Leghemoglobin is nitrated in functional legume nodules in a tyrosine residue within the heme cavity by a nitrite/peroxide-dependent mechanism.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  The Plant Journal

• Publication date

  2015-03-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1111/tpj.12762PMID 25603991PMCID PMC4346251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
• Need of biomarkers of nitrosative stress in plants.

  2007cited by this paper
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  1999cited by this paper
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