Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2011-10-05

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1021/jf2029785PMID 21919437
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

  2011cited by this paper
• Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells.

  2010cited by this paper
• Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice.

  2009cited by this paper
• Ectodermal-Neural Cortex 1 Down-Regulates Nrf2 at the Translational Level

  2009cited by this paper
• Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication.

  2009cited by this paper
• Prooxidant actions of carotenoids in biologic systems.

  2009cited by this paper
• Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage.

  2009cited by this paper
• Direct and indirect antioxidant properties of inducers of cytoprotective proteins.

  2008cited by this paper
• NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals

  2008cited by this paper
• Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

  2008cited by this paper
• Fucoxanthin restrains oxidative stress induced by retinol deficiency through modulation of Na+Ka+-ATPase and antioxidant enzyme activities in rats

  2008cited by this paper
• Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.

  2008cited by this paper
• Cytoprotective effect of fucoxanthin isolated from brown algae Sargassum siliquastrum against H2O2-induced cell damage

  2008cited by this paper
• Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D.

  2008cited by this paper
• The significance of Nrf2 pathway in (photo)‐oxidative stress response in melanocytes and keratinocytes of the human epidermis

  2007cited by this paper
• The use of fetal bovine serum as delivery vehicle to improve the uptake and stability of lycopene in cell culture studies

  2007cited by this paper
• Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites.

  2007cited by this paper
• Biochemistry of oxidative stress.

  2007cited by this paper
• Iron chelation in the biological activity of curcumin.

  2006cited by this paper
• Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

  2006cited by this paper
• Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention.

  2006cited by this paper
• Nrf2 as a novel molecular target for chemoprevention.

  2005cited by this paper
• Comparison of (−)-Epigallocatechin-3-Gallate Elicited Liver and Small Intestine Gene Expression Profiles Between C57BL/6J Mice and C57BL/6J/Nrf2 (−/−) Mice

  2005cited by this paper
• The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress.

  2004cited by this paper
• Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein.

  2003cited by this paper
• Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.

  2003cited by this paper
• Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

  2003cited by this paper
• Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

  2003cited by this paper
• Antioxidant and prooxidant properties of carotenoids.

  2001cited by this paper
• Induction of Cellular Antioxidative Stress Genes through Heterodimeric Transcription Factor Nrf2/Small Maf by Antirheumatic Gold(I) Compounds*

  2001cited by this paper
• Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention.

  2001cited by this paper
• Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene*

  1999cited by this paper
• Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed.

  1999cited by this paper
• Mechanisms of reaction of benzo(a)pyrene-7,8-diol-9,10-epoxide with DNA in aqueous solutions.

  1984cited by this paper
• Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

  1983cited by this paper

• Dietary fucoxanthin alleviates skin aging and modulates systemic aging markers in naturally aged C57BL/6J mice.

  2026cites this paper
• Structure Meets Function: Dissecting Fucoxanthin’s Bioactive Architecture

  2025cites this paper
• Fucoxanthin mitigates aflatoxin B1-triggered hepatotoxicity in HepG2 cells via modulation of oxidative stress, inflammatory cytokines, and caspases cascade.

  2025cites this paper
• Progress on the biological characteristics and physiological activities of fucoxanthin produced by marine microalgae

  2024cites this paper
• Recent update on cerebral sparganosis: A bibliometric analysis and scientific mapping

  2024cites this paper
• Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model

  2023cites this paper
• Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model

  2023cites this paper
• Supplement of food functional factor ergothioneine can effectively prevent liver injury in mice

  2023cites this paper
• Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

  2022cites this paper
• Ameliorative Effects of Peptide Phe-Leu-Ala-Pro on Acute Liver and Kidney Injury Caused by CCl4 via Attenuation of Oxidative Stress and Inflammation

  2022cites this paper
• Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves' Orbitopathy

  2022cites this paper
• Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets

  2022cites this paper
• Brown Algae as Functional Food Source of Fucoxanthin: A Review

  2022cites this paper
• Evaluate the Protective Effect of Antioxidants on Retinal Pigment Cell Hazard Induced by Blue Light: A Mini-Review

  2022cites this paper
• Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3‐O‐rhamnoside ameliorate lipopolysaccharide‐induced inflammation and oxidative stress in RAW264.7 cells

  2022cites this paper
• Nutraceutical and Cosmeceutical Potential of Seaweed Derived Fucoxanthin

  2021cites this paper
• Fucoxanthin alleviates methamphetamine-induced neurotoxicity possibly via the inhibition of interaction between Keap1 and Nrf2

  2021cites this paper
• Cancer Chemopreventive Role of Dietary Terpenoids by Modulating Keap1-Nrf2-ARE Signaling System—A Comprehensive Update

  2021cites this paper
• Prevention of cardiovascular disease through modulation of endothelial cell function by dietary seaweed intake

  2021cites this paper
• Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro

  2021cites this paper
• Meeting Sustainable Development Goals: Alternative Extraction Processes for Fucoxanthin in Algae

  2021cites this paper
• Fucoxanthin@Polyvinylpyrrolidone Nanoparticles Promoted Oxidative Stress-Induced Cell Death in Caco-2 Human Colon Cancer Cells

  2021cites this paper
• The edible seaweed Laminaria japonica contains cholesterol analogues that inhibit lipid peroxidation and cyclooxygenase enzymes

  2021cites this paper
• Fucoxanthin Holds Potential to Become a Drug Adjuvant in Breast Cancer Treatment: Evidence from 2D and 3D Cell Cultures

  2021cites this paper
• Carotenoids as Antioxidants

  2021cites this paper
• Modulation of the ubiquitin-proteasome system by marine natural products

  2021cites this paper
• Floridoside Exhibits Antioxidant Properties by Activating HO-1 Expression via p38/ERK MAPK Pathway

  2020cites this paper
• Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence.

  2020cites this paper
• Fucoxanthin: A promising compound for human inflammation-related diseases.

  2020cites this paper
• Carotenoids and Chlorophylls as Antioxidants

  2020cites this paper
• Terpenoids as Potential Geroprotectors

  2020cites this paper
• A novel wheat germ polysaccharide: Structural characterization, potential antioxidant activities and mechanism.

  2020cites this paper
• Chitopentaose protects HaCaT cells against H2O2-induced oxidative damage through modulating MAPKs and Nrf2/ARE signaling pathways

  2020cites this paper
• Astaxanthin and Fucoxanthin

  2020cites this paper
• Potential Anti-Aging Substances Derived from Seaweeds

  2020cites this paper
• Anti-obesity Effects of Fucoxanthin, a Major Marine Carotenoid Isolated from Edible Brown Seaweeds- A Narrative Review

  2020cites this paper
• Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase (NQO1)

  2020cites this paper
• Health benefits of fucoxanthin in the prevention of chronic diseases.

  2020cites this paper
• Siphonaxanthin, a carotenoid from green algae, suppresses advanced glycation end product-induced inflammatory responses

  2019cites this paper
• Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention.

  2019cites this paper
• Retracted Article: Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages

  2019cites this paper
• Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.

  2019cites this paper
• Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathways

  2018cites this paper
• Seaweeds as Source of Bioactive Substances and Skin Care Therapy—Cosmeceuticals, Algotheraphy, and Thalassotherapy

  2018cites this paper
• Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells

  2018cites this paper
• Activation of Nrf2 by Ginsenoside Rh3 protects retinal pigment epithelium cells and retinal ganglion cells from UV

  2018cites this paper
• Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling.

  2018cites this paper
• Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride‐induced acute liver injury by activating Nrf2 signaling pathway in mice

  2018cites this paper
• Astaxanthin Induces the Nrf2/HO-1 Antioxidant Pathway in Human Umbilical Vein Endothelial Cells by Generating Trace Amounts of ROS.

  2018cites this paper
• Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1/AMPK signaling pathway.

  2018cites this paper
• Circulating exosomal microRNAs reveal the mechanism of Fructus Meliae Toosendan-induced liver injury in mice

  2018cites this paper
• Phycochemical Constituents and Biological Activities of Fucus spp.

  2018cites this paper
• Fucoxanthin Inhibits β-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments.

  2017cites this paper
• Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

  2017cites this paper
• Screening active components of modified Xiaoyao powder as NRF2 agonists

  2017cites this paper
• Functional foods and their role in cancer prevention and health promotion: a comprehensive review.

  2017cites this paper
• miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells

  2017cites this paper
• Dual Biological Functions of a Cytoprotective Effect and Apoptosis Induction by Bioavailable Marine Carotenoid Fucoxanthinol through Modulation of the Nrf2 Activation in RAW264.7 Macrophage Cells

  2017cites this paper
• Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation.

  2017cites this paper
• Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells

  2017cites this paper
• Health beneficial effects of carotenoids & polyphenols from locally grown fruits & vegetables determined by in-vitro assessment of Caco-2 cells following simulated gastro-intestinal digestion

  2017cites this paper
• The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation.

  2016cites this paper
• Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals.

  2016cites this paper
• Protective Effect of Fucoxanthin Isolated from Laminaria japonica against Visible Light-Induced Retinal Damage Both in Vitro and in Vivo.

  2016cites this paper
• SC79 protects retinal pigment epithelium cells from UV radiation via activating Akt-Nrf2 signaling

  2016cites this paper
• Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress.

  2016cites this paper
• SC79 rescues osteoblasts from dexamethasone though activating Akt-Nrf2 signaling.

  2016cites this paper
• Eugenia uniflora leaves essential oil induces toxicity in Drosophila melanogaster: involvement of oxidative stress mechanisms

  2015cites this paper
• Anti-Obesity Activity of the Marine Carotenoid Fucoxanthin

  2015cites this paper
• Sodium fluoride generates ROS and alters transcription of genes for xenobiotic metabolizing enzymes in adult zebrafish (Danio rerio) liver: expression pattern of Nrf2/Keap1 (INrf2)

  2015cites this paper
• Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases

  2015cites this paper
• Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes.

  2015cites this paper
• Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans.

  2015cites this paper
• Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition.

  2015cites this paper
• Marine Organisms in Cancer Chemoprevention

  2015cites this paper
• Seaweed Carotenoids for Cancer Therapeutics

  2015cites this paper
• Production of fucoxanthin-rich fraction (FxRF) from a diatom, Chaetoceros calcitrans (Paulsen) Takano 1968

  2015cites this paper
• Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention.

  2014cites this paper
• Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.

  2014cites this paper
• Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

  2014cites this paper
• Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity

  2014cites this paper
• Acute exposure to 3‐methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice

  2014cites this paper
• Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes.

  2014cites this paper
• Toxicity Induced by Prasiola crispa to Fruit Fly Drosophila melanogaster and Cockroach Nauphoeta cinerea: Evidence for Bioinsecticide Action

  2014cites this paper
• Oligomeric proanthocyanidins alleviate hexabromocyclododecane-induced cytotoxicity in HepG2 cells through regulation on ROS formation and mitochondrial pathway.

  2014cites this paper
• Fumigant Activity of the Psidium guajava Var. Pomifera (Myrtaceae) Essential Oil in Drosophila melanogaster by Means of Oxidative Stress

  2014cites this paper
• Bioactive components from seaweeds: Cosmetic applications and future development

  2014cites this paper
• Certain carotenoids enhance the intracellular glutathione level in a murine cultured macrophage cell line by inducing glutamate-cysteine-ligase.

  2014cites this paper
• Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways.

  2014cites this paper
• Potential ability of xanthophylls to prevent obesity-associated cancer

  2014cites this paper
• Characterization and hepatoprotective effect of polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp.

  2014cites this paper
• Hexane fraction from Laminaria japonica exerts anti-inflammatory effects on lipopolysaccharide-stimulated RAW 264.7 macrophages via inhibiting NF-kappaB pathway

  2013cites this paper
• Anti-inflammatory properties of algae

  2013cites this paper
• Gastric and hepatic protective effects of algal components.

  2013cites this paper
• The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity.

  2013influential citation
• Cultivated Sea Lettuce is a Multiorgan Protector from Oxidative and Inflammatory Stress by Enhancing the Endogenous Antioxidant Defense System

  2013cites this paper
• Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway.

  2013cites this paper
• Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet

  2013cites this paper
• Biosynthetic Pathway and Health Benefits of Fucoxanthin, an Algae-Specific Xanthophyll in Brown Seaweeds

  2013cites this paper
• Fucoxanthin Protects Cultured Human Keratinocytes against Oxidative Stress by Blocking Free Radicals and Inhibiting Apoptosis

  2013cites this paper