Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast

Septin proteins hetero-oligomerize to form filaments. Mutant septins that subtly misfold a key oligomerization interface retain some function when expressed alone but are excluded from filaments when the wild-type allele is present. Cytosolic chaperones mediate this “quality control” via prolonged interactions with the mutant polypeptides.

• Publication year

  2015

• Venue

  Molecular Biology of the Cell

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E14-11-1531PMID 25673805PMCID 4454179
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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