Food bioactives in the epigenomic regulation of metabolic disease

Abstract Nutritional epigenomics is an active area of study in the fields of medicine, nutrition and dietetics. Historically, macro- and micro-nutrients were studied to better understand their role in metabolic regulation, water retention, blood glucose absorption and ion regulation among others. However, advancements in technology have furthered our understanding for the role of macro- and micro-nutrients, including food bioactives like curcumin, resveratrol and Epigallocatechin-3-O-gallate (EGCG), as regulators of the epigenome. In addition, genome-wide association studies (GWAS) coupled with epigenome-wide association studies (EWAS) have shown the importance for environment in the development of chronic diseases. As epigenetic adaptations, as opposed to genetic mutations, are modifiable, there is emerging hope that dietary modifications and, perhaps, personalized nutrition therapy can be used to treat disease in the future. This chapter will focus on three polyphenolic compounds (curcumin, resveratrol and EGCG) as regulators of the epigenome.

• Publication year

  2019

• Venue

  Nutritional Epigenomics

• Publication date

  Unknown publication date

• Fields of study

  Agricultural and Food Sciences, Biology

• Identifiers
  DOI 10.1016/B978-0-12-816843-1.00020-5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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