N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2009-03-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmcl.2009.01.084PMID 19217286
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

  2008cited by this paper
• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

  2007cited by this paper
• Role of adiponectin and adipocyte fatty acid binding protein in the metabolic syndrome.

  2007cited by this paper
• Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

  2007cited by this paper
• A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

  2006cited by this paper
• Inflammation and metabolic disorders

  2006cited by this paper
• NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

  2006cited by this paper
• Computational study of antagonist/alpha1A adrenoceptor complexes--observations of conformational variations on the formation of ligand/receptor complexes.

  2006cited by this paper
• The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis

  2005cited by this paper
• Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.

  2004cited by this paper
• Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors.

  2004cited by this paper
• New insights into the structure and function of fatty acid-binding proteins

  2002cited by this paper
• Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia

  2002cited by this paper
• Structure-based screening as applied to human FABP4: a highly efficient alternative to HTS for hit generation.

  2002cited by this paper
• Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

  2001cited by this paper
• Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2.

  2000cited by this paper
• Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

  2000cited by this paper
• Requirement for the heart‐type fatty acid binding protein in cardiac fatty acid utilization

  1999cited by this paper
• Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein

  1996cited by this paper
• Lipid-binding proteins: a family of fatty acid and retinoid transport proteins.

  1994cited by this paper
• Structural and functional features of different types of cytoplasmic fatty acid-binding proteins.

  1991cited by this paper
• Tissue specific expression of p422 protein, a putative lipid carrier, in mouse adipocytes.

  1985cited by this paper

• Photo-driven bifunctional iron-catalyzed one-pot assembling of indoles from arylamines and alkanes/carboxylic acids

  2026cites this paper
• Elucidating the microscopic properties of a β-barrel protein and the solvent confined in and around it.

  2025cites this paper
• Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation-Related Diseases.

  2025cites this paper
• Copper-enalcarbenoids: Rapid access to 1,7-disubstituted indoles via [4+2] benzannulation between diazoenals and N-substituted pyrroles

  2024cites this paper
• One-Pot Photocascade Catalysis: Access to Pyrrole Derivatives from N-Arylglycines and Morita-Baylis-Hillman (MBH) Acetates.

  2024cites this paper
• Catalytic Cascade: Efficient Synthesis of Cyclohepta[b]indoles and Cyclohepta[b]indole-Indoline Conjugates via RCM, Hydrogenation, and Acid-Catalyzed Ring Expansion.

  2024cites this paper
• In(OTf)3-catalyzed synthesis of 7-acylindoles and 2-aminoquinolines from ynamides and anthranils

  2024cites this paper
• Recent Advances on Small-Molecule Inhibitors of Lipocalin-like Proteins.

  2024cites this paper
• Synthesis of cyclohepta[b]indoles via gold mediated energy transfer photocatalysis.

  2024cites this paper
• Cascade radical cyclization on 3-propargyl-2-alkenyl indole gives stereoselective access to cyclohepta[b]indole over carbazole.

  2023cites this paper
• An MCM-41-immobilized dichloro(pyridine-2-carboxylato)gold(III) complex: an efficient and recyclable catalyst for the annulation of anthranils and ynamides.

  2023cites this paper
• Palladium-Catalyzed Asymmetric [3＋4] Cycloadditions for the Construction of Cyclohepta[b]indoles

  2023cites this paper
• Construction of a Pentacyclic Framework Enabled by Nickel Catalysis.

  2023cites this paper
• Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking-aided study.

  2023cites this paper
• Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment.

  2023cites this paper
• Discovery of Cobimetinib as a novel A-FABP inhibitor using machine learning and molecular docking-based virtual screening

  2022cites this paper
• Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease

  2022cites this paper
• On the mechanism of the Au(I)‐mediated addition of alkynes to anthranils to furnish 7‐acylindoles

  2022cites this paper
• Function of lipid binding proteins of parasitic helminths: still a long road

  2022cites this paper
• Fatty acid-binding protein 4 in kidney diseases: From mechanisms to clinics.

  2022cites this paper
• Recent Advances in the Synthesis of 5‐Membered N ‐Heterocycles via Rhodium Catalysed Cascade Reactions

  2022cites this paper
• Update of Indoles: Promising molecules for ameliorating metabolic diseases.

  2022cites this paper
• Cooperative Study Combining X-ray Crystal Structure Analysis and FMO Calculation: Interaction Analysis of FABP4 Inhibitors

  2021cites this paper
• Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

  2021cites this paper
• Growing the molecular architecture of imidazole-like ligands in HO-1 complexes.

  2021cites this paper
• A-FABP in Metabolic Diseases and the Therapeutic Implications: An Update

  2021cites this paper
• Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy

  2021cites this paper
• Machine learning vs. field 3D-QSAR models for serotonin 2A receptor psychoactive substances identification

  2021cites this paper
• Molecular mechanisms of inhibitor bindings to A-FABP deciphered by using molecular dynamics simulations and calculations of MM-GBSA

  2021cites this paper
• Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study

  2020influential citation
• Photochemical Approach to the Cyclohepta[b]indole Scaffold by Annulative Two‐Carbon Ring‐Expansion

  2020cites this paper
• Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets

  2020cites this paper
• Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation.

  2020cites this paper
• Inhibitors of SARS-CoV-2 Main Protease from a Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study

  2020influential citation
• Computational Tools in the Discovery of FABP4 Ligands: A Statistical and Molecular Modeling Approach †

  2019influential citation
• 1 Computational Tools in the Discovery of FABP 4 2 Ligands : A Statistical and Molecular Modeling 3 Approach 4

  2019influential citation
• Calcium-Catalyzed Formal [5 + 2] Cycloadditions of Alkylidene β-Ketoesters with Olefins: Chemodivergent Synthesis of Highly Functionalized Cyclohepta[b]indole Derivatives.

  2019cites this paper
• 3D-QSAR assisted identification of FABP4 inhibitors: An effective scaffold hopping analysis/QSAR evaluation.

  2019cites this paper
• Synthesis and larvicidal activity of indole derivatives against Aedes aegypti (Diptera: Culicidae)

  2019cites this paper
• Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products

  2019influential citation
• Synthesis of Rosmarinic Acid Amides as Antioxidative and Hypoglycemic Agents.

  2019cites this paper
• Synthesis and evaluation of indole derivatives as photosynthesis and plant growth inhibitors

  2019cites this paper
• Inhibition of MPTP‐induced &agr;‐synuclein oligomerization by fatty acid‐binding protein 3 ligand in MPTP‐treated mice

  2019cites this paper
• RhCl3·3H2O-Catalyzed C7-Selective C-H Carbonylation of Indolines with CO and Alcohols.

  2019cites this paper
• Metyrapone-β-cyclodextrin supramolecular interactions inferred by complementary spectroscopic/spectrometric and computational studies

  2019cites this paper
• Rhodium-Catalyzed Asymmetric Dearomative [4 + 3]-Cycloaddition of Vinylindoles with Vinyldiazoacetates: Access to Cyclohepta[ b]indoles.

  2018cites this paper
• Electrostatic interaction-mediated conformational changes of adipocyte fatty acid binding protein probed by molecular dynamics simulation

  2018cites this paper
• Discovery of High-Affinity Cannabinoid Receptors Ligands through a 3D-QSAR Ushered by Scaffold-Hopping Analysis †

  2018cites this paper
• A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands

  2018influential citation
• Crystal structure of human FABP4 complexed with ligand 4-Fluoro-3-((4-methoxynaphthalene)-1-sulfonamido) benzoic acid

  2018cites this paper
• FABP4 inhibitors 3D-QSAR model and isosteric replacement of BMS309403 datasets

  2018cites this paper
• Cyclohepta[ b]indole Synthesis through [5 + 2] Cycloaddition: Bifunctional Indium(III)-Catalyzed Stereoselective Construction of 7-Membered Ring Fused Indoles.

  2018cites this paper
• From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4.

  2018cites this paper
• Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes.

  2018cites this paper
• β-Nitroacrylates: A Versatile and Growing Class of Functionalized Nitroalkenes

  2018cites this paper
• Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors

  2017cites this paper
• Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles.

  2017cites this paper
• Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease.

  2017cites this paper
• Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.

  2017cites this paper
• Serum Level of Adipocyte Fatty Acid Binding Protein in Obesity

  2017cites this paper
• Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database

  2016cites this paper
• Goldkatalysierte C‐H‐Anellierung von Anthranilen mit Alkinen: flexible, atomökonomische Synthese ungeschützter 7‐Acylindole

  2016cites this paper
• Intermediate‐Dependent Unusual [4+3], [3+2] and Cascade Reactions of 3‐Indolylmethanols: Controllable Chemodivergent and Stereoselective Synthesis of Diverse Indole Derivatives

  2016cites this paper
• New syntheses of cycloalka[b]indoles

  2016cites this paper
• Fluorinated alcohol-mediated [4 + 3] cycloaddition reaction of indolyl alcohols with cyclopentadiene.

  2016cites this paper
• Cyclohepta[b]indoles: A Privileged Structure Motif in Natural Products and Drug Design.

  2016cites this paper
• Fischer Indole Synthesis

  2016cites this paper
• Herbalog: A tool for target-based identification of herbal drug efficacy through molecular docking.

  2016influential citation
• Gold-Catalyzed C-H Annulation of Anthranils with Alkynes: A Facile, Flexible, and Atom-Economical Synthesis of Unprotected 7-Acylindoles.

  2016cites this paper
• Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.

  2016cites this paper
• Interaction Analysis of FABP4 Inhibitors by X-ray Crystallography and Fragment Molecular Orbital Analysis.

  2016cites this paper
• Metabolic functions of FABPs—mechanisms and therapeutic implications

  2015cites this paper
• Pimozide, a novel fatty acid binding protein 4 inhibitor, promotes adipogenesis of 3T3-L1 cells by activating PPARγ.

  2015cites this paper
• Mild arylboronic acid catalyzed selective [4 + 3] cycloadditions: access to cyclohepta[b]benzofurans and cyclohepta[b]indoles.

  2015cites this paper
• Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations.

  2015cites this paper
• Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination.

  2015cites this paper
• Molecular dynamics simulations of heart-type fatty acid binding protein in apo and holo forms, and hydration structure analyses in the binding cavity.

  2015cites this paper
• Gold as Catalyst for the Hydroarylation and Domino Hydroarylation/N1-C4 Cleavage of β-Lactam-Tethered Allenyl Indoles.

  2015cites this paper
• Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4).

  2015cites this paper
• An Approach to Cyclohepta[b]indoles through an Allenamide (4 + 3) Cycloaddition–Grignard Cyclization–Chugaev Elimination Sequence

  2014cites this paper
• Tandem C-3/C-2 annulation of indole, benzofuran, and benzothiophene with 2-alkynyl benzylalcohol: an efficient approach to the diverse tetracyclic heteroazulene ring systems

  2014cites this paper
• Discovery of FDA-Approved Drugs as Inhibitors of Fatty Acid Binding Protein 4 Using Molecular Docking Screening

  2014cites this paper
• Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases

  2014cites this paper
• Rhodium enalcarbenoids: direct synthesis of indoles by rhodium(II)-catalyzed [4+2] benzannulation of pyrroles.

  2014cites this paper
• Synthesis and evaluation of indole based molecules for treatment of oxidative stress related diseases.

  2014cites this paper
• Small molecule inhibitors of human adipocyte fatty acid binding protein (FABP4).

  2014cites this paper
• Lipid Chaperones andMetabolic Inflammation

  2014cites this paper
• Binding Modes of Three Inhibitors 8CA, F8A and I4A to A-FABP Studied Based on Molecular Dynamics Simulation

  2014cites this paper
• Double Gold‐Catalysed Annulation of Indoles by Enynones

  2013cites this paper
• Stereoselective synthesis of highly functionalized tetrahydrocarbazoles through a domino Michael–Henry reaction: an easy access to four contiguous chiral centers

  2013cites this paper
• Enantioselective synthesis of cyclohepta[b]indoles: gram-scale synthesis of (S)-SIRT1-inhibitor IV.

  2013cites this paper
• Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice

  2013cites this paper
• Rhodium- and platinum-catalyzed [4+3] cycloaddition with concomitant indole annulation: synthesis of cyclohepta[b]indoles.

  2013cites this paper
• Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.

  2013cites this paper
• Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

  2012cites this paper
• Systemic and Intracellular Trafficking of Long-chain Fatty Acids in Lactating Dairy Cattle

  2012cites this paper
• Gallium(III)-catalyzed three-component (4+3) cycloaddition reactions.

  2012cites this paper
• New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein.

  2011cites this paper
• A New One-Pot Synthesis of Polysubstituted Indoles from Pyrroles and β-Nitroacrylates

  2011cites this paper
• Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity

  2011cites this paper