Retinal Incorporation and Differentiation of Neural Precursors Derived from Human Embryonic Stem Cells

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Stem Cells

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1634/stemcells.2005-0009PMID 16123388
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development.

  2001influential reference
• Identification of 5-HT(3A) and 5-HT(3B) receptor subunits in mammalian retinae: potential pre-synaptic modulators of photoreceptors.

  2001cited by this paper
• The fate of heterotopically grafted neural precursor cells in the normal and dystrophic adult mouse retina.

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  2000cited by this paper
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  1999cited by this paper
• Pax 6: mastering eye morphogenesis and eye evolution.

  1999cited by this paper
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  1999cited by this paper
• Management of hereditary retinal degenerations: present status and future directions.

  1999cited by this paper
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  1999cited by this paper
• The genetic sequence of retinal development in the ciliary margin of the Xenopus eye.

  1998cited by this paper
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  1997cited by this paper
• The Rx homeobox gene is essential for vertebrate eye development

  1997cited by this paper
• Current views on eye development.

  1997cited by this paper
• Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.

  1997influential reference
• Antibodies against Pax6 immunostain amacrine and ganglion cells and neuronal progenitors, but not rod precursors, in the normal and regenerating retina of the goldfish.

  1996cited by this paper
• Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation

  1996cited by this paper
• Cell fate determination in the vertebrate retina.

  1996cited by this paper
• Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.

  1995cited by this paper
• Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.

  1995cited by this paper
• Taurine promotes the differentiation of a vertebrate retinal cell type in vitro.

  1993cited by this paper
• Pax-6, a murine paired box gene, is expressed in the developing CNS.

  1991cited by this paper
• Newborn rat retinal cells transplanted into a retinal lesion site in adult host eyes.

  1986cited by this paper
• Estimation of nuclear population from microtome sections

  1946cited by this paper

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