A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Structure

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.STR.2004.11.006PMID 15642262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structural Basis for Amplifying Vinculin Activation by Talin*

  2004influential reference
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  2004cited by this paper
• Vinculin activation by talin through helical bundle conversion

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• A Fluorescence Cell Biology Approach to Map the Second Integrin-binding Site of Talin to a 130-Amino Acid Sequence within the Rod Domain*

  2004cited by this paper
• Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

  2004influential reference
• Phosphatidylinositol Phosphate Kinase Type 1γ and β1-Integrin Cytoplasmic Domain Bind to the Same Region in the Talin FERM Domain*

  2003influential reference
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  2003cited by this paper
• Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain.

  2003cited by this paper
• Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

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• Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

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• Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans

  2003cited by this paper
• Faculty Opinions recommendation of Talin binding to integrin beta tails: a final common step in integrin activation.

  2003cited by this paper
• Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

  2003cited by this paper
• Talin1 is critical for force-dependent reinforcement of initial integrin–cytoskeleton bonds but not tyrosine kinase activation

  2003cited by this paper
• Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.

  2002cited by this paper
• Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin

  2002cited by this paper
• Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

  2002influential reference
• Talin is essential for integrin function in Drosophila.

  2002cited by this paper
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  2002cited by this paper
• A method for efficient isotopic labeling of recombinant proteins

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• Automatic determination of protein backbone resonance assignments from triple resonance nuclear magnetic resonance data.

  2001cited by this paper
• Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides*

  2001cited by this paper
• Localization of an Integrin Binding Site to the C Terminus of Talin*

  2001cited by this paper
• Automated assignment of ambiguous nuclear overhauser effects with ARIA.

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• Actin Activates a Cryptic Dimerization Potential of the Vinculin Tail Domain*

  2000cited by this paper
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  2000cited by this paper
• Disruption of the talin gene arrests mouse development at the gastrulation stage

  2000cited by this paper
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  1999cited by this paper
• XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.

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• Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix.

  1999cited by this paper
• Protein backbone angle restraints from searching a database for chemical shift and sequence homology

  1999cited by this paper
• Crystal structure of the vinculin tail suggests a pathway for activation.

  1999cited by this paper
• Disruption of the Talin Gene Compromises Focal Adhesion Assembly in Undifferentiated but Not Differentiated Embryonic Stem Cells

  1998cited by this paper
• The interaction of the cell-contact proteins VASP and vinculin is regulated by phosphatidylinositol-4,5-bisphosphate.

  1998cited by this paper
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  1998cited by this paper
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• The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals.

  1997cited by this paper
• Monoclonal antibodies recognizing the N- and C-terminal regions of talin disrupt actin stress fibers when microinjected into human fibroblasts.

  1997cited by this paper
• Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains.

  1997cited by this paper
• VMD: visual molecular dynamics.

  1996cited by this paper
• Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site.

  1996influential reference
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  1996cited by this paper
• Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

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• Down regulation of talin alters cell adhesion and the processing of the alpha 5 beta 1 integrin.

  1995cited by this paper
• Down regulation of talin alters cell adhesion and the processing of the α5β1 integrin

  1995cited by this paper
• Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin (*)

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• The 13C Chemical-Shift Index: A simple method for the identification of protein secondary structure using 13C chemical-shift data

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• Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling

  2025cites this paper
• Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation

  2025cites this paper
• Regulation and functions of the DLC family of RhoGAP proteins: Implications for development and cancer.

  2024cites this paper
• The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein

  2024cites this paper
• Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force

  2024cites this paper
• The Actin Network Interfacing Diverse Integrin-Mediated Adhesions

  2023cites this paper
• The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP)

  2023cites this paper
• Next-generation protein-based materials capture and preserve projectiles from supersonic impacts

  2022cites this paper
• Talin-1 interaction network in cellular mechanotransduction (Review)

  2022cites this paper
• Inhibition of Talin-induced Integrin Activation by a Double-hit Stapled Peptide

  2022cites this paper
• Chemo-Mechanical Factors That Limit Cellular Force Generation

  2022cites this paper
• Force-Independent Cleavage of Talin by Calpain Promotes Platelet-Mediated Fibrin Clot Contraction

  2021cites this paper
• Force-Independent Cleavage of Talin by Calpain Promotes Platelet-Mediated Fibrin Clot Contraction

  2021cites this paper
• Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction

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• Mechanotransduction: Cellular dynamic mechanical behavior quantification and control

  2020cites this paper
• Cancer associated talin point mutations disorganise cell adhesion and migration

  2020cites this paper
• A distinct talin2 structure directs isoform specificity in cell adhesion

  2020cites this paper
• Mechanical Unfolding of Proteins—A Comparative Nonequilibrium Molecular Dynamics Study

  2020cites this paper
• Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

  2020cites this paper
• The Architecture of Talin1 Reveals an Autoinhibition Mechanism

  2019cites this paper
• Cell Adhesion by Integrins.

  2019cites this paper
• Force Directed 'Mechanointeractome' of Talin-Integrin.

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  2018cites this paper
• Epigenetic Regulation of Skin Development and Regeneration

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  2018cites this paper
• Talin as a mechanosensitive signaling hub

  2018cites this paper
• Mechanosensing at Cellular Interfaces.

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• Nonlinear Cellular Mechanical Behavior Adaptation to Substrate Mechanics Identified by Atomic Force Microscope

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• Adaptive mechanosensory mechanism of α-catenin revealed by single-molecule biomechanics

  2017cites this paper
• Conformational states during vinculin unlocking differentially regulate focal adhesion properties

  2017cites this paper
• Talin – the master of integrin adhesions

  2017cites this paper
• Pressure-Dependent Chemical Shifts in the R3 Domain of Talin Show that It Is Thermodynamically Poised for Binding to Either Vinculin or RIAM.

  2017cites this paper
• Function of the laminin-derived protein LaNt α31 in corneal epithelium

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• Nano-mechanical characterization of tension-sensitive helix bundles in talin rod.

  2017cites this paper
• Talin: a mechanosensitive molecule in health and disease

  2016influential citation
• The Structural Basis of Actin Organization by Vinculin and Metavinculin.

  2016cites this paper
• LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

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• Characterising the effect of S100P overexpression in cell adhesion

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• Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.

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• Force-induced remodelling of proteins and their complexes

  2015cites this paper
• Talin is required to position and expand the luminal domain of the Drosophila heart tube.

  2015cites this paper
• Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane

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• Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity

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  2014cites this paper
• Actin flow and talin dynamics govern rigidity sensing in actin–integrin linkage through talin extension

  2014cites this paper
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  2014cites this paper
• A review of the effects of the cell environment physicochemical nanoarchitecture on stem cell commitment.

  2014cites this paper
• Talin Dependent Mechanosensitivity of Cell Focal Adhesions

  2014cites this paper
• αPS3βPS1 integrin and its adaptor Talin are essential for Drosophila embryonic heart tubulogenesis

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• Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

  2014cites this paper
• Molecular mechanisms underlying the force-dependent regulation of actin-to-ECM linkage at the focal adhesions.

  2014cites this paper
• Mechano-Transduction: From Molecules to Tissues

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• Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions.

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• RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover*

  2013cites this paper
• Mechanotransduction at focal adhesions: from physiology to cancer development

  2013cites this paper
• Comparison of Temperature Coupling Algorithms in SMD simulations and Mutation Design in Talin I/LWEQ Domain

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• Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin

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• Subcellular Localization of Talin Is Regulated by Inter-domain Interactions*

  2012cites this paper
• Turnover of Focal Adhesions and Cancer Cell Migration

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• The Cytoskeletal Protein α-Catenin Unfurls upon Binding to Vinculin*

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• Novel Vinculin Binding Site of the IpaA Invasin of Shigella*♦

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• Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives

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• Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin

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• The Rickettsia Surface Cell Antigen 4 Applies Mimicry to Bind to and Activate Vinculin*

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• New insights into vinculin function and regulation.

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• The function and regulation of vinculin in cell-cell adhesions

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• The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site

  2010cites this paper
• Mechanical Forces Matter in Health and Disease: From Cancer to Tissue Engineering

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• Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

  2010cites this paper
• The Cytoskeletal Connection: Understanding Adaptor Proteins

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• A molecular dynamics investigation of vinculin activation.

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• Structural analysis of sensor domains from the TMAO-responsive histidine kinase receptor TorS.

  2009cites this paper
• Stretching Single Talin Rod Molecules Activates Vinculin Binding

  2009cites this paper
• Genetic and cell biological analysis of integrin outside-in signaling.

  2009cites this paper
• Biochemical and structural properties of the integrin-associated cytoskeletal protein talin.

  2009cites this paper
• Structural and biophysical properties of the integrin-associated cytoskeletal protein talin

  2009cites this paper
• The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions.

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• Structural Studies of Talin-Mediated Integrin Activation

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• Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways.

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• Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.

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  2008cites this paper
• Cell-matrix adhesion complexes: master control machinery of cell migration.

  2008cites this paper
• The Structural and Functional Study of GIT1 Paxillin Binding Domain

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• The Talin Rod IBS2 α-Helix Interacts with the β3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges*

  2008cites this paper
• Structural basis for the autoinhibition of talin in regulating integrin activation.

  2008influential citation
• Integrin connections to the cytoskeleton through talin and vinculin.

  2008cites this paper
• How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

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• The structure of the C-terminal actin-binding domain of talin

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
• The Integrin Binding Site 2 (IBS2) in the Talin Rod Domain Is Essential for Linking Integrin β Subunits to the Cytoskeleton*

  2007cites this paper
• Vinculin controls focal adhesion formation by direct interactions with talin and actin

  2007cites this paper
• Coincidence of Actin Filaments and Talin Is Required to Activate Vinculin*

  2006cites this paper
• Shigella applies molecular mimicry to subvert vinculin and invade host cells

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• The Activity of the Vinculin Binding Sites in Talin Is Influenced by the Stability of the Helical Bundles That Make Up The Talin Rod*

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