Therapeutic Hypothermia for Neuroprotection

No abstract is available for this paper.

• Publication year

  2014

• Venue

  The Neurohospitalist

• Publication date

  2014-02-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.1177/1941874413519802PMID 24982721PMCID PMC4056415
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypothermia for acute spinal cord injury--a review.

  2014cited by this paper
• Hypothermia for acute ischaemic stroke.

  2013influential reference
• Effect of therapeutic hypothermia on oxidative stress and outcome in term neonates with perinatal asphyxia: a randomized controlled trial.

  2013cited by this paper
• Hypothermia protects against oxygen-glucose deprivation-induced neuronal injury by down-regulating the reverse transport of glutamate by astrocytes as mediated by neurons.

  2013cited by this paper
• Mild Prolonged Hypothermia for Large Intracerebral Hemorrhage

  2013cited by this paper
• Inflammatory Response Following Diffuse Axonal Injury

  2013cited by this paper
• Cardiac index during therapeutic hypothermia: which target value is optimal?

  2013cited by this paper
• Timing of Intracranial Hypertension Following Severe Traumatic Brain Injury

  2013cited by this paper
• Perceptions and Practices of Therapeutic Hypothermia in American Neonatal Intensive Care Units

  2013cited by this paper
• Subarachnoid hemorrhage complicated with neurogenic pulmonary edema and takotsubo-like cardiomyopathy.

  2012cited by this paper
• Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

  2012cited by this paper
• Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest*

  2012cited by this paper
• [EuroHYP-1 trial: EU-funded therapy study on the effectiveness of mild therapeutic hypothermia for acute ischemic stroke].

  2012cited by this paper
• Acute lung injury in critical neurological illness*

  2012cited by this paper
• Neuroprotective mechanisms of hypothermia in brain ischaemia

  2012influential reference
• Systemic hypothermia in acute cervical spinal cord injury: a case-controlled study

  2012cited by this paper
• Posttraumatic hypothermia increases doublecortin expressing neurons in the dentate gyrus after traumatic brain injury in the rat.

  2012cited by this paper
• Therapeutic hypothermia for the management of intracranial hypertension in severe traumatic brain injury: A systematic review

  2012cited by this paper
• Therapeutic hypothermia in the management of acute liver failure.

  2012influential reference
• Mild Hypothermia Therapy Reduces Blood Glucose and Lactate and Improves Neurologic Outcomes in Patients With Severe Traumatic Brain Injury

  2012cited by this paper
• European society of intensive care medicine study of therapeutic hypothermia (32-35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)

  2011cited by this paper
• What is a systematic review?

  2011cited by this paper
• Hypothermia does not increase the risk of infection: a case control study

  2011cited by this paper
• ECG Changes in Subarachnoid Haemorrhage: A Synopsis

  2011cited by this paper
• Targeted temperature management in critical care: A report and recommendations from five professional societies*

  2011influential reference
• The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function

  2011cited by this paper
• Mild hypothermia therapy reduces blood glucose and lactate and improves neurologic outcomes in patients with severe traumatic brain injury.

  2011cited by this paper
• Hypothermia in patients with brain injury: the way forward? – Author's reply

  2011cited by this paper
• Hypothermia in patients with brain injury: the way forward?

  2011cited by this paper
• The 2010 Guidelines on Neonatal Resuscitation (AHA, ERC, ILCOR): Similarities and Differences – What Progress Has Been Made since 2005?

  2011cited by this paper
• Stroke: Highlights of Selected Articles

  2011cited by this paper
• Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial.

  2011influential reference
• Therapeutic Hypothermia Influences Cell Genesis and Survival in the Rat Hippocampus following Global Ischemia

  2011cited by this paper
• Induction of Therapeutic Hypothermia by Paramedics After Resuscitation From Out-of-Hospital Ventricular Fibrillation Cardiac Arrest: A Randomized Controlled Trial

  2010cited by this paper
• Is pH-stat or alpha-stat the best technique to follow in patients undergoing deep hypothermic circulatory arrest?

  2010cited by this paper
• Part 14: Pediatric Advanced Life Support

  2010cited by this paper
• Clinical Outcomes Using Modest Intravascular Hypothermia After Acute Cervical Spinal Cord Injury

  2010cited by this paper
• A randomised controlled trial to evaluate the efficacy of a 6 month dietary and physical activity intervention for prostate cancer patients receiving androgen deprivation therapy

  2010influential reference
• Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest

  2010cited by this paper
• Outcome and cost of aneurysmal subarachnoid hemorrhage.

  2010cited by this paper
• The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients.

  2010cited by this paper
• THERAPEUTIC HYPOTHERMIA IN PATIENTS WITH ANEURYSMAL SUBARACHNOID HEMORRHAGE, REFRACTORY INTRACRANIAL HYPERTENSION, OR CEREBRAL VASOSPASM

  2009cited by this paper
• The effect of hypothermia on neuronal viability following cardiopulmonary bypass and circulatory arrest in newborn piglets.

  2009cited by this paper
• Mechanisms of action, physiological effects, and complications of hypothermia

  2009influential reference
• [Intravascular hypothermia for the management of Intracranial hypertension in acute liver failure: case report].

  2009cited by this paper
• Post-ischemic hypothermia for 24h in P7 rats rescues hippocampal neuron: association with decreased astrocyte activation and inflammatory cytokine expression.

  2009cited by this paper
• Outcome, timing and adverse events in therapeutic hypothermia after out‐of‐hospital cardiac arrest

  2009cited by this paper
• Near fatal posterior reversible encephalopathy syndrome complicating chronic liver failure and treated by induced hypothermia and dialysis: a case report

  2009cited by this paper
• Prolonged Hypothermia as a Bridge to Recovery for Cerebral Edema and Intracranial Hypertension Associated with Fulminant Hepatic Failure

  2009cited by this paper
• Hipotermia intravascular inducida en el manejo de la hipertensión intracraneana en insuficiencia hepática aguda: Caso clínico

  2009cited by this paper
• Mild Hypothermia Has No Long-Term Impact on Postischemic Neurogenesis in Rats

  2009cited by this paper
• Intensive care 1650: the revival of Anne Greene (c. 1628–59)

  2009cited by this paper
• Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia

  2008cited by this paper
• Intra-arrest rapid head cooling improves postresuscitation myocardial function in comparison with delayed postresuscitation surface cooling

  2008cited by this paper
• Therapeutic hypothermia: past, present, and future.

  2008cited by this paper
• IL-10 Production Is Reduced by Hypothermia but Augmented by Hyperthermia in Rat Microglia

  2008cited by this paper
• Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia.

  2007cited by this paper
• Effect of mild hypothermia on glucose metabolism and glycerol of brain tissue in patients with severe traumatic brain injury.

  2007cited by this paper
• The inflammatory response in stroke.

  2007cited by this paper
• Occurrence of “J Waves” in 12‐Lead ECG as a Marker of Acute Ischemia and Their Cellular Basis

  2007cited by this paper
• Mild hypothermia for temporary brain ischemia during cardiopulmonary support systems: Report of three cases

  2006cited by this paper
• Cold as a therapeutic agent

  2006influential reference
• Resuscitation great. Breaking the thermal barrier: Dr. Temple Fay.

  2006cited by this paper
• Breaking the thermal barrier: Dr. Temple Fay

  2006cited by this paper
• Closed head injury--an inflammatory disease?

  2005cited by this paper
• Effect of hypothermia on serum electrolyte, inflammation, coagulation, and nutritional parameters in patients with severe traumatic brain injury

  2004influential reference
• Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension.

  2004cited by this paper
• Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidence

  2004cited by this paper
• Long‐Term Hypothermia in Patients with Severe Brain Edema After Poor‐Grade Subarachnoid Hemorrhage Feasibility and Intensive Care Complications

  2003cited by this paper
• Effects of Hypothermia on Energy Metabolism in Mammalian Central Nervous System

  2003cited by this paper
• Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury

  2002cited by this paper
• Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

  2002influential reference
• Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.

  2002cited by this paper
• Hypothermia as an adjunctive treatment for severe bacterial meningitis.

  2000cited by this paper
• Treatment of traumatic brain injury with moderate hypothermia

  1997cited by this paper
• Treatment of traumatic brain injury with moderate hypothermia.

  1997cited by this paper
• Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.

  1996cited by this paper
• Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury.

  1993cited by this paper
• Mild Hypothermia Reduces Infarct Size Resulting From Temporary but Not Permanent Focal Ischemia In Rats

  1992cited by this paper
• Resuscitation from clinical death: Pathophysiologic limits and therapeutic potentials

  1988cited by this paper
• Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

  1987cited by this paper
• Another chance for therapeutic hypothermia?

  1985cited by this paper
• Cerebral anoxia: effect of deep hypothermia and pH.

  1979cited by this paper
• Improvement in multiple sclerosis during prolonged induced hypothermia

  1977cited by this paper
• Management of the comatose patient.

  1965cited by this paper
• COMMUNITY-WIDE CARDIOPULMONARY RESUSCITATION.

  1964cited by this paper
• THE USE OF EXTRACORPOREAL CIRCULATION AND PROFOUND HYPOTHERMIA IN THE TREATMENT OF RUPTURED INTRACRANIAL ANEURYSM.

  1964cited by this paper
• The clinical use of hypothermia following cardiac arrest.

  1959cited by this paper
• Early experiences with local and generalized refrigeration of the human brain.

  1959cited by this paper
• The clinical use of hypothermia following cardiac arrest.

  1958cited by this paper
• Hypothermia in the treatment of craniocerebral traumatism.

  1958cited by this paper
• Hypothermia, and interruption of carotid, or carotid and vertebral circulation, in the surgical management of intracranial aneurysms.

  1956cited by this paper
• Cerebral blood flow and cerebral oxygen consumption during hypothermia.

  1954cited by this paper
• Further experiences with hypothermia for intracardiac surgery in monkeys and groundhogs.

  1953cited by this paper
• Journal of Cerebral Blood Flow and Metabolism Mild Cerebral Hypothermia during and after Cardiac Arrest Improves Neurologic Outcome in Dogs

  year unknowncited by this paper
• open access to scientific and medical research Open Access Full Text Article Review Maximizing neuroprotection: where do we stand?

  year unknowninfluential reference

• Anesthetic Management for Proximal Aortic Repair

  2025cites this paper
• Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents

  2025cites this paper
• Targeted Temperature Management Strategies in Pediatric Patients with Return of Spontaneous Circulation after Out-of-Hospital Cardiac Arrest: A Grading of Recommendations, Assessment, Development, and Evaluation-Assessed Systematic Review and Meta-Analysis.

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• HOPE or hopeless? Unexpected neurological recovery after ECPR rewarming in a patient with severely hypothermic cardiac arrest with multiple haemorrhagic complications: a case report

  2025cites this paper
• Pharmacotherapy variability and precision medicine in neurocritical care

  2025cites this paper
• Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: Technical challenges and controversies

  2025cites this paper
• Management and short-term outcomes of hypoxic-ischemic encephalopathy in neonates: A Study from the neonatal intensive care unit at Atbara Teaching Hospital, Sudan

  2025cites this paper
• Earlier Initiation of Targeted Temperature Management for Out-of-Hospital Cardiac Arrest Patients: A Quality Improvement Project.

  2025cites this paper
• Differences in Brain Metabolite Profiles Between Normothermia and Hypothermia

  2024cites this paper
• Evaluation of Neuroprotective Effects of Local Hypothermia in a Porcine Spinal Cord Injury Model

  2024cites this paper
• Targeted Temperature Management for Out-of-Hospital Cardiac Arrest Survivors

  2024cites this paper
• Seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A1 receptor agonist as an adjunct to standard medical treatment.

  2024cites this paper
• Hypothermia as Potential Therapeutic Approach to Attenuating Soman-Induced Seizure, Neuropathology, and Mortality with an Adenosine A1 Receptor Agonist and Body Cooling.

  2024cites this paper
• Mild Therapeutic Hypothermia Alleviated Myocardial Ischemia/Reperfusion Injury via Targeting SLC25A10 to Suppress Mitochondrial Apoptosis

  2024cites this paper
• Motor Recovery after Spinal Cord Trauma and Effect of Local Hypothermia in a Porcine Experimental Model

  2024cites this paper
• RAN translation of C9orf72-related dipeptide repeat proteins in zebrafish recapitulates hallmarks of amyotrophic lateral sclerosis and identifies hypothermia as a therapeutic strategy

  2024cites this paper
• Linking Hypothermia and Altered Metabolism with TrkB Activation

  2023cites this paper
• Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4

  2023cites this paper
• Intra Operative Mild Cooling of Large Tumors Reduces Their Invasive and Metastatic Functions While Increasing Their Resistance to Apoptosis

  2023cites this paper
• Hypothermic Circulatory Arrest in Adult Aortic Arch Surgery: A Review of Hypothermic Circulatory Arrest and its Anesthetic Implications.

  2023cites this paper
• Mitochondrial polymorphism m.3017C>T of SHLP6 relates to heterothermy

  2023cites this paper
• Implementing a Stepwise Shivering Protocol During Targeted Temperature Management

  2023cites this paper
• Therapeutic Hypothermia in Treating Glioblastoma: A Review

  2023cites this paper
• Brain Hypothermia Therapy and Targeted Temperature Management for Acute Encephalopathy in Children: Status and Prospects

  2023cites this paper
• Targeted Temperature Management: A Program Evaluation.

  2022cites this paper
• Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

  2022cites this paper
• A Case Series of Clinical Limitations to the Clinical Course of Neurogenic Fever

  2022cites this paper
• Depolarization time and extracellular glutamate levels aggravate ultraearly brain injury after subarachnoid hemorrhage

  2022cites this paper
• Hypothermia as a potential remedy for canine and feline acute spinal cord injury: a review

  2022cites this paper
• Modelling epidural space heat transfer with air cooling via catheter insertion for spinal cord injury treatment

  2022cites this paper
• Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.

  2022cites this paper
• Development and Clinical Validation of a Finite Element Method Model Mapping Focal Intracranial Cooling

  2022cites this paper
• Interactions between central nervous system and peripheral metabolic organs

  2022cites this paper
• Cooling Uncouples Differentially ROS Production from Respiration and Ca2+ Homeostasis Dynamic in Brain and Heart Mitochondria

  2022cites this paper
• Mild hypothermia facilitates mitochondrial transfer from astrocytes to injured neurons during oxygen-glucose deprivation/reoxygenation.

  2021cites this paper
• Adjuvant therapeutic potential of moderate hypothermia for glioblastoma

  2021cites this paper
• TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection

  2021cites this paper
• Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors

  2021cites this paper
• Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia

  2021cites this paper
• Neuroprotection in Acute Ischemic Stroke: A Brief Review

  2021cites this paper
• Physiological basis underlying antidepressant-induced activation of TrkB receptors

  2021cites this paper
• Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
• Thiazoline-related TRPA1 agonist odorants orchestrate survival fate in mice

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Targeted temperature management in acute liver failure: A systematic review

  2020cites this paper
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  2020cites this paper
• Hypothermia in the course of acute traumatic spinal cord injury.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Hypothermia and Stroke: Pros and Cons

  2019cites this paper
• Basics of Neuroanesthesia: Anatomy, Physiology, and Pharmacology

  2018cites this paper
• Varying Evidence on Deep Hypothermic Circulatory Arrest in Thoracic Aortic Aneurysm Surgery.

  2018cites this paper
• Does the Environment Influence the Frequency of Concussion Incidence in Professional Football?

  2018cites this paper
• From Hypothermia to Cephalosomatic Anastomoses: The Legacy of Robert White (1926-2010) at Case Western Reserve University of Cleveland.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Targeted Temperature Management in Pediatric Neurocritical Care.

  2018cites this paper
• Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper