The current understanding of sepsis and research priorities for the future

This special issue of Virulence is entirely devoted to the topic of sepsis and septic shock. Septic shock continues to pose formidable challenges for emergency room physicians, critical care specialists, surgeons, and infectious disease clinicians alike in caring for these critically ill patients. Early recognition of sepsis and improved therapies to manage the multi-organ dysfunction that frequently follows sepsis pathophysiology remain major unmet medical needs. The interplay between virulence factors of the pathogen and the antimicrobial defenses of the host are critical determinants of outcome in sepsis and septic shock.1 This issue of Virulence will specifically focus on both the pathogen-related factors and the host defense mechanisms that lead to septic shock and contribute to its resolution or fatal outcome. We have assembled a stellar group of international experts in the field of sepsis research and compiled their ideas and collective wisdom in this special issue. We hope to provide a detailed review of the state of the art and science of septic shock research as it currently exists, extending from the molecular level to the population level.

• Publication year

  2013

• Venue

  Virulence

• Publication date

  2013-10-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.4161/viru.26803PMID 24153016PMCID 3916364
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer?

  2015cited by this paper
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  2014cited by this paper
• Animal models of sepsis

  2013cited by this paper
• Epidemiology of severe sepsis

  2013cited by this paper
• Host innate immune responses to sepsis

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• Pediatric sepsis

  2013cited by this paper
• Severe sepsis and septic shock

  2013cited by this paper
• Severe sepsis and septic shock.

  2013cited by this paper
• Rapid diagnosis of sepsis

  2013cited by this paper
• Meningococcal disease and the complement system

  2013influential reference
• Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

  2013cited by this paper
• The PIRO (predisposition, insult, response, organ dysfunction) model

  2013cited by this paper
• A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

  2013cited by this paper
• An alternate pathophysiologic paradigm of sepsis and septic shock

  2013cited by this paper
• The clinical impact of multidrug-resistant gram-negative bacilli in the management of septic shock

  2013cited by this paper
• The changing immune system in sepsis

  2013cited by this paper
• Invasive candidiasis as a cause of sepsis in the critically ill patient

  2013cited by this paper
• The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis

  2013influential reference
• Anti-endotoxin vaccines

  2013cited by this paper
• Gram-positive and gram-negative bacterial toxins in sepsis

  2013cited by this paper
• The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

  2013cited by this paper
• Genomic responses in mouse models poorly mimic human inflammatory diseases

  2013cited by this paper
• Neonatal sepsis

  2013cited by this paper
• Clinical controversies in the management of critically ill patients with severe sepsis

  2013cited by this paper
• Gender differences in sepsis

  2013cited by this paper
• Systemic inflammatory response syndrome (SIRS)

  2013cited by this paper
• The complex link between influenza and severe sepsis

  2013cited by this paper
• Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.

  2013cited by this paper
• Sepsis definitions: time for change.

  2013cited by this paper
• The complex pathogenesis of bacteremia

  2013cited by this paper
• Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

  2007cited by this paper
• Management of severe sepsis and septic shock

  2004cited by this paper
• Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

  2004cited by this paper

• Coagulation Disorders in Sepsis and COVID-19—Two Sides of the Same Coin? A Review of Inflammation–Coagulation Crosstalk in Bacterial Sepsis and COVID-19

  2023cites this paper
• miR-19a-3p inhibition alleviates sepsis-induced lung injury via enhancing USP13 expression.

  2021cites this paper
• Descriptive Study of Septicemia among Children Under Five Years in Wasit Province, Iraq in 2019

  2021cites this paper
• The Role of Histones and Heparin in Sepsis: A Review

  2021cites this paper
• Activation of cellular immune response in insect model host Galleria mellonella by fungal α-1,3-glucan

  2020cites this paper
• Abdominal Sepsis. Some Genetic-Molecular Mechanisms of Its Occurrence

  2020cites this paper
• Resistome analysis of bloodstream infection bacterial genomes reveals a specific set of proteins involved in antibiotic resistance and drug efflux

  2020cites this paper
• Myeloid cells in sepsis‐acquired immunodeficiency

  2020cites this paper
• The Antitumor Properties of Dinitrosyl Iron Complexes with Thiol-Containing Ligands and S-Nitrosoglutathione in Experiments

  2020cites this paper
• How is Nitric Oxide (NO) Converted into Nitrosonium Cations (NO+) in Living Organisms? (Based on the Results of Optical and EPR Analyses of Dinitrosyl Iron Complexes with Thiol-Containing Ligands)

  2020cites this paper
• Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections.

  2020cites this paper
• A prospective, multi-center study of Candida bloodstream infections in Chile

  2019cites this paper
• Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis

  2019cites this paper
• Research on effect of adiponectin on sepsis-induced lung injury in rats through IL-6/STAT3 signaling pathway.

  2019cites this paper
• Butorphanol attenuates inflammation via targeting NF-κB in septic rats with brain injury.

  2019cites this paper
• Morphological Characteristics of the Thymus and Spleen and the Subpopulation Composition of Lymphocytes in Peripheral Blood during Systemic Inflammatory Response in Male Rats with Different Resistance to Hypoxia

  2019cites this paper
• Carbapenem-resistant Pseudomonas aeruginosa bloodstream infection: in vitro synergy, virulence and clinical outcome

  2018cites this paper
• The Pathogenesis of Sepsis: “If We Cannot beat them Alone Join Them?”

  2018cites this paper
• The impact of chemotherapeutic treatment on the oral microbiota of patients with cancer: a systematic review.

  2018cites this paper
• The relative resistance of children to sepsis mortality: from pathways to drug candidates

  2018cites this paper
• Infection assays in Arabidopsis reveal candidate effectors from the poplar rust fungus that promote susceptibility to bacteria and oomycete pathogens.

  2018cites this paper
• Bacteriolysis – a mere laboratory curiosity?

  2018cites this paper
• Chromatin Profiling of the Repetitive and Nonrepetitive Genomes of the Human Fungal Pathogen Candida albicans

  2018cites this paper
• Tissue damage in post infectious sequelae is caused by a synergism between microbial and neutrophils-derived agonists: a concern for a disregard for already published data

  2018cites this paper
• (1,3)-β-D-glucan-based diagnosis of invasive Candida infection versus culture-based diagnosis in patients with sepsis and with an increased risk of invasive Candida infection (CandiSep): study protocol for a randomized controlled trial

  2018cites this paper
• Up-Regulation of Antimicrobial Peptides Gallerimycin and Galiomicin in Galleria mellonella Infected with Candida Yeasts Displaying Different Virulence Traits

  2018cites this paper
• From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective

  2017cites this paper
• Novel Approach in Monocyte Intracellular TNF Measurement: Application to Sepsis-Induced Immune Alterations

  2017cites this paper
• Is Histone a Solitary Vile Sepsis-Inducing Agent or Just "a Member of the Gang"?

  2017cites this paper
• The antitumor effect of dinitrosyl iron complexes with glutathione in a murine solid-tumor model

  2017cites this paper
• PAMPs, PRRs, effectors and R‐genes associated with citrus‐pathogen interactions

  2017cites this paper
• Avian influenza overview September – November 2017

  2017cites this paper
• Dinitrosyl iron complexes with thiol-containing ligands as a base for developing drugs with diverse therapeutic activities: Physicochemical and biological substantiation

  2017cites this paper
• Sepsis Pathogenicity and Histones: Are we “Re-discovering the Wheel”?

  2017cites this paper
• Differential cellular immune response of Galleria mellonella to Actinobacillus pleuropneumoniae

  2017cites this paper
• Characterizing the Role of Pre-Pubertal Status in Sepsis: Why Do Children Survive When Adults Do Not

  2017cites this paper
• Mitochondria-meditated pathways of organ failure upon inflammation

  2017cites this paper
• Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and Clostridium.

  2017cites this paper
• Analysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans

  2017cites this paper
• Macroscopic amyloid fiber formation by staphylococcal biofilm associated SuhB protein.

  2016cites this paper
• Dinitrosyl iron complexes with thiol-containing ligands as a "working form" of endogenous nitric oxide.

  2016cites this paper
• Restraining of reactive oxygen species promotes invasion of Listeria monocytogenes into glia cells.

  2016cites this paper
• Regulation, sensory domains and roles of two Desulfovibrio desulfuricans ATCC27774 Crp family transcription factors, HcpR1 and HcpR2, in response to nitrosative stress

  2016cites this paper
• Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery.

  2016cites this paper
• An antinitrosative system as a factor in malignant tumor resistance to the cytotoxic effect of nitrogen monoxide

  2015cites this paper
• Study on the comparative activity of echinocandins on murine gut colonization by Candida albicans.

  2015cites this paper
• Antibiotic resistance and integrons in Shiga toxin-producing Escherichia coli (STEC)

  2015cites this paper
• Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

  2015cites this paper
• RIEMS: a software pipeline for sensitive and comprehensive taxonomic classification of reads from metagenomics datasets

  2015cites this paper
• Clinical characteristics and risk factors of enterococcal infections in Nagasaki, Japan: a retrospective study

  2015cites this paper
• The microbiome mutiny hypothesis: can our microbiome turn against us when we are old or seriously ill?

  2015cites this paper
• De Novo Assembly and Genome Analyses of the Marine-Derived Scopulariopsis brevicaulis Strain LF580 Unravels Life-Style Traits and Anticancerous Scopularide Biosynthetic Gene Cluster

  2015cites this paper
• The antitumor activity of the S-nitrosoglutathione and dinitrosyl iron complex with glutathione: Comparative studies

  2015cites this paper
• Synergistic Aspects to Explain the Pathophysiology of Sepsis and Septic Shock-An Opinion

  2015cites this paper
• Cutaneous, Subcutaneous and Systemic Mycology

  2015cites this paper
• Sepsis in the Severely Immunocompromised Patient

  2015cites this paper
• Is Bacteriolysis In vivo a Friend or a Foe? Relation to Sepsis, Chronic Granulomatous Inflammation and to Oral Disorders: an Overview Hypothesis

  2015cites this paper
• Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients.

  2015cites this paper
• Infection in late preterm infants.

  2014cites this paper
• Remote monitoring of the progression of primary pneumonic plague in Brown Norway rats in high-capacity, high-containment housing.

  2014cites this paper
• Omics approaches in food safety: fulfilling the promise?

  2014cites this paper
• Comparative effects of hypoxia and hypoxia mimetic cobalt chloride on in vitro adhesion, biofilm formation and susceptibility to amphotericin B of Candida glabrata.

  2014cites this paper
• Antitumor activity of dinitrosyl iron complexes with glutathione

  2014cites this paper
• Physicochemistry of dinitrosyl iron complexes with thiolate ligands underlying their beneficial effect in endometriosis

  2014cites this paper
• Effects of bacteriophage on the quality and shelf life of Paralichthys olivaceus during chilled storage.

  2014cites this paper
• Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect

  2013cites this paper