Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Virology

• Publication date

  1995-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.69.11.6687-6696.1995PMID 7474078PMCID PMC189578
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

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• CD26 antigen and HIV fusion?

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• Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses

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• Genetic analysis of the human immunodeficiency virus type 1 integrase protein

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• Human immunodeficiency virus type 1 virions composed of unprocessed Gag and Gag-Pol precursors are capable of reverse transcribing viral genomic RNA

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• Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.

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• Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations

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• Identification of discrete functional domains of HIV‐1 integrase and their organization within an active multimeric complex.

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• Integration is essential for efficient gene expression of human immunodeficiency virus type 1

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• Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae

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• Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

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• The N-terminal region of HIV-1 integrase is required for integration activity, but not for DNA-binding.

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• Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.

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• Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro.

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• Integration is not necessary for expression of human immunodeficiency virus type 1 protein products

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• Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting

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• Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence.

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• A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.

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• Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection.

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• Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication

  2025cites this paper
• [Integrase and reversetranscriptase: New insights into the HIV genome replication system in line.]

  2023cites this paper
• Integrase inhibitors: current protagonists in antiretroviral therapy.

  2023cites this paper
• Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase

  2022cites this paper
• Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA

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• Multimodal Functionalities of HIV-1 Integrase

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• Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M.

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• Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

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• Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication

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• N-terminally truncated POM121C inhibits HIV-1 replication

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• Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection.

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• Characterization of the single cycle replication of HIV-1 expressing Gaussia luciferase in human PBMCs, macrophages, and in CD4(+) T cell-grafted nude mouse.

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• Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase

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  2015cites this paper
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  2012cites this paper
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