An investigation of the innate inflammatory properties of immune stimulating complexes (ISCOMs) and their importance for the generation of adaptive immunity

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Resting B Lymphocytes as APC for Naive T Lymphocytes: Dependence on CD40 Ligand/CD401

  2000cited by this paper
• Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS).

  1999cited by this paper
• Mucosal immunity to influenza without IgA: an IgA knockout mouse model.

  1999cited by this paper
• Regional specialization in the mucosal immune system: what happens in the microcompartments?

  1999cited by this paper
• Human pathogen subversion of antigen presentation

  1999cited by this paper
• Oral tolerance: mechanisms and therapeutic applications.

  1999cited by this paper
• Enhanced immune responses in mice lacking the thromboxane A2 receptor

  1999cited by this paper
• ISCOMs vaccine against experimental leishmaniasis.

  1998cited by this paper
• Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both.

  1998cited by this paper
• Chemokines and the arrest of lymphocytes rolling under flow conditions.

  1998cited by this paper
• Dendritic cells and the control of immunity

  1998cited by this paper
• Chemokines and leukocyte traffic

  1998cited by this paper
• Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

  1998cited by this paper
• The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses.

  1998cited by this paper
• Interleukin-4 and interleukin-13: their similarities and discrepancies.

  1998cited by this paper
• Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

  1998cited by this paper
• Expanding dendritic cells in vivo enhances the induction of oral tolerance.

  1998cited by this paper
• Interleukin-18: a novel cytokine that augments both innate and acquired immunity.

  1998cited by this paper
• Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

  1997cited by this paper
• Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.

  1997cited by this paper
• Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses.

  1997cited by this paper
• CTL generation in the presence of IL-4 is inhibited by free p40: evidence for early and late IL-12 function.

  1997cited by this paper
• Immunization of Macaca mulatta with aroA attenuated Salmonella typhimurium expressing the SIVp27 antigen

  1997cited by this paper
• Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit.

  1997cited by this paper
• The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective up-regulation of B7.2 expression.

  1997cited by this paper
• Origin, maturation and antigen presenting function of dendritic cells.

  1997cited by this paper
• Impaired mast cell-dependent natural immunity in complement C3-deficient mice

  1997cited by this paper
• Effects of carbohydrate modification of Quillaja saponaria Molina QH-B fraction on adjuvant activity, cholesterol-binding capacity and toxicity.

  1997cited by this paper
• In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

  1997cited by this paper
• The Mast Cell: A Versatile Effector Cell for a Challenging World

  1997cited by this paper
• Interleukin-12 and tumor necrosis factor-? levels in cerebrospinal fluid of multiple sclerosis patients

  1997cited by this paper
• Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.

  1996cited by this paper
• Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

  1996cited by this paper
• Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12

  1996cited by this paper
• Oral tolerance to myelin basic protein in mice : suppression of experimental autoimmune encephalomyelitis /

  1996cited by this paper
• Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

  1996cited by this paper
• Mouse NK1.1+ T cells: a new family of T cells.

  1996cited by this paper
• Epithelial M cells: gateways for mucosal infection and immunization.

  1996cited by this paper
• Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.

  1996cited by this paper
• The Instructive Role of Innate Immunity in the Acquired Immune Response

  1996cited by this paper
• Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

  1996cited by this paper
• Saponins as vaccine adjuvants.

  1996cited by this paper
• Studying Immunological Tolerance by Physically Monitoring Antigen‐specific T Cells in Vivo a

  1996cited by this paper
• Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG

  1996cited by this paper
• CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

  1996cited by this paper
• In vitro activation of antigen‐presenting cells (APC) by defined composition of Quillaja saponaria Molina triterpenoids

  1996cited by this paper
• Fluorescent labelling of virus, bacteria and iscoms: in vivo systemic and mucosal localisation patterns.

  1995cited by this paper
• Induction of systemic and mucosal immune responses following immunization with somatostatin-avidin complexes incorporated into ISCOMS.

  1995cited by this paper
• Activation and recruitment of neutrophil leukocytes

  1995cited by this paper
• Altered immune responses in mice lacking inducible nitric oxide synthase

  1995cited by this paper
• Preparation of Immune Stimulating Complexes (ISCOMs) as Adjuvants

  1995cited by this paper
• Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

  1995influential reference
• Interleukin‐12 profoundly up‐regulates the synthesis of antigen‐specific complement‐fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

  1995cited by this paper
• Antigen presentation by naive macrophages, dendritic cells and B cells to primed T lymphocytes and their cytokine production following exposure to immunostimulating complexes

  1995cited by this paper
• The cell biology of CTL killing.

  1995cited by this paper
• Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme.

  1995cited by this paper
• Recombinant bacille Calmette-Guérin priming against measles.

  1995cited by this paper
• Distinct roles of L-selectin and integrins alpha 4 beta 7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined.

  1995cited by this paper
• Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

  1994cited by this paper
• Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

  1994cited by this paper
• Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors.

  1994cited by this paper
• Immune responses and protective effect in mice vaccinated orally with surface sporozoite protein of Eimeria falciformis in ISCOMs.

  1994cited by this paper
• Nitric oxide stimulates Ca(2+)-independent synaptic vesicle release.

  1994cited by this paper
• Inhibition of macrophage Ia expression by nitric oxide.

  1994cited by this paper
• Transepithelial transport of immunoglobulins.

  1994cited by this paper
• Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).

  1994cited by this paper
• The acute phase response.

  1994influential reference
• Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

  1994cited by this paper
• Impaired immune and acute-phase responses in interleukin-6-deficient mice

  1994cited by this paper
• Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.

  1994cited by this paper
• IFN-gamma receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses.

  1994cited by this paper
• Delivery of pseudorabies virus envelope antigens enclosed in immunostimulating complexes (ISCOMs); elicitation of neutralizing antibody and lymphoproliferative responses in swine and protection in mice.

  1994cited by this paper
• Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets.

  1994cited by this paper
• Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

  1993cited by this paper
• Disruption of the murine IL-4 gene blocks Th2 cytokine responses

  1993cited by this paper
• Collectins: pattern recognition molecules involved in first line host defense.

  1993cited by this paper
• Adjuvants--a balance between toxicity and adjuvanticity.

  1993cited by this paper
• Immune-stimulating complexes as adjuvants for inducing local and systemic immunity after oral immunization with protein antigens.

  1993influential reference
• Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.

  1993cited by this paper
• Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization.

  1993cited by this paper
• Antitumor and antimetastatic activity of interleukin 12 against murine tumors

  1993cited by this paper
• Regulation by glutathione of interleukin-4 activity on cytotoxic T cells.

  1992cited by this paper
• A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells.

  1992cited by this paper
• Soluble proteins incorporate into ISCOMs after covalent attachment of fatty acid.

  1992cited by this paper
• Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

  1992cited by this paper
• Antigen processing in the mucosal immune system.

  1992cited by this paper
• The rat c-kit ligand, stem cell factor, induces c-kit receptor- dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function

  1992cited by this paper
• Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin.

  1992cited by this paper
• Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

  1992cited by this paper
• Incorporation of soluble antigens into ISCOMs: HIV gp120 ISCOMs induce virus neutralizing antibodies.

  1992cited by this paper
• The mannose receptor and other macrophage lectins.

  1992cited by this paper
• Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route.

  1991cited by this paper
• Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules

  1991cited by this paper
• Immune response after immunization with an experimental Toxoplasma gondii ISCOM vaccine.

  1991cited by this paper
• The role of T-cell subsets and cytokines in the regulation of infection.

  1991cited by this paper
• Intraepithelial lymphocytes of the intestinal mucosa: curiouser and curiouser.

  1991cited by this paper
• Secretory immune responses in the mouse vagina after parenteral or intravaginal immunization with an immunostimulating complex (ISCOM).

  1991cited by this paper
• Effects of interferon‐gamma and tumour necrosis factor‐alpha on the development of cytotoxic T lymphocytes in autologous mixed lymphocyte tumour cultures with human melanoma

  1991cited by this paper
• Molecular basis of interferon-gamma and lipopolysaccharide enhancement of phagocyte respiratory burst capability. Studies on the gene expression of several NADPH oxidase components.

  1990cited by this paper
• Intestinal γ/δ Receptor-Bearing T Lymphocytes in Celiac Disease and Inflammatory Bowel Diseases in Children. Constant Increase in Celiac Disease

  1990cited by this paper

• No citing papers are available for this paper.