Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus.

R. Simmen,Dustin M Brown,C. Quick,Iad Alhallak,Tyler Rose,Shi J. Liu,A. S. Kelley

Published 2019 in Journal of Endocrinology

ABSTRACT

Type 1 diabetes mellitus and endometriosis separately affect millions of women worldwide. Reproductive-age women diagnosed with type 1 diabetes may also suffer from endometriosis, but the asymptomatic pre-clinical period of highly variable duration for each condition can lead to challenges in the timely recognition of co-morbid disease onset and misdiagnosis. While knowledge of the pathogenesis of each condition has grown substantially, co-morbid endometriosis and type 1 diabetes has not been widely considered and much less addressed. This review discusses the molecular rationale for the likelihood of their co-existence, and prospects for improvements in therapeutic strategies and reduced complications, if this paradigm is included as a significant variable in disease management.

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