Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Biochemistry (Tokyo)

• Publication date

  2014-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/jb/mvu032PMID 24825911
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human Heterochromatin Protein 1α Promotes Nucleosome Associations That Drive Chromatin Condensation*

  2014cited by this paper
• A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.

  2013cited by this paper
• Heterochromatin Protein 1a (HP1a) Partner Specificity Is Determined by Critical Amino Acids in the Chromo Shadow Domain and C-terminal Extension*

  2013cited by this paper
• A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly

  2013cited by this paper
• Structural Plasticity in Human Heterochromatin Protein 1β

  2013cited by this paper
• Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression

  2013cited by this paper
• Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes.

  2013cited by this paper
• HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts.

  2012cited by this paper
• Phylogenomic Analysis Reveals Dynamic Evolutionary History of the Drosophila Heterochromatin Protein 1 (HP1) Gene Family

  2012cited by this paper
• Intrinsic nucleic acid-binding activity of Chp1 chromodomain is required for heterochromatic gene silencing.

  2012cited by this paper
• Methylation of Lysine 9 in Histone H3 Directs Alternative Modes of Highly Dynamic Interaction of Heterochromatin Protein hHP1β with the Nucleosome*

  2012cited by this paper
• Correction: HP1gamma function is required for male germ cell survival and spermatogenesis

  2012cited by this paper
• HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in Drosophila melanogaster

  2012cited by this paper
• Structural analysis of the hexasome, lacking one histone H2A/H2B dimer from the conventional nucleosome.

  2012cited by this paper
• Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription.

  2011cited by this paper
• Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.

  2011cited by this paper
• SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin

  2011cited by this paper
• N-Terminal Phosphorylation of HP1α Promotes Its Chromatin Binding

  2011influential reference
• Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice

  2011cited by this paper
• Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in Mice1

  2011cited by this paper
• The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners

  2011cited by this paper
• Role of Swi6/HP1 Self-association-mediated Recruitment of Clr4/Suv39 in Establishment and Maintenance of Heterochromatin in Fission Yeast*

  2011cited by this paper
• HP1: Heterochromatin binding proteins working the genome

  2010cited by this paper
• Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation

  2010cited by this paper
• Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

  2010cited by this paper
• Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.

  2010cited by this paper
• Recognition and Specificity Determinants of the Human Cbx Chromodomains*

  2010cited by this paper
• HP1γ function is required for male germ cell survival and spermatogenesis

  2010cited by this paper
• Heterochromatin Protein 1 Is Extensively Decorated with Histone Code-like Post-translational Modifications *

  2009cited by this paper
• Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.

  2009cited by this paper
• HP1-β is required for development of the cerebral neocortex and neuromuscular junctions

  2008cited by this paper
• Balance between Distinct HP1 Family Proteins Controls Heterochromatin Assembly in Fission Yeast

  2008cited by this paper
• HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

  2008cited by this paper
• ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

  2008cited by this paper
• Dynamic Regulation of Effector Protein Binding to Histone Modifications: The Biology of HP1 Switching

  2006cited by this paper
• Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition.

  2006cited by this paper
• Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin

  2006cited by this paper
• Aurora-B/AIM-1 Regulates the Dynamic Behavior of HP1α at the G2–M Transition

  2006cited by this paper
• Evidence for the existence of an HP1-mediated subcode within the histone code

  2006cited by this paper
• The Heterochromatin Protein 1 family

  2006cited by this paper
• Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

  2006cited by this paper
• SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast.

  2005cited by this paper
• Heterochromatin protein 1: a pervasive controlling influence

  2005cited by this paper
• Regulation of HP1–chromatin binding by histone H3 methylation and phosphorylation

  2005cited by this paper
• Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin

  2005cited by this paper
• In Vivo Dynamics of Swi6 in Yeast: Evidence for a Stochastic Model of Heterochromatin

  2004cited by this paper
• HP1 and the dynamics of heterochromatin maintenance

  2004cited by this paper
• Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin

  2004cited by this paper
• Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3

  2004cited by this paper
• Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase

  2003cited by this paper
• HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain

  2003influential reference
• Heterochromatin and Epigenetic Control of Gene Expression

  2003cited by this paper
• Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

  2003cited by this paper
• Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

  2003cited by this paper
• The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.

  2003cited by this paper
• Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.

  2003cited by this paper
• Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α

  2002cited by this paper
• Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component

  2002cited by this paper
• Heterochromatin: new possibilities for the inheritance of structure.

  2002cited by this paper
• Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

  2002cited by this paper
• A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development

  2002cited by this paper
• Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects.

  2002cited by this paper
• Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail

  2002cited by this paper
• Phosphorylation Site Mutations in Heterochromatin Protein 1 (HP1) Reduce or Eliminate Silencing Activity*

  2001influential reference
• Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

  2001cited by this paper
• Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

  2001cited by this paper
• Specificity of the HP1 chromo domain for the methylated N‐terminus of histone H3

  2001cited by this paper
• The Hinge and Chromo Shadow Domain Impart Distinct Targeting of HP1-Like Proteins

  2001cited by this paper
• Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.

  2001cited by this paper
• Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

  2001cited by this paper
• The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer

  2000cited by this paper
• Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.

  2000cited by this paper
• Conservation of Heterochromatin Protein 1 Function

  2000cited by this paper
• Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations.

  2000cited by this paper
• Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis.

  2000cited by this paper
• The HP1 chromo shadow domain binds a consensus peptide pentamer.

  2000cited by this paper
• Regulation of chromatin structure by site-specific histone H3 methyltransferases

  2000cited by this paper
• Phosphorylation of Heterochromatin Protein 1 by Casein Kinase II Is Required for Efficient Heterochromatin Binding inDrosophila *

  1999cited by this paper
• Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells

  1999cited by this paper
• Domain-specific Interactions of Human HP1-type Chromodomain Proteins and Inner Nuclear Membrane Protein LBR*

  1997cited by this paper
• Structure of the chromatin binding (chromo) domain from mouse modifier protein 1

  1997cited by this paper
• Human homolog of Drosophila heterochromatin-associated protein 1 (HP1) is a DNA-binding protein which possesses a DNA-binding motif with weak similarity to that of human centromere protein C (CENP-C).

  1996cited by this paper
• The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1.

  1995cited by this paper
• Functional analysis of the chromo domain of HP1.

  1995cited by this paper
• The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

  1991cited by this paper
• Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila.

  1989cited by this paper
• Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene

  1986cited by this paper

• ARID4B Promotes the Progression of Hepatocellular Carcinoma Through the PI3K/AKT Pathway

  2025cites this paper
• Mitotic Phosphorylation of Swi6/HP1 Regulates Its Chromatin Binding and Chromosome Segregation

  2025cites this paper
• Mechanistic Insights into HP1α CSD Oligomerization and the Role of PxVxL Motif-Containing Proteins

  2025cites this paper
• Telomeric RNA and HP1α form interfacial clusters that stabilize HP1α-DNA condensates

  2025cites this paper
• TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells

  2025cites this paper
• Forced expression of MSR repeat transcripts above a threshold limit breaks heterochromatin organisation

  2025cites this paper
• The HP1 hinge region: more than just a linker for heterochromatin.

  2025cites this paper
• A dynamic structural unit of phase-separated heterochromatin protein 1α as revealed by integrative structural analyses

  2025cites this paper
• Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin.

  2025cites this paper
• Characterization of the Swi6/HP1 binding motif in its partner protein reveals the basis for the functional divergence of the HP1 family proteins in fission yeast

  2025cites this paper
• Heterochromatin in plant meiosis

  2024cites this paper
• Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice

  2024cites this paper
• Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation.

  2024cites this paper
• Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance

  2023cites this paper
• Multimodal interactions drive chromatin phase separation and compaction

  2023cites this paper
• Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance

  2023cites this paper
• Simulation of STAT and HP1 interaction by molecular docking.

  2023cites this paper
• Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly.

  2023cites this paper
• Dominant-negative variants in CBX1 cause a neurodevelopmental disorder.

  2023cites this paper
• Dominant-negative mutations in CBX1 cause a neurodevelopmental disorder

  2023cites this paper
• Dynamics of the HP1 Hinge Region with DNA Measured by Site-Directed Spin Labeling-EPR Spectroscopy

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• ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers

  2023cites this paper
• HP1-driven phase separation recapitulates the thermodynamics and kinetics of heterochromatin condensate formation

  2023cites this paper
• Chromatin structure meets cryo-EM: Dynamic building blocks of the functional architecture.

  2022cites this paper
• Characterization of a Novel Heterochromatin Protein 1 Homolog “HP1c” in the Silkworm, Bombyx mori

  2022cites this paper
• Epigenetic rewriting at centromeric DNA repeats leads to increased chromatin accessibility and chromosomal instability

  2021cites this paper
• Multiple interfaces to recognize nucleosomal targets.

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• Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling

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• PTMdyna: exploring the influence of post-translation modifications on protein conformational dynamics

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• ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes

  2021cites this paper
• The 20S proteasome activator PA28γ controls the compaction of chromatin

  2021cites this paper
• Solvent Exposure and Ionic Condensation Drive Fuzzy Dimerization of Disordered Heterochromatin Protein Sequence

  2021cites this paper
• Beyond the nucleosome: nucleosome-protein interactions and higher order chromatin structure.

  2021cites this paper
• Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide, as measured by site-directed spin-labeling EPR spectroscopy.

  2021cites this paper
• Unravelling HP1 functions: post-transcriptional regulation of stem cell fate

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• Organoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors

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• Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency‐associated gene pou5f3.2/oct25 in Xenopus

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• Ru Catalyst Facilitates Total Chemical Protein Synthesis to Investigate the Effect of Epigenetic Modifications Decorated on Linker Histone H1.2 and Heterochromatin Protein 1α (HP1α)

  2020cites this paper
• Oxidative stress induces transcription of telomeric repeat-containing RNA (TERRA) by engaging PKA signaling and cytoskeleton dynamics.

  2020cites this paper
• Heterochromatin protein 1 (HP1): interactions with itself and chromatin components

  2020influential citation
• Various modes of HP1a interactions with the euchromatic chromosome arms in Drosophila ovarian somatic cells

  2020cites this paper
• Multi-scale computational studies of heterochromatin protein-1

  2020cites this paper
• The mouse HP1 proteins are essential for preventing liver tumorigenesis

  2020cites this paper
• Mitotic phosphorylation of HP1α regulates its cell cycle-dependent chromatin binding.

  2019cites this paper
• Do the charges matter?—balancing the charges of the chromodomain proteins on the nucleosome

  2019cites this paper
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  2019cites this paper
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