Crucial Role of ROCK2 in Vascular Smooth Muscle Cells for Hypoxia-Induced Pulmonary Hypertension in Mice

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1161/ATVBAHA.113.301357PMID 24135024
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

  2013influential reference
• Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans.

  2012cited by this paper
• PDGF-Induced Migration of Vascular Smooth Muscle Cells Is Inhibited by Heme Oxygenase-1 Via VEGFR2 Upregulation and Subsequent Assembly of Inactive VEGFR2/PDGFR&bgr; Heterodimers

  2012cited by this paper
• [Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma].

  2011cited by this paper
• Rho-kinase: important new therapeutic target in cardiovascular diseases.

  2011cited by this paper
• Recent progress in the management of pulmonary hypertension.

  2011cited by this paper
• Rho-Associated Kinase Activity, Endothelial Function, and Cardiovascular Risk Factors

  2011cited by this paper
• Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment.

  2011cited by this paper
• Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.

  2011cited by this paper
• Vascular remodeling in pulmonary arterial hypertension: multiple cancer-like pathways and possible treatment modalities.

  2011cited by this paper
• RhoA/ROCK signaling is essential for multiple aspects of VEGF‐mediated angiogenesis

  2010influential reference
• Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

  2010influential reference
• Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

  2010cited by this paper
• Rho Kinase-2 Activation in Human Endothelial Cells Drives Lysophosphatidic Acid-mediated Expression of Cell Adhesion Molecules via NF-κB p65*

  2010influential reference
• Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

  2010cited by this paper
• ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells

  2009influential reference
• Cellular and molecular basis of pulmonary arterial hypertension.

  2009influential reference
• Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

  2009cited by this paper
• Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

  2009cited by this paper
• Rho‐kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion

  2009cited by this paper
• RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.

  2009influential reference
• Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

  2008cited by this paper
• Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

  2008cited by this paper
• Role of smooth muscle cells in the initiation and early progression of atherosclerosis.

  2008cited by this paper
• Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.

  2008cited by this paper
• Molecular pathogenesis of pulmonary arterial hypertension.

  2008influential reference
• ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.

  2008cited by this paper
• Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells

  2008cited by this paper
• In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

  2007cited by this paper
• Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

  2007influential reference
• Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension.

  2007cited by this paper
• ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging

  2007cited by this paper
• The NOX on pulmonary hypertension.

  2007cited by this paper
• Effects of Combined Therapy With a Rho-Kinase Inhibitor and Prostacyclin on Monocrotaline-Induced Pulmonary Hypertension in Rats

  2007cited by this paper
• Development of Rho-kinase inhibitors for cardiovascular medicine.

  2007cited by this paper
• Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration

  2006cited by this paper
• Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.

  2006influential reference
• Long-Term Inhibition of Rho-kinase Ameliorates Hypoxia-Induced Pulmonary Hypertension in Mice

  2006cited by this paper
• Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).

  2006influential reference
• Important Role of Endogenous Erythropoietin System in Recruitment of Endothelial Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension in Mice

  2006cited by this paper
• Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

  2006influential reference
• ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

  2005cited by this paper
• Prednisolone Inhibits Proliferation of Cultured Pulmonary Artery Smooth Muscle Cells of Patients With Idiopathic Pulmonary Arterial Hypertension

  2005cited by this paper
• Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice

  2005cited by this paper
• High‐efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22α‐Cre transgenic mice

  2005cited by this paper
• Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

  2005cited by this paper
• ROCK‐I and ROCK‐II cooperatively regulate closure of eyelid and ventral body wall in mouse embryo

  2005cited by this paper
• Long-Term Treatment With a Rho-Kinase Inhibitor Improves Monocrotaline-Induced Fatal Pulmonary Hypertension in Rats

  2004cited by this paper
• Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer.

  2003cited by this paper
• Role of JNK, p38, and ERK in Platelet-Derived Growth Factor–Induced Vascular Proliferation, Migration, and Gene Expression

  2003cited by this paper
• Targeted Disruption of the Mouse Rho-Associated Kinase 2 Gene Results in Intrauterine Growth Retardation and Fetal Death

  2003cited by this paper
• Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells.

  2003cited by this paper
• The Rho-associated protein kinase p160ROCK is required for centrosome positioning

  2002influential reference
• Rho kinases play an obligatory role in vertebrate embryonic organogenesis.

  2001influential reference
• Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways.

  2001cited by this paper
• Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

  2001cited by this paper
• Tumor necrosis factor-alpha activates smooth muscle cell migration in culture and is expressed in the balloon-injured rat aorta.

  1997cited by this paper
• ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

  1996cited by this paper
• Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features.

  1979influential reference

• Differential effects of traditional cigarette, electronic cigarette, and tobacco heating product on human vascular smooth muscle cell phenotypic switch: A comparative functional perspective.

  2025cites this paper
• Integrated Transcriptomic and Metabolomic Analysis of Rat PASMCs Reveals the Underlying Mechanism for Pulmonary Arterial Hypertension.

  2025cites this paper
• Endothelial Rho kinase controls blood vessel integrity and angiogenesis.

  2025cites this paper
• Rho/ROCK Pathway as a Therapeutic Target in Multiple Diseases

  2025cites this paper
• Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice

  2024cites this paper
• Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats

  2024cites this paper
• Effect of fasudil on clinical outcomes of pulmonary hypertension: a systematic review and meta-analysis

  2024cites this paper
• Rock2 heterozygosity improves recognition memory and endothelial function in a mouse model of 16p11.2 deletion autism syndrome.

  2024cites this paper
• SOX17 Prevents Endothelial-Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling.

  2024cites this paper
• Endothelial Rho kinase controls blood vessel integrity and angiogenesis

  2024cites this paper
• Paving the ROCKy Path to Novel Antifibrotics

  2024cites this paper
• Hydrogen sulfide-mediated inhibition of ROCK2 exerts a vasoprotective effecton ischemic brain injury.

  2024cites this paper
• Therapeutic potential of natural alkaloid emetine against emerging COVID-19 and future viral pandemics

  2024cites this paper
• Myosin light chain phosphatase is a downstream target of Rho-kinase in endothelin-1-induced transactivation of the TGF-β receptor

  2024cites this paper
• Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission.

  2023cites this paper
• Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1.

  2023cites this paper
• Mechanisms of Coronary Artery Spasm

  2023cites this paper
• Sex-Specific Acute Cerebrovascular Responses to Photothrombotic Stroke in Mice

  2023cites this paper
• Identification of immune‐associated signatures and potential therapeutic targets for pulmonary arterial hypertension

  2023cites this paper
• T18/S19 diphosphorylation of myosin regulatory light chain impairs pulmonary artery relaxation in monocrotaline-induced pulmonary hypertensive rats

  2023cites this paper
• Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.

  2023cites this paper
• Vascular Mechanotransduction.

  2023cites this paper
• Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling

  2022cites this paper
• Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells

  2022cites this paper
• Different Aspects of Emetine’s Capabilities as a Highly Potent SARS-CoV-2 Inhibitor against COVID-19

  2022cites this paper
• BMAL1 modulates smooth muscle cells phenotypic switch towards fibroblast-like cells and stabilizes atherosclerotic plaques by upregulating YAP1.

  2022cites this paper
• Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice.

  2022cites this paper
• Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis.

  2022cites this paper
• ROCK Inhibition as Potential Target for Treatment of Pulmonary Hypertension

  2021cites this paper
• Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach

  2021cites this paper
• Title Rho signaling research: history, current status and future directions

  2021cites this paper
• Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension

  2021cites this paper
• Drug discovery focused on novel pathogenic proteins for pulmonary arterial hypertension.

  2021cites this paper
• Genetic Delivery and Gene Therapy in Pulmonary Hypertension

  2021cites this paper
• Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension

  2021cites this paper
• Vascular Stiffening Mediated by Rho‐Associated Coiled‐Coil Containing Kinase Isoforms

  2021cites this paper
• Regulation of myosin light-chain phosphorylation and its roles in cardiovascular physiology and pathophysiology

  2021cites this paper
• MicroRNA-145-5p inhibits hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes by targeting ROCK1

  2021cites this paper
• Pathophysiology and Molecular Mechanisms of Coronary Artery Spasm

  2020cites this paper
• Endothelial Dysfunction in Diabetes

  2020cites this paper
• LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension.

  2020cites this paper
• Protective effects of resveratrol and SR1001 on hypoxia-induced pulmonary hypertension in rats

  2020cites this paper
• Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

  2020cites this paper
• Development of Novel Therapies for Pulmonary Hypertension by Clinical Application of Basic Research

  2020cites this paper
• Cellular Pathways Promoting Pulmonary Vascular Remodeling by Hypoxia.

  2020cites this paper
• 3,4-dihydroxyacetophenone inhibits hypoxia-associated human pulmonary artery smooth muscle cell proliferation by reducing Ca2+ influx.

  2020cites this paper
• KD025 Shifts Pulmonary Endothelial Cell Bioenergetics and Decreases Baseline Lung Permeability.

  2020cites this paper
• Treadmill exercise prevents reduction of bone mineral density after myocardial infarction in apolipoprotein E-deficient mice

  2020cites this paper
• HDAC5 inhibition reduces angiotensin II-induced vascular contraction, hypertrophy, and oxidative stress in a mouse model.

  2020cites this paper
• The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension.

  2020cites this paper
• The Physiology, Pathology, and Therapeutic Interventions for ROCK Isoforms in Diabetic Kidney Disease

  2020cites this paper
• Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy

  2019cites this paper
• Pulmonary arterial hypertension associated with protein kinase inhibitors: a pharmacovigilance–pharmacodynamic study

  2019cites this paper
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  2019cites this paper
• Valsartan inhibits RhoA-ROCK2-MYL pathway in rat model of alcoholic cardiomyopathy

  2019cites this paper
• ROCK-2-selective targeting and its therapeutic outcomes.

  2019cites this paper
• Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells

  2018influential citation
• Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target

  2018cites this paper
• Rho signaling research: history, current status and future directions

  2018cites this paper
• Recent Advances in the Development of Cardiovascular Biomarkers

  2018influential citation
• Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension

  2018cites this paper
• Hypoxia-induced changes in plasma micro-RNAs correlate with pulmonary artery pressure at high altitude.

  2018cites this paper
• The level of ROCK1 and ROCK2 in patients with pulmonary hypertension in plateau area

  2018cites this paper
• Mechanobiological Feedback in Pulmonary Vascular Disease

  2018cites this paper
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  2018cites this paper
• Deletion of long noncoding RNA EFNA3 aggravates hypoxia‐induced injury in PC‐12 cells by upregulation of miR‐101a

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats.

  2017cites this paper
• Effects of fasudil on pulmonary hypertension in clinical practice.

  2017cites this paper
• Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target

  2017influential citation
• Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research.

  2017cites this paper
• Rho-Kinase as a Therapeutic Target for Pulmonary Hypertension

  2017cites this paper
• Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.

  2017cites this paper
• Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension

  2016cites this paper
• Rho Kinases in Autoimmune Diseases.

  2016cites this paper
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  2016cites this paper
• Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction.

  2016cites this paper
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  2016cites this paper
• Novel Therapeutic Targets of Pulmonary Hypertension

  2016cites this paper
• RhoA/Rho-Kinase in the Cardiovascular System.

  2016influential citation
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  2016cites this paper
• Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice.

  2016cites this paper
• Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways.

  2016cites this paper
• Reactive Oxygen Species in the Cardiovascular System

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• High glucose activates Raw264.7 macrophages through RhoA kinase-mediated signaling pathway.

  2015cites this paper
• Cyclophilin A in cardiovascular homeostasis and diseases.

  2015cites this paper
• Light and Dark of Reactive Oxygen Species for Vascular Function: 2014 ASVB (Asian Society of Vascular Biology)

  2015cites this paper