BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Oncogene

• Publication date

  2012-08-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2011.531PMID 22120723
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer.

  2011cited by this paper
• Repression of Mammary Stem/Progenitor Cells by p53 Is Mediated by Notch and Separable from Apoptotic Activity

  2011cited by this paper
• β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

  2011cited by this paper
• Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim.

  2011cited by this paper
• Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

  2010cited by this paper
• Higher levels of GATA3 predict better survival in women with breast cancer.

  2010cited by this paper
• DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

  2010cited by this paper
• FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer.

  2010cited by this paper
• BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer

  2010cited by this paper
• Capecitabine combined with weekly docetaxel in Chinese patients > 65 years with anthracycline-resistant metastatic breast cancer.

  2010cited by this paper
• BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

  2010cited by this paper
• Mesenchymal/Stromal Gene Expression Signature Relates to Basal-Like Breast Cancers, Identifies Bone Metastasis and Predicts Resistance to Therapies

  2010cited by this paper
• Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores

  2010cited by this paper
• GATA3 Inhibits Breast Cancer Metastasis through the Reversal of Epithelial-Mesenchymal Transition*

  2010cited by this paper
• Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells

  2010cited by this paper
• Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

  2010influential reference
• Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours

  2009cited by this paper
• The evolution of Fox genes and their role in development and disease

  2009cited by this paper
• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

  2009cited by this paper
• GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis

  2009cited by this paper
• The basics of epithelial-mesenchymal transition.

  2009cited by this paper
• Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer

  2009cited by this paper
• Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression

  2009cited by this paper
• Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

  2008cited by this paper
• Docetaxel for metastatic breast cancer: two consecutive phase II trials.

  2008cited by this paper
• Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment.

  2008cited by this paper
• GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.

  2008cited by this paper
• Cell type-specific DNA methylation patterns in the human breast

  2008cited by this paper
• Molecular Basis for Estrogen Receptor α Deficiency in BRCA1-Linked Breast Cancer

  2007cited by this paper
• BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs.

  2007cited by this paper
• FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.

  2007cited by this paper
• Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

  2007cited by this paper
• Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

  2007cited by this paper
• BRCA1 Regulates IFN-γ Signaling through a Mechanism Involving the Type I IFNs

  2007cited by this paper
• Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

  2007cited by this paper
• A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

  2006cited by this paper
• GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.

  2006cited by this paper
• Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors

  2005cited by this paper
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

  2005cited by this paper
• Hallmarks of 'BRCAness' in sporadic cancers

  2004cited by this paper
• Mutation of GATA3 in human breast tumors

  2004cited by this paper
• Repeated observation of breast tumor subtypes in independent gene expression data sets

  2003cited by this paper
• Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomas

  2001cited by this paper
• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  2001cited by this paper
• BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.

  2000cited by this paper
• Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.

  1999cited by this paper
• Front-line treatment of metastatic breast cancer with docetaxel and epirubicin: a multicenter dose-escalation study. The Greek Breast Cancer Cooperative Group (GBCCG).

  1999cited by this paper
• BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

  1998cited by this paper
• BRCA1 physically associates with p53 and stimulates its transcriptional activity

  1998cited by this paper
• BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

  1998cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Epithelial (E‐) and placentae (P‐) cadherin cell adhesion molecule expression in breast carcinoma

  1993cited by this paper

• Discovery of epigenetically silenced tumour suppressor genes in aggressive breast cancer through a computational approach

  2025cites this paper
• GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation.

  2025cites this paper
• Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancer.

  2025cites this paper
• The Role of the Fox Gene in Breast Cancer Progression

  2025cites this paper
• Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

  2024cites this paper
• GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer

  2024influential citation
• Conserved role of FOXC1 in TNBC is parallel to FOXA1 in ER+ breast cancer

  2024cites this paper
• Replication stress inducing ELF3 upregulation promotes BRCA1-deficient

  2023influential citation
• Research progress on the regulatory mechanisms of FOXC1 expression in cancers and its role in drug resistance.

  2023cites this paper
• GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors

  2023cites this paper
• Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis

  2023cites this paper
• p18INK4C and BRCA1 inhibit follicular cell proliferation and dedifferentiation in thyroid cancer

  2023cites this paper
• Involvement in Tumorigenesis and Clinical Significance of CXCL1 in Reproductive Cancers: Breast Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer and Prostate Cancer

  2023cites this paper
• 14-3-3τ drives estrogen receptor loss via ERα36 induction and GATA3 inhibition in breast cancer

  2022cites this paper
• Upregulated GATA3/miR205-5p Axis Inhibits MFNG Transcription and Reduces the Malignancy of Triple-Negative Breast Cancer

  2022cites this paper
• SOX4-mediated FBW7 transcriptional upregulation confers Tamoxifen resistance in ER+ breast cancers via GATA3 downregulation.

  2022cites this paper
• FOXC1 Binds Enhancers and Promotes Cisplatin Resistance in Bladder Cancer

  2022cites this paper
• Single-gene diagnostic assay for rapid subclassification of basal like breast cancer with mRNA targeted antisense oligonucleotide capped molecular probe.

  2022cites this paper
• The role of FOXC1/FOXCUT/DANCR axis in triple negative breast cancer: a bioinformatics and experimental approach

  2022cites this paper
• Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway

  2022cites this paper
• CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space

  2022cites this paper
• BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy.

  2022cites this paper
• BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract

  2021cites this paper
• FOXC1.

  2021cites this paper
• Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis

  2021cites this paper
• GATA3 functions downstream of BRCA1 to suppress EMT in breast cancer

  2021cites this paper
• GATA3 as an Adjunct Prognostic Factor in Breast Cancer Patients with Less Aggressive Disease: A Study with a Review of the Literature

  2021cites this paper
• Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

  2021cites this paper
• PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors

  2021cites this paper
• The molecular mechanisms and therapeutic potential of EZH2 in breast cancer.

  2021cites this paper
• BRCA1 and Metastasis: Outcome of Defective DNA Repair

  2021cites this paper
• A Specific Biomarker for Triple-Negative Breast Cancer Diagnosis and Classification

  2021influential citation
• Nuclear accumulation of MKL1 in luminal breast cancer cells impairs genomic activity of ERα and is associated with endocrine resistance.

  2020cites this paper
• The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

  2020cites this paper
• BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells

  2019cites this paper
• The Diverse Consequences of FOXC1 Deregulation in Cancer

  2019cites this paper
• The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

  2019cites this paper
• Landscape of cancer diagnostic biomarkers from specifically expressed genes

  2019cites this paper
• BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

  2019cites this paper
• BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression

  2018cites this paper
• Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development

  2018cites this paper
• Racial disparity in breast cancer: can it be mattered for prognosis and therapy

  2018cites this paper
• Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer.

  2018cites this paper
• The potential pathway of FOXC1 high expression in regulating the proliferation, migration, cell cycle and epithelialmesenchymal transition of basal-like breast cancer and in vivo imaging.

  2018cites this paper
• FOXC1: an emerging marker and therapeutic target for cancer

  2017cites this paper
• FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles

  2017cites this paper
• Research progress on the forkhead box C1

  2017cites this paper
• Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

  2017cites this paper
• A Decade of GWAS Results in Lung Cancer

  2017cites this paper
• The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression

  2017cites this paper
• Combined Analysis of ChIP Sequencing and Gene Expression Dataset in Breast Cancer

  2017cites this paper
• FOXC1 Regulates FGFR1 Isoform Switching to Promote Invasion Following TGFβ-Induced EMT

  2017influential citation
• A New Gene Expression Signature for Triple-Negative Breast Cancer using Frozen Fresh Tissue before Neoadjuvant chemotherapy

  2017cites this paper
• Breast cancer intrinsic subtypes: a critical conception in bioinformatics

  2017cites this paper
• An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells

  2016influential citation
• FOXC1 identifies basal-like breast cancer in a hereditary breast cancer cohort

  2016cites this paper
• Foxc1 controls cell fate decisions during transforming growth factor β induced epithelial to mesenchymal transition through the regulation of fibroblast growth factor receptor 1 expression

  2016cites this paper
• Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

  2016cites this paper
• The role of GATA3 in breast carcinomas: a review.

  2016cites this paper
• Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

  2016cites this paper
• Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

  2016cites this paper
• Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation

  2016cites this paper
• Dynamics of mRNA and microRNA expression in the estrogen response of breast cancer cells

  2016cites this paper
• Hypoparathyroidism, Deafness, and Renal Anomaly Syndrome

  2015cites this paper
• The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set

  2015cites this paper
• Epithelial cell identity in hyperplastic precursors of breast cancer

  2015cites this paper
• DNA Damage Signalling in BRCA1-Deficient Mammary Progenitor Cells Activates Autologous p52/RelB NF-κB

  2015cites this paper
• Estrogen receptor coregulators and pioneer factors: the orchestrators of mammary gland cell fate and development

  2014cites this paper
• Title FOXA 1 repression is associated with loss of BRCA 1 and increased promoter methylation and chromatin silencing in breast cancer

  2014cites this paper
• development stem cell dedifferentiation during mammary and tumor BRCA 1 suppresses epithelial-to-mesenchymal transition and Updated

  2014influential citation
• The Role of BRCA1 in Suppressing Epithelial Mesenchymal Transition in Mammary Gland and Tumor Development

  2014cites this paper
• GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation

  2014cites this paper
• FOXC1 is a Critical Mediator of EGFR Function in Human Basal-like Breast Cancer

  2014influential citation
• Shift in GATA3 functions, and GATA3 mutations, control progression and clinical presentation in breast cancer

  2014cites this paper
• FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer

  2014cites this paper
• BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development.

  2014cites this paper
• S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability

  2014cites this paper
• Biology and Treatment of Basal-Like Breast Cancer

  2013cites this paper
• Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation

  2013cites this paper
• Prognostic impact of FOXP3 expression in triple-negative breast cancer

  2013cites this paper
• Molecular Phenotypes in Triple Negative Breast Cancer from African American Patients Suggest Targets for Therapy

  2013influential citation
• GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas.

  2013cites this paper
• A convex pseudolikelihood framework for high dimensional partial correlation estimation with convergence guarantees

  2013cites this paper
• Role of C/EBPβ in two luminal progenitor populations in the mouse mammary gland

  2013cites this paper
• BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers

  2013cites this paper
• Low trichorhinophalangeal syndrome 1 gene transcript levels in basal-like breast cancer associate with mesenchymal-to-epithelial transition.

  2013cites this paper
• BRCA1 – Conductor of the Breast Stem Cell Orchestra: The Role of BRCA1 in Mammary Gland Development and Identification of Cell of Origin of BRCA1 Mutant Breast Cancer

  2012cites this paper
• Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population

  2012cites this paper
• Identifying and exploiting defects in the Fanconi anemia/BRCA pathway in oncology.

  2012cites this paper
• The Forkhead Box Transcription Factor FOXC1 Promotes Breast Cancer Invasion by Inducing Matrix Metalloprotease 7 (MMP7) Expression*

  2012cites this paper
• GATA3 (GATA binding protein 3)

  2012cites this paper