Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-10-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1208074PMID 15489916
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation

  2004cited by this paper
• Enrichment of Lck in Lipid Rafts Regulates Colocalized Fyn Activation and the Initiation of Proximal Signals through TCRαβ1

  2004cited by this paper
• Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

  2004cited by this paper
• The influence of the src‐family kinases, Lck and Fyn, on T cell differentiation, survival and activation

  2003cited by this paper
• Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

  2003cited by this paper
• Location is everything: lipid rafts and immune cell signaling.

  2003cited by this paper
• Transmembrane adapters: attractants for cytoplasmic effectors

  2003cited by this paper
• Low Activation Threshold As a Mechanism for Ligand-Independent Signaling in Pre-T Cells 1

  2003cited by this paper
• Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

  2003cited by this paper
• CD45: a critical regulator of signaling thresholds in immune cells.

  2003cited by this paper
• LAT links the pre-BCR to calcium signaling.

  2003cited by this paper
• Phosphorylation-Dependent Regulation of T-Cell Activation by PAG/Cbp, a Lipid Raft-Associated Transmembrane Adaptor

  2003cited by this paper
• Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts

  2003cited by this paper
• Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

  2003cited by this paper
• A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8

  2003cited by this paper
• The formation and functions of the 21‐ and 23‐kDa tyrosine‐phosphorylated TCR ζ subunits

  2003cited by this paper
• TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells1

  2002cited by this paper
• Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

  2002cited by this paper
• Maintaining the norm: T-cell homeostasis

  2002cited by this paper
• T-cell development and the CD4–CD8 lineage decision

  2002cited by this paper
• Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

  2002cited by this paper
• Lineage plasticity and commitment in T‐cell development

  2002cited by this paper
• New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision.

  2002cited by this paper
• TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells1

  2002cited by this paper
• Release from Tonic Inhibition of T Cell Activation through Transient Displacement of C-terminal Src Kinase (Csk) from Lipid Rafts*

  2001cited by this paper
• Positive and Negative Selection of Thymocytes Depends on Lck Interaction with the CD4 and CD8 Coreceptors1

  2001influential reference
• Autonomous Maturation of α/β T Lineage Cells in the Absence of Cooh-Terminal Src Kinase (Csk)

  2001cited by this paper
• Proximal protein tyrosine kinases in immunoreceptor signaling.

  2001cited by this paper
• Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.

  2000cited by this paper
• Lck Domains Differentially Contribute to Pre–T Cell Receptor (Tcr)–And TCR-α/β–Regulated Developmental Transitions

  2000cited by this paper
• An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.

  2000cited by this paper
• Tyrosine kinase SYK: essential functions for immunoreceptor signalling.

  2000cited by this paper
• Branching out to gain control: how the pre-TCR is linked to multiple functions.

  2000cited by this paper
• Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

  2000cited by this paper
• Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes.

  2000cited by this paper
• Long-term survival but impaired homeostatic proliferation of Naïve T cells in the absence of p56lck.

  2000cited by this paper
• Lck activity controls CD4/CD8 T cell lineage commitment.

  2000cited by this paper
• Different initiation of pre-TCR and gammadeltaTCR signalling.

  2000cited by this paper
• Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

  2000cited by this paper
• Homeostasis of alpha beta TCR+ T cells.

  2000cited by this paper
• Different initiation of pre-TCR and γδTCR signalling

  2000cited by this paper
• Selection of the T cell repertoire.

  1999cited by this paper
• Crystal structures of c-Src reveal features of its autoinhibitory mechanism.

  1999cited by this paper
• Essential role of LAT in T cell development.

  1999influential reference
• Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts.

  1999cited by this paper
• Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge.

  1998cited by this paper
• Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

  1998influential reference
• Csk controls antigen receptor-mediated development and selection of T-lineage cells

  1998cited by this paper
• The Syk family of protein tyrosine kinases in T‐cell activation and development

  1998cited by this paper
• Cross-lineage expression of Ig-beta (B29) in thymocytes: positive and negative gene regulation to establish T cell identity.

  1998cited by this paper
• Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.

  1997cited by this paper
• Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

  1997cited by this paper
• Replacement of Pre-T Cell Receptor Signaling Functions by the CD4 Coreceptor

  1997cited by this paper
• Structures of Src-family tyrosine kinases.

  1997cited by this paper
• Cellular functions regulated by Src family kinases.

  1997cited by this paper
• CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

  1996cited by this paper
• alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.

  1996cited by this paper
• Early T lymphocyte progenitors.

  1996cited by this paper
• Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

  1996cited by this paper
• Requirement for p56lck tyrosine kinase activation in T cell receptor- mediated thymic selection

  1996cited by this paper
• Fyn can partially substitute for Lck in T lymphocyte development.

  1996cited by this paper
• p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.

  1996cited by this paper
• MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span.

  1996cited by this paper
• αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

  1996cited by this paper
• Receptors and signals in early thymic selection.

  1995cited by this paper
• Genetic and biochemical studies of protein N-myristoylation.

  1994cited by this paper
• Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif.

  1994cited by this paper
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

  1994cited by this paper
• Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes

  1994cited by this paper
• An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

  1994cited by this paper
• Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta

  1993cited by this paper
• Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice.

  1993cited by this paper
• A dominant‐negative transgene defines a role for p56lck in thymopoiesis.

  1993cited by this paper
• Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.

  1993cited by this paper
• Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.

  1992influential reference
• pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells.

  1992cited by this paper
• Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.

  1992cited by this paper
• Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

  1992cited by this paper
• No requirement for p56lck in the antigen-stimulated clonal deletion of thymocytes.

  1992cited by this paper
• Inhibition of T‐cell receptor beta‐chain gene rearrangement by overexpression of the non‐receptor protein tyrosine kinase p56lck.

  1992cited by this paper
• Profound block in thymocyte development in mice lacking p56lck

  1992influential reference
• p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

  1992cited by this paper
• Thymic tumorigenesis induced by overexpression of p56lck.

  1991cited by this paper
• Delayed thymocyte development induced by augmented expression of p56lck

  1991cited by this paper
• Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

  1991cited by this paper
• Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

  1991cited by this paper
• Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.

  1990influential reference
• Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

  1990cited by this paper
• Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

  1989cited by this paper
• Antigen receptor tail clue

  1989cited by this paper
• Molecular Interactions, T‐Cell Subsets and a Role of the CD4/CD8:p56lck Complex in Human T‐Cell Activation

  1989cited by this paper
• Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

  1989cited by this paper
• Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck)

  1988cited by this paper
• The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

  1988cited by this paper
• Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

  1987cited by this paper
• Expression of a molecularly cloned human c-src oncogene by using a replication-competent retroviral vector

  1986cited by this paper

• Interleukin signaling mitigates the inhibitory effects of combined Src/BCR-ABL1 blockade on T-cell activity in Philadelphia chromosome-positive acute lymphoblastic leukemia.

  2026cites this paper
• Elucidating HER2-directed chimeric antigen receptor (CAR) activation mechanism using homology modeling and all-atom molecular dynamics simulation

  2026cites this paper
• Diacylglycerol kinases: Molecular mechanism of cellular and physiological functions.

  2026cites this paper
• The stress-activated kinase p38 mediates non-canonical activation of Src and tyrosine phosphorylation of the adapter protein TAB1.

  2026cites this paper
• The TCR and LCK: foundations for T-cell activation and therapeutic innovation

  2026cites this paper
• Inhibition of head and neck squamous cell carcinoma by Bruton’s tyrosine kinase inhibitor ibrutinib is associated with reduction of immunosuppressive T cells

  2025cites this paper
• Regulation of Adaptive Immunity by Lipid Post-translational Modifications

  2025cites this paper
• The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function

  2025cites this paper
• Transfer learning with multiomics integration and deep neural networks reveals drug resistance mechanisms in cancer

  2025cites this paper
• Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle

  2025cites this paper
• Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus

  2025cites this paper
• Immune Checkpoint Molecules: A Review on Pathways and Immunotherapy Implications

  2025cites this paper
• T-cell receptor therapy in ovarian cancer: concepts and challenges

  2025cites this paper
• PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity

  2025cites this paper
• Developmental epigenetic programming by Tet1/3 determines peripheral CD8 T cell fate

  2025cites this paper
• T cells in cancer: mechanistic insights and therapeutic advances

  2025cites this paper
• Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis

  2025cites this paper
• Long-read single-cell RNA sequencing uncovers cell-type specific transcript regulation in COVID-19

  2025cites this paper
• Recent advances in adoptive cell therapy for cancer immunotherapy

  2025cites this paper
• Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles

  2025cites this paper
• Conformational landscape adaptations enable processive phosphorylation by Src family kinases.

  2025cites this paper
• Advances in targeting protein S-palmitoylation in tumor immunity and therapy

  2025cites this paper
• Zinc-mediated dynamics of CD4/CD8α co-receptors and Lck kinase: implications for zinc homeostasis, immune response, and biotechnological innovations

  2025cites this paper
• Discovery of a Novel Potent and Orally Efficacious PROTAC Degrader of HPK1 for Tumor Immunotherapy.

  2025cites this paper
• CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation

  2024cites this paper
• Redox Regulation of LAT Enhances T Cell-Mediated Inflammation

  2024cites this paper
• T cell receptor signaling and cell immunotherapy

  2024cites this paper
• Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP

  2024cites this paper
• Inhibition of Lck/Fyn kinase activity promotes the differentiation of induced Treg cells through AKT/mTOR pathway.

  2024cites this paper
• Novel components in the nuclear factor-kappa B (NF-κB) signaling pathways of endothelial cells under hyperglycemic-ischemic conditions

  2024influential citation
• CAR-T therapy and targeted treatments: Emerging combination strategies in solid tumors.

  2024cites this paper
• Construction of a pathway-level model for preeclampsia based on gene expression data

  2024cites this paper
• Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus.

  2024cites this paper
• Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation

  2024cites this paper
• Phospho-mimetic CD3ε variants prevent TCR and CAR signaling

  2024cites this paper
• The recent advancement of TCR-T cell therapies for cancer treatment

  2024cites this paper
• Immunologic Factors Associated with Differential Response to Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer

  2024cites this paper
• Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase

  2024cites this paper
• Strategies for the development of metalloimmunotherapies

  2024cites this paper
• Genome-Wide Methylation Profiling of Peripheral T–Cell Lymphomas Identifies TRIP13 as a Critical Driver of Tumor Proliferation and Survival

  2024cites this paper
• Antimicrobial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase

  2024cites this paper
• Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs

  2024cites this paper
• Predicting protein interactions of the kinase Lck critical to T cell modulation.

  2024cites this paper
• Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event

  2024cites this paper
• Deep phosphotyrosine characterisation of primary murine T cells using broad spectrum optimisation of selective triggering

  2024cites this paper
• Genome-wide methylation profiling of Peripheral T-cell lymphomas identifies TRIP13 as a critical driver of tumor proliferation and survival

  2024cites this paper
• A non-invasive nanobody probe for high precision mapping of Lck spatial distribution

  2024cites this paper
• Gene clusters-based pathway enrichment analysis identifies four pan-cancer subtypes with distinct molecular and clinical features

  2024cites this paper
• Siglec cis-ligands and their roles in the immune system.

  2023cites this paper
• Advances in the expression and function of Fyn in different human tumors

  2023cites this paper
• Beyond Corticoresistance, A Paradoxical Corticosensitivity Induced by Corticosteroid Therapy in Pediatric Acute Lymphoblastic Leukemias

  2023cites this paper
• Biomolecular condensates tunes immune signaling at the Host-Pathogen interface.

  2023cites this paper
• A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish

  2023cites this paper
• Co-opting signalling molecules enables logic-gated control of CAR T cells

  2023cites this paper
• TCR Pathway Mutations in Mature T Cell Lymphomas.

  2023cites this paper
• Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression

  2023cites this paper
• A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature

  2023cites this paper
• New insights into the Lck-NF-κB signaling pathway

  2023cites this paper
• Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance

  2023cites this paper
• Palmitoylation in apoptosis

  2023cites this paper
• scDILT: a model-based and constrained deep learning framework for single-cell Data Integration, Label Transferring, and clustering

  2023influential citation
• A Novel Peptide that Disrupts the Lck-IP3R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma

  2023cites this paper
• Impact of senolytic treatment on immunity, aging, and disease

  2023cites this paper
• Identifying Immune-Specific Subtypes of Adrenocortical Carcinoma Based on Immunogenomic Profiling

  2023cites this paper
• Role of RNA Alternative Splicing in T Cell Function and Disease

  2023cites this paper
• Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma

  2023cites this paper
• The Tyrosine Phosphatase Activity of PTPN22 Is Involved in T Cell Development via the Regulation of TCR Expression

  2023cites this paper
• WASP facilitates tumor mechanosensitivity in T lymphocytes

  2023cites this paper
• Harnessing CD3 diversity to optimize CAR T cells

  2023influential citation
• Sarcoidosis-associated pulmonary fibrosis: joining the dots

  2023cites this paper
• Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes

  2023cites this paper
• End-binding protein 1 regulates the metabolic fate of CD4+ T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network

  2023cites this paper
• A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation

  2023influential citation
• Self-programmed dynamics of T cell receptor condensation

  2023cites this paper
• Expression of genes potentially involved in loss of response in patients with Chronic Myeloid Leukemia.

  2023cites this paper
• CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance

  2023cites this paper
• Crosstalk between trace elements and T-cell immunity during early-life health in pigs

  2023cites this paper
• Ectopic ATP synthase stimulates the secretion of extracellular vesicles in cancer cells

  2023cites this paper
• STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses.

  2023cites this paper
• Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK

  2023influential citation
• Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)

  2022cites this paper
• Combination therapies to inhibit LCK tyrosine kinase and mTOR signaling in T-cell Acute Lymphoblastic Leukemia.

  2022cites this paper
• Mouse primary T cell phosphotyrosine proteomics enabled by BOOST

  2022cites this paper
• Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans

  2022cites this paper
• BCR::ABL1 tyrosine kinase inhibitors hamper the therapeutic efficacy of blinatumomab in vitro

  2022cites this paper
• Tet2 coordinates with Foxo1 and Runx1 to balance T follicular helper cell and T helper 1 cell differentiation

  2022cites this paper
• Identification of RCC1–LCK as a novel fusion gene in pediatric erythroid sarcoma

  2022cites this paper
• Immune checkpoint proteins: Signaling mechanisms and molecular interactions in cancer immunotherapy.

  2022cites this paper
• Advances in CD247

  2022cites this paper
• Impact of Manufacturing Procedures on CAR T Cell Functionality

  2022cites this paper
• Machine Learning using Genetic and Clinical Data Identifies a Signature that Robustly Predicts Methotrexate Response in Rheumatoid Arthritis.

  2022cites this paper
• A discovery pipeline for identification and in vivo validation of drugs that alter T cell/ dendritic cell interaction

  2022cites this paper
• STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals

  2022cites this paper
• Vitiligo: Etiological Study

  2022cites this paper
• Hamster polyomavirus-associated T-cell lymphomas in Syrian hamsters (Mesocricetus auratus)

  2022cites this paper
• Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs

  2022cites this paper
• Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia

  2022cites this paper
• Субпопуляционный состав лимфоцитов периферической крови при COVID-19

  2022cites this paper
• Integrated analysis and exploration of potential shared gene signatures between carotid atherosclerosis and periodontitis

  2022cites this paper
• Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways

  2022cites this paper