Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever

46% of sera from 30 children with rheumatic chorea showed IgG antibody reacting with neuronal cytoplasm of human caudate and subthalamic nuclei. The antibody was also detected in 14% of 50 children with active rheumatic carditis. 55 normal control sera, as well as 148 sera from a broad variety of other disease states showed a low prevalence (1.8-4.0%) of positive reactions. In rheumatic chorea the presence of anti-neuronal antibody appeared to correlate with severity and duration of clinical attacks. Antibody reacting with neuronal cytoplasm was completely removed by absorption with Group A streptococcal membranes or with isolated human neurons from caudate nucleus. Partial absorption of antibody was also recorded using Group A cell wall preparations but not with Group A carbohydrate. No absorption of positive reactions was seen with streptococcal Group D membranes or cell walls. In rheumatic chorea, anti-neuronal antibody appeared to represent cross-reaction with antigens shared by Group A streptococcal membranes.

• Publication year

  1976

• Venue

  Journal of Experimental Medicine

• Publication date

  1976-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1084/JEM.144.4.1094PMID 789810PMCID 2190435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-streptococcal antibodies reacting with brain tissue. I. Immunofluourescent studies.

  1976cited by this paper
• Proceedings: Epidemiological study of rheumatic fever and rheumatic heart disease in India.

  1975cited by this paper
• Studies on the pathogenesis of rheumatic heart disease. An immunological relationship between the polysaccharide of group A streptococcus and the glycoprotein of heart valve.

  1975cited by this paper
• Catecholamines and neurologic diseases.

  1975cited by this paper
• Localization of T and B cells and alpha fetoprotein in hepatic biopsies from patients with liver disease.

  1975cited by this paper
• Proceedings: Epidemiological study of rheumatic fever and rheumatic heart disease in India.

  1975cited by this paper
• Catecholamines and neurologic diseases (first of two parts).

  1975cited by this paper
• Plasma uptake of dopamine and 5-hydroxytryptamine and plasma-catecholamine levels in patients with Huntington's chorea.

  1974cited by this paper
• Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis.

  1973cited by this paper
• Detection of immunoglobulins in paraffin-embedded liver biopsies. Studies in 100 patients with special regard to immunological findings in active chronic hepatitis.

  1973cited by this paper
• A cross-reaction between Str. pyogenes and human fibroblasts, endothelial cells and astrocytes.

  1971cited by this paper
• Independence of protein synthesis and drug uptake in nerve cell bodies and glial cells isolated by a new technique.

  1971cited by this paper
• PURIFICATION AND PHYSICAL PROPERTIES OF GROUP C STREPTOCOCCAL PHAGE-ASSOCIATED LYSIN

  1971cited by this paper
• Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance.

  1970cited by this paper
• Isolation from Heart Valves of Glycopeptides which share Immunological Properties with Streptococcus haemolyticus Group A Polysaccharides

  1968cited by this paper
• Mimetic relationships between group A streptococci and mammalian tissues.

  1967cited by this paper
• AN IMMUNOLOGICAL RELATIONSHIP BETWEEN THE GROUP A STREPTOCOCCUS AND MAMMALIAN MUSCLE

  1966cited by this paper
• Jones criteria (revised) for guidance in the diagnosis of rheumatic fever.

  1965cited by this paper
• STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI.

  1964cited by this paper
• IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. III. PRESENCE IN HUMAN SERA OF STREPTOCOCCAL ANTIBODY CROSS-REACTIVE WITH HEART TISSUE. ASSOCIATION WITH STREPTOCOCCAL INFECTION, RHEUMATIC FEVER, AND GLOMERULONEPHRITIS.

  1964cited by this paper
• IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS. I. PROPERTIES OF AN ANTIGEN IN CERTAIN STRAINS OF GROUP A STREPTOCOCCI EXHIBITING AN IMMUNOLOGIC CROSS-REACTION WITH HUMAN HEART TISSUE.

  1963cited by this paper
• IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS

  1963cited by this paper
• DISEASES OF THE BASAL GANGLIA

  1960cited by this paper
• COUNCIL ON RHEUMATIC FEVER AND CONGENITAL HEART DISEASE

  1956cited by this paper
• The Diseases of the Basal Ganglia

  1943cited by this paper

• Pediatric early-onset neuropsychiatric obsessive compulsive disorders.

  2025cites this paper
• Dorsomedial Striatal Scube1 Expression Correlates With Perseveration in a Rat Reversal-Learning Task

  2025cites this paper
• Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

  2025cites this paper
• Neurobehavioral changes associated with rheumatic fever and rheumatic heart disease: A narrative review

  2024cites this paper
• PANDAS coexisting with gastrointestinal and cerebellar manifestation

  2024cites this paper
• Pediatric neuropsychiatric disorders with motor and nonmotor phenomena.

  2023cites this paper
• Autoantibodies in patients with obsessive-compulsive disorder: a systematic review

  2023cites this paper
• IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes

  2023cites this paper
• Neuroinflammation in Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome.

  2023cites this paper
• Infection and speech: Disfluency and other speech symptoms in Pediatric Acute-onset Neuropsychiatric Syndrome.

  2022cites this paper
• Pediatric neuropsychiatric syndromes associated with infection and microbiome alterations: clinical findings, possible role of the mucosal epithelium, and strategies for the development of new animal models

  2022cites this paper
• Tics and Emotions

  2022cites this paper
• PANDAS in an Adult?: A Case Report

  2022cites this paper
• The global assessment of OCD.

  2022cites this paper
• Limbic encephalitis in a child with ovarian teratoma and influenza B. Case report and critical review of the history of autoimmune anti-N-methyl-d-aspartate receptor encephalitis.

  2021cites this paper
• Inflammation, Obsessive-Compulsive Disorder, and Related Disorders.

  2021cites this paper
• Infections, Immunodeficiency, and Complications of Immunomodulatory Therapies in Neuroimmunology

  2021cites this paper
• Sydenham’s Chorea as the First Manifestation of Rheumatic Fever in Two Boys

  2021cites this paper
• Sydenham’s chorea: from pathophysiology to therapeutics

  2021cites this paper
• Diagnosis in PANDAS: An Update

  2020cites this paper
• Increased vulnerability to impulsive behavior after streptococcal antigen exposure and antibiotic treatment in rats.

  2020cites this paper
• Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections

  2020cites this paper
• Post-infectious neurological disorders

  2020cites this paper
• Neuropsychiatric consequences of childhood group A streptococcal infection: A systematic review of preclinical models.

  2020cites this paper
• Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae

  2019cites this paper
• Sydenham's Chorea.

  2019cites this paper
• Treatment of PANDAS and PANS: a systematic review

  2018cites this paper
• Infection, Immunodeficiency, and Inflammatory Diseases in Autoimmune Neurology

  2018cites this paper
• Rheumatic Complications of Streptococcus pyogenes

  2018cites this paper
• Inherited and Acquired Choreas.

  2018cites this paper
• Chapter 11 Neurobiology of Tourette ’ s syndrome : do immune factors really matter ?

  2018cites this paper
• Obsessive-Compulsive Disorder

  2018cites this paper
• Association of inflammation markers in young adult patients with Obsessive-compulsive disorder

  2018cites this paper
• Treatment of Sydenham’s Chorea: A Review of the Current Evidence

  2017cites this paper
• Chorea, Ballism, and Athetosis

  2017cites this paper
• Autoimmune Movement Disorders in Children.

  2017cites this paper
• This information is current as Implications in Human Disease and Signals Dopamine D2 Receptor: Dopaminergic Neurons in Transgenic Mice from Sydenham Chorea Targets Brain Human Monoclonal Autoantibody

  2017cites this paper
• Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part II—Use of Immunomodulatory Therapies

  2017cites this paper
• Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

  2017cites this paper
• Autoantibody-Associated Movement Disorders in Children: Proven and Proposed.

  2017cites this paper
• Parkinsonism and Related Disorders

  2016cites this paper
• Brain Atrophy, Anti-Smooth Muscle Antibody and Cognitive Impairment: An Association Study.

  2016cites this paper
• Autoimmunity against dopamine receptors in neuropsychiatric and movement disorders: a review of Sydenham chorea and beyond

  2016influential citation
• Reversible striatal hypermetabolism in chorea associated with moyamoya disease: a report of two cases

  2016cites this paper
• Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS)

  2016cites this paper
• Post-Streptococcal Autoimmune Sequelae: Rheumatic Fever and Beyond

  2016cites this paper
• Diagnostic Methods for Group A Streptococcal Infections

  2016cites this paper
• Chorea, Athetosis, and Ballism

  2016cites this paper
• Understanding Developmental Psychopathology: How Useful Are Evolutionary Perspectives?

  2016cites this paper
• Autoimmune choreas

  2016cites this paper
• Chapter 18 – Movement Disorders in Autoimmune Diseases

  2016cites this paper
• Chapter 44 – Acute Rheumatic Fever and Poststreptococcal Reactive Arthritis

  2016cites this paper
• Acute rheumatic fever and rheumatic heart disease

  2015cites this paper
• Antineuronal Antibodies in a Heterogeneous Group of Youth and Young Adults with Tics and Obsessive-Compulsive Disorder

  2015influential citation
• Streptococcal Antibody Probe Crosses the Blood Brain Barrier and Interacts within the Basal Ganglia

  2015cites this paper
• Autoantibodies to Brain Components and Antibodies to Acinetobacter Are Present in Bovine Spongiform Encephalopathy

  2015cites this paper
• The Controversy over the Classification of Gilles De La Tourette's Syndrome, 1800-1995

  2015cites this paper
• Paroxysmal non-kinesigenic dyskinesia, post-streptococcal syndromes and psychogenic movement disorders: a diagnostic challenge

  2015cites this paper
• Hydrogen peroxide mediated the neurotoxicity of an antibody against plasmalemmal neuronspecific enolase in primary cortical neurons.

  2015cites this paper
• Multidisciplinary Clinic Dedicated to Treating Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome: Presenting Characteristics of the First 47 Consecutive Patients

  2015cites this paper
• Sydenham Chorea and PANDAS in South Africa

  2015cites this paper
• Chorea: A Journey through History

  2015cites this paper
• Post-infectious autoimmune disorders: Sydenham's chorea, PANDAS and beyond.

  2015cites this paper
• Increased β‐haemolytic group A streptococcal M6 serotype and streptodornase B‐specific cellular immune responses in Swedish narcolepsy cases

  2015cites this paper
• Language Impairment in Adolescents With Sydenham Chorea.

  2015cites this paper
• Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats.

  2014influential citation
• Idiopathic progressive chorea: misnomer or still reality? A case with neuropathological disconfirmation

  2014cites this paper
• Role of Complements and Immunoglobulins in Alzheimer’s Disease

  2014cites this paper
• Obsessive–Compulsive Disorder

  2014cites this paper
• Neurologic indications for therapeutic plasma exchange: 2013 update

  2014cites this paper
• On the Connection Between Autoimmunity, tic Disorders and Obsessive-Compulsive Disorders: A Meta-Analysis on Anti-Streptolysin O Titres

  2014cites this paper
• A history of viral infections of the central nervous system: foundations, milestones, and patterns.

  2014cites this paper
• Rheumatic Fever, Autoimmunity, and Molecular Mimicry: The Streptococcal Connection

  2014cites this paper
• Brain Human Monoclonal Autoantibody from Sydenham Chorea Targets Dopaminergic Neurons in Transgenic Mice and Signals Dopamine D2 Receptor: Implications in Human Disease

  2013cites this paper
• 115 – Poststreptococcal Arthritis and Rheumatic Fever

  2013cites this paper
• Sydenham’s Chorea, PANDAS, and Other Post-streptococcal Neurological Disorders

  2013cites this paper
• Brain-reactive antibodies and disease.

  2013cites this paper
• Hallucinations in severe, repeated Sydenham's chorea in an Indigenous girl in North‐West Queensland

  2013cites this paper
• Autoantibodies in Sydenham's Chorea Tubulin Is a Neuronal Target of

  2013cites this paper
• Pervasive Refusal Syndrome

  2012cites this paper
• Pathogenesis of group A streptococcal infections.

  2012cites this paper
• Acute and chronic corticosteroid treatment of ten patients with paralytic form of Sydenham's chorea.

  2012cites this paper
• Parkinsonian signs and symptoms in adults with a history of Sydenham's chorea.

  2012cites this paper
• immunological-behavioral relationship? Serum immunoglobulins and cognitive status in the elderly: 2. An

  2012cites this paper
• Managing first-time seizures and epilepsy in children : main article

  2012cites this paper
• Managing first-time seizures and epilepsy in children: A first seizure is a relatively common problem in paediatric general practice

  2012cites this paper
• Paedatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection in an Indian Adolescent - A Case Report

  2012influential citation
• Treatment of Sydenham Chorea With Intravenous Immunoglobulin

  2012cites this paper
• Movement disorders in autoimmune diseases

  2012cites this paper
• Autoimmune Basal Ganglia Disorders

  2012cites this paper
• Behavioral, Pharmacological, and Immunological Abnormalities after Streptococcal Exposure: A Novel Rat Model of Sydenham Chorea and Related Neuropsychiatric Disorders

  2012influential citation
• The adaptive immune system in diseases of the central nervous system.

  2012cites this paper
• Anti-streptococcus IgM antibodies induce repetitive stereotyped movements: cell activation and co-localization with Fcα/μ receptors in the striatum and motor cortex.

  2012cites this paper
• Neurologic indications for therapeutic plasma exchange: 2011 update

  2012cites this paper
• Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome

  2011cites this paper
• Immune and Endocrine Function in Child and Adolescent Obsessive Compulsive Disorder

  2011cites this paper
• Neurologic indications for therapeutic plasma exchange: An update

  2011cites this paper
• Chapter 40 – ACUTE RHEUMATIC FEVER AND POSTSTREPTOCOCCAL REACTIVE ARTHRITIS

  2011cites this paper
• Antinuclear, Cytoskeletal, Antineuronal Antibodies in the Serum Samples of Children with Tic Disorders and Obsessive Compulsive Disorders

  2011cites this paper
• Sydenham's chorea.

  2011cites this paper