High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor.

Kehua Xu,Feng Wang,Xiaohong Pan,Renpu Liu,Jing Ma,Fanpeng Kong,B. Tang

Published 2013 in Chemical Communications

ABSTRACT

A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial-mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.

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