Targeting Cancer with Genetically Engineered TCR T Cells.

Thomas W Smith,M. Nishimura

Published 2020 in Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

ABSTRACT

No abstract is available for this paper.

PUBLICATION RECORD

Publication year
2020
Venue
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Publication date
Unknown publication date
Fields of study
Biology, Medicine
Identifiers
DOI 10.1007/978-3-030-23765-3_4 PMID 31473851
External record
Open on Semantic Scholar
Source metadata
Semantic Scholar, PubMed

CITATION MAP

EXTRACTION MAP

CLAIMS

No claims are published for this paper.

CONCEPTS

No concepts are published for this paper.

REFERENCES

CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
2018cited by this paper
HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer
2017cited by this paper
Targeting neoantigens to augment antitumour immunity
2017cited by this paper
Advancing Cancer Therapy with Present and Emerging Immuno-Oncology Approaches
2017cited by this paper
Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells
2017cited by this paper
Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification
2017cited by this paper
Human leucocyte antigen class I‐redirected anti‐tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells
2016cited by this paper
Strategies to genetically engineer T cells for cancer immunotherapy
2016cited by this paper
An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells
2016cited by this paper
Hepatitis C virus‐cross‐reactive TCR gene‐modified T cells: a model for immunotherapy against diseases with genomic instability
2016cited by this paper
T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy
2016cited by this paper
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
2016cited by this paper
Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes.
2015cited by this paper
Immunologische Tumortherapie
2015cited by this paper
CD4+ T Cell Help Selectively Enhances High-Avidity Tumor Antigen-Specific CD8+ T Cells
2015cited by this paper
NY-ESO-1 specific TCR engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma
2015cited by this paper
New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target Malignancies
2015cited by this paper
Identification of T-cell Receptors Targeting KRAS-Mutated Human Tumors
2015cited by this paper
IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy
2015cited by this paper
Human Leukocyte Antigen (HLA) A*1101-Restricted Epstein-Barr Virus–Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma
2015cited by this paper
Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
2014cited by this paper
Advanced generation anti‐prostate specific membrane antigen designer T Cells for prostate cancer immunotherapy
2014cited by this paper
Immune modulation in cancer with antibodies.
2014cited by this paper
Reassessing target antigens for adoptive T cell therapy
2013cited by this paper
Endogenous Retroviruses as Targets for Antitumor Immunity in Renal Cell Cancer and Other Tumors
2013cited by this paper
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.
2013cited by this paper
Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells
2013cited by this paper
Lessons from the cancer genome.
2013cited by this paper
Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection.
2013cited by this paper
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
2013cited by this paper
Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy
2013cited by this paper
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
2012cited by this paper
Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition
2012cited by this paper
Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host.
2012cited by this paper
The blockade of immune checkpoints in cancer immunotherapy
2012cited by this paper
Trafficking of High Avidity HER-2/neu-Specific T Cells into HER-2/neu-Expressing Tumors after Depletion of Effector/Memory-Like Regulatory T Cells
2012cited by this paper
TCR-Redirected Human T Cells Inhibit Hepatitis C Virus Replication: Hepatotoxic Potential Is Linked to Antigen Specificity and Functional Avidity
2012cited by this paper
MAGE-A family: attractive targets for cancer immunotherapy.
2011cited by this paper
Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.
2011cited by this paper
Human TH17 Cells Are Long-Lived Effector Memory Cells
2011cited by this paper
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.
2011cited by this paper
Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer
2011cited by this paper
Inducible apoptosis as a safety switch for adoptive cell therapy.
2011cited by this paper
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1.
2011cited by this paper
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.
2011cited by this paper
Of mice, not men: no evidence for graft-versus-host disease in humans receiving T-cell receptor-transduced autologous T cells.
2010cited by this paper
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.
2010cited by this paper
Effector T cell plasticity: flexibility in the face of changing circumstances
2010cited by this paper
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
2010cited by this paper
Cancer esearch oenvironment and Immunology or-Specific CD 8 + T Cells Expressing Interleukin-12 R dicate Established Cancers in Lymphodepleted Hosts
2010cited by this paper
Advances in Cellular Therapy for the Treatment of Thyroid Cancer
2010cited by this paper
Improved survival with ipilimumab in patients with metastatic melanoma.
2010cited by this paper
Coexpression of the T-cell receptor constant alpha domain triggers tumor reactivity of single-chain TCR-transduced human T cells.
2010cited by this paper
T-Cell Receptor Gene–Modified T Cells with Shared Renal Cell Carcinoma Specificity for Adoptive T-Cell Therapy
2010cited by this paper
Mixed T cell receptor dimers harbor potentially harmful neoreactivity
2010cited by this paper
Minimal Amino Acid Exchange in Human TCR Constant Regions Fosters Improved Function of TCR Gene-Modified T Cells
2010cited by this paper
Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells
2009cited by this paper
Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition
2009cited by this paper
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen.
2009cited by this paper
Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR.
2009cited by this paper
Characterization of MHC class-I restricted TCRαβ+ CD4− CD8− double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination
2008cited by this paper
Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
2008cited by this paper
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
2008cited by this paper
Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette
2008cited by this paper
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
2008cited by this paper
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity
2008cited by this paper
Infusion of Melan-A/Mart-1 specific tumor-infiltrating lymphocytes enhanced relapse-free survival of melanoma patients
2007cited by this paper
Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.
2007cited by this paper
Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T‐cells
2007cited by this paper
Facilitating matched pairing and expression of TCR chains introduced into human T cells.
2007cited by this paper
Selecting highly affine and well-expressed TCRs for gene therapy of melanoma.
2007cited by this paper
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience.
2006cited by this paper
Identification of a hepatitis C virus–reactive T cell receptor that does not require CD8 for target cell recognition
2006cited by this paper
Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.
2006cited by this paper
Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability.
2006cited by this paper
Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells.
2006cited by this paper
Development of a novel strategy for engineering high-affinity proteins by yeast display.
2006cited by this paper
Blockade of PD‐L1 (B7‐H1) augments human tumor‐specific T cell responses in vitro
2006cited by this paper
Designer T cells by T cell receptor replacement
2006cited by this paper
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006cited by this paper
Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy.
2005cited by this paper
Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor.
2005cited by this paper
Antigen recognition and T-cell biology.
2005cited by this paper
Directed evolution of human T-cell receptors with picomolar affinities by phage display
2005cited by this paper
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
2005cited by this paper
Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR.
2005cited by this paper
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma.
2005cited by this paper
Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions
2005cited by this paper
The α vβ 3 integrin as a tumor homing ligand for lymphocytes
2004cited by this paper
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells
2004cited by this paper
Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes.
2004cited by this paper
Therapeutic Efficacy of MUC1-Specific Cytotoxic T Lymphocytes and CD137 Co-Stimulation in a Spontaneous Breast Cancer Model
2004cited by this paper
Reconstitution of anti‐HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV‐specific αβ TCR genes
2004cited by this paper
CD8-Independent Tumor Cell Recognition Is a Property of the T Cell Receptor and Not the T Cell 1
2003cited by this paper
Prostate‐specific antigen‐derived epitopes capable of inducing cellular and humoral responses in HLA‐A24+ prostate cancer patients
2003cited by this paper
Anti-p53-directed immunotherapy of malignant disease
2003cited by this paper
Generation of Tumor-Infiltrating Lymphocyte Cultures for Use in Adoptive Transfer Therapy for Melanoma Patients
2003cited by this paper
Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man
2002cited by this paper
Redirecting Migration of T Cells to Chemokine Secreted from Tumors by Genetic Modification with CXCR2
2002cited by this paper
A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma
2002cited by this paper

CITED BY

A Novel Cell-based Luciferase Reporter Platform for the Development and Characterization of T-Cell Redirecting Therapies and Vaccine Development
2023cites this paper
Emerging immune-based technologies for high-grade gliomas
2022cites this paper
Neoantigen-targeted TCR-T cell therapy for solid tumors: How far from clinical application.
2022cites this paper
Application of Genome-Editing Technologies for Off-the-Shelf T Cell-Based Cancer Immunotherapy
2021cites this paper
Against the Resilience of High-Grade Gliomas: The Immunotherapeutic Approach (Part I)
2021cites this paper
Updates on mechanistic insights and targeting of tumour metastasis
2020cites this paper
Gene transfer to plants by electroporation: methods and applications
2020cites this paper