Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Structure

• Publication date

  1999-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0969-2126(99)80020-3PMID 10368281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclic V3-loop-related HIV-1 conjugate vaccines. Synthesis, conformation and immunological properties.

  2009cited by this paper
• Structural aspects of antibodies and antibody-antigen complexes.

  2007cited by this paper
• A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.

  1998cited by this paper
• The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.

  1998cited by this paper
• Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

  1998cited by this paper
• The antigenic structure of the HIV gp120 envelope glycoprotein

  1998cited by this paper
• Glycosylation affects both the three-dimensional structure and antibody binding properties of the HIV-1IIIB GP120 peptide RP135.

  1997cited by this paper
• NMR study of the peptide present in the principal neutralizing determinant (PND) of HIV-1 envelope glycoprotein gp120.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells

  1997cited by this paper
• Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop

  1997cited by this paper
• An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

  1997cited by this paper
• Chemokine receptors and HIV

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site.

  1997cited by this paper
• Conformation of the principal neutralizing determinant of human immunodeficiency virus type 1 in complex with an anti-gp120 virus neutralizing antibody studied by two-dimensional nuclear magnetic resonance difference spectroscopy.

  1997cited by this paper
• Standard conformations for the canonical structures of immunoglobulins.

  1997cited by this paper
• Co-receptors for HIV-1 entry.

  1997cited by this paper
• NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein.

  1997cited by this paper
• Structural families in loops of homologous proteins: automatic classification, modelling and application to antibodies.

  1996cited by this paper
• Positioning of Positively Charged Residues in the V3 Loop Correlates with HIV Type 1 Syncytium-Inducing Phenotype

  1996cited by this paper
• Conformational features of a synthetic cyclic peptide corresponding to the complete V3 loop of the RF HIV-1 strain in water and water/trifluoroethanol solutions.

  1996cited by this paper
• Conformational preferences of a chimeric peptide HIV-1 immunogen from the C4-V3 domains of gp120 envelope protein of HIV-1 CAN0A based on solution NMR: comparison to a related immunogenic peptide from HIV-1 RF.

  1996cited by this paper
• Structural comparison of a 15 residue peptide from the V3 loop of HIV‐1IIIb and an O‐glycosylated analogue

  1996cited by this paper
• Structural classification of CDR‐H3 in antibodies

  1996cited by this paper
• Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes

  1996cited by this paper
• Structure of the Heat Shock Protein Chaperonin-10 of Mycobacterium leprae

  1996cited by this paper
• Secondary structural elements as a basis for antibody recognition in the immunodominant region of human immunodeficiency viruses 1 and 2.

  1996cited by this paper
• The application of hydrogen bonding analysis in X-ray crystallography to help orientate asparagine, glutamine and histidine side chains.

  1995cited by this paper
• The principal neutralizing determinant of HIV‐1 located in V3 of gp120 forms a 12‐residue loop by internal hydrophobic interactions

  1995cited by this paper
• Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera

  1995cited by this paper
• Local and Global Structural Properties of the HIV-MN V3 Loop (*)

  1995cited by this paper
• The crystal structure of the antibody N10-staphylococcal nuclease complex at 2.9 A resolution.

  1995cited by this paper
• Crystal structure of the principal neutralization site of HIV-1.

  1994cited by this paper
• Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 A resolution.

  1994cited by this paper
• Raster3D Version 2.0. A program for photorealistic molecular graphics.

  1994cited by this paper
• Solution structure of the V3 loop of a Thailand HIV isolate.

  1993cited by this paper
• X-Ray Crystallographic Studies of Antibody–Peptide Complexes

  1993cited by this paper
• Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker.

  1993cited by this paper
• Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex.

  1993cited by this paper
• Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.

  1993cited by this paper
• Defining critical residues in the epitope for a HIV-neutralizing monoclonal antibody using phage display and peptide array technologies.

  1993cited by this paper
• Broadly neutralizing monoclonal antibodies to the V3 region of HIV-1 can be elicited by peptide immunization.

  1993cited by this paper
• Major antigen-induced domain rearrangements in an antibody.

  1993cited by this paper
• A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex.

  1992cited by this paper
• Stereochemical quality of protein structure coordinates

  1992cited by this paper
• Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A.

  1992cited by this paper
• Synergistic interaction between ligands binding to the CD4 binding site and V3 domain of human immunodeficiency virus type I gp120.

  1992cited by this paper
• Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1.

  1992cited by this paper
• Synergistic interaction between ligands binding to the CD4 binding site and V3 domain of human immunodeficiency virus type I gpl20

  1992cited by this paper
• Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution

  1992cited by this paper
• Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule

  1992cited by this paper
• Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type 1.

  1992cited by this paper
• Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: corrections and clarifications.

  1991cited by this paper
• Sequences of proteins of immunological interest

  1991cited by this paper
• Conic: a fast renderer for space-filling molecules with shadows.

  1991cited by this paper
• Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant: further clarifications

  1991cited by this paper
• Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.

  1991cited by this paper
• Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120.

  1991cited by this paper
• Alteration of HIV-1 Infectivity and Neutralization by a Single Amino Acid Replacement in the V3 Loop Domain

  1991cited by this paper
• Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

  1991cited by this paper
• 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten.

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991cited by this paper
• Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding

  1991cited by this paper
• Accurate Bond and Angle Parameters for X-ray Protein Structure Refinement

  1991cited by this paper
• Slow-cooling protocols for crystallographic refinement by simulated annealing.

  1990cited by this paper
• Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant.

  1990cited by this paper
• Extension of molecular replacement: a new search strategy based on Patterson correlation refinement

  1990cited by this paper
• Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein.

  1989cited by this paper
• A fast algorithm for rendering space-filling molecule pictures

  1988cited by this paper
• The MIDAS display system

  1988cited by this paper
• Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus.

  1988cited by this paper
• Analysis and prediction of the different types of beta-turn in proteins.

  1988cited by this paper
• Analysis and prediction of the different types of β-turn in proteins

  1988cited by this paper
• MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement

  1988cited by this paper
• Structure of myohemerythrin in the azidomet state at 1.7/1.3 A resolution.

  1987cited by this paper
• Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO.

  1985cited by this paper
• Complete nucleotide sequence of the AIDS virus, HTLV-III

  1985cited by this paper
• Software for a diffractometer with multiwire area detector.

  1985cited by this paper
• Strategy for data collection from protein crystals using a multiwire counter area detector diffractometer

  1985cited by this paper
• Solvent-accessible surfaces of proteins and nucleic acids.

  1983cited by this paper
• A translation function combining packing and diffraction information: an application to lysozyme (high-temperature form)

  1981cited by this paper
• Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution.

  1980cited by this paper
• Side-chain torsional potentials: effect of dipeptide, protein, and solvent environment.

  1979cited by this paper
• The Protein Data Bank: a computer-based archival file for macromolecular structures.

  1977cited by this paper
• An obligatory alpha-helical amino acid residue.

  1973cited by this paper
• An obligatory α‐helical amino acid residue

  1973cited by this paper
• Angiotensin II: STUDIES ON THE BIOLOGICALLY ACTIVE CONFORMATION

  1972cited by this paper

• Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone

  2023cites this paper
• Novel small synthetic HIV-1 V3 crown variants: CCR5 targeting ligands

  2022cites this paper
• The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease

  2022cites this paper
• Design, synthesis, and evaluation of HIV-1 entry inhibitors based on broadly neutralizing antibody 447-52D and gp120 V3loop interactions.

  2021cites this paper
• Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2

  2021cites this paper
• Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens

  2020cites this paper
• Crystal Structures of Protein-Bound Cyclic Peptides.

  2019cites this paper
• Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients

  2019cites this paper
• Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126

  2019cites this paper
• Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developing an Effective HIV Vaccine

  2019cites this paper
• Proteins and Protein Structure

  2019cites this paper
• HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research

  2019influential citation
• Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials

  2018cites this paper
• A toolkit to quantify the sampling quality of molecular dynamics trajectories: studying highly flexible biomolecules

  2017cites this paper
• Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory

  2016cites this paper
• Computational Refinement and Validation Protocol for Proteins with Large Variable Regions Applied to Model HIV Env Spike in CD4 and 17b Bound State.

  2015cites this paper
• Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation

  2015cites this paper
• Conformational dynamics of a short antigenic peptide in its free and antibody bound forms gives insight into the role of β‐turns in peptide immunogenicity

  2015cites this paper
• ω‐Turn: A novel β‐turn mimic in globular proteins stabilized by main‐chain to side‐chain CH···O interaction

  2015cites this paper
• On the redox biology of the immuno-virological receptor CD4: biological function and applications in HIV-1 drug and vaccine development

  2014cites this paper
• Structural dynamics of V3 loop in a trimeric ambiance, a molecular dynamics study on gp120-CD4 trimeric mimic.

  2014cites this paper
• Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization

  2014cites this paper
• Antibody modeling assessment II. Structures and models

  2014cites this paper
• Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of Antibodies

  2014cites this paper
• Intrinsically Disordered Proteins

  2014cites this paper
• Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope

  2014cites this paper
• Structure and immune recognition of trimeric prefusion HIV-1 Env

  2014cites this paper
• , Rajnish Loops of HIV-1 Envelope Neutralizing Epitopes in the V 2 and V 3 Distinct Mechanisms Regulate Exposure of

  2014cites this paper
• Energetics of β-turn formation in a mutant peptide YPGDV from influenza hemagglutinin: an MD simulation study.

  2013cites this paper
• HIV-1 envelope glycoprotein structure.

  2013cites this paper
• Structural and thermodynamic insights into the recognition of native proteins by anti-peptide antibodies.

  2013cites this paper
• Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

  2013cites this paper
• Structural analysis of the envelope gp120 V3 loop for some HIV-1 variants circulating in the countries of Eastern Europe

  2013cites this paper
• Rabbit Anti-HIV-1 Monoclonal Antibodies Raised by Immunization Can Mimic the Antigen-Binding Modes of Antibodies Derived from HIV-1-Infected Humans

  2013cites this paper
• Max Bergmann lecture Protein epitope mimetics in the age of structural vaccinology

  2013cites this paper
• Tilting the balance between canonical and noncanonical conformations for the H1 hypervariable loop of a llama VHH through point mutations.

  2013cites this paper
• Importance of V3 Loop Flexibility and Net Charge in the Context of Co-Receptor Recognition. A Molecular Dynamics Study on HIV gp120

  2012cites this paper
• ELICITATION AND ENHANCEMENT OF T AND B CELL RESPONSES

  2012cites this paper
• Intraprotomer masking of third variable loop (V3) epitopes by the first and second variable loops (V1V2) within the native HIV-1 envelope glycoprotein trimer

  2011cites this paper
• Analysis of the antibody structure based on high-resolution crystallographic studies.

  2011cites this paper
• Discovery of Novel Promising Targets for Anti-AIDS Drug Developments by Computer Modeling: Application to the HIV-1 gp120 V3 Loop

  2011cites this paper
• Making Order in the Intrinsically Disordered Regions of HIV‐1 Vif Protein

  2011cites this paper
• Determination of the invariant structural elements for the third variable domain of the HIV-1 gp120 protein by molecular modeling

  2011cites this paper
• Human immunodeficiency virus-1 gp120 V3 loop for anti-acquired immune deficiency syndrome drug discovery: computer-aided approaches to the problem solving

  2011influential citation
• Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125

  2011influential citation
• Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine

  2011cites this paper
• Activation of the zymogen to urokinase-type plasminogen activator is associated with increased interdomain flexibility.

  2011cites this paper
• Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus

  2011cites this paper
• Analysis and Modeling of the Variable Region of Camelid Single-Domain Antibodies

  2011cites this paper
• Antibodies Region of Camelid Single-Domain Analysis and Modeling of the Variable

  2011cites this paper
• Camelid Single-Domain Antibodies Analysis and Modeling of the Variable Region of

  2011cites this paper
• Synthetic Virus‐Like Particles and Conformationally Constrained Peptidomimetics in Vaccine Design

  2011cites this paper
• Prediction of Co-Receptor Usage of HIV-1 from Genotype

  2010cites this paper
• Antibody epitope exposure and neutralization of HIV-1.

  2010cites this paper
• Antibody–Antigen Recognition and Conformational Changes

  2010cites this paper
• Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.

  2010cites this paper
• Computational antibody structure prediction and antibody-antigen docking

  2010cites this paper
• Mimicking the structure of the V3 epitope bound to HIV-1 neutralizing antibodies.

  2009cites this paper
• NMR evidence of charge‐dependent interaction between various PND V3 and CCR5 N‐terminal peptides

  2009cites this paper
• Potential New Therapeutic Agents: Effects on HIV Replication and Viral Escape

  2009cites this paper
• A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

  2009influential citation
• Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8.

  2009cites this paper
• Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5‐13 (C10A)

  2009cites this paper
• Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.

  2008cites this paper
• In vivo CXCR4 expression, lymphoid cell phenotype, and feline immunodeficiency virus infection.

  2008cites this paper
• The structure of the anti‐c‐myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops

  2008cites this paper
• Protein intrinsic disorder toolbox for comparative analysis of viral proteins

  2008cites this paper
• Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set.

  2008cites this paper
• Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.

  2007cites this paper
• Glycosylation of HIV-1 gp120 V3 loop: towards the rational design of a synthetic carbohydrate vaccine.

  2007cites this paper
• Conformational study of palindromic tripeptides (GPG, IPI and KPK) in HIV-1 protease--a density functional theory study.

  2007cites this paper
• Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis.

  2007cites this paper
• Structural Basis for Coreceptor Selectivity by The HIV Type 1 V3 Loop

  2007cites this paper
• Structural Analysis of the HIV-1 gp120 V3 Loop: Application to the HIV-Haiti Isolates

  2007cites this paper
• Elucidation of some Bax conformational changes through crystallization of an antibody–peptide complex

  2007cites this paper
• Structure of the Receptor-Binding Protein of Bacteriophage Det7: a Podoviral Tail Spike in a Myovirus

  2007cites this paper
• Crystal Structures of Human Immunodeficiency Virus Type 1 (HIV-1) Neutralizing Antibody 2219 in Complex with Three Different V3 Peptides Reveal a New Binding Mode for HIV-1 Cross-Reactivity

  2006cites this paper
• Determination of structurally conservative amino acids of the HIV-1 protein gp120 V3 loop as promising targets for drug design by protein engineering approaches

  2006cites this paper
• Fold Recognition of the Human Immunodeficiency Virus Type 1 V3 Loop and Flexibility of Its Crown Structure During the Course of Adaptation to a Host

  2006cites this paper
• Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-of-Fitness Mutations Compensate for V3 Loss-of-Fitness Mutations

  2006cites this paper
• Modeling of the spatial structure of an HIV-haiti immunodominant epitope

  2006cites this paper
• Stabilization of the biologically active conformation of the principal neutralizing determinant of HIV-1(IIIB) containing a cis-proline surrogate: 1H NMR and molecular modeling study.

  2006cites this paper
• Biologia molecular do HIV-1 e genética da resistência humana à AIDS

  2006cites this paper
• [Modeling of the 3D structure of the HIV-Haiti immunodominant epitope].

  2006cites this paper
• Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.

  2005cites this paper
• HIV-1 gp120 V3 loop for structure-based drug design.

  2005cites this paper
• Computer modelling of the immunoreactive conformation of the HIV-RF immunodominant epitope

  2005cites this paper
• V3: HIV's Switch-Hitter

  2005cites this paper
• Induced fit in HIV-neutralizing antibody complexes: evidence for alternative conformations of the gp120 V3 loop and the molecular basis for broad neutralization.

  2005cites this paper
• Structural studies of human HIV-1 V3 antibodies

  2005influential citation
• Fold recognition of the HIV-1 V3 loop and flexibility of its crown structure during the course of adaptation to a host

  2005cites this paper
• Local structure for the HIV-1 gp120 V3 loop. Comparative analysis of the fragment conformations in HIV-MN and HIV-Thailand isolates

  2005cites this paper
• Conformational properties of HIV-1 gp120/V3 immunogenic domains.

  2005cites this paper
• Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

  2005cites this paper
• NMR studies of V3 peptide complexes with antibodies suggest a mechanism for HIV-1 co-receptor selectivity.

  2005cites this paper
• Conformational Preferences of the HIV-1 Principal Neutralizing Determinant

  2005cites this paper
• Biomolecular recognition mechanisms studied by NMR spectroscopy and MD simulations

  2004influential citation
• The 447-52D antibody: hitting HIV-1 where its armor is thickest.

  2004cites this paper
• STRUCTURE AND POLYMORPHISM OF THE HIV-1 PRINCIPAL NEUTRALIZING EPITOPE

  2004cites this paper
• Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment.

  2004cites this paper