HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain

No abstract is available for this paper.

• Publication year

  2003

• Venue

  EMBO Journal

• Publication date

  2003-06-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/cdg306PMID 12805230PMCID PMC162158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail

  2002cited by this paper
• Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α

  2002influential reference
• Does heterochromatin protein 1 always follow code?

  2002influential reference
• Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals

  2002cited by this paper
• Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects.

  2002influential reference
• Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

  2002cited by this paper
• Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.

  2001influential reference
• Translating the Histone Code

  2001cited by this paper
• Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

  2001influential reference
• Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

  2001influential reference
• Preferential interaction of the core histone tail domains with linker DNA

  2001cited by this paper
• The Hinge and Chromo Shadow Domain Impart Distinct Targeting of HP1-Like Proteins

  2001influential reference
• Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.

  2000influential reference
• Conservation of Heterochromatin Protein 1 Function

  2000cited by this paper
• Functional domain structure of human heterochromatin protein HP1(Hsalpha): involvement of internal DNA-binding and C-terminal self-association domains in the formation of discrete dots in interphase nuclei.

  1999cited by this paper
• Funtional Domain Structure of Human Heterochromatin Protein HP1 Hsa: Involvement of Internal DNA-Building DNA-Binding and C-Terminasl Self-Association Domains in the Formation of Discrete Dots in Interphase Nuclei

  1999cited by this paper
• Chicken chromobox proteins: cDNA cloning of CHCB1, -2, -3 and their relation to W-heterochromatin.

  1998influential reference
• Self-association of chromo domain peptides.

  1997cited by this paper
• Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes.

  1997cited by this paper
• Human homolog of Drosophila heterochromatin-associated protein 1 (HP1) is a DNA-binding protein which possesses a DNA-binding motif with weak similarity to that of human centromere protein C (CENP-C).

  1996cited by this paper
• Functional analysis of the chromo domain of HP1.

  1995cited by this paper
• Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA.

  1993cited by this paper
• Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

  1990cited by this paper
• Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila.

  1989cited by this paper
• Characterization of the chicken histone H1 gene complement. Generation of a complete set of vertebrate H1 protein sequences.

  1987cited by this paper
• Histones H1 and H5: one or two molecules per nucleosome?

  1981cited by this paper
• High-resolution proton-magnetic-resonance studies of chromatin core particles.

  1978influential reference
• The generation and propagation of variegated chromosome structures.

  1978cited by this paper

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• Differential oligomerization regulates PHF13 chromatin affinity and function

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• Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato.

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• Telomeric RNA and HP1α form interfacial clusters that stabilize HP1α-DNA condensates

  2025cites this paper
• The HP1 hinge region: more than just a linker for heterochromatin.

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• Characterization of the Swi6/HP1 binding motif in its partner protein reveals the basis for the functional divergence of the HP1 family proteins in fission yeast

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• HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization

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• Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture

  2024cites this paper
• Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction

  2024cites this paper
• Diverse heterochromatin states restricting cell identity and reprogramming.

  2023cites this paper
• Multimodal interactions drive chromatin phase separation and compaction

  2023cites this paper
• Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction

  2023cites this paper
• Dynamics of the HP1 Hinge Region with DNA Measured by Site-Directed Spin Labeling-EPR Spectroscopy

  2023cites this paper
• Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly.

  2023cites this paper
• Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells

  2022cites this paper
• Functions of HP1 proteins in transcriptional regulation

  2022cites this paper
• The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin

  2022cites this paper
• Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain

  2022cites this paper
• Principles Governing the Phase Separation of Multidomain Proteins.

  2022cites this paper
• Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite <named-content content-type='genus-species'>Plasmodium falciparum</named-content> Using a Conditional Domain Deletion and Swapping Approach

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  2021cites this paper
• Characterization of functional disordered regions within chromatin-associated proteins

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• Low complexity domains, condensates, and stem cell pluripotency

  2021cites this paper
• Residues flanking the ARKme3T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations.

  2020cites this paper
• CMAR_A_271807 10113..10125

  2020cites this paper
• CBX1 variants cause a neurodevelopmental syndrome due to facultative heterochromatin dysfunction

  2020cites this paper
• Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite Plasmodium falciparum Using a Conditional Domain Deletion and Swapping Approach

  2020influential citation
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  2020cites this paper
• CBX3 Promotes Gastric Cancer Progression and Affects Factors Related to Immunotherapeutic Responses

  2020cites this paper
• CBX1 mutations cause a neurodevelopmental syndrome due to heterochromatin organizational alterations

  2020cites this paper
• Synthetic immunomodulation with a CRISPR super-repressor in vivo

  2020cites this paper
• Insights into HP1a-Chromatin Interactions

  2020cites this paper
• Biology and Physics of Heterochromatin-Like Domains/Complexes

  2020influential citation
• Biophysical Properties of HP1-Mediated Heterochromatin

  2020cites this paper
• On the relations of phase separation and Hi-C maps to epigenetics

  2020cites this paper
• DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1β-Ser88

  2019cites this paper
• Role of Fine Structural Dynamics in Recognition of Histone H3 by HP1γ(CSD) Dimer and Ability of Force Fields to Describe Their Interaction Network.

  2019cites this paper
• Decrease in DNA methylation 1 interacts with chromomethylase and like heterochromatin protein 1 in Physcomitrella patens

  2019cites this paper
• Mitotic phosphorylation of HP1α regulates its cell cycle-dependent chromatin binding.

  2019cites this paper
• Loss of HP1α alters nuclear integrity to promote cellular invasion

  2019cites this paper
• The role of the histone variant macroH2A in the regulation of chromatin architecture

  2019cites this paper
• Phosphorylation of repressive histone code readers by casein kinase 2 plays diverse roles in heterochromatin regulation.

  2019cites this paper
• Do the charges matter?—balancing the charges of the chromodomain proteins on the nucleosome

  2019cites this paper
• Investigating the structural features of chromodomain proteins in the human genome and predictive impacts of their mutations in cancers.

  2019cites this paper
• Attraction of Likenesses: Mechanisms of Self-Association and Compartmentalization of Eukaryotic Chromatin

  2019cites this paper
• Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

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• On the relation of phase separation and Hi-C maps to epigenetics

  2019cites this paper
• Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum

  2019cites this paper
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  2018cites this paper
• Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function

  2018cites this paper
• Interactions of HP1 Bound to H3K9me3 Dinucleosome by Molecular Simulations and Biochemical Assays.

  2018cites this paper
• Recurrent Amplification of the Heterochromatin Protein 1 (HP1) Gene Family across Diptera

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  2018cites this paper
• The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin

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• Germline Genome Protection on an Evolutionary Treadmill.

  2017cites this paper
• Adaptive Evolution Leads to Cross-Species Incompatibility in the piRNA Transposon Silencing Machinery.

  2017cites this paper
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• Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.

  2016cites this paper
• Heterochromatin and the molecular mechanisms of ‘parent-of-origin’ effects in animals

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016influential citation
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  2016cites this paper
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  2015cites this paper
• Spatiotemporal regulation of Heterochromatin Protein 1- alpha oligomerization and dynamics in live cells

  2015cites this paper
• Nucleosome compaction facilitates HP1γ binding to methylated H3K9

  2015cites this paper
• The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation

  2015cites this paper
• Intrabody-mediated diverting of HP1β to the cytoplasm induces co-aggregation of H3-H4 histones and lamin-B receptor.

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  2015cites this paper
• Phosphorylation–dephosphorylation cycle of HP1α governs accurate mitotic progression

  2014cites this paper
• Analysis of the heterochromatin protein 1 (HP1) interactome in Drosophila.

  2014cites this paper
• Mechanisms of functional promiscuity by HP1 proteins.

  2014cites this paper
• Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β

  2014cites this paper
• Dynamic Phosphorylation of HP1α Regulates Mitotic Progression in Human Cells

  2014cites this paper
• N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity

  2014influential citation
• H3 clipping activity of glutamate dehydrogenase is regulated by stefin B and chromatin structure

  2014cites this paper
• Biochemical and structural properties of heterochromatin protein 1: understanding its role in chromatin assembly.

  2014influential citation
• Structural Plasticity in Human Heterochromatin Protein 1β

  2013influential citation
• Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes.

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• Stepwise Evolution of Essential Centromere Function in a Drosophila Neogene

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• The organization, regulation and functions of genes in the pericentric heterochromatin of the Drosophila melanogaster third chromosome

  2013cites this paper
• Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3*

  2012influential citation
• Understanding Higher Order Heterochromatin Structure And Its Determinants

  2012cites this paper
• The importance of epigenetics in embryonic development and reproductive biotechnology.

  2012influential citation
• Heterochromatin effects in Friedreich's ataxia and sexual dimorphism

  2012cites this paper
• Role of ASF1 in histone deposition during replication

  2012cites this paper
• Suppression and recovery of BRCA1-mediated transcription by HP1γ via modulation of promoter occupancy

  2012cites this paper
• HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in Drosophila melanogaster

  2012cites this paper
• Methylation of Lysine 9 in Histone H3 Directs Alternative Modes of Highly Dynamic Interaction of Heterochromatin Protein hHP1β with the Nucleosome*

  2012influential citation
• Phylogenomic Analysis Reveals Dynamic Evolutionary History of the Drosophila Heterochromatin Protein 1 (HP1) Gene Family

  2012influential citation
• The adjustable nucleosome: an epigenetic signaling module.

  2012cites this paper
• Epigenetic virtues of chromodomains

  2011cites this paper
• HP1α is not necessary for the structural maintenance of centromeric heterochromatin

  2011cites this paper
• The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression

  2011cites this paper
• N-Terminal Phosphorylation of HP1α Promotes Its Chromatin Binding

  2011influential citation