Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2015-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2015.02.005PMID 25662280
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid intra-adrenal feedback regulation of glucocorticoid synthesis

  2015cited by this paper
• Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery*

  2015influential reference
• Impact of duration of critical illness on the adrenal glands of human intensive care patients.

  2014cited by this paper
• HPA axis-rhythms.

  2014cited by this paper
• Autocrine positive regulatory feedback of glucocorticoid secretion: glucocorticoid receptor directly impacts H295R human adrenocortical cell function.

  2014influential reference
• Constant light disrupts the circadian rhythm of steroidogenic proteins in the rat adrenal gland.

  2013cited by this paper
• The use of saliva for assessment of cortisol pulsatile secretion by deconvolution analysis.

  2013cited by this paper
• Transcriptional regulation of episodic glucocorticoid secretion.

  2013cited by this paper
• Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery.

  2013cited by this paper
• Reduced cortisol metabolism during critical illness.

  2013cited by this paper
• Automated 24-hours sampling of subcutaneous tissue free cortisol in humans

  2013influential reference
• Transcriptional implications of ultradian glucocorticoid secretion in homeostasis and in the acute stress response.

  2012cited by this paper
• The Origin of Glucocorticoid Hormone Oscillations

  2012cited by this paper
• Ultradian corticosterone secretion is maintained in the absence of circadian cues

  2012cited by this paper
• Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain

  2012influential reference
• The glucocorticoid receptor and its expression in the anterior pituitary and the adrenal cortex: a source of variation in hypothalamic-pituitary-adrenal axis function; implications for pituitary and adrenal tumors.

  2011cited by this paper
• ACTH-dependent ultradian rhythm of corticosterone secretion.

  2011cited by this paper
• Temporal Effect of Adrenocorticotrophic Hormone on Adrenal Glucocorticoid Steroidogenesis: Involvement of the Transducer of Regulated Cyclic AMP-Response Element-Binding Protein Activity

  2011cited by this paper
• Stress responsiveness varies over the ultradian glucocorticoid cycle in a brain-region-specific manner.

  2010cited by this paper
• Rapid Glucocorticoid Receptor-Mediated Inhibition of Hypothalamic–Pituitary–Adrenal Ultradian Activity in Healthy Males

  2010cited by this paper
• Origin of ultradian pulsatility in the hypothalamic–pituitary–adrenal axis

  2010cited by this paper
• Glucocorticoid Ultradian Rhythmicity Directs Cyclical Gene Pulsing of the Clock Gene Period 1 in Rat Hippocampus

  2010influential reference
• Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy.

  2009influential reference
• Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

  2009influential reference
• Dax-1 and Steroid Receptor RNA Activator (SRA) Function as Transcriptional Coactivators for Steroidogenic Factor 1 in Steroidogenesis

  2009cited by this paper
• Neural regulation of endocrine and autonomic stress responses

  2009influential reference
• Development of an automated blood sampling system for use in humans

  2009influential reference
• Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1.

  2008influential reference
• Regulation of CREB-mediated gene expression by salt inducible kinase.

  2008cited by this paper
• Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress.

  2008cited by this paper
• Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors.

  2008cited by this paper
• Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland.

  2008cited by this paper
• Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone.

  2007cited by this paper
• Dephosphorylation of TORC initiates expression of the StAR gene.

  2007cited by this paper
• Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome.

  2006cited by this paper
• Adrenocorticotropin-dependent changes in SF-1/DAX-1 ratio influence steroidogenic genes expression in a novel model of glucocorticoid-producing adrenocortical cell lines derived from targeted tumorigenesis.

  2006cited by this paper
• Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study

  2006cited by this paper
• Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex.

  2006cited by this paper
• Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation.

  2006cited by this paper
• Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin.

  2005cited by this paper
• Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2

  2005cited by this paper
• The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation.

  2004cited by this paper
• The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

  2004cited by this paper
• A quantitative study of the pulsatile parameters of CRH-41 secretion in unanesthetized free-moving rats

  2004cited by this paper
• Gonadal Steroid Replacement Reverses Gonadectomy‐Induced Changes in the Corticosterone Pulse Profile and Stress‐Induced Hypothalamic‐Pituitary‐Adrenal Axis Activity of Male and Female Rats

  2004cited by this paper
• Hormones and the stressed brain.

  2004influential reference
• Gonadectomy Reverses The Sexually Diergic Patterns Of Circadian and Stress‐Induced Hypothalamic‐Pituitary‐Adrenal Axis Activity In Male and Female Rats

  2004cited by this paper
• TORCs: transducers of regulated CREB activity.

  2003cited by this paper
• Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

  2003cited by this paper
• Mitochondrial Processing of Newly Synthesized Steroidogenic Acute Regulatory Protein (StAR), but Not Total StAR, Mediates Cholesterol Transfer to Cytochrome P450 Side Chain Cleavage Enzyme in Adrenal Cells*

  2001cited by this paper
• LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells.

  2001influential reference
• Increased Corticosterone Pulse Frequency During Adjuvant‐Induced Arthritis and its Relationship to Alterations in Stress Responsiveness

  2001cited by this paper
• The Active Phase‐Related Increase in Corticosterone and Aggression are Linked

  2000cited by this paper
• Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in Rats

  2000cited by this paper
• Possible Function of IL‐6 and TNF as Intraadrenal Factors in the Regulation of Adrenal Steroid Secretion

  2000cited by this paper
• Perioperative serum levels of tumour‐necrosis‐factor alpha (TNF‐α), IL‐1β, IL‐6, IL‐10 and soluble IL‐2 receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution

  1999cited by this paper
• Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1

  1998cited by this paper
• The pulsatile characteristics of hypothalamo-pituitary-adrenal activity in female Lewis and Fischer 344 rats and its relationship to differential stress responses.

  1998influential reference
• Ultradian rhythm of basal corticosterone release in the female rat: dynamic interaction with the response to acute stress.

  1998influential reference
• Characterization of the promoter region of the mouse gene encoding the steroidogenic acute regulatory protein.

  1997influential reference
• Phosphorylation of Steroidogenic Acute Regulatory Protein (StAR) Modulates Its Steroidogenic Activity*

  1997cited by this paper
• Regulation of the acute production of steroids in steroidogenic cells.

  1996cited by this paper
• Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene.

  1996influential reference
• Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.

  1995cited by this paper
• Short-term but not long-term adrenalectomy modulates amplitude and frequency of the CRH41 episodic release in push-pull cannulated median eminence of free-moving rats.

  1994cited by this paper
• Splanchnic neural activity modulates ultradian and circadian rhythms in adrenocortical secretion in awake rats.

  1994cited by this paper
• Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

  1994influential reference
• Transcriptional regulation of human genes for steroidogenic enzymes.

  1993cited by this paper
• Dissociation of pulsatile cortisol and adrenocorticotropin secretion in fetal sheep during late gestation.

  1992cited by this paper
• Evidence of a corticotropin-releasing hormone pulse generator in the macaque hypothalamus.

  1992cited by this paper
• Serum levels of IL‐1, IL‐6 and tumour necrosis factors in patients undergoing coronary artery bypass grafts or cholecystectomy

  1992cited by this paper
• Synchronous ultradian rhythms in adrenocortical secretion detected by microdialysis in awake rats.

  1991cited by this paper
• Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. II. Evidence for in vivo ultradian hypersecretion of proopiomelanocortin peptides by the isolated anterior and intermediate pituitary.

  1990cited by this paper
• Evidence for an ultradian secretion of adrenocorticotropin, beta-endorphin and alpha-melanocyte-stimulating hormone by the ovine anterior and intermediate pituitary.

  1989cited by this paper
• Evidence for an ultradian secretion of adrenocorticotropin, β-endorphin and α-melanocyte-stimulating hormone by the ovine anterior and intermediate pituitary

  1989cited by this paper
• Plasma adrenocorticotropic hormone in the rat demonstrates three different rhythms within 24 h.

  1989cited by this paper
• Secretion of corticotropin releasing factor (CRF) and vasopressin (AVP) into the hypophysial portal blood of conscious, unrestrained rams.

  1988cited by this paper
• Changes in mean plasma ACTH reflect changes in amplitude and frequency of secretory pulses.

  1988cited by this paper
• Pulsatile ACTH secretion: variation with time of day and relationship to cortisol.

  1988cited by this paper
• Regulation of ACTH secretion: variations on a theme of B.

  1987cited by this paper
• Characterization of Corticosterone Feedback Regulation of ACTH Secretion a

  1987cited by this paper
• Automated repetitive microsampling of blood: growth hormone profiles in conscious male rats.

  1986cited by this paper
• Episodic secretion of ACTH in rats.

  1986cited by this paper
• Ultradian glucocorticoid rhythms in monkeys and rats continue during stress.

  1984cited by this paper
• Characteristics of corticosteroid inhibition of adrenocorticotrophin release from the anterior pituitary gland of the rat.

  1984cited by this paper
• The effects of corticotropin-releasing factor on adrenocorticotropin secretion from perifused pituitaries in vitro: rapid inhibition by glucocorticoids.

  1984cited by this paper
• Algorithms for the study of episodic hormone secretion.

  1982cited by this paper
• Demonstration of glucocorticoid receptors in the adrenal cortex: evidence for a direct dexamethasone suppressive effect on the rat adrenal gland.

  1980cited by this paper
• Topological studies of cytochromes P-450scc and P-45011 beta in bovine adrenocortical inner mitochondrial membranes. Effects of controlled tryptic digestion.

  1979influential reference
• Acute self-suppression of corticosteroidogenesis in isolated adrenocortical cells.

  1979cited by this paper
• Synchronous episodic release of cortisol in the sheep.

  1978cited by this paper
• Dynamics and mechanics of corticosteroid feedback at the hypothalamus and anterior pituitary gland.

  1977cited by this paper
• Synchronized ultradian cortisol rhythms in monkeys: persistence during corticotropin infusion

  1977cited by this paper
• Feedback inhibition of adrenocorticotropin release by corticosterone infusions in the adrenalectomized rat.

  1975cited by this paper
• Relationship between ACTH release and corticosterone binding by the receptor sites of the adenohypophysis and dorsal hippocampus following infusion of corticosterone at a constant rate in the adrenalectomized rat.

  1975cited by this paper
• Evidence for dual corticosteroid-receptor mechanisms in the feedback control of adrenocorticotrophin secretion.

  1974cited by this paper
• Corticosteroid feedback control of ACTH secretion: effect of stress-induced corticosterone ssecretion on subsequent stress responses in the rat.

  1973cited by this paper
• Characteristics of fast feedback control of corticotrophin release by corticosteroids.

  1972cited by this paper
• Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects.

  1971cited by this paper
• The effect of previous stimulation of the adrenal cortex by adrenocorticotrophin on the function of the pituitary—adrenocortical axis in response to stress

  1966cited by this paper

• Prediabetes May Alter HPA Axis Activity and Regulation: A Study on Patients with Prediabetes

  2025cites this paper
• Effects of the Pituitary-targeted Gland Axes on Hepatic Lipid Homeostasis in Endocrine-associated Fatty Liver Disease-A Concept Worth Revisiting

  2024cites this paper
• Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish

  2024cites this paper
• Analytical and quantitative assessment of the structural components of the adrenal glands of rats under the conditions of exposure to the venom of vipers Vipera berus berus and Vipera berus nikolskii

  2024cites this paper
• Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression

  2024cites this paper
• The canonical HPA axis facilitates and maintains light adaptive behavior

  2023cites this paper
• Corticosteroid-binding globulin (SERPINA6) consolidates sexual dimorphism of adult rat liver.

  2023cites this paper
• Increased Hippocampal Glucocorticoid Receptor Expression and Reduced Anxiety-Like Behavior Following Tuina in a Rat Model With Allergic Airway Inflammation.

  2023cites this paper
• Multi-Systemic Evaluation of Biological and Emotional Responses to the Trier Social Stress Test: A Meta-Analysis and Systematic Review.

  2022cites this paper
• Neuroendocrine stress hormones associated with short-term exposure to nitrogen dioxide and fine particulate matter in individuals with and without chronic obstructive pulmonary disease: A panel study in beijing, China.

  2022cites this paper
• Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model.

  2021cites this paper
• Chronic stress and Alzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia

  2021cites this paper
• Mechanism of glucocorticoid action in immunology—Basic concepts

  2021cites this paper
• Altered expression of clock and clock‐controlled genes in a hSOD1‐linked amyotrophic lateral sclerosis mouse model

  2021cites this paper
• Correlation analysis between extracts and endogenous metabolites to characterise the influence of salt-processing on compatibility mechanism of 'Psoraleae Fructus & Foeniculi Fructus'.

  2021cites this paper
• The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection

  2021cites this paper
• Alpha- and beta- adrenergic receptors regulate inflammatory responses to acute and chronic sleep fragmentation in mice

  2021cites this paper
• The Peacock study: feasibility of the dynamic characterisation of the paediatric hypothalamic-pituitary-adrenal function during and after cardiac surgery

  2020cites this paper
• Responses to chronic corticosterone on brain glucocorticoid receptors, adrenal gland, and gut microbiota in mice lacking neuronal serotonin.

  2020cites this paper
• Liver at the nexus of rat postnatal HPA axis maturation and sexual dimorphism.

  2020cites this paper
• Effects of Alpha- and Beta-Adrenergic Receptor Blockade upon Inflammatory Responses to Acute And Chronic Sleep Fragmentation

  2020cites this paper
• Investigating the mechanisms mediating the outcomes of prenatal stress

  2020cites this paper
• Gene activation and repression by the glucocorticoid receptor are mediated by sequestering Ep300 and two modes of chromatin binding

  2019cites this paper
• Dynamics of ACTH-Mediated Regulation of Gene Transcription in ATC1 and ATC7 Adrenal Zona Fasciculata Cell Lines

  2019cites this paper
• Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.

  2019cites this paper
• Dynamic Endocrine Rhythms

  2019cites this paper
• Prednisone and Its Active Metabolite Prednisolone Attenuate Lipid Accumulation in Macrophages

  2019cites this paper
• Unemployment and mortality in a large Italian cohort.

  2019cites this paper
• Residual Adrenal Function in Autoimmune Addison’s Disease—Effect of Dual Therapy With Rituximab and Depot Tetracosactide

  2019influential citation
• Residual adrenal function in autoimmune addison s disease effect of dual therapy with rituximab and depot tetracosactide

  2018cites this paper
• Contributions of cortisol and corticosterone to metabolic regulation in humans

  2018influential citation
• Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

  2018cites this paper
• Blunted basal corticosterone pulsatility predicts post-exposure susceptibility to PTSD phenotype in rats.

  2018cites this paper
• Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats

  2018cites this paper
• Advances in mathematical modelling of the hypothalamic–pituitary–adrenal (HPA) axis dynamics and the neuroendocrine response to stress

  2018cites this paper
• Stress and functional neurological disorders: mechanistic insights

  2018cites this paper
• The effects of restricted feeding on the ultradian rhythm of corticosterone secretion and steroidogenesis in the rat adrenal

  2017cites this paper
• Glucocorticoid-Dependent Circadian Modulation of Prefrontal Cortex Molecular Clocks and Functioning

  2017cites this paper
• Chapter 43 – Ultradian Rhythms

  2017cites this paper
• 4.12 – Glucocorticoid Replacement in Man

  2017cites this paper
• Corticosteroids and the brain.

  2017cites this paper
• Immune-Neuro-Endocrine Reflexes, Circuits, and Networks: Physiologic and Evolutionary Implications.

  2017cites this paper
• Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats

  2017cites this paper
• Interleukin‐6 increases the expression of key proteins associated with steroidogenesis in human NCI‐H295R adrenocortical cells

  2017influential citation
• Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems.

  2017cites this paper
• (2017). The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids. (1), 3-45.

  2017cites this paper
• Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex

  2017cites this paper
• A users guide to HPA axis research.

  2017cites this paper
• Corticosteroids in septic shock: a systematic review and network meta-analysis

  2017cites this paper
• (2017). The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids. (1), 3-45.

  2017cites this paper
• Association of adrenal hormone metabolites and mortality over a 6-year follow-up in COPD patients with acute exacerbation

  2017cites this paper
• ACTH-Independent Hypercorticism in Adrenal Tumors and Adrenocortical Hyperplasia

  2016cites this paper
• Dynamic transitions in a model of the hypothalamic-pituitary-adrenal axis.

  2016cites this paper
• Endogenous glucocorticoid analysis by liquid chromatography-tandem mass spectrometry in routine clinical laboratories.

  2016cites this paper
• Presencia de corticosteroid-binding globulin (CBG) en tejidos extrahepáticos y alteraciones fisiológicas consecuencia de su déficit

  2016cites this paper
• Rhythms Within Rhythms: The Importance of Oscillations for Glucocorticoid Hormones

  2016cites this paper
• The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.

  2016cites this paper
• The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

  2016cites this paper
• 60 YEARS OF NEUROENDOCRINOLOGY: Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies.

  2015cites this paper
• The Importance of Biological Oscillators for Hypothalamic-Pituitary-Adrenal Activity and Tissue Glucocorticoid Response: Coordinating Stress and Neurobehavioural Adaptation

  2015cites this paper
• Dynamics of the human stress system in depression

  2015cites this paper
• OF MORPHOLOGY

  year unknowncites this paper