The Regulation of Murine Lupus a

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  1997-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1749-6632.1997.tb52055.xPMID 9186650
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pathogenesis of autoimmunity in αβ T cell‐deficient lupus‐prone mice

  1998cited by this paper
• Propagation and regulation of systemic autoimmunity by gammadelta T cells.

  1996cited by this paper
• Depletion of gamma/delta T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis.

  1996cited by this paper
• The expanding universe of T-cell subsets: Th1, Th2 and more.

  1996cited by this paper
• Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand

  1996cited by this paper
• Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease

  1996cited by this paper
• The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance.

  1996cited by this paper
• Murine lupus in the absence of alpha beta T cells.

  1996cited by this paper
• The role of NK cells during in vivo antigen-specific antibody responses.

  1996cited by this paper
• Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease

  1996cited by this paper
• Murine lupus in the absence of αβ T cells

  1996cited by this paper
• B cells solicit their own help from T cells

  1996cited by this paper
• Depletion of γ/δ T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis

  1996cited by this paper
• Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.

  1995cited by this paper
• B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice.

  1995cited by this paper
• gamma/delta T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes

  1995cited by this paper
• Functional analysis of the TCR alpha- beta+ cells that accumulate in the pneumonic lung of influenza virus-infected TCR-alpha-/- mice.

  1995cited by this paper
• Issues concerning the nature of antigen recognition by alpha beta and gamma delta T-cell receptors.

  1995cited by this paper
• Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

  1995cited by this paper
• Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo.

  1995cited by this paper
• Lupus: key pathogenic mechanisms and contributing factors.

  1995cited by this paper
• Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

  1995cited by this paper
• CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

  1995cited by this paper
• The origin of CD4−CD8−TCRαβ+ thymocytes: a model based on T-cell receptor avidity

  1995cited by this paper
• T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus

  1995cited by this paper
• Issues concerning the nature of antigen recognition by αβ and γδ T-cell receptors

  1995cited by this paper
• Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway.

  1995cited by this paper
• Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice.

  1995cited by this paper
• Activated human NK cells can stimulate resting B cells to secrete immunoglobulin.

  1995cited by this paper
• Inquiry into Murine and Human Lupus

  1995cited by this paper
• Complement-immunoglobulin interactions.

  1995cited by this paper
• The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity.

  1995cited by this paper
• Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus

  1995cited by this paper
• Fas-mediated cytotoxicity by freshly isolated natural killer cells

  1995cited by this paper
• Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells

  1995cited by this paper
• Macrophages, but not dendritic cells, present collagen to T cells

  1995cited by this paper
• The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice.

  1994cited by this paper
• Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

  1994cited by this paper
• Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria.

  1994cited by this paper
• Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells.

  1994cited by this paper
• Prevention of nephritis in major histocompatibility complex class II- deficient MRL-lpr mice

  1994cited by this paper
• T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted.

  1994cited by this paper
• Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in alpha beta(+) T cells.

  1994cited by this paper
• T cell receptor alpha-chain repertoire of pathogenic autoantibody-inducing T cells in lupus mice.

  1994cited by this paper
• The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.

  1994cited by this paper
• Exacerbation of established collagen-induced arthritis in mice treated with an anti-T cell receptor antibody.

  1994cited by this paper
• The role of B cells in lpr/lpr-induced autoimmunity

  1994cited by this paper
• Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

  1994cited by this paper
• T cell-independent and T cell-dependent B cell activation increases IFN-gamma R expression and renders B cells sensitive to IFN-gamma-mediated inhibition.

  1994cited by this paper
• Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.

  1994cited by this paper
• Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

  1993cited by this paper
• The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms

  1993cited by this paper
• V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.

  1993cited by this paper
• Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus

  1993cited by this paper
• Natural killer cells induce activated murine B cells to secrete Ig.

  1993cited by this paper
• Role of gamma delta T cells in murine collagen-induced arthritis.

  1993cited by this paper
• Selection of the T cell receptor repertoire in Lpr mice.

  1993cited by this paper
• MRL mice produce anti-Su autoantibody, a specificity associated with systemic lupus erythematosus.

  1993cited by this paper
• Generation and characterization of cloned T helper cell lines for anti-DNA responses in NZB.H-2bm12 mice.

  1992cited by this paper
• Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help

  1992cited by this paper
• Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

  1992cited by this paper
• IL-2 and a contact-mediated signal provided by TCR alpha beta + or TCR gamma delta + CD4+ T cells induce polyclonal Ig production by committed human B cells. Enhancement by IL-5, specific inhibition of IgA synthesis by IL-4.

  1992cited by this paper
• Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites.

  1992cited by this paper
• Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens.

  1991cited by this paper
• B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras.

  1991cited by this paper
• An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity

  1991cited by this paper
• T cell receptor Vβ genes expressed by IgG anti‐DNA autoantibody‐inducing T cells in lupus nephritis: Forbidden receptors and double‐negative T cells

  1990cited by this paper
• Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor.

  1990cited by this paper
• Detection of circulating immune complexes in MRL mice with different forms of glomerulonephritis.

  1990cited by this paper
• Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras.

  1990cited by this paper
• Tolerance-related V beta clonal deletions in normal CD4-8-, TCR- alpha/beta + and abnormal lpr and gld cell populations

  1989cited by this paper
• T cell tolerance to self antigens in New Zealand hybrid mice with lupus-like disease.

  1989cited by this paper
• Regulation of B lymphocytes by natural killer cells. Role of IFN-gamma.

  1989cited by this paper
• Specificity and function of T cells bearing gamma delta receptors.

  1988cited by this paper
• [Pathogenesis of spontaneous chronic polyarthritis in MRL mice].

  1988cited by this paper
• The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice

  1988cited by this paper
• Frequency and epitope recognition of anti-ribosome P antibodies from humans with systemic lupus erythematosus and MRL/lpr mice are similar.

  1988cited by this paper
• Specificity and function of T cells bearing γδ receptors

  1988cited by this paper
• The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation

  1988cited by this paper
• Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 murine SLE model.

  1987cited by this paper
• The role of clonal selection and somatic mutation in autoimmunity

  1987cited by this paper
• Sequential study of vasculitis in MRL mice

  1987cited by this paper
• Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

  1987cited by this paper
• Polyreactive autoantibodies are nephritogenic in murine lupus nephritis.

  1987cited by this paper
• Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4.

  1987cited by this paper
• Systemic autoimmune disease arises from polyclonal B cell activation

  1987cited by this paper
• Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis

  1987cited by this paper
• Glomerular lesions in MRL mice. A light and immunofluorescence microscopic study.

  1986cited by this paper
• The lupus autoantigens and the pathogenesis of systemic lupus erythematosus.

  1986cited by this paper
• Role of the Sm antigen in the generation of anti-Sm autoantibodies in the SLE-prone MRL mouse.

  1986cited by this paper
• Murine models of systemic lupus erythematosus.

  1985cited by this paper
• The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice.

  1984cited by this paper
• Induction of various autoantibodies by mutant gene lpr in several strains of mice.

  1984cited by this paper
• Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.

  1983cited by this paper
• Genetic analysis of the inheritance of B cell hyperactivity in relation to the development of autoantibodies and glomerulonephritis in NZB x SWR crosses.

  1983cited by this paper
• Congenic autoimmune murine models of central nervous system diseas in connective tissue disorders

  1983cited by this paper
• Natural killer cell in systemic lupus erythematosus. Defects in effector lytic activity and response to interferon and interferon inducers.

  1983cited by this paper
• Interferon and natural killer cells in systemic lupus erythematosus.

  1982cited by this paper
• Abnormal natural killer cell activity in systemic lupus erythematosus: an intrinsic defect in the lytic event.

  1982cited by this paper
• Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity.

  1982cited by this paper

• B-lymphocyte tolerance and effector function in immunity and autoimmunity

  2013cites this paper
• Genetics of Lupus in Mice

  2011cites this paper
• The MRL/lpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus

  2011cites this paper
• Autoimmune Disease: Animal Models

  2010cites this paper
• An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus.

  2008cites this paper
• Interferon regulatory factor‐1 gene deletion decreases glomerulonephritis in MRL/lpr mice

  2006cites this paper
• Experimental use of murine lupus models.

  2004cites this paper
• 8 – GENES AND GENETICS OF MURINE LUPUS

  2004cites this paper
• Autoimmune Disease: Animal Models

  2001cites this paper
• Prevention of autoimmune hearing loss in MRL/lpr mice by bone marrow transplantation

  2000cites this paper
• Autoreactive T cells in murine lupus

  1999cites this paper
• Antibody deposition in the stria vascularis of the MRL-Fas(lpr) mouse.

  1999cites this paper
• Ultrastructural pathology in the stria vascularis of the MRL-Fasl(lpr) mouse.

  1999cites this paper
• Effects of Immunosuppression on the Development of Cochlear Disease in the MRL‐Faslpr Mouse

  1999cites this paper
• Relevance of systemic lupus erythematosus nephritis animal models to human disease.

  1999cites this paper
• Lessons from Knockout and Transgenic Lupus-Prone Mice

  1999cites this paper
• Perforin protects against autoimmunity in lupus-prone mice.

  1998cites this paper
• Self antigens and epitope spreading in systemic autoimmunity.

  1997cites this paper