Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Brain Research

• Publication date

  1988-09-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0006-8993(88)91222-XPMID 2905922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of a monoclonal anti-calpain antibody on responses of stimulated human neutrophils. Evidence for a role for proteolytically modified protein kinase C.

  1988cited by this paper
• Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses.

  1988cited by this paper
• Lesions of entorhinal cortex produce a calpain-mediated degradation of brain spectrin in dentate gyrus. I. Biochemical studies.

  1988cited by this paper
• Role of N-methyl-D-aspartate receptors in the induction of synaptic potentiation by burst stimulation patterned after the hippocampal theta-rhythm.

  1988cited by this paper
• Presence of brain spectrin in dendrites of mammalian brain: Technical factors involved in immunocytochemical detection

  1988cited by this paper
• Calmodulin stimulates the degradation of brain spectrin by calpain

  1987cited by this paper
• Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activation.

  1987cited by this paper
• Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

  1987cited by this paper
• The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non‐lysosomal proteolytic system

  1986cited by this paper
• NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

  1986cited by this paper
• Brain spectrin(240/235) and brain spectrin(240/235E): two distinct spectrin subtypes with different locations within mammalian neural cells

  1986cited by this paper
• Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

  1986cited by this paper
• Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration.

  1986cited by this paper
• Glutamate neurotoxicity in cortical cell culture is calcium dependent.

  1985cited by this paper
• Regulation of glutamate receptor binding by the cytoskeletal protein fodrin

  1985cited by this paper
• Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.

  1985cited by this paper
• The biochemistry of memory: a new and specific hypothesis.

  1984cited by this paper
• Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities.

  1984cited by this paper
• Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice.

  1984cited by this paper
• Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors.

  1984cited by this paper
• Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

  1984cited by this paper
• Intracellular injections of EGTA block induction of hippocampal long-term potentiation

  1983cited by this paper
• Neurotoxic action of kainic acid.

  1983cited by this paper
• Identification of fodrin as a major calmodulin-binding protein in postsynaptic density preparations

  1983cited by this paper
• Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

  1983cited by this paper
• Neurotoxic action of kainic acid.

  1983cited by this paper
• Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro.

  1983cited by this paper
• Effects of high-frequency synaptic stimulation on glumate receptor binding studied with a modified in vitro hippocampal slice preparation.

  1982cited by this paper
• Intracellular sites of early calcium accumulation in the rat hippocampus during status epilepticus.

  1982cited by this paper
• Fodrin: axonally transported polypeptides associated with the internal periphery of many cells

  1981cited by this paper
• Brief bursts of high-frequency stimulation produce two types of structural change in rat hippocampus.

  1980cited by this paper
• Intracellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin).

  1980cited by this paper
• Regulation of hippocampal glutamate receptors: evidence for the involvement of a calcium-activated protease.

  1980cited by this paper
• Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve.

  1979cited by this paper
• Calcium-induced inactivation of microtubule formation in brain extracts. Presence of a calcium-dependent protease acting on polymerization-stimulating microtubule-associated proteins.

  1978cited by this paper
• An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration.

  1976cited by this paper
• Neurofilament disguise, destruction and discipline

  1975cited by this paper

• Revisiting the calpain hypothesis of learning and memory 40 years later

  2024cites this paper
• Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.

  2019cites this paper
• A viral approach to translatome profiling of CA1 neurons during associative recognition memory formation

  2018cites this paper
• Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences.

  2017cites this paper
• Are There Sex-Linked Differences Across the Longitudinal Axis of the Rat Hippocampus Following Ischemic Injury?

  2016influential citation
• 3,4-methylenedioxy-methamphetamine(MDMA)-induced increases in hippocampal glutamate concentrations and its impact on the dentate gyrus

  2015cites this paper
• Hyperglycaemia in acute ischaemic stroke : brain imaging studies in a rodent model of stroke

  2015cites this paper
• Excitotoxicity and stroke: identifying novel targets for neuroprotection.

  2014cites this paper
• Role of the Axonal Initial Segment in Psychiatric Disorders: Function, Dysfunction, and Intervention

  2014cites this paper
• Spectrin Breakdown Products (SBDPs) as Potential Biomarkers for Neurodegenerative Diseases

  2012cites this paper
• Early neurodegenerative changes in a rat model of multiple sclerosis

  2012cites this paper
• Ubiquitin C‐terminal hydrolase‐L1 as a biomarker for ischemic and traumatic brain injury in rats

  2010cites this paper
• Regulation of Calpain-2 in Neurons: Implications for Synaptic Plasticity

  2010cites this paper
• Calpain Activation by Wingless-type Murine Mammary Tumor Virus Integration Site Family, Member 5A (Wnt5a) Promotes Axonal Growth*

  2010cites this paper
• NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia

  2008cites this paper
• Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells.

  2007cites this paper
• Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury.

  2007cites this paper
• Sequential Degradation of αII and βII Spectrin by Calpain in Glutamate or Maitotoxin-Stimulated Cells†

  2007cites this paper
• Clinical Significance of αII-Spectrin Breakdown Products in Cerebrospinal Fluid after Severe Traumatic Brain Injury

  2007cites this paper
• ETUDE DE L'AMPLIFICATION DE LA NEURODEGENERESCENCE EXCITOTOXIQUE PAR UNE DYSFONCTION MITOCHONDRIALE : IMPLICATIONS POUR LA MALADIE DE HUNTINGTON

  2006influential citation
• An immunocytochemical study of calpain II in the hippocampus of rats injected with kainate

  2006cites this paper
• Methamphetamine‐induced spectrin proteolysis in the rat striatum

  2006cites this paper
• Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain‐dependent manner

  2005cites this paper
• Spectrin and calpain: a ‘target’ and a ‘sniper’ in the pathology of neuronal cells

  2005cites this paper
• Differential distribution of 68 Kd and 200 Kd neurofilament proteins in the gerbil hippocampus and their early distributional changes following transient forebrain ischemia

  2004cites this paper
• Cellular and molecular pathways of ischemic neuronal death.

  2002cites this paper
• Cellular defenses against excitotoxic insults

  2001cites this paper
• Postsynaptic Scaffolds of Excitatory and Inhibitory Synapses in Hippocampal Neurons: Maintenance of Core Components Independent of Actin Filaments and Microtubules

  2000cites this paper
• Dendritic cytoskeletal protein expression in mental retardation: an immunohistochemical study of the neocortex in Rett syndrome.

  2000cites this paper
• The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states

  2000influential citation
• High Calcium Concentrations, Calpain Activation and Cytoskeleton Remodeling in Neuronal Regeneration after Axotomy

  2000cites this paper
• A Predominant Apoptotic Death Pathway of Neuronal PC12 Cells Induced by Activated Microglia Is Displaced by A Non-apoptotic Death Pathway Following Blockage of Caspase-3-dependent Cascade*

  1999cites this paper
• Lamina-Specific Synaptic Activation Causes Domain-Specific Alterations in Dendritic Immunostaining for MAP2 and CAM Kinase II

  1999cites this paper
• Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.

  1999cites this paper
• Differential changes in glutamatergic transmission via N-methyl-D-aspartate receptors in the hippocampus and striatum of rats behaviourally sensitized to methamphetamine.

  1999cites this paper
• Cytoskeletal dynamics in dendritic spines: direct modulation by glutamate receptors?

  1999cites this paper
• Asymmetrical changes in the fodrin α subunit in the superior temporal cortices in schizophrenia

  1998cites this paper
• Excitotoxin‐Induced Neuronal Death Is Associated with Response of a Unique Intracellular Aspartic Proteinase, Cathepsin E

  1998cites this paper
• Real time imaging of calcium-induced localized proteolytic activity after axotomy and its relation to growth cone formation.

  1998cites this paper
• Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia.

  1998cites this paper
• Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex

  1998cites this paper
• Trial to Prevent Neurodegeneration in Persons Genetically Predisposed to Alzheimer’s Disease

  1998cites this paper
• Modulation of the Cytoskeletal Architecture by Calcium

  1998cites this paper
• Cellular Responses to Ischaemic CNS Injury

  1998cites this paper
• Integrative Aspects of Calcium Signalling

  1998cites this paper
• Asymmetrical changes in the fodrin alpha subunit in the superior temporal cortices in schizophrenia.

  1998cites this paper
• MODULATION OF THE CYTOSKELETAL ARCHITECTURE BY CALCIUM A Putative Role in Plastic Synapses

  1998cites this paper
• Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons.

  1998cites this paper
• Activation of NMDA receptors stimulates extracellular proteolysis of cell adhesion molecules in hippocampus.

  1998cites this paper
• Possible Neurophysiological Markers of Genetic Predisposition to Alzheimer’s Disease

  1998cites this paper
• Ca(2+)-dependent mechanisms of cell injury in cultured cortical neurons.

  1998cites this paper
• Distribution of Ankyrin Isoforms and Their Proteolysis After Ischemia and Reperfusion in Rat Brain

  1997cites this paper
• N-methyl-D-aspartate evokes rapid net depolymerization of filamentous actin in cultured rat cerebellar granule cells.

  1997cites this paper
• Activation of the Neutrophil Respiratory Burst Requires Both Intracellular and Extracellular Calcium

  1997cites this paper
• Anti-brain spectrin immunoreactivity in Alzheimer's disease: degradation of spectrin in an animal model of cholinergic degeneration.

  1997cites this paper
• Experimental neuronal protection in cerebral ischaemia part I: experimental models and pathophysiological responses.

  1997cites this paper
• Calpain Activation Contributes to Dendritic Remodeling after Brief Excitotoxic Injury In Vitro

  1997cites this paper
• Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin

  1997cites this paper
• Calcium‐Activated Proteolysis as a Therapeutic Target in Cerebrovascular Disease a

  1997cites this paper
• Regulation of cerebral microvessels by glutamatergic mechanisms.

  1997cites this paper
• NMDA Receptor‐Mediated Regulation of AMPA Receptor Properties in Organotypic Hippocampal Slice Cultures

  1997cites this paper
• Prolonged Calpain‐mediated Spectrin Breakdown Occurs Regionally Following Experimental Brain Injury in the Rat

  1996cites this paper
• Brain β-spectrin is a component of senile plaques in Alzheimer's disease

  1996cites this paper
• Spatial learning and memory in calpastatin-deficient rats.

  1996cites this paper
• Mechanisms underlying the neuropathological consequences of epileptic activity in the rat hippocampus in vitro

  1996cites this paper
• [Memory and synaptic plasticity].

  1996cites this paper
• Brain beta-spectrin is a component of senile plaques in Alzheimer's disease.

  1996cites this paper
• A genetic deficiency in calpastatin and isovalerylcarnitine treatment is associated with enhanced hippocampal long‐term potentiation

  1995cites this paper
• Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices.

  1995cites this paper
• Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices.

  1995cites this paper
• Effect of calpain on the composition and structure of postsynaptic densities

  1995cites this paper
• Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices.

  1995cites this paper
• Characterization of cathepsins E and D accumulated at early stages of neuronal damage in hippocampal neurons of rats.

  1995cites this paper
• Excitatory Amino Acids and Neurotoxicity in the Human Neocortex

  1995cites this paper
• Strategic Approaches to in Vitro Neurotoxicology

  1995cites this paper
• The relationship between hippocampal long-term potentiation and spatial learning

  1995cites this paper
• N-type Ca2+ channels are located on somata, dendrites, and a subpopulation of dendritic spines on live hippocampal pyramidal neurons

  1994cites this paper
• Stimulation of NMDA receptors activates calpain in cultured hippocampal slices.

  1994cites this paper
• Calpain‐mediated regulation of AMPA receptors in adult rat brain

  1994cites this paper
• Subcellular Distribution of Calpain and Calpastatin Immunoreactivity and Fodrin Proteolysis in Rabbit Hippocampus After Hypoxia and Glucocorticoid Treatment

  1994cites this paper
• Excitotoxic mechanisms in the pathogenesis of dementia.

  1994cites this paper
• Neuroprotection With a Calpain Inhibitor in a Model of Focal Cerebral Ischemia

  1994cites this paper
• INVITED REVIEW EXCITOTOXIC MECHANISMS IN THE PATHOGENESIS OF DEMENTIA

  1994cites this paper
• SubcellularDistribution of Calpainand Calpastatin Immunoreactivityand FodrinProteolysisinRabbit Hippocampus AfterHypoxia and GlucocorticoidTreatment

  1994cites this paper
• Actin-binding proteins. 1: Spectrin super family.

  1994cites this paper
• Calcium‐Activated Neutral Proteinase (Calpain) System in Aging and Alzheimer's Disease a

  1994cites this paper
• Postischemic Administration of AK275, a Calpain Inhibitor, Provides Substantial Protection against Focal Ischemic Brain Damage

  1994cites this paper
• Effects of Extracellular ATP on Fe2+‐Induced Cytotoxicity in PC‐12 Cells

  1994cites this paper
• Proteases and Pathological Neurodegeneration

  1994cites this paper
• Etiopathogenesis

  1994cites this paper
• Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons

  1994cites this paper
• The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane.

  1993cites this paper
• In vitro tests of neurotoxicity.

  1993cites this paper
• Calcium-induced actin depolymerization reduces NMDA channel activity.

  1993cites this paper
• Corticosterone Exacerbates Kainate‐Induced Alterations in Hippocampal Tau Immunoreactivity and Spectrin Proteolysis In Vivo

  1993cites this paper
• Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.

  1993cites this paper
• Decrease in amyloid precursor protein precedes hippocampal degeneration in rat brain following transient global ischemia.

  1993cites this paper
• Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor.

  1993cites this paper
• Upregulation of calpain activity in neonatal rat brain after hypoxic-ischemia.

  1993cites this paper
• Calcium‐mediated modulation of N‐methyl‐D‐aspartate (NMDA) responses in cultured rat hippocampal neurones.

  1993cites this paper