Potential application of resveratrol in nanocarriers against cancer: Overview and future trends

Abstract Resveratrol is a polyphenol that has been identified as an antitumor, chemoprotective and chemosensitizer agent that enhances the sensitivity of cancer-resistant cells to chemotherapy. Additionally, resveratrol has many other benefits in reducing neurodegenerative diseases, losing weight by reducing lipogenesis, and other topical applications such as treating skin hyperpigmentation. The undesirable pharmacokinetic and physicochemical properties of resveratrol can be overcome by loading it into nanocarriers. Liposomes, polymeric NP, nanotubes, and lipid-based nanoparticles, among others, were developed to entrap the required dose of resveratrol in order to increase water solubility and stability, improve cytotoxicity and cellular internalization, and enhance bioavailability. Other nanoformulations were also exploited to deliver resveratrol topically such as ethosomes and phytosomes that increase its systemic concentration through skin absorption. However, some setbacks for such nanocarriers were reported such as the expensive fabrication process, low loading capacity, and short shelf-life. Exceptionally, lipid-based NPs have the best feasibility for scaling up production with less toxic ingredients compared to other nanocarriers. The combinatory nanoformulations of resveratrol alongside other drugs, phytochemicals and genes were indicated to subside multidrug resistance, reduce therapeutic doses, and consequently decrease the side effects of chemotherapeutic agents. In conclusion, more in vitro, preclinical and clinical studies are needed to convey the resveratrol-loaded nanocarriers from bench to the bedside.

• Publication year

  2019

• Venue

  Journal of Drug Delivery Science and Technology

• Publication date

  2019-10-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/J.JDDST.2019.101187
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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