The potentiation of cardiac inotropic responses to norepinephrine by theophylline.

The inotropic response to norepinephrine by segments of electrically driven rabbit atria was increased in the presence of 2 x 10-4 M to 1 x 10-4 M theophylline. This potentiation, calculated as the ratio of concentrations of norepinephrine inducing the same response, amounted to about 3-fold at 2 x 10-4 M and about 8-fold at 1 x 10-3 M theophylline. Aminophylline gave qualitatively and quantitatively similar results, but caffeine was less effective. The inotropic effects of tyramine also were potentiated by theophylline. Cocaine, in the presence of theophylline, potentiated the effects of norepinephrine while antagonizing those of tyramine. These data are considered to be consistent with the hypothesis that adenosine 3',5'-phosphate is a mediator of the inotropic actions of sympathomimetic amines, and that theophylline potentiates these actions by inhibiting cyclic 3',5'-nucleotide phospho-diesterase.

• Publication year

  1963

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1963-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)26490-4PMID 13990605
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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