Expression of reg protein in rat regenerating islets and its co-localization with insulin in the Beta cell secretory granules

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Diabetologia

• Publication date

  1990-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF00404804PMID 2189771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Biology of the Islets of Langerhans: A novel gene, reg , expressed in regenerating islets

  1990cited by this paper
• N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.

  1989cited by this paper
• The human reg gene encodes pancreatic stone protein.

  1989cited by this paper
• Immunocytochemical localization of cathepsins B, H, and their endogenous inhibitor, cystatin beta, in islet endocrine cells of rat pancreas.

  1988influential reference
• A novel gene activated in regenerating islets.

  1988cited by this paper
• Immunocytochemical Localization of Pancreatic Stone Protein in the Human Digestive Tract

  1986cited by this paper
• Molecular basis of experimental diabetes: Degeneration, oncogenesis and regeneration of pancreatic B‐cells of islets of Langerhans

  1985cited by this paper
• A new method of preparing gold probes for multiple-labeling cytochemistry.

  1985cited by this paper
• Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

  1984influential reference
• Double immunocytochemical labeling applying the protein A-gold technique.

  1982cited by this paper

• Identification of biomarkers and potential therapeutic targets for pancreatic cancer by proteomic analysis in two prospective cohorts

  2024cites this paper
• Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure

  2023cites this paper
• Frederick Banting's observations leading to the potential for islet neogenesis without transplantation

  2021cites this paper
• GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells

  2021cites this paper
• Mini Review ISLET Neogenesis in Man Without the Need for Transplants

  2021cites this paper
• Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca2+ mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration

  2021cites this paper
• Correlative Light-Electron Microscopy (CLEM) and 3D Volume Imaging of Serial Block-Face Scanning Electron Microscopy (SBF-SEM) of Langerhans Islets

  2018cites this paper
• Improved Serial Sectioning Techniques for Correlative Light-Electron Microscopy Mapping of Human Langerhans Islets

  2018cites this paper
• Reference β-cell regeneration : the pancreatic intrinsic faculty

  2017cites this paper
• The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII

  2017cites this paper
• of Diabetes and Treatment Islet Neogenesis Therapy from Endogenous Pancreatic Stem Cells without Transplantation: Will Type 1 and Type 2 Diabetes Soon be Diseases of the Past?

  2017cites this paper
• Suppression of islet homeostasis protein thwarts diabetes mellitus progression

  2017cites this paper
• Pancreatic Regeneration After Partial Pancreatectomy in Rodents

  2016cites this paper
• The role of the Src Homology-2 domain containing protein B (SHB) in β cells.

  2016cites this paper
• Regenerating islet-derived protein 1 inhibits the activation of islet stellate cells isolated from diabetic mice

  2015cites this paper
• RNA-seq methods for identifying differentially expressed gene in human pancreatic islet cells treated with pro-inflammatory cytokines

  2014cites this paper
• Increased susceptibility to streptozotocin and impeded regeneration capacity of beta‐cells in adult offspring of malnourished rats

  2014cites this paper
• Valoración de protocolos de diferenciación in vitro de células madre embrionarias de ratón hacia endodermo pancreático mediante el análisis de poblaciones celulares que expresan marcadores característicos

  2014cites this paper
• The Contribution of Reg Family Proteins to Cell Growth and Survival in Pancreatic Islets

  2014cites this paper
• Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes.

  2013cites this paper
• Current status of regeneration of pancreatic β‐cells

  2013cites this paper
• Regeneration of pancreatic beta-cell mass for the treatment of diabetes

  2012cites this paper
• Regenerating (Reg) Gene Family

  2012cites this paper
• Regenerating proteins and their expression, regulation, and signaling

  2012cites this paper
• Differentiation of Embryonic Stem Cells Using Pancreatic Bud-Conditioned Medium Gives Rise to Neuroectoderm-Derived Insulin-Secreting Cells

  2011cites this paper
• β-cell regeneration: the pancreatic intrinsic faculty.

  2011cites this paper
• The Effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in Mice

  2011cites this paper
• INS-1 Cells Undergoing Caspase-Dependent Apoptosis Enhance the Regenerative Capacity of Neighboring Cells

  2010cites this paper
• The Effects of Low Protein During Gestation on Mouse Pancreatic Development and Beta Cell Regeneration

  2010cites this paper
• Study on pancreatic islet adaptation and gene expression during pregnancy in rats

  2010cites this paper
• In vivo evidence for the role of RegI in gastric regeneration: transgenic overexpression of RegI accelerates the healing of experimental gastric ulcers

  2010cites this paper
• Expression of Reg Family Proteins in Embryonic Stem Cells and Its Modulation by Wnt/β-Catenin Signaling

  2010cites this paper
• Exogenous Ghrelin Enhances Endocrine and Exocrine Regeneration in Pancreatectomized Rats

  2009cites this paper
• Pancreatic Regenerating Gene I and Acinar Cell Differentiation: Influence on Cellular Lineage

  2009cites this paper
• Pancreatic Stem Cells

  2009cites this paper
• The role of islet neogeneis-associated protein (INGAP) in pancreatic islet neogenesis.

  2009cites this paper
• Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes

  2009cites this paper
• Expression and localization of regenerating gene I in a rat liver regeneration model.

  2009cites this paper
• Pancreatic Islet Immunoreactivity to the Reg Protein INGAP

  2008influential citation
• Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells.

  2008cites this paper
• The Reg Family Member INGAP Is a Marker of Endocrine Patterning in the Embryonic Pancreas

  2008influential citation
• Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine

  2007cites this paper
• Transcription, expression and tissue binding in vivo of INGAP and INGAP-related peptide in normal hamsters.

  2007cites this paper
• The role of Islet Neogenesis-Associated Protein (INGAP) in islet neogenesis

  2007cites this paper
• Prospects and Challenges for Islet Regeneration as a Treatment for Diabetes: A Review of Islet Neogenesis Associated Protein

  2007cites this paper
• Increased Expression of Protein in Neonatal Rat Streptozotocin a Regenerating ( reg ) Pancreas Treated wi Gene th

  2006cites this paper
• Exocrine meets endocrine: pancreatic stone protein and regenerating protein--two sides of the same coin.

  2006cites this paper
• Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis.

  2006cites this paper
• Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNβ

  2006influential citation
• Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas.

  2006cites this paper
• Differentially Expressed Proteins in the Pancreas of Diabetic Mice

  2005cites this paper
• Regenerative medicine of the pancreatic beta cells.

  2005cites this paper
• Opposite Roles of Human Pancreatitis-Associated Protein and REG1A Expression in Hepatocellular Carcinoma: Association of Pancreatitis-Associated Protein Expression with Low-Stage Hepatocellular Carcinoma, β-Catenin Mutation, and Favorable Prognosis

  2005cites this paper
• Differentially Expressed Proteins in the Pancreas of Diet-induced Diabetic Mice*

  2005cites this paper
• Activation of regenerating gene Reg in rat and human hearts in response to acute stress.

  2005cites this paper
• Are There Any Stem Cells in the Pancreas?

  2005cites this paper
• Expression of progenitor cell markers during expansion of sorted human pancreatic beta cells.

  2005cites this paper
• The multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide.

  2005cites this paper
• Regenerative medicine of the pancreatic β cells

  2005cites this paper
• Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages

  2004cites this paper
• Differentielle Genexpression in der Insulinoma-Zelllinie RINm5F nach Stimulation mit Leptin

  2004cites this paper
• Implication of Reg I in Human Pancreatic Duct-like Cells In Vivo in the Pathological Pancreas and In Vitro During Exocrine Dedifferentiation

  2004cites this paper
• Reg protein is a unique growth factor of gastric mucosal cells

  2004cites this paper
• Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

  2004cites this paper
• Islet Growth Factors

  2003cites this paper
• Expression of islet neogenesis-associated protein in islets of normal hamsters.

  2003influential citation
• A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice.

  2002cites this paper
• Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.

  2002cites this paper
• Dynamic Pattern of Reg-2 Expression in Rat Sensory Neurons after Peripheral Nerve Injury

  2002cites this paper
• [Regulatory mechanism of gastric acid secretion and mucosal integrity--an analysis with various gene deficient mice].

  2002cites this paper
• Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth

  2002cites this paper
• Localization of Reg receptor in rat fundic mucosa.

  2002cites this paper
• Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation.

  2001cites this paper
• Increased c-met Expression During Ductal β Cell Neogenesis in Experimental Autoimmune Diabetes

  2001cites this paper
• A Family of 16-kDa Pancreatic Secretory Stress Proteins Form Highly Organized Fibrillar Structures upon Tryptic Activation*

  2001cites this paper
• Human REG I gene is up‐regulated in intrahepatic cholangiocarcinoma and its precursor lesions

  2001cites this paper
• A Brief History of Pancreatic Reg: Implications as to its Clinical Importance.

  2000cites this paper
• Overexpression of the reg Gene In Non-obese Diabetic Mouse Pancreas During Active Diabetogenesis Is Restricted to Exocrine Tissue

  2000cites this paper
• Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region.

  2000cites this paper
• Mechanism of gastric mucosal proliferation induced by gastrin

  2000cites this paper
• Possible relationship between changes in islet neogenesis and islet neogenesis-associated protein-positive cell mass induced by sucrose administration to normal hamsters.

  2000cites this paper
• Neutrophil chemoattractant 2 beta regulates expression of the Reg gene in injured gastric mucosa in rats.

  2000cites this paper
• Identification of a Receptor for Reg (Regenerating Gene) Protein, a Pancreatic β-Cell Regeneration Factor*

  2000cites this paper
• Diabetes and tumor formation in transgenic mice expressing Reg I.

  2000cites this paper
• The role of the target organ in cytokine-mediated beta-cell destruction. Possible relevance for the pathogenesis of insulin dependent diabetes mellitus.

  1999cites this paper
• pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis.

  1999cites this paper
• Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes.

  1999cites this paper
• Development of pancreatic islets (review).

  1999cites this paper
• Biophysical Characterization of Lithostathine

  1999cites this paper
• Expression of REG Protein During Cell Growth and Differentiation of Two Human Colon Carcinoma Cell Lines

  1999cites this paper
• Characteristics of rat pancreatic regenerating protein.

  1998cites this paper
• Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment.

  1998cites this paper
• Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats.

  1998cites this paper
• Effect of Reg Protein on Rat Pancreatic Ductal Cells

  1998cites this paper
• Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model

  1998cites this paper
• Analysis of Islet Regenerating (reg) Gene Polymorphisms in Fibrocalculous Pancreatic Diabetes

  1997cites this paper
• Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters.

  1997cites this paper
• Induction of Pancreatic Islet Neogenesis

  1997cites this paper
• Regenerating gene expression in normal gastric mucosa and indomethacin-induced mucosal lesions of the rat

  1997cites this paper
• New aspects to the functioning and regeneration of pancreatic beta-cells. Cyclic ADP-ribose and Reg gene.

  1997cites this paper