Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion

No abstract is available for this paper.

• Publication year

  2007

• Venue

  International Journal of Cancer

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.22596PMID 17290391
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• [Expression of adrenomedullin and its receptor mRNA in the tissues of normal adrenal medulla and pheochromocytoma].

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• Cancer Statistics, 2005

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• [Adrenomedullin antagonist suppresses in vivo proliferation of cancer cells in SCID mice via angiogenesis inhibition].

  2005cited by this paper
• Evaluation of potential Stat3-regulated genes in human breast cancer.

  2005cited by this paper
• [Expression of adrenomedullin in the tissue with laryngeal carcinoma].

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• Angiogenic Effects of Adrenomedullin in Ischemia and Tumor Growth

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• Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: Involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors

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• Adrenomedullin (AM) and AM receptor type 2 expression is up-regulated in prostate carcinomas (PC), and AM stimulates in vitro growth of a PC-derived cell line by enhancing proliferation and decreasing apoptosis rates.

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• Augmented expression of chromogranin A and serotonin in peri-malignant benign prostate epithelium as compared to adenocarcinoma.

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• Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

  2003cited by this paper
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• Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis

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• An Introduction to Pancreatic Adenocarcinoma Genetics, Pathology and Therapy

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• Differential induction of early response genes by adrenomedullin and transforming growth factor-beta1 in human lung cancer cells.

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  2001cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Autocrine/paracrine role of adrenomedullin in cultured endothelial and mesangial cells.

  1998cited by this paper
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  1998cited by this paper
• Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells.

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.

  1991cited by this paper
• Cancer statistics

  1989cited by this paper
• Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

  1989cited by this paper

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  2019cites this paper
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