SIRT6, a Mammalian deacylase with multitasking abilities.

Mammalian Sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration and aging. In this Review, we will describe the multiple roles of SIRT6, a chromatin deacylase with unique and important functions in maintaining cellular homeostasis. We will attempt to provide a framework for such different functions, for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.

• Publication year

  2019

• Venue

  Physiological Reviews

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/physrev.00030.2018PMID 31437090PMCID PMC7002868
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

  2019cited by this paper
• Identification of a cellularly active SIRT6 allosteric activator

  2018cited by this paper
• Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6

  2018cited by this paper
• SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

  2018cited by this paper
• An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality

  2018cited by this paper
• SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway

  2018cited by this paper
• SIRT6 facilitates directional telomere movement upon oxidative damage

  2018cited by this paper
• Natural polyphenols as sirtuin 6 modulators

  2018cited by this paper
• SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling

  2018cited by this paper
• Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster

  2018cited by this paper
• Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

  2018cited by this paper
• Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

  2018cited by this paper
• Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

  2017cited by this paper
• Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis

  2017cited by this paper
• Sirt6 Promotes DNA End Joining in iPSCs Derived from Old Mice.

  2017cited by this paper
• Neuroprotective Functions for the Histone Deacetylase SIRT6.

  2017cited by this paper
• SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion

  2017cited by this paper
• Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet–Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype

  2017cited by this paper
• SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox‐LDL condition

  2017cited by this paper
• Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.

  2017cited by this paper
• Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells

  2017cited by this paper
• Characterization of physiological defects in adult SIRT6-/- mice

  2017cited by this paper
• SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men

  2017cited by this paper
• Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

  2017cited by this paper
• The Sirt6 gene: Does it play a role in tooth development?

  2017cited by this paper
• Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.

  2017cited by this paper
• Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

  2017cited by this paper
• SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

  2017cited by this paper
• SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.

  2016cited by this paper
• SIRT6 deacetylates H3K18Ac at pericentric chromatin to prevent mitotic errors and cell senescence

  2016cited by this paper
• SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

  2016cited by this paper
• Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

  2016cited by this paper
• Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.

  2016cited by this paper
• SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein–Dependent Apoptotic Pathway

  2016cited by this paper
• Lysine fatty acylation promotes lysosomal targeting of TNF-α

  2016cited by this paper
• SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

  2016cited by this paper
• SIRT6 Is a Positive Regulator of Aldose Reductase Expression in U937 and HeLa cells under Osmotic Stress: In Vitro and In Silico Insights

  2016cited by this paper
• SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling.

  2016cited by this paper
• Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.

  2016cited by this paper
• Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

  2016cited by this paper
• A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

  2016cited by this paper
• Knockdown of SIRT6 Enables Human Bone Marrow Mesenchymal Stem Cell Senescence

  2016cited by this paper
• SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

  2016cited by this paper
• A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.

  2016cited by this paper
• p53-dependent SIRT6 expression protects Aβ42-induced DNA damage

  2016cited by this paper
• LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56.

  2016cited by this paper
• Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

  2016cited by this paper
• SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

  2016cited by this paper
• JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

  2016cited by this paper
• Identifying the functional contribution of the defatty-acylase activity of SIRT6

  2016cited by this paper
• SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

  2016cited by this paper
• High glucose‐induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects

  2016cited by this paper
• Association of SIRT6 Gene Polymorphisms with Human Longevity

  2016cited by this paper
• SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation

  2016cited by this paper
• Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling

  2016cited by this paper
• A FRET-based assay for screening SIRT6 modulators.

  2015cited by this paper
• SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

  2015cited by this paper
• The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

  2015cited by this paper
• Putative tumor suppression function of SIRT6 in endometrial cancer

  2015cited by this paper
• ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation.

  2015cited by this paper
• E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

  2015cited by this paper
• Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway*

  2015cited by this paper
• Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

  2015cited by this paper
• SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9–Rad1–Hus1 checkpoint clamp

  2015cited by this paper
• SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target.

  2015cited by this paper
• Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents

  2015cited by this paper
• Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte

  2015cited by this paper
• SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.

  2014cited by this paper
• Tackling the cancer stem cells — what challenges do they pose?

  2014cited by this paper
• MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

  2014cited by this paper
• SIRT6 Is Required for Normal Retinal Function

  2014cited by this paper
• Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

  2014cited by this paper
• Sirtuins, metabolism, and DNA repair.

  2014cited by this paper
• SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor‐κB Signaling Pathway

  2014cited by this paper
• Chromatin and beyond: the multitasking roles for SIRT6.

  2014cited by this paper
• SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

  2014cited by this paper
• SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort

  2014cited by this paper
• Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

  2014cited by this paper
• miR-34a/SIRT6 in squamous differentiation and cancer

  2014cited by this paper
• Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.

  2014cited by this paper
• Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

  2014cited by this paper
• Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

  2014cited by this paper
• The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells*

  2013cited by this paper
• The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination

  2013cited by this paper
• Multiple regulatory layers of SREBP1/2 by SIRT6.

  2013cited by this paper
• Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling

  2013cited by this paper
• Sirt6 regulates TNFα secretion via hydrolysis of long chain fatty acyl lysine

  2013cited by this paper
• TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

  2013cited by this paper
• SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

  2013cited by this paper
• The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

  2013cited by this paper
• A miR‐34a‐SIRT6 axis in the squamous cell differentiation network

  2013cited by this paper
• SIRT6 exhibits nucleosome-dependent deacetylase activity

  2013cited by this paper
• Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6[S]

  2013cited by this paper
• SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

  2013cited by this paper
• SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

  2013cited by this paper
• FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression*

  2013cited by this paper
• USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.

  2013cited by this paper
• Acetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency

  2013cited by this paper
• Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins* ♦

  2013cited by this paper
• The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.

  2013cited by this paper

• Novel small-molecule positive allosteric modulator 1 with blood-brain barrier penetration activity exerts anti-cellular senescence effects via the PAC1-R/YY1/SIRT6 pathway

  2026cites this paper
• The critical role of ferroptosis in thyroid cancer development and potential therapeutic implications

  2026cites this paper
• Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival.

  2026cites this paper
• Dynamic regulation of TBK1 lactylation shapes antiviral immune responses

  2026cites this paper
• Integrative computational simulations and functional assays decode allosteric dysregulation in a pathogenic SIRT6 variant.

  2026cites this paper
• The association of the SIRT6 rs117385980 variant with frailty and longevity: an exploratory study

  2025cites this paper
• Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation

  2025cites this paper
• Targeting Genome Stability to Mitigate Human Aging and Disease.

  2025cites this paper
• The crosstalk between MicroRNAs and sirtuins: a bit unexpected therapeutic target for cardiovascular diseases

  2025cites this paper
• The Influence of Sirtuin 6 on Chondrocyte Senescence in Osteoarthritis Under Aging: Focusing on Mitochondrial Dysfunction and Oxidative Stress

  2025cites this paper
• Association of SIRT1 rs12415800 and SIRT6 rs350844 polymorphisms with preeclampsia: A case-control study.

  2025cites this paper
• Sirtuin 6 mitigates thoracic aortic aneurysm progression via maintenance of mitochondria homeostasis in vascular smooth muscle cells

  2025cites this paper
• Sirtuins and tumor immunity: mechanistic insights, immunotherapy prospects, and therapeutic horizons

  2025cites this paper
• SIRT6 in Cancer: Mechanistic Insights into Its Dual Roles in Cancer Biology and Implications for Precision Therapeutic Development

  2025cites this paper
• Sirtuins in Alzheimer's disease: mechanistic insights and therapeutic opportunities.

  2025cites this paper
• Berberine inhibits NLRP3 inflammasome activation by upregulating the SIRT6-AMPK pathway to prevent angiotensin II-induced fibrosis and vulnerability to atrial fibrillation.

  2025cites this paper
• Sirtuin 2 regulates NOD‐like receptor protein 3/nuclear factor kappa B axis to promote cartilage repair in osteoarthritis

  2025cites this paper
• Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy

  2025cites this paper
• SIRT7 deletion inhibits Glaesserella parasuis-mediated inflammatory responses in porcine alveolar macrophages

  2025cites this paper
• Epigenetic Insights Into Aging: Emerging Roles of Natural Products in Therapeutic Interventions

  2025cites this paper
• Rifampicin prevents diet-induced obesity through Sirt6-dependent lipolysis, adipocyte browning and lipogenesis inhibition.

  2025cites this paper
• Down-regulation of serum SIRT6 levels is associated with an increased risk of chronic intestinal inflammation in children exposed to airborne particulate matter and polycyclic aromatic hydrocarbons from e-waste.

  2025cites this paper
• Computer-Aided Drug Discovery for Undruggable Targets.

  2025cites this paper
• Structural Insights Into centSIRT6: Bioinformatic Analysis of N308K and A313S Substitution Effects

  2025cites this paper
• Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6-mediated suppression of oxidative stress and fetuin-A.

  2025cites this paper
• Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair

  2025cites this paper
• The Multifaceted Role of Sirtuins in Inflammatory Bowel Diseases.

  2025cites this paper
• DNA stimulates the deacetylase SIRT6 to mono-ADP-ribosylate proteins with histidine repeats

  2025cites this paper
• MDL800, a SIRT6 activator, mitigates neuroinflammation-induced retinal damage by modulating microglial M1/M2 polarization in experimental glaucoma.

  2025cites this paper
• Friend or foe? The role of SIRT6 on macrophage polarized to M2 subtype in acute kidney injury to chronic kidney disease

  2025cites this paper
• Tea polyphenol EGCG enhances the improvements of calorie restriction on hepatic steatosis and obesity while reducing its adverse outcomes in obese rats.

  2025cites this paper
• Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma

  2025cites this paper
• SIRT6 mitigates acute kidney injury by enhancing lipid metabolism and reducing tubular epithelial cell apoptosis via suppression of the ACMSD signaling pathway.

  2025cites this paper
• The Role and Molecular Pathways of SIRT6 in Senescence and Age‐related Diseases

  2025cites this paper
• Potential of SIRT6 modulators in targeting molecular pathways involved in cardiovascular diseases and their treatment-A comprehensive review.

  2025cites this paper
• Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development

  2025cites this paper
• Sirtuins in kidney homeostasis and disease: where are we now?

  2025cites this paper
• Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

  2025cites this paper
• Propofol Protects against Pyroptosis of Photoreceptors in Subretinal Hemorrhage via Regulating SIRT6/NLRP3 Signaling.

  2025cites this paper
• Sirtuins as Endogenous Regulators of Cardiac Fibrosis: A Current Perspective

  2025cites this paper
• Geniposidic acid alleviated metabolic dysfunction-associated steatotic liver disease by exciting SIRT6 signaling.

  2025cites this paper
• The APOE Gene Cluster in Normal Aging.

  2025cites this paper
• Sirtuins in Central Nervous System Tumors—Molecular Mechanisms and Therapeutic Targeting

  2025cites this paper
• Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.

  2024cites this paper
• Sirtuins in intervertebral disc degeneration: current understanding

  2024cites this paper
• Sirtuins in kidney diseases: potential mechanism and therapeutic targets

  2024cites this paper
• The histone deacetylase SRT2 enhances the tolerance of chrysanthemum to low temperatures through the ROS scavenging system.

  2024cites this paper
• Sirt6 ablation in the liver causes fatty liver that increases cancer risk by upregulating Serpina12

  2024cites this paper
• SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging

  2024cites this paper
• The deacetylase SIRT6 reduces amyloid pathology and supports cognition in mice by reducing the stability of APP in neurons.

  2024cites this paper
• SIRT6-dependent functional switch via K494 modifications of RE-1 silencing transcription factor

  2024cites this paper
• Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis

  2024cites this paper
• Unraveling aging from transcriptomics.

  2024cites this paper
• Sirt6 Mono‐ADP‐Ribosylates YY1 to Promote Dystrophin Expression for Neuromuscular Transmission

  2024cites this paper
• Baicalein Inhibits Cerebral Ischemia-Reperfusion Injury through SIRT6-Mediated FOXA2 Deacetylation to Promote SLC7A11 Expression

  2024influential citation
• SIRT6 alleviates senescence induced by Porphyromonas gingivalis in human gingival fibroblasts

  2024cites this paper
• Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility

  2024cites this paper
• The evolving process of ferroptosis in thyroid cancer: Novel mechanisms and opportunities

  2024cites this paper
• The miR‐26a/SIRT6/HIF‐1α axis regulates glycolysis and inflammatory responses in host macrophages during Mycobacterium tuberculosis infection

  2024cites this paper
• Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

  2024cites this paper
• Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation

  2024cites this paper
• Sirtuin 3 in renal diseases and aging：from mechanisms to potential therapies.

  2024cites this paper
• Ferroptosis in thyroid cancer: Potential mechanisms, effective therapeutic targets and predictive biomarker.

  2024cites this paper
• The dual role of sirtuins in cancer: biological functions and implications

  2024cites this paper
• Remdesivir ameliorates ulcerative colitis-propelled cell inflammation and pyroptosis in acetic acid rats by restoring SIRT6/FoxC1 pathway.

  2024cites this paper
• Oleuropein attenuates the nephrotoxic effect of sunitinib in rats: Unraveling the potential role of SIRT6/Notch-1/NLRP-3/IL-1β axis.

  2024cites this paper
• The many faces of SIRT6 in the retina and retinal pigment epithelium

  2023influential citation
• SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3).

  2023cites this paper
• HIPK2 as a Novel Regulator of Fibrosis

  2023cites this paper
• How protein topology controls allosteric regulations.

  2023cites this paper
• Role of sirtuins in metabolic disease-related renal injury.

  2023cites this paper
• SIRT6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes

  2023cites this paper
• SIRT6 ameliorates LPS-induced apoptosis and tight junction injury in ARDS through the ERK1/2 pathway and autophagy

  2023cites this paper
• SIRT6 attenuates LPS‐induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling

  2023cites this paper
• 20-Hydroxyecdysone inhibits inflammation via SIRT6-mediated NF-κB signaling in endothelial cells.

  2023cites this paper
• Ellagic acid ameliorates cisplatin-induced acute kidney injury by regulating inflammation and SIRT6/TNF-α signaling

  2023cites this paper
• Tea polyphenol EGCG ameliorates obesity-related complications by regulating lipidomic pathway in leptin receptor knockout rats.

  2023cites this paper
• SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress

  2023cites this paper
• Sirtuin 6 ameliorates bleomycin‐induced pulmonary fibrosis via activation of lipid catabolism

  2023cites this paper
• Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives.

  2023cites this paper
• Sirtuin 6 is a negative regulator of the anti-tumor function of natural killer cells in murine inflammatory colorectal cancer.

  2023cites this paper
• Histone deacetylase (HDACs) inhibitors: Clinical applications.

  2023cites this paper
• The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging Pathomechanisms

  2023cites this paper
• Overexpression of SIRT6 alleviates apoptosis and enhances cell viability and monoclonal antibody expression in CHO-K1 cells

  2023cites this paper
• Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process.

  2023cites this paper
• SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence

  2023cites this paper
• Sirtuins: Promising Therapeutic Targets to Treat Ischemic Stroke

  2023cites this paper
• Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis

  2023cites this paper
• Harnessing the Therapeutic Potential of Ginsenoside Rd for Activating SIRT6 in Treating a Mouse Model of Nonalcoholic Fatty Liver Disease

  2023cites this paper
• Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice

  2023cites this paper
• Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity

  2023cites this paper
• Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6

  2023cites this paper
• Serum SIRT6 Levels Are Associated with Frailty in Older Adults

  2023cites this paper
• Genomic Instability and Epigenetic Changes during Aging

  2023cites this paper
• SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells

  2023cites this paper
• Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality

  2023influential citation
• Overexpression of SIRT6 regulates NRF2/HO-1 and NF-κB signaling pathways to alleviate UVA-induced photoaging in skin fibroblasts.

  2023cites this paper
• Activation of SIRT6 Deacetylation by DNA Strand Breaks

  2023cites this paper
• The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair.

  2023cites this paper
• Lifestyle effects on aging and CVD: a spotlight on the nutrient-sensing network.

  2023cites this paper