluid nutritional composition during the early development of the marine gastropod Hemifusus tuba Gmelin

  2022cites this paper
• Exposure to non-esterified fatty acids in vitro results in changes in the ovarian and follicular environment in cattle.

  2022cites this paper
• Dysregulated sphingolipid metabolism and autophagy in granulosa cells of women with endometriosis

  2022cites this paper
• Estradiol production of granulosa cells is unaffected by the physiological mix of nonesterified fatty acids in follicular fluid

  2022cites this paper
• Metabolic and antioxidant status during transition is associated with changes in the granulosa cell transcriptome in the preovulatory follicle in high-producing dairy cows at the time of breeding.

  2022cites this paper
• Apoptosis Induction through MAPK Signaling Pathway in LoVo Cells by Fatty Acid Fraction from Rice Bran Oil

  2021cites this paper
• Cocultured porcine granulosa cells respond to excess non-esterified fatty acids during in vitro maturation

  2021cites this paper
• Genome wide effects of oleic acid on cultured bovine granulosa cells: evidence for the activation of pathways favoring folliculo-luteal transition

  2021cites this paper
• Cardiometabolic impacts of saturated fatty acids: are they all comparable?

  2021cites this paper
• Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin

  2021cites this paper
• TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids

  2021cites this paper
• Estudo Etnobotânico, Médico, Terapêutico e Farmacológico de Carapa guianensis Aublet – uma Revisão

  2021cites this paper
• Altered VDAC-HK association and apoptosis in mouse peripheral blood lymphocytes exposed to diabetic condition: an in vitro and in vivo study

  2021cites this paper
• Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy

  2021cites this paper
• Integration of transcriptomics and non-targeted metabolomics reveals the underlying mechanism of follicular atresia in Chinese buffalo.

  2021cites this paper
• Therapeutical and Pharmacological Study of Carapa guianensis Aublet – a Review

  2021cites this paper
• Melatonin alleviates insulin resistance through the PI3K/AKT signaling pathway in ovary granulosa cells of polycystic ovary syndrome.

  2021cites this paper
• A novel p.K116Q SNP in the OLR1 gene and its relation to fecundity in Awassi ewes.

  2021cites this paper
• Bioactive Molecules From Native Mexican Avocado Fruit (Persea americana var. drymifolia): A Review

  2021cites this paper
• Necroptosis and apoptosis in the primate ovary

  2020cites this paper
• Andiroba oil (Carapa guianensis Aubl) shows cytotoxicity but no mutagenicity in the ACPP02 gastric cancer cell line

  2020cites this paper
• Chemical Composition, Antibacterial and Cytotoxic Activities of the Essential Oil from Ficus tikoua Bur.

  2020cites this paper
• Identification of the Perturbed Metabolic Pathways Associating With Renal Fibrosis and Evaluating Metabolome Changes of Pretreatment With Astragalus polysaccharide Through Liquid Chromatography Quadrupole Time-Of-Flight Mass Spectrometry

  2020cites this paper
• Intrafollicular injection of nonesterified fatty acids impaired dominant follicle growth in cattle.

  2020cites this paper
• Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity

  2020cites this paper
• Cytotoxic of ethanol extract & n-hexane fraction of solo black garlic (Allium sativum L.) to breast cancer cell line T47D

  2020cites this paper
• Analysis of the fatty acids from Ferula elaeochytris root extract by GC/FID

  2020cites this paper
• Why male modern contraception?

  2020cites this paper
• Non-esterified fatty acids in the ovary: friends or foes?

  2020cites this paper
• Exploration of the effects of goose TCs on GCs at different follicular stages using a co-culture model

  2020cites this paper
• Rosiglitazone ameliorates palmitic acid-induced endoplasmic reticulum stress and steroidogenic capacity in granulosa cells.

  2020cites this paper
• Lipid droplets in granulosa cells are correlated with reduced pregnancy rates

  2020cites this paper
• Vigilin interacts with ER-β to protect against palmitic acid-induced granulosa cells apoptosis via inhibiting calcineurin-mediated Drp1 signaling pathway.

  2020cites this paper
• Chloroform fraction of Chaetomorpha brachygona, a marine green alga from Indian Sundarbans inducing autophagy in cervical cancer cells in vitro

  2020cites this paper
• Journal of Reproduction and Development

  2020cites this paper
• FASN-Mediated Lipid Metabolism Regulates Goose Granulosa Cells Apoptosis and Steroidogenesis

  2020cites this paper
• GC/FID ile ekstrakte edilen Ferula elaeochytris kök ekstresinden yağ asidlerinin analizi

  2020cites this paper
• Proteomics and metabolomics in cow fertility: a systematic review.

  2020cites this paper
• Chemical Composition and In-vitro Antioxidant Activity of Pleurospermum angelicoides Collected from Western Himalayan Region

  2020cites this paper
• Nutrient requirements in Hanwoo cows with artificial insemination: effects on blood metabolites and embryo recovery rate

  2020cites this paper
• Distinguish fatty acids impact survival, differentiation and cellular function of periodontal ligament fibroblasts

  2020cites this paper
• The Effects of FAR1 and TGFBRAP1 on the Proliferation and Apoptosis of Follicular Granulosa Cells in Goose (Anser cygnoides).

  2020cites this paper
• Fatty acids of follicular fluid phospholipids and triglycerides display distinct association with IVF outcomes.

  2020cites this paper
• Adverse effect of higher waist circumference in assisted reproductive technology outcomes

  2020cites this paper
• Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.

  2019cites this paper
• Investigating metabolomics and the effects of oxyresveratrol in experimental Parkinson's disease

  2019cites this paper
• Oleic Acid Attenuates Palmitic Acid-Induced Impairments in Mouse Blastocyst Development

  2019cites this paper
• Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells

  2019cites this paper
• Metabolic Changes in the Blood of Dromedary Camel at Early Post-partum

  2019cites this paper
• Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress

  2019cites this paper
• Identification of bioactive compounds in Lactobacillus paracasei subsp. paracasei NTU 101-fermented reconstituted skimmed milk and their anti-cancer effect in combination with 5-fluorouracil on colorectal cancer cells.

  2019cites this paper
• Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study.

  2019cites this paper
• Impacts of fat mobilization on bovine endometrium function

  2019cites this paper
• An overview on how cumulus cells interact with the oocyte in a condition with elevated NEFA levels in dairy cows.

  2019cites this paper
• Metabonomics analysis of Zi goose follicular granulosa cells using ENO1 gene expression interference.

  2019cites this paper
• Palmitate and Stearate are Increased in the Plasma in a 6-OHDA Model of Parkinson’s Disease

  2019cites this paper
• Stearoyl-coenzyme A desaturase 1 is required for lipid droplet formation in pig embryo

  2019cites this paper
• Characterization of the Intestinal Microbiota and Metabolites of Broiler Breeders with Different Egg Laying Rate

  2019cites this paper
• Arachidonic Acid Regulation of Intracellular Signaling Pathways and Target Gene Expression in Bovine Ovarian Granulosa Cells

  2019cites this paper
• Stearoyl-coenzyme A desaturase 1 is required for lipid droplet formation in pig embryo.

  2019cites this paper
• Antioxidant Studies and GCMS Analysis of the Phytochemical Compounds of Some Endangered Plant Species Collected from the Western Ghats

  2019cites this paper