Vinculin binding in its closed conformation by a helix addition mechanism

No abstract is available for this paper.

• Publication year

  2007

• Venue

  EMBO Journal

• Publication date

  2007-10-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.emboj.7601863PMID 17932491PMCID PMC2063484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Vinculin Binding Sites of Talin and α-Actinin Are Sufficient to Activate Vinculin*

  2006cited by this paper
• Structural and dynamic characterization of a vinculin binding site in the talin rod.

  2006influential reference
• Shigella applies molecular mimicry to subvert vinculin and invade host cells

  2006cited by this paper
• The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.

  2006cited by this paper
• The structure and regulation of vinculin.

  2006cited by this paper
• Structural Dynamics of α-Actinin-Vinculin Interactions

  2005cited by this paper
• Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod*

  2005influential reference
• A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

  2005cited by this paper
• Vinculin acts as a sensor in lipid regulation of adhesion-site turnover

  2005cited by this paper
• Structural dynamics of alpha-actinin-vinculin interactions.

  2005cited by this paper
• Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

  2004influential reference
• Structural basis for vinculin activation at sites of cell adhesion

  2004cited by this paper
• Vinculin activation by talin through helical bundle conversion

  2004cited by this paper
• Cell biology: How to build a cell junction

  2004cited by this paper
• Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

  2004influential reference
• NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide

  2004cited by this paper
• Crystal structure of human vinculin.

  2004cited by this paper
• Structural Basis for Amplifying Vinculin Activation by Talin*

  2004cited by this paper
• Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.

  2003influential reference
• From the first to the second domain of gelsolin: a common path on the surface of actin?1

  2003cited by this paper
• Further characterization of the interaction between the cytoskeletal proteins talin and vinculin.

  2002cited by this paper
• The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

  2002influential reference
• Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix.

  1999cited by this paper
• Vinculin knockout results in heart and brain defects during embryonic development.

  1998cited by this paper
• A conserved motif in the tail domain of vinculin mediates association with and insertion into acidic phospholipid bilayers.

  1998cited by this paper
• [23] Bayesian statistical viewpoint on structure determination: Basic concepts and examples.

  1997cited by this paper
• Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

  1996influential reference
• F-actin binding site masked by the intramolecular association of vinculin head and tail domains

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Identification of the vinculin-binding site in the cytoskeletal protein alpha-actinin.

  1994cited by this paper
• Identification of the vinculin-binding site in the cytoskeletal protein α-actinin

  1994cited by this paper
• Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells

  1993cited by this paper
• Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells.

  1992cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• Identification of a talin binding site in the cytoskeletal protein vinculin

  1989cited by this paper
• Identification of two distinct functional domains on vinculin involved in its association with focal contacts

  1989cited by this paper
• An Efficient General-Purpose Least-Squares Refinement Program for Macromolecular Structures

  1987cited by this paper
• An efficient general-purpose least-squares refinement program for macromolecular structures

  1987cited by this paper
• Solvent content of protein crystals.

  1968influential reference

• The Actin Network Interfacing Diverse Integrin-Mediated Adhesions

  2023cites this paper
• IpaA reveals distinct modes of vinculin activation during Shigella invasion and cell-matrix adhesion

  2023cites this paper
• Molecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular Mechanotransduction

  2023cites this paper
• Functional comparison of full-length palladin to isolated actin binding domain

  2022cites this paper
• Shigella ipaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

  2022cites this paper
• The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain

  2021cites this paper
• Manipulation of Focal Adhesion Signaling by Pathogenic Microbes

  2021cites this paper
• A distinct talin2 structure directs isoform specificity in cell adhesion

  2020cites this paper
• Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity.

  2020cites this paper
• Vinculin targeting by Shigella IpaA promotes stable cell adhesion independent of mechanotransduction

  2019cites this paper
• Shigella IpaA Binding to Talin Stimulates Filopodial Capture and Cell Adhesion.

  2019cites this paper
• An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin

  2019influential citation
• ipaA triggers vinculin oligomerization to strengthen cell adhesion during Shigella invasion

  2019influential citation
• The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation

  2018cites this paper
• Cell adhesion promoted by a unique Shigella IpaA vinculin- and talin-binding site

  2018cites this paper
• Common Themes in Cytoskeletal Remodeling by Intracellular Bacterial Effectors.

  2017cites this paper
• Cancer Research in Space

  2017cites this paper
• Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization

  2016cites this paper
• Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration

  2016cites this paper
• Using a novel "Integrated Biomarker Proteomic" index to assess the effects of freshwater pollutants in European eel peripheral blood mononuclear cells.

  2016cites this paper
• Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes

  2016cites this paper
• Downregulation of CD 147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

  2015cites this paper
• Design, improvement, and benchmarking of a light-induced heterodimer pair: The awakening of iLID

  2015influential citation
• Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane

  2015influential citation
• Cytoskeletal mechanics during Shigella invasion and dissemination in epithelial cells

  2015cites this paper
• Spatiotemporal coordination of the actin cytoskeleton and integrin adhesion

  2014cites this paper
• USING VINCULIN MUTANTS TO ASCERTAIN THE ROLE OF VINCULIN IN CELLULAR MOTILITY AND MECHANOTRANSDUCTION

  2014cites this paper
• The Interaction of Vinculin with Actin

  2013cites this paper
• Tips and tricks about Shigella invasion of epithelial cells.

  2013cites this paper
• αE-catenin is an autoinhibited molecule that coactivates vinculin

  2012influential citation
• Designing photoswitchable peptides using the AsLOV2 domain.

  2012cites this paper
• Vinculin, cadherin mechanotransduction and homeostasis of cell–cell junctions

  2012cites this paper
• The Cytoskeletal Protein α-Catenin Unfurls upon Binding to Vinculin*

  2012influential citation
• α-Catenin Uses a Novel Mechanism to Activate Vinculin*

  2012cites this paper
• Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin

  2012cites this paper
• Activators of vinculin enhance cell adhesion and sensitize melanomas to chemotherapy

  2011cites this paper
• Vinculin Motion Modes Analysis with Elastic Network Model

  2011cites this paper
• Angiogenesis , Metastasis , and the Cellular Microenvironment Vinculin Activators Target Integrins from Within the Cell to Increase Melanoma Sensitivity to Chemotherapy

  2011cites this paper
• Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin

  2011cites this paper
• The Rickettsia Surface Cell Antigen 4 Applies Mimicry to Bind to and Activate Vinculin*

  2011cites this paper
• Apo raver1 structure reveals distinct RRM domain orientations

  2011cites this paper
• Forcing a connection: Impacts of single‐molecule force spectroscopy on in vivo tension sensing

  2011cites this paper
• Novel Vinculin Binding Site of the IpaA Invasin of Shigella*♦

  2011cites this paper
• Vinculin activation is necessary for complete talin binding.

  2011cites this paper
• Vinculin Is a Dually Regulated Actin Filament Barbed End-capping and Side-binding Protein

  2010cites this paper
• Improving the diffraction of full-length human selenomethionyl metavinculin crystals by streak-seeding.

  2010cites this paper
• Proteomic analysis of PBMCs: characterization of potential HIV-associated proteins

  2010cites this paper
• The Cytoskeletal Connection: Understanding Adaptor Proteins

  2010cites this paper
• A Helix Replacement Mechanism Directs Metavinculin Functions

  2010cites this paper
• Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.

  2009cites this paper
• Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.

  2009cites this paper
• The Role of Vinculin in the Regulation of the Mechanical Properties of Cells

  2009cites this paper
• Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

  2008cites this paper
• Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

  2008cites this paper
• An alternatively spliced exon links intermediate filaments to adhesions.

  2008cites this paper