The vascular actions of relaxin.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Advances in Experimental Medicine and Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-0-387-74672-2_6PMID 18161482
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Protective effects of relaxin in ischemia/reperfusion‐induced intestinal injury due to splanchnic artery occlusion

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• Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats.

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• Human Recombinant Relaxin Reduces Heart Injury and Improves Ventricular Performance in a Swine Model of Acute Myocardial Infarction

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• Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy.

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• Relaxin as an Additional Protective Substance in Preserving and Reperfusion Solution for Liver Transplantation, Shown in a Model of Isolated Perfused Rat Liver

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• Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response.

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• Relaxin Pretreatment Decreases Infarct Size in Male Rats after Middle Cerebral Artery Occlusion

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• Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats

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• Relaxin Favors the Morphofunctional Integration between Skeletal Myoblasts and Adult Cardiomyocytes in Coculture

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• Myocardial Relaxin Counteracts Hypertrophy in Hypertensive Rats

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• Relaxin‐Induced Angiogenesis in Ovary Contributes to Follicle Development

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• Relaxin Increases Cardiac Output and Reduces Systemic Arterial Load in Hypertensive Rats

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• Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat.

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• Relaxin in vascular physiology and pathophysiology: possible implications in ischemic brain disease.

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• Effect of relaxin on myocardial ischemia injury induced by isoproterenol.

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• Basic Progress and Future Therapeutic Perspectives of Relaxin in Ischemic Heart Disease

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• Relaxin potentiates the expression of inducible nitric oxide synthase by endothelial cells from human umbilical vein in in vitro culture.

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• Relaxin-1-deficient mice develop an age-related progression of renal fibrosis.

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• Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats.

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  2003cited by this paper
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• Relaxin inhibits lipopolysaccharide‐induced adhesion of neutrophils to coronary endothelial cells by a nitric oxide‐mediated mechanism

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• Essential Role for Vascular Gelatinase Activity in Relaxin-Induced Renal Vasodilation, Hyperfiltration, and Reduced Myogenic Reactivity of Small Arteries

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• Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats.

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• Relaxin Gene and Protein Expression and Its Regulation of Procollagenase and Vascular Endothelial Growth Factor in Human Endometrial Cells1

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• Effect of Relaxin in Two Models of Renal Mass Reduction

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• Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway

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• Is the Pregnancy Hormone Relaxin Also a Vasodilator Peptide Secreted by the Heart?

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• Relaxin up‐regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells

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• Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin

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• Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats.

  2002cited by this paper
• The vasorelaxant hormone relaxin induces changes in liver sinusoid microcirculation: a morphologic study in the rat.

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• Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats.

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• The pregnancy hormone relaxin is a player in human heart failure

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• Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway.

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• Relaxin decreases renal interstitial fibrosis and slows progression of renal disease.

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• Relaxin is essential for renal vasodilation during pregnancy in conscious rats.

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• Systemic administration of recombinant human relaxin (RHRLX) ameliorates the acute cyclosporine nephrotoxicity in rats.

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• Effect of relaxin on normal and impaired wound healing in rodents

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• Relaxin clinical trials in systemic sclerosis

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• Systemic relaxin administration stimulates angiogenic cytokine expression and vessel formation in a rat myocardial infarct model

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• Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

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• Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats.

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• Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats.

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• Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women.

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• Relaxin is a potent renal vasodilator in conscious rats.

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• Identification of specific relaxin-binding cells in the human female.

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• Evidence for a novel source of relaxin: atrial cardiocytes.

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• A single-copy relaxin-like gene sequence is present in sheep.

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