Tailored porphyrin–gold nanoparticles for biomedical applications

In this review we present an updated survey of the main synthesis methods of gold nanoparticles (AuNPs) in order to obtain various tailored nanosystems for biomedical imaging. The synthesis approach significantly impacts on the AuNPs properties such as surface chemistry, biocompatibility and cytotoxicity. In recent years, nanomedicine emphasized the development of functionalized AuNPs for biomedical imaging. AuNPs are a good option for used as delivery photosensitizer agents for PDT of cancer. For example, the complex formed from AuNPs functionalized with PEGylate porphyrins presents several advantages in the medical field such as a better use in photodynamic therapy because of high triplet states and singlet oxygen quantum yield efficiency of porphyrin molecules.

• Publication year

  2019

• Venue

  Porphyrin Science by Women

• Publication date

  2019-07-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1142/S108842461930012X
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhanced cytotoxicity of gold porphyrin complexes after inclusion in cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles.

  2019cited by this paper
• Synthesis of porphyrin-conjugated silica-coated Au nanorods for synergistic photothermal therapy and photodynamic therapy of tumor

  2019cited by this paper
• Photophysicochemical properties and photodynamic therapy activity of chloroindium(III) tetraarylporphyrins and their gold nanoparticle conjugates

  2019cited by this paper
• Porphyrinic Metal–Organic Frameworks Coated Gold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor

  2018cited by this paper
• Photodynamic therapy evaluation of methoxypolyethyleneglycol-thiol-SPIONs-gold-meso-tetrakis(4-hydroxyphenyl)porphyrin conjugate against breast cancer cells.

  2018cited by this paper
• Gold nanoparticles-pyrrolidinonyl metal phthalocyanine nanoconjugates: Synthesis and photophysical properties

  2018cited by this paper
• Combined Photodynamic and Photothermal Therapy Using Cross-Linked Polyphosphazene Nanospheres Decorated with Gold Nanoparticles

  2018cited by this paper
• Porphyrin–Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells

  2018cited by this paper
• Porphyrin Derivative Conjugated with Gold Nanoparticles for Dual-Modality Photodynamic and Photothermal Therapies In Vitro.

  2018cited by this paper
• Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

  2018cited by this paper
• Photosensitized Protein-Damaging Activity, Cytotoxicity, and Antitumor Effects of P(V)porphyrins Using Long-Wavelength Visible Light through Electron Transfer.

  2018cited by this paper
• Novel Hexadeca-Substituted Metal Free and Zinc(II) Phthalocyanines; Design, Synthesis and Photophysicochemical Properties

  2018cited by this paper
• Water-soluble Manganese and Iron Mesotetrakis(carboxyl)porphyrin: DNA Binding, Oxidative Cleavage, and Cytotoxic Activities

  2017cited by this paper
• Effect of Gamma-irradiation on biosynthesized gold nanoparticles using Chenopodium murale leaf extract

  2017cited by this paper
• Development of gold-based phototheranostic nanoagents through bioinspired route and their applications in photodynamic therapy

  2017cited by this paper
• Modification and application of metal phthalocyanines in heterogeneous systems

  2017cited by this paper
• Porphyrins and Phthalocyanines: Photosensitizers and Photocatalysts

  2017cited by this paper
• Biodistribution and excretion of colloidal gold nanoparticles after intravenous injection: Effects of particle size

  2017cited by this paper
• A review on biogenic synthesis of gold nanoparticles, characterization, and its applications

  2017cited by this paper
• Recent applications of phthalocyanines and naphthalocyanines for imaging and therapy.

  2017cited by this paper
• Strategies for optimizing the delivery to tumors of macrocyclic photosensitizers used in photodynamic therapy (PDT)

  2017cited by this paper
• Renal‐Clearable PEGylated Porphyrin Nanoparticles for Image‐Guided Photodynamic Cancer Therapy

  2017cited by this paper
• Hybrid systems based on gold nanostructures and porphyrins as promising photosensitizers for photodynamic therapy.

  2017cited by this paper
• Zinc phthalocyanines attached to gold nanorods for simultaneous hyperthermic and photodynamic therapies against melanoma in vitro.

  2017cited by this paper
• Recent trends and methodologies in gold nanoparticle synthesis – A prospective review on drug delivery aspect

  2017cited by this paper
• Biological response of HeLa cells to gold nanoparticles coated with organic molecules.

  2017cited by this paper
• Current methods for synthesis of gold nanoparticles

  2016cited by this paper
• Gold and Silver Nanoparticles: Synthesis Methods, Characterization Routes and Applications towards Drugs

  2016cited by this paper
• Application of gold nanoparticles in biomedical and drug delivery

  2016cited by this paper
• Transporter protein and drug-conjugated gold nanoparticles capable of bypassing the blood-brain barrier

  2016cited by this paper
• Biomedical applications of gold nanoparticles.

  2016cited by this paper
• Remarkable thermal stability of gold nanoparticles functionalised with ruthenium phthalocyanine complexes

  2016cited by this paper
• Effect of caffeic acid adsorption in controlling the morphology of gold nanoparticles: role of surface coverage and functional groups.

  2016cited by this paper
• Formation of gold decorated porphyrin nanoparticles and evaluation of their photothermal and photodynamic activity.

  2016cited by this paper
• Porphyrin-loaded nanoparticles for cancer theranostics.

  2016cited by this paper
• Melanogenesis and DNA damage following photodynamic therapy in melanoma with two meso-substituted porphyrins.

  2016cited by this paper
• Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma

  2016cited by this paper
• The in vitro cytotoxicity of metal-complexes of porphyrin sensitizer intended for photodynamic therapy.

  2016cited by this paper
• Phthalocyanine-Gold Nanoparticle Hybrids: Modulating Quenching with a Silica Matrix Shell.

  2016cited by this paper
• Dendrimer porphyrin-coated gold nanoshells for the synergistic combination of photodynamic and photothermal therapy.

  2016cited by this paper
• A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy.

  2016cited by this paper
• Surface chemistry of porphyrins and phthalocyanines

  2015cited by this paper
• The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model

  2015cited by this paper
• The synthesis of gold nanoparticles by a citrate-radiolytical method

  2015cited by this paper
• Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense.

  2015cited by this paper
• Binding strength of porphyrin-gold nanoparticle hybrids based on number and type of linker moieties and a simple method to calculate inner filter effects of gold nanoparticles using fluorescence spectroscopy.

  2015cited by this paper
• Functionalized Gold Nanoparticles: Synthesis, Properties and Applications--A Review.

  2015cited by this paper
• Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

  2015cited by this paper
• Porphyrin-based photosensitizers and the corresponding multifunctional nanoplatforms for cancer-imaging and phototherapy

  2015cited by this paper
• Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)

  2015cited by this paper
• Gold(III) phthalocyanine chloride: Optical and structural characterization of thin films

  2015cited by this paper
• How toxic are gold nanoparticles? The state-of-the-art

  2015cited by this paper
• Advanced drug delivery systems: Nanotechnology of health design A review

  2014cited by this paper
• Fungal biosynthesis of gold nanoparticles: mechanism and scale up

  2014cited by this paper
• Physico-Chemical Characteristics of Gold Nanoparticles

  2014cited by this paper
• Gold Nanoparticles: Synthesis and Applications in Drug Delivery

  2014cited by this paper
• Gold nanoparticles: various methods of synthesis and antibacterial applications.

  2014cited by this paper
• Gold nanoparticle assemblies stabilized by bis(phthalocyaninato)lanthanide(III) complexes through van der Waals interactions

  2014cited by this paper
• Effects of Internalized Gold Nanoparticles with Respect to Cytotoxicity and Invasion Activity in Lung Cancer Cells

  2014cited by this paper
• Electron beam/γ-ray irradiation synthesis of gold nanoparticles and investigation of antioxidant activity

  2014cited by this paper
• Anisotropic gold nanoparticles: synthesis, properties, applications, and toxicity.

  2014cited by this paper
• Protoporphyrin IX-gold nanoparticle conjugates as an efficient photosensitizer in cervical cancer therapy.

  2013cited by this paper
• Synthesis, photophysical properties and photocatalytic activity of tungsten porphyrin (TPPWCl4)

  2013cited by this paper
• Photodynamic Therapy (PDT): PDT Mechanisms

  2013cited by this paper
• Gold nanoparticles in chemical and biological sensing.

  2012cited by this paper
• Gold nanoparticles: preparation, properties, and applications in bionanotechnology.

  2012cited by this paper
• Polymer nanogels: a versatile nanoscopic drug delivery platform.

  2012cited by this paper
• Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy.

  2012cited by this paper
• Comparative Study on Methods for Preparation of Gold Nanoparticles

  2012cited by this paper
• Effect of Process Factors on the Properties of Doxycycline Nanovesicles

  2012cited by this paper
• Biological synthesis of gold nanoparticles by Bacillus subtilis and evaluation of increased antimicrobial activity against clinical isolates

  2012cited by this paper
• The golden age: gold nanoparticles for biomedicine.

  2012cited by this paper
• Gold(II) phthalocyanine revisited: synthesis and spectroscopic properties of gold(III) phthalocyanine and an unprecedented ring-contracted phthalocyanine analogue.

  2012cited by this paper
• Capping and in vivo toxicity studies of gold nanoparticles

  2012cited by this paper
• Oxidative photodamage induced by photodynamic therapy with methoxyphenyl porphyrin derivatives in tumour-bearing rats.

  2011cited by this paper
• Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration.

  2011cited by this paper
• Pulse train fluorescence technique for measuring triplet state dynamics.

  2011cited by this paper
• Photodamaging effects of porphyrins and chitosan on primary human keratinocytes and carcinoma cell cultures

  2011cited by this paper
• Inorganic nanoparticles for cancer imaging and therapy.

  2011cited by this paper
• Fungus-mediated biological synthesis of gold nanoparticles: potential in detection of liver cancer

  2011cited by this paper
• Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis

  2011cited by this paper
• Synthesis and photophysical studies of phthalocyanine-gold nanoparticle conjugates.

  2011cited by this paper
• One-pot synthesis of gold nanoparticles using tetradentate porphyrins

  2011cited by this paper
• Synthesis and photophysical properties of a novel zinc photosensitizer and its gold nanoparticle conjugate

  2011cited by this paper
• Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy

  2010cited by this paper
• Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats.

  2010cited by this paper
• Gold nanoparticles for biology and medicine.

  2010cited by this paper
• Biological synthesis of gold and silver nanoparticles mediated by the bacteria Bacillus subtilis.

  2010cited by this paper
• Fullerene-porphyrin nanostructures in photodynamic therapy.

  2010cited by this paper
• A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway.

  2010cited by this paper
• Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time

  2010cited by this paper
• Gold nanoparticles: opportunities and challenges in nanomedicine

  2010cited by this paper
• Modified porphyrin-brucine conjugated to gold nanoparticles and their application in photodynamic therapy.

  2010cited by this paper
• Analysis of the toxicity of gold nano particles on the immune system: effect on dendritic cell functions

  2010cited by this paper
• Biological synthesis of metallic nanoparticles.

  2010cited by this paper
• Assessment of the In Vivo Toxicity of Gold Nanoparticles

  2009cited by this paper
• Functionalized gold nanoparticles: synthesis, structure and colloid stability.

  2009cited by this paper
• Nanoparticles for biomedical imaging

  2009cited by this paper
• Biological synthesis of gold nanoparticles using Magnolia kobus and Diopyros kaki leaf extracts

  2009cited by this paper
• Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles.

  2009cited by this paper

• Dendritic porphyrins as promising sensitizers in aqueous media. From synthesis to potential applications

  2024cites this paper
• Fabrication of Sn(IV)porphyrin-Imbedded Silica Aerogel Composite

  2023cites this paper
• Recycling E-Waste and the Sustainable Economy: A Bibliometric Exploration

  2023cites this paper
• Synthesis of Metal Nanoparticles Encapsulated with Skewered Porphyrins Assembled by Siloxane Coupling

  2023cites this paper
• Sn(IV)-Porphyrin-Based Nanostructures Featuring Pd(II)-Mediated Supramolecular Arrays and Their Photocatalytic Degradation of Acid Orange 7 Dye

  2022cites this paper
• Sn(IV) Porphyrin-Based Ionic Self-Assembled Nanostructures and Their Application in Visible Light Photo-Degradation of Malachite Green

  2022cites this paper
• Rigid, yet flexible: formation of unprecedented silver MB-DIPY dimers with orthogonal chromophore geometry.

  2020cites this paper
• Recent advances in electroanalytical drug detection by porphyrin/phthalocyanine macrocycles: developments and future perspectives.

  2020cites this paper
• Nanomaterials Used in Conservation and Restoration of Cultural Heritage: An Up-to-Date Overview

  2020cites this paper
• Photodynamic antimicrobial chemotherapy of asymmetric porphyrin-silver conjugates towards photoinactivation of Staphylococcus aureus

  2020cites this paper