Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting millions of people worldwide. Diabetes is associated with various complications like nephropathy, neuropathy, retinopathy, diabetic foot, cognitive impairment, and many more. Evidence suggests that cognitive dysfunction is a rising complication of diabetes which adversely affects the brain of patients suffering from diabetes. Age‐related memory impairment is a complication having its major effect on people suffering from diabetes and Alzheimer's. Patients suffering from diabetes are at two times higher risk of developing cognitive dysfunction as compared with normal individuals. Multiple factors which are involved in diabetes related complications are found to play a role in the development of neurodegeneration in Alzheimer's. The problem of insulin deficiency and insulin resistance is well reported in diabetes but there are many studies which suggest dysregulation of insulin levels as a reason behind the development of Alzheimer's. As the link between diabetes and Alzheimer disease (AD) is deepening, there is a need to understand the plausible tie‐ins between the two. Emerging role of major factors like insulin imbalance, advanced glycation end products and micro‐RNA's involved in diabetes and Alzheimer's have been discussed here. This review helps in understanding the plausible mechanism underlying the pathophysiology of amyloid beta (Aβ) plaque formation and tau hyperphosphorylation as well provides information about studies carried out in this area of research. The final thought is to enhance the scientific knowledge on this correlation and develop future therapeutics to treat the same.

• Publication year

  2019

• Venue

  Drug development research (Print)

• Publication date

  2019-08-05

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/ddr.21579PMID 31820484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression analysis of inflammatory response-associated genes in coronary artery disease

  2020cited by this paper
• 1786-P: The New Insulin Sensitizer MSDC-0602K Synergizes with the GLP-1 Receptor Agonist Liraglutide

  2020cited by this paper
• Amylin Signaling in Diabetes and Alzheimer's Disease: Therapy or Pathology?

  2019cited by this paper
• The Action of Polyphenols in Diabetes Mellitus and Alzheimer's Disease: A Common Agent for Overlapping Pathologies

  2019cited by this paper
• Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease

  2019cited by this paper
• Zingerone (4-(4-hydroxy-3-methylphenyl)butan-2-one) ameliorates renal function via controlling oxidative burst and inflammation in experimental diabetic nephropathy

  2019cited by this paper
• Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress

  2019cited by this paper
• Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

  2019cited by this paper
• Metformin attenuates diabetes‐induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

  2019cited by this paper
• Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

  2019cited by this paper
• Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease

  2019cited by this paper
• Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer’s Disease

  2019cited by this paper
• Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin‐diabetic mice by sponging microRNA‐221 through upregulation of FOS

  2019cited by this paper
• ε3/4 genotype of the apolipoprotein E is associated with higher risk of Alzheimer's disease in patients with type 2 diabetes mellitus.

  2019cited by this paper
• Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer's Disease.

  2018cited by this paper
• The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations.

  2018cited by this paper
• Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma.

  2018cited by this paper
• Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity

  2018cited by this paper
• A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1.

  2018cited by this paper
• Atrophy in Distributed Networks Predicts Cognition in Alzheimer’s Disease and Type 2 Diabetes

  2018cited by this paper
• Cyanidin-3-O-glucoside ameliorates diabetic nephropathy through regulation of glutathione pool.

  2018cited by this paper
• Rapamycin inhibits activation of AMPK-mTOR signaling pathway-induced Alzheimer’s disease lesion in hippocampus of rats with type 2 diabetes mellitus

  2018cited by this paper
• The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

  2018cited by this paper
• Gene therapy with the angiogenic neuropeptide secretoneurin ameliorates experimental diabetic neuropathy

  2018cited by this paper
• Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure

  2018cited by this paper
• Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus

  2018cited by this paper
• The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease

  2018cited by this paper
• Anti-diabetic vanadyl complexes reduced Alzheimer’s disease pathology independent of amyloid plaque deposition

  2018cited by this paper
• Evaluation of a combination digital retinal camera with spectral-domain optical coherence tomography (SD-OCT) that might be used for the screening of diabetic retinopathy with telemedicine: A pilot study.

  2018cited by this paper
• The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.

  2018cited by this paper
• Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κB pathway

  2018cited by this paper
• Are Tanycytes the Missing Link Between Type 2 Diabetes and Alzheimer’s Disease?

  2018cited by this paper
• Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP‐activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin‐induced mouse model of diabetes

  2018cited by this paper
• Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes.

  2018cited by this paper
• Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

  2018cited by this paper
• Vildagliptin, a DPP4 inhibitor, alleviates diabetes-associated cognitive deficits by decreasing the levels of apoptosis-related proteins in the rat hippocampus.

  2018cited by this paper
• Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats.

  2018cited by this paper
• Thyroid hormone improves insulin signaling and reduces the activation of neurodegenerative pathway in the hippocampus of diabetic adult male rats

  2018cited by this paper
• Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

  2018cited by this paper
• Metformin treatment ameliorates diabetes‐associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

  2018cited by this paper
• [Nicorandil improves cognitive dysfunction in mice with streptozotocin-induced diabetes].

  2018cited by this paper
• cAMP/PKA signaling pathway contributes to neuronal apoptosis via regulating IDE expression in a mixed model of type 2 diabetes and Alzheimer's disease

  2018cited by this paper
• DA5‐CH, a novel GLP‐1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

  2018cited by this paper
• Modelling incremental benefits on complications rates when targeting lower HbA1c levels in people with Type 2 diabetes and cardiovascular disease

  2018cited by this paper
• Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation

  2018cited by this paper
• Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin

  2018cited by this paper
• The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline

  2018cited by this paper
• Gallic acid attenuates type I diabetic nephropathy in rats.

  2018cited by this paper
• Atorvastatin and insulin equally mitigate brain pathology in diabetic rats

  2018cited by this paper
• The beta secretase BACE1 regulates the expression of insulin receptor in the liver

  2018cited by this paper
• Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus

  2018cited by this paper
• Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.

  2018cited by this paper
• IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045.

  2018influential reference
• Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis

  2018cited by this paper
• Global Prevalence of Type 2 Diabetes over the Next Ten Years (2018-2028)

  2018cited by this paper
• Retracted Article: Ligustrazine attenuates renal damage by inhibiting endoplasmic reticulum stress in diabetic nephropathy by inactivating MAPK pathways

  2018cited by this paper
• Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

  2018cited by this paper
• Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis

  2018cited by this paper
• Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy

  2018cited by this paper
• Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria.

  2018cited by this paper
• Lower risk of dementia with pioglitazone, compared with other second-line treatments, in metformin-based dual therapy: a population-based longitudinal study

  2018cited by this paper
• HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing

  2018cited by this paper
• Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome.

  2018cited by this paper
• Comparative Study between the Effect of Pentoxifylline versus Diltiazem versus Rosuvastatin on the Development and Progression of Nephropathy in Streptozotocin Induced Diabetic Rats

  2018cited by this paper
• Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF-κB pathway.

  2018cited by this paper
• Metformin ameliorates learning and memory deficits in streptozotocin-induced diabetic rats

  2018cited by this paper
• Spontaneous recovery of fear differs among early – late adolescent and adult male mice

  2018cited by this paper
• Secreted amyloid precursor protein alpha activates neuronal insulin receptors and prevents diabetes‐induced encephalopathy

  2018cited by this paper
• Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia

  2018cited by this paper
• Probucol prevents blood–brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet

  2018cited by this paper
• Low glucagon-like peptide-1 (GLP-1) concentration in serum is indicative of mild cognitive impairment in type 2 diabetes patients.

  2018influential reference
• Matrix metalloproteinase 14 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

  2018cited by this paper
• Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

  2018cited by this paper
• A curcumin derivative J 147 ameliorates diabetic peripheral neuropathy in streptozotocin ( STZ )-induced DPN rat models through negative regulation AMPK on TRPA

  2018cited by this paper
• Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism.

  2018cited by this paper
• Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice

  2018cited by this paper
• The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

  2018cited by this paper
• The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance.

  2018cited by this paper
• The Research on the Relationship of RAGE, LRP-1, and Aβ Accumulation in the Hippocampus, Prefrontal Lobe, and Amygdala of STZ-Induced Diabetic Rats

  2017cited by this paper
• Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation.

  2017cited by this paper
• The role of melatonin in the onset and progression of type 3 diabetes

  2017cited by this paper
• Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives

  2017cited by this paper
• Insulin resistance and cognitive test performance in elderly adults: National health and nutrition examination survey (NHANES).

  2017cited by this paper
• Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

  2017cited by this paper
• Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease.

  2017cited by this paper
• High Hemoglobin A1c and Diabetes Predict Memory Decline in the Health and Retirement Study

  2017cited by this paper
• The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

  2017cited by this paper
• Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.

  2017cited by this paper
• Dementia‐like pathology in type‐2 diabetes: A novel microRNA mechanism

  2017cited by this paper
• Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway.

  2017cited by this paper
• Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

  2017cited by this paper
• The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction

  2017cited by this paper
• Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease.

  2017cited by this paper
• [The effects of dihydromyricetin on cognitive dysfunction in type 2 diabetes mice].

  2017cited by this paper
• Reduced Gray Matter Volume in Patients with Type 2 Diabetes Mellitus

  2017cited by this paper
• Agmatine ameliorates type 2 diabetes induced‐Alzheimer's disease‐like alterations in high‐fat diet‐fed mice via reactivation of blunted insulin signalling

  2017cited by this paper
• Experimentally induced diabetes worsens neuropathology, but not learning and memory, in middle aged 3xTg mice

  2017cited by this paper
• Plasma Amyloid-β Peptides in Type 2 Diabetes: A Matched Case-Control Study

  2017cited by this paper
• Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway.

  2017cited by this paper
• White Matter Hyperintensity in Elderly Patients with Diabetes Mellitus Is Associated with Cognitive Impairment, Functional Disability, and a High Glycoalbumin/Glycohemoglobin Ratio

  2017cited by this paper

• The Association Between Diabetic Retinopathy Severity and Dementia Risk: A TriNetX Longitudinal Cohort Study.

  2026cites this paper
• Ferroptosis and Alzheimer's disease: a new insight into neurodegeneration.

  2026cites this paper
• Therapeutic potential of Lycium barbarum polysaccharide on diabetes and its associated complications: a narrative review

  2026cites this paper
• The Association Between SLIT2 in Human Vitreous Humor and Plasma and Neurocognitive Test Scores

  2025cites this paper
• Antimony induces mitochondria-dependent and ER stress-triggered apoptosis via the oxidative stress-activated JNK signaling pathway in pancreatic islet β-cells.

  2025cites this paper
• Epidemiology and Risk Factors Characteristics of Alzheimer’s Disease in Southwestern China: A Cross-Sectional Study

  2025cites this paper
• Facial emotion recognition and empathy for pain in patients with type 2 diabetes mellitus.

  2025cites this paper
• 1,2,4-Trimethoxybenzene alleviates cognitive dysfunction in type 2 diabetes model rats by inhibiting NLRP3 inflammasome and restoring gut microbiota disorders.

  2025cites this paper
• Biomarkers for Alzheimer's disease are upregulated in patients with diabetic retinopathy

  2025cites this paper
• The association between SLIT2 in human vitreous humor and plasma and neurocognitive test scores

  2025influential citation
• Detecting cognitive impairment in diabetics based on retinal photos by a deep learning method

  2025cites this paper
• Therapeutic impact of vildagliptin vs. gliclazide on insulin resistance and advanced glycated end product levels in newly diagnosed Egyptian diabetics: a randomized controlled trial

  2025cites this paper
• Royal Jelly and 10-Hydroxy-2-Decenoic acid activate autophagy through mTOR/ULK1 pathway to improve cognitive function in diabetic mice

  2025cites this paper
• Medical Comorbidities in Alzheimer’s Disease: An Autopsy Confirmed Study with a Focus on Sex-Differences?

  2025cites this paper
• Association of Low Protein-to-Carbohydrate Energy Ratio with Cognitive Impairment in Elderly Type 2 Diabetes Patients

  2024cites this paper
• Be Alert to Diabetes Nephropathy with Cognitive Dysfunction [Letter]

  2024cites this paper
• Small heat shock protein B8: from cell functions to its involvement in diseases and potential therapeutic applications

  2024cites this paper
• Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline

  2024cites this paper
• Evaluating the Preferences and Willingness-to-Pay for Oral Antidiabetic Drugs Among Patients with Type 2 Diabetes Mellitus in China: A Discrete Choice Experiment

  2024cites this paper
• Tear Proteomics in Children and Adolescents with Type 1 Diabetes: A Promising Approach to Biomarker Identification of Diabetes Pathogenesis and Complications

  2024cites this paper
• Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

  2024influential citation
• Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer’s disease

  2024cites this paper
• In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer’s Disease

  2024cites this paper
• Alzheimer’s disease as a causal risk factor for diabetic retinopathy: a Mendelian randomization study

  2024cites this paper
• Oral phytate supplementation on the progression of mild cognitive impairment, brain iron deposition and diabetic retinopathy in patients with type 2 diabetes: a concept paper for a randomized double blind placebo controlled trial (the PHYND trial)

  2024cites this paper
• True or False? Alzheimer's disease is Type 3 Diabetes: Evidences from Bench to Bedside.

  2024influential citation
• APOE 5’UTR Methylation Pattern Analysis in Blood and Brain Tissue from Alzheimer’s Disease Affected Patients

  2024cites this paper
• The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation.

  2024cites this paper
• Positive impact of DPP-4 or SGLT2 inhibitors on mild cognitive impairment in type 2 diabetes patients on metformin therapy: A metabolomic mechanistic insight.

  2024cites this paper
• Probing the risk markers of mild cognitive impairment and Alzheimer's disease in alloxan-induced diabetic rats

  2024cites this paper
• Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid‐β Aggregation in Cardiovascular Disease

  2024cites this paper
• Cross-Species Modeling Identifies Gene Signatures in Type 2 Diabetes Mouse Models Predictive of Inflammatory and Estrogen Signaling Pathways Associated with Alzheimer’s Disease Outcomes in Humans

  2024cites this paper
• Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer’s Disease

  2023cites this paper
• Association of metabolic dysfunction with cognitive decline and Alzheimer's disease: A review of metabolomic evidence.

  2023cites this paper
• Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

  2023cites this paper
• Amelioration of histological changes of the hippocampus in experimentally-induced diabetic rats via Antox composite of multi-antioxidant

  2023cites this paper
• Prevailing Antagonistic Risks in Pleiotropic Associations with Alzheimer’s Disease and Diabetes

  2023cites this paper
• Relationship between glycemic control and cognitive impairment: A systematic review and meta-analysis

  2023cites this paper
• Rooibos tea—in the cross fire of ROS, mitochondrial dysfunction and loss of proteostasis—positioned for healthy aging

  2023cites this paper
• Inhibition of ferroptosis through regulating neuronal calcium homeostasis: an emerging therapeutic target for Alzheimer's disease.

  2023cites this paper
• Aberrant lncRNA expression in patients with proliferative diabetic retinopathy: preliminary results from a single-center observational study

  2023cites this paper
• Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment

  2023cites this paper
• Association of stressful life events with cognitive impairment in patients with type 2 diabetes mellitus

  2023cites this paper
• Assessment of cognitive impairment and depressive signs in patients with type 2 diabetes treated with metformin from Southeast Mexico: A cross-sectional study.

  2023cites this paper
• Cognitive protection of incretin‐based therapies in patients with type 2 diabetes mellitus: A systematic review and meta‐analysis based on clinical studies

  2023cites this paper
• Voxel-based morphometry reveals the correlation between gray matter volume and serum P-tau-181 in type 2 diabetes mellitus patients with different HbA1c levels

  2023cites this paper
• MiR-29b modulates DNA methylation in promoter region of miR-130b in mouse model of Diabetic nephropathy

  2023cites this paper
• Metformin use is associated with a reduced risk of cognitive impairment in adults with diabetes mellitus: A systematic review and meta-analysis

  2022cites this paper
• A Study of the Protective Effect of Bushen Huoxue Prescription on Cerebral Microvascular Endothelia Based on Proteomics and Bioinformatics

  2022cites this paper
• Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases

  2022cites this paper
• Dietary polyphenols: regulate the advanced glycation end products-RAGE axis and the microbiota-gut-brain axis to prevent neurodegenerative diseases

  2022cites this paper
• Emerging Pathophysiological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: An Old Wine in a New Bottle

  2022influential citation
• Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B

  2022cites this paper
• The regulatory role of Gnao1 protein in diabetic encephalopathy in KK-Ay mice and streptozotocin-induced diabetic rats.

  2022cites this paper
• Epigenetic regulation of synaptic disorder in Alzheimer’s disease

  2022cites this paper
• New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs

  2022cites this paper
• Saffron as a promising therapy for diabetes and Alzheimer's disease: mechanistic insights

  2022cites this paper
• LncRNA-MEG3 attenuates hyperglycemia-induced damage by enhancing mitochondrial translocation of HSP90A in the primary hippocampal neurons.

  2022cites this paper
• Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats

  2022cites this paper
• Designing a Mobile Application for Working Memory Training through Understanding the Psychological and Physiological Characteristics of Older Adults

  2022cites this paper
• Arginine Reduces Glycation in γ2 Subunit of AMPK and Pathologies in Alzheimer’s Disease Model Mice

  2022cites this paper
• Molecular mechanisms underlying hyperglycemia associated cognitive decline

  2022cites this paper
• Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer’s Disease

  2021cites this paper
• Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer's disease.

  2021cites this paper
• Phytotherapy: A promising approach for the treatment of Alzheimer's disease

  2021cites this paper
• Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis

  2021cites this paper
• Multimodal brain imaging effect of “Adjust Zang-fu and Arouse Spirit” electroacupuncture on diabetic cognitive impairment: study protocol of a randomized, sham-controlled pilot trial

  2021cites this paper
• Genetic mutations of APOEε4 carriers in cardiovascular patients lead to the development of insulin resistance and risk of Alzheimer's disease

  2021cites this paper
• The Effect of Cannabidiol Coated by Nano-Chitosan on Learning and Memory, Hippocampal CB1 and CB2 Levels, and Amyloid Plaques in an Alzheimer’s Disease Rat Model

  2021cites this paper
• Alzheimer’s disease, epigenetics, and exercise

  2021cites this paper
• Effect of Acupuncture on Cognitive Function of Insomnia Patients Compared with Drugs: A Protocol for Meta-analysis and Systematic Review

  2021cites this paper
• ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

  2021cites this paper
• Oleic Acid and Insulin as Key Characteristics of T2D Promote Colorectal Cancer Deterioration in Xenograft Mice Revealed by Functional Metabolomics

  2021cites this paper
• The role of traditional Chinese medicine in the treatment of cognitive dysfunction in type 2 diabetes.

  2021cites this paper
• Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity

  2021cites this paper
• Amelioration of Neurobehavioral and Biochemical Changes by Withania somnifera Root Extract During Type 2 Diabetes Mellitus Induced Cognitive Deficit in Rats

  2021cites this paper
• Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

  2021cites this paper
• Exercise as a Therapeutic Intervention in Gestational Diabetes Mellitus

  2021cites this paper
• Alzheimer's disease: A need for personalized therapeutic approaches

  2020cites this paper
• Morphometric characteristics of the brain in patients with type 1 diabetes mellitus on diff erent modes of basic bolus insulin therapy

  2020cites this paper
• Hypertension and Age-Related Cognitive Impairment: Common Risk Factors and a Role for Precision Aging

  2020cites this paper
• Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer’s Disease: the Receptor for Advanced Glycation End Products (RAGE)

  2020cites this paper
• Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease

  2020cites this paper
• Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level

  2020cites this paper
• Advanced Glycation End Products: Formation, Role in Diabetic Complications, and Potential in Clinical Applications

  2019cites this paper