Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Blood

• Publication date

  2011-10-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood-2011-05-355107PMID 21900194PMCID PMC3208289
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cohesin Mediates Chromatin Interactions That Regulate Mammalian β-globin Expression*

  2011cited by this paper
• The multifunctional role of EKLF/KLF1 during erythropoiesis.

  2011cited by this paper
• Cohesin Mediates Chromatin Interactions That Regulate Mammalian (cid:1) -globin Expression *

  2011cited by this paper
• Relocalizing Genetic Loci into Specific Subnuclear Neighborhoods*

  2011cited by this paper
• Erythroid phenotypes associated with KLF1 mutations

  2011cited by this paper
• Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Krüppel-like factor

  2010cited by this paper
• Haploinsufficiency for the erythroid transcription factor KLF1 causes Hereditary Persistence of Fetal Hemoglobin

  2010cited by this paper
• A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia.

  2010cited by this paper
• KLF1 regulates BCL11A expression and γ- to β-globin gene switching

  2010cited by this paper
• Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.

  2010cited by this paper
• A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.

  2010cited by this paper
• The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation.

  2010cited by this paper
• Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model.

  2010cited by this paper
• Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells

  2010cited by this paper
• Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy.

  2009cited by this paper
• Applications of new sequencing technologies for transcriptome analysis.

  2009cited by this paper
• Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.

  2009cited by this paper
• Chromatin Architecture and Transcription Factor Binding Regulate Expression of Erythrocyte Membrane Protein Genes

  2009cited by this paper
• Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression.

  2009cited by this paper
• Krüppel-like transcription factors: a functional family.

  2008cited by this paper
• Model-based Analysis of ChIP-Seq (MACS)

  2008cited by this paper
• SCL and associated proteins distinguish active from repressive GATA transcription factor complexes.

  2008cited by this paper
• Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2

  2008cited by this paper
• MEME: discovering and analyzing DNA and protein sequence motifs

  2006cited by this paper
• Alterations in Expression and Chromatin Configuration of the Alpha Hemoglobin-Stabilizing Protein Gene in Erythroid Krüppel-Like Factor-Deficient Mice

  2006cited by this paper
• Major erythrocyte membrane protein genes in EKLF-deficient mice.

  2006cited by this paper
• Gene expression during terminal erythroid differentiation

  2006cited by this paper
• A global role for EKLF in definitive and primitive erythropoiesis.

  2005cited by this paper
• The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

  2005cited by this paper
• The active spatial organization of the beta-globin locus requires the transcription factor EKLF.

  2004cited by this paper
• Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.

  2004cited by this paper
• Stage-Specific Repression by the EKLF Transcriptional Activator

  2004cited by this paper
• Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

  2003cited by this paper
• Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system.

  2003cited by this paper
• In vitro expansion of human cord blood CD36+ erythroid progenitors: temporal changes in gene and protein expression.

  2003cited by this paper
• The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12

  2003cited by this paper
• Transcriptional regulation of erythropoiesis: an affair involving multiple partners

  2002cited by this paper
• Krüppel-like Zinc Fingers Bind to Nuclear Import Proteins and Are Required for Efficient Nuclear Localization of Erythroid Krüppel-like Factor*

  2002cited by this paper
• Site-Specific Acetylation by p300 or CREB Binding Protein Regulates Erythroid Krüppel-Like Factor Transcriptional Activity via Its Interaction with the SWI-SNF Complex

  2001cited by this paper
• Erythroblasts from Friend virus infected‐ and phenylhydrazine‐treated mice accurately model erythroid differentiation

  1999cited by this paper
• A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.

  1998cited by this paper
• Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.

  1996cited by this paper
• Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

  1995cited by this paper
• Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF

  1995cited by this paper
• Hematology: Basic Principles and Practice

  1995cited by this paper
• Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

  1995cited by this paper
• Erythroid differentiation of mouse erythroleukemia cells results in reorganization of protein-DNA complexes in the mouse beta maj globin promoter but not its distal enhancer.

  1993cited by this paper
• Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

  1991cited by this paper

• Divergence between transcriptomes and chromatin accessibility during differentiation from a bipotential progenitor cell population to erythroblasts and megakaryocytes

  2025cites this paper
• KLF1 (Krüppel-like factor 1) as a key regulator of erythroid gene expression

  2025cites this paper
• Evidence for vitellogenin DNA‐binding in honey bees

  2025cites this paper
• Transcriptome and chromatin accessibility divergence during differentiation of a bipotential progenitor cell population to erythroblasts and megakaryocytes

  2025cites this paper
• Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

  2024cites this paper
• pJoseph2: a family of plasmids as positive controls for bacterial protein expression, transfections, and western blots

  2024cites this paper
• EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts

  2023cites this paper
• Association of DDX5/p68 protein with the upstream erythroid enhancer element (EHS1) of the gene encoding the KLF1 transcription factor

  2023cites this paper
• Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory elements for hematopoietic lineage specification

  2023cites this paper
• Impact of Genetic Polymorphisms in Modifier Genes in Determining Fetal Hemoglobin Levels in Beta-Thalassemia

  2023cites this paper
• Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice

  2022cites this paper
• Krüppel-Like Factor 1: A Pivotal Gene Regulator in Erythropoiesis

  2022cites this paper
• Comprehensive assessment of differential ChIP-seq tools guides optimal algorithm selection

  2022cites this paper
• A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis

  2021influential citation
• What do transcription factors interact with?

  2021cites this paper
• HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis

  2021cites this paper
• Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants

  2020cites this paper
• GATA factor transcriptional activity: Insights from genome‐wide binding profiles

  2020cites this paper
• Negative Regulation of the Differentiation of Flk2− CD34− LSK Hematopoietic Stem Cells by EKLF/KLF1

  2020cites this paper
• RNA sequencing of whole blood in dogs with primary immune-mediated hemolytic anemia (IMHA) reveals novel insights into disease pathogenesis

  2020cites this paper
• Methylation of a CGATA element inhibits binding and regulation by GATA-1

  2020cites this paper
• An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

  2019cites this paper
• A Unique Epigenomic Landscape Defines Human Erythropoiesis

  2019cites this paper
• Association of Ddx5/p68 protein with the upstream erythroid enhancer element (EHS1) of the Klf1 gene

  2019cites this paper
• Blood disease-causing and -suppressing transcriptional enhancers: general principles and GATA2 mechanisms.

  2019cites this paper
• Functional genomic approaches to elucidate the role of enhancers during development

  2019cites this paper
• A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity

  2019cites this paper
• The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation

  2018cites this paper
• Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

  2018cites this paper
• Design Principles of Mammalian Transcriptional Regulation

  2018cites this paper
• Evolution of hemoglobin loci and their regulatory elements.

  2018cites this paper
• Cell Reports Resource Comprehensive Proteomic Analysis of Human Erythropoiesis

  2017cites this paper
• RED CELLS, IRON, AND ERYTHROPOIESIS EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro

  2017cites this paper
• GATA1 Activity Governed by Configurations of cis-Acting Elements

  2017cites this paper
• A Scalable Epitope Tagging Approach for High Throughput ChIP-Seq Analysis.

  2017cites this paper
• Investigating the Molecular Pathogenesis of Inherited Childhood Anaemia

  2017cites this paper
• Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders

  2016cites this paper
• Polycomb-like 2 (Mtf2/Pcl2) is Required for Epigenetic Regulation of Hematopoiesis

  2016cites this paper
• Active DNA demethylation in the mononuclear phagocyte system

  2016cites this paper
• Comprehensive Proteomic Analysis of Human Erythropoiesis

  2016cites this paper
• Navigating Transcriptional Coregulator Ensembles to Establish Genetic Networks: A GATA Factor Perspective.

  2016cites this paper
• Université de Montréal-Thèse numérique

  2016influential citation
• A novel comparative pattern count analysis reveals a chronic ethanol-induced dynamic shift in immediate early NF-κB genome-wide promoter binding during liver regeneration.

  2016cites this paper
• Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.

  2016cites this paper
• Resetting the epigenome for heart regeneration.

  2016cites this paper
• The Journal of Clinical Investigation

  2016cites this paper
• A graphical model approach visualizes regulatory relationships between genome-wide transcription factor binding profiles

  2016cites this paper
• Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

  2015influential citation
• KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus.

  2015cites this paper
• Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression

  2015cites this paper
• CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins

  2015cites this paper
• Modulation of lineage-specific cell differentiation by long non-coding RNAs

  2015cites this paper
• SBR-Blood: systems biology repository for hematopoietic cells

  2015cites this paper
• The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

  2015cites this paper
• Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues.

  2015cites this paper
• Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development

  2015cites this paper
• Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.

  2015cites this paper
• The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells

  2015cites this paper
• Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation.

  2014cites this paper
• Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

  2014cites this paper
• KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.

  2014cites this paper
• Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche

  2014cites this paper
• Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis.

  2014cites this paper
• Ldb1 complexes: the new master regulators of erythroid gene transcription.

  2014cites this paper
• Krüppel-like factors are effectors of nuclear receptor signaling.

  2014cites this paper
• NLS-tagging: an alternative strategy to tag nuclear proteins

  2014cites this paper
• TMEM14C is required for erythroid mitochondrial heme metabolism.

  2014cites this paper
• The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

  2014cites this paper
• Epigenetic and genetic mechanisms in red cell biology

  2014cites this paper
• Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

  2014cites this paper
• Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.

  2014influential citation
• Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation.

  2014cites this paper
• Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation.

  2014cites this paper
• of global erythroid gene activation Ldb1-nucleated transcription complexes function as primary mediators

  2014cites this paper
• Syddansk Universitet Browning of human adipocytes requires KLF 11 and reprogramming of PPARgamma

  2014cites this paper
• Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis

  2014influential citation
• A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification

  2014cites this paper
• Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor.

  2014cites this paper
• Analysis of disease-causing GATA1 mutations in murine gene complementation systems.

  2013cites this paper
• GATA-1 genome-wide occupancy associates with distinct epigenetic profiles in mouse fetal liver erythropoiesis

  2013cites this paper
• Identification of Biologically Relevant Enhancers in Human Erythroid Cells*

  2013cites this paper
• Iron and Heme Transport and Trafficking

  2013cites this paper
• in vivo and in vitro expression is critical for mouse erythroid maturation PIT1 EKLF-driven

  2013cites this paper
• Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation.

  2013cites this paper
• Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

  2013cites this paper
• EKLF-driven PIT1 expression is critical for mouse erythroid maturation in vivo and in vitro.

  2013cites this paper
• Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

  2013cites this paper
• Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.

  2013cites this paper
• ATP-dependent Mitochondrial Porphyrin Importer ABCB6 Protects against Phenylhydrazine Toxicity*

  2012cites this paper
• Genome-Scale Technology Driven Advances to Research into Normal and Malignant Haematopoiesis

  2012cites this paper
• Functional Interactions between Erythroid Kruppel-like Factor (EKLF/KLF1) and Protein Phosphatase PPM1B/PP2Cβ*

  2012influential citation
• of KLF3 results in a mild compensated anemia

  2012cites this paper
• Krüppel-Like Factor 1 (KLF1), KLF2, and Myc Control a Regulatory Network Essential for Embryonic Erythropoiesis

  2012cites this paper
• Regulation of Delta-Aminolevulinic Acid Dehydratase by Krüppel-Like Factor 1

  2012cites this paper
• Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.

  2012cites this paper
• Transcription factors: from enhancer binding to developmental control

  2012cites this paper
• Dissecting Molecular Pathways That Underlie Disease-Causing Gata1 Mutations

  2012cites this paper
• Nuclear RNA Sequencing of the Mouse Erythroid Cell Transcriptome

  2012cites this paper
• Upstream Distal Regulatory Elements Contact the Lmo2 Promoter in Mouse Erythroid Cells

  2012cites this paper
• The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo

  2012influential citation