Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Clinical Investigation

• Publication date

  1993-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI116485PMID 8514862PMCID PMC443310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic Renal Failure

  2007cited by this paper
• Basic and Clinical Biostatistics

  1993cited by this paper
• Increased plasma homocysteine concentration in patients with chronic renal failure.

  1992cited by this paper
• Parathyroid Hormone and the Myocardiopathy of Chronic Renal Failure

  1992cited by this paper
• Human erythrocyte D-aspartyl/L-isoaspartyl methyltransferases: enzymes that recognize age-damaged proteins.

  1991cited by this paper
• Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation.

  1991cited by this paper
• Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase.

  1991cited by this paper
• On the mechanism of impaired insulin secretion in chronic renal failure.

  1991cited by this paper
• Current status of protein methylation in carcinogenesis.

  1991cited by this paper
• Alterations of the Cl-/NaCO3- anion exchanger in erythrocytes of uraemic patients.

  1990cited by this paper
• Mechanism of the synergistic antiviral and cytostatic activity of (RS)-3-(adenin-9-yl)-2-hydroxypropanoic acid isobutyl ester and D,L-homocysteine.

  1990cited by this paper
• Inhibitors of membrane transmethylation reactions prevent the lymphocyte chemokinetic response.

  1990cited by this paper
• Hemodialysis and red cell cation transport in uremia: role of membrane free fatty acids.

  1989cited by this paper
• Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.

  1989cited by this paper
• Effects of verapamil on the abnormalities in fatty acid oxidation of myocardium.

  1989cited by this paper
• Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes.

  1988cited by this paper
• Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease.

  1988cited by this paper
• Inhibition of phosphoinositide metabolism in human polymorphonuclear leukocytes by S-adenosylhomocysteine.

  1988cited by this paper
• Repair of isopeptide bonds by protein carboxyl O-methyltransferase: seminal ribonuclease as a model system.

  1988cited by this paper
• Mechanism of protein carboxyl methyl transfer reactions: structural requirements of methyl accepting substrates.

  1988cited by this paper
• Sulfur amino acids in maintenance hemodialysis patients.

  1987cited by this paper
• Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial.

  1987cited by this paper
• Protein carboxyl methyltransferase facilitates conversion of atypical L-isoaspartyl peptides to normal L-aspartyl peptides.

  1987cited by this paper
• Partial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase.

  1987cited by this paper
• Na+-K+ pump in chronic renal failure.

  1987cited by this paper
• Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins.

  1987cited by this paper
• Correction of the anemia of end-stage renal disease with recombinant human erythropoietin.

  1987cited by this paper
• A kinetic study of cation transport in erythrocytes from uremic patients.

  1987cited by this paper
• Labile methyl groups and the promotion of cancer.

  1986cited by this paper
• Erythrocyte survival in chronic renal failure. Role of secondary hyperparathyroidism.

  1985cited by this paper
• Inhibitors of cyclic nucleotide phosphodiesterases inhibit protein carboxyl methylation in intact blood platelets.

  1984cited by this paper
• Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.

  1984influential reference
• Impairment of insulin release by methylation inhibitors.

  1984cited by this paper
• Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.

  1984cited by this paper
• Membrane protein carboxyl methylation increases with human erythrocyte age. Evidence for an increase in the number of methylatable sites.

  1983cited by this paper
• S-adenosyl-L-methionine synthetase from human erythrocytes: role in the regulation of cellular S-adenosylmethionine levels.

  1983cited by this paper
• Increased methyl esterification of membrane proteins in aged red-blood cells. Preferential esterification of ankyrin and band-4.1 cytoskeletal proteins.

  1983cited by this paper
• Erythrocyte deformability in dialysed and non‐dialysed uraemic patients

  1982cited by this paper
• Reversible methylation of cytoskeletal and membrane proteins in intact human erythrocytes.

  1981influential reference
• Effect of Inhibitors of Methylation on Early and Late Interferon Synthesis in Bovine Kidney Cell Cultures

  1981cited by this paper
• Accumulation of sulphur-containing amino acids including cysteine-homocysteine in patients on maintenance haemodialysis.

  1980cited by this paper
• Studies on substrate specificity of S-adenosylmethionine: protein-carboxyl methyltransferase from calf brain.

  1980cited by this paper
• In vivo carboxyl methylation of human eruthrocyte membrane proteins.

  1980cited by this paper
• The Role of S-Adenosylhomocysteine and S-Adenosylhomocysteine Hydrolase in the Control of Biological Methylations

  1980influential reference
• Methyl acceptors for protein methylase II from human-erythrocyte membrane.

  1979cited by this paper
• Uremic toxins.

  1978cited by this paper
• International Committee for Standardization in Haematology: Recommended Methods for Red‐Cell Enzyme Analysis *

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.

  1971cited by this paper
• The specificity of S-adenosylmethionine derivatives in methyl transfer reactions.

  1969cited by this paper
• Haemolysis in chronic renal failure.

  1967cited by this paper
• The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine.

  1959influential reference

• Metabolic and genetic imbalance of the homocysteine-methionine cycle in trisomy 21.

  2025cites this paper
• Does Risk of Hyperhomocysteinemia Depend on Thiol-Disulfide Exchange Reactions of Albumin and Homocysteine?

  2022cites this paper
• Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency.

  2020cites this paper
• DNA Methylation Dysfunction in Chronic Kidney Disease

  2020cites this paper
• The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art

  2019cites this paper
• The Link Between Hyperhomocysteinemia and Hypomethylation: Implications for Cardiovascular Disease

  2017cites this paper
• Immunoassay of S-adenosylmethionine and S-adenosylhomocysteine: the methylation index as a biomarker for disease and health status

  2016cites this paper
• Homocysteine in Renal Injury

  2016cites this paper
• S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation.

  2016cites this paper
• Methylation and Atherosclerosis

  2015cites this paper
• Homocysteine in Chronic Kidney Disease.

  2015cites this paper
• Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites.

  2014cites this paper
• Metabolomics of ADSOL (AS-1) red blood cell storage.

  2014cites this paper
• S-adenosylhomocysteine is associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population.

  2014cites this paper
• S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase

  2013cites this paper
• dietary perturbation -synthase and apolipoprotein E double knockout mice with and without β Hyperhomocysteinemia accelerates atherosclerosis in cystathionine

  2013cites this paper
• Accumulation of altered aspartyl residues in erythrocyte membrane proteins from patients with sporadic amyotrophic lateral sclerosis.

  2013cites this paper
• Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

  2013cites this paper
• The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation.

  2013cites this paper
• Homocysteine in Red Blood Cells Metabolism - Pharmacological Approaches

  2012cites this paper
• Role of homocysteine in end-stage renal disease.

  2012cites this paper
• Homocysteine and Hydrogen Sulfide, Two Opposing Aspects in the Pathobiology of Sulfur Compounds in Chronic Renal Failure

  2012cites this paper
• Radical SAM enzymes in methylation and methylthiolation.

  2012cites this paper
• The MicroRNA 15a/16–1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells

  2011cites this paper
• Beyond genetics: epigenetic code in chronic kidney disease.

  2011cites this paper
• Oxidative stress-associated shape transformation and membrane proteome remodeling in erythrocytes of end stage renal disease patients on hemodialysis.

  2011cites this paper
• Regulation of homocysteine metabolism and methylation in human and mouse tissues

  2010cites this paper
• Homocysteine and arterial thrombosis: Challenge and opportunity

  2010influential citation
• In vitro methylation by methanol: proteomic screening and prevalence investigation.

  2010cites this paper
• The kidney is the major site of S-adenosylhomocysteine disposal in humans.

  2009cites this paper
• Metabolomic analyses of the malaria parasite after inhibition of polyamine biosynthesis

  2009cites this paper
• Epigenetics in hyperhomocysteinemic states. A special focus on uremia.

  2009cites this paper
• Effects of S‐adenosylhomocysteine and homocysteine on DNA damage and cell cytotoxicity in murine hepatic and microglia cell lines

  2009cites this paper
• Is homocysteine toxic in uremia?

  2008cites this paper
• Die Rolle von Homocystein bei der Kohlenmonoxid- induzierten Erythropoetinsekretion in der Niere

  2008cites this paper
• Protein Isoaspartate Methyltransferase Prevents Apoptosis Induced by Oxidative Stress in Endothelial Cells: Role of Bcl-Xl Deamidation and Methylation

  2008cites this paper
• Hyperhomocysteinemia, DNA methylation and vascular disease

  2007cites this paper
• Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemia.

  2007cites this paper
• Mechanisms of Homocysteine-Induced Glomerular Injury and Sclerosis

  2007cites this paper
• Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene.

  2007cites this paper
• zur Veränderung des Methylierungspotenzials durch einmalige orale Homocysteinzufuhr bei gesunden Freiwilligen

  2007cites this paper
• Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome

  2007cites this paper
• The Role of Erythrocytes Phosphatidylserine Exposure in Anemia in Peritoneal Dialysis Patients

  2006cites this paper
• Toxic effects of hyperhomocysteinemia in chronic renal failure and in uremia: cardiovascular and metabolic consequences.

  2006cites this paper
• Hyperhomocysteinemia inhibits post-injury reendothelialization in mice.

  2006cites this paper
• Relationship between plasma S-adenosylhomocysteine concentration and glomerular filtration rate in children.

  2006cites this paper
• [Folate and homocysteine levels during pregnancy affect DNA methylation in human placenta].

  2005cites this paper
• Hyperhomocysteinemia and macromolecule modifications in uremic patients

  2005influential citation
• Hyperhomocysteinaemia in chronic kidney disease: focus on transmethylation

  2005cites this paper
• Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats

  2005cites this paper
• Hyperhomocysteinemia and atherosclerosis.

  2005cites this paper
• Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.

  2005cites this paper
• yperhomocysteinemia and ardiovascular Disease in Uremia : The Newest vidence in Epidemiology and Mechanisms of Action

  2004cites this paper
• Hyperhomocysteinemia and the cardiovascular disease of uremia

  2004cites this paper
• Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry.

  2004cites this paper
• S-adenosylhomocysteine is a more sensitive indicator of renal insufficiency than homocysteine

  2004cites this paper
• S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia.

  2004cites this paper
• The potential role of homocysteine in percutaneous coronary interventions (PCI): review of current evidence and plausibility of action.

  2004cites this paper
• Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences.

  2004influential citation
• NMR regulatory analysis: determination and characterization of S-adenosyl-L-methionine in dietary supplements.

  2004cites this paper
• Homocysteine metabolism in renal failure

  2004cites this paper
• Hyperhomocysteinemia and cardiovascular disease in uremia: the newest evidence in epidemiology and mechanisms of action.

  2004cites this paper
• Homocysteine in uremia.

  2003cites this paper
• Hyperhomocysteinaemia and vascular disease--a role for DNA hypomethylation?

  2003cites this paper
• Altered methionine metabolism in long living Ames dwarf mice.

  2003influential citation
• Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.

  2003cites this paper
• Homocysteine and oxidative stress

  2003cites this paper
• Simultaneous detection of S‐adenosylmethionine and S‐adenosylhomocysteine in mouse and rat tissues by capillary electrophoresis

  2003cites this paper
• Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation.

  2003cites this paper
• Hyperhomocysteinemia and protein damage in chronic renal failure and kidney transplant pediatric patients--Italian initiative on uremic hyperhomocysteinemia (IIUH).

  2003cites this paper
• Enhanced adherence of human uremic erythrocytes to vascular endothelium: role of phosphatidylserine exposure.

  2002cites this paper
• Mechanisms of apoptosis induced by purine nucleosides in astrocytes

  2002cites this paper
• Quantification of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent 1,N(6)-etheno derivatives: an adaptation of previously described methodology.

  2002cites this paper
• Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation.

  2002cites this paper
• Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases

  2002cites this paper
• Association between serum aspartate transaminase and homocysteine levels in hemodialysis patients.

  2002cites this paper
• Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition.

  2002cites this paper
• Tissue levels of S-adenosylhomocysteine in the rat kidney: effects of ischemia and homocysteine.

  2002cites this paper
• Pathophysiology and Treatment of Hyperhomocysteinemia in End‐Stage Renal Disease Patients

  2001cites this paper
• Plasma proteins containing damaged L-isoaspartyl residues are increased in uremia: implications for mechanism.

  2001cites this paper
• Homocysteine and transmethylations in uremia.

  2001cites this paper
• Pathogenesis of Hyperhomocysteinemia—New Insights

  2001cites this paper
• UVA irradiation induces L-isoaspartyl formation in melanoma cell proteins.

  2001cites this paper
• Metabolic consequences of hyperhomocysteinemia in uremia.

  2001cites this paper
• Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: correlations with diet.

  2001cites this paper
• Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.

  2001cites this paper
• Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease.

  2001cites this paper
• Involvement of phosphatidylserine exposure in the recognition and phagocytosis of uremic erythrocytes.

  2001cites this paper
• Occurrence of D‐aspartic acid and N‐methyl‐D‐aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release

  2000cites this paper
• Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine.

  2000cites this paper
• A Controlled Trial of the Effect of Folate Supplements on Homocysteine, Lipids and Hemorheology in End-Stage Renal Disease

  2000cites this paper
• Homocysteine, Coagulation, Platelet Function, and Thrombosis

  2000cites this paper
• Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry.

  2000cites this paper
• Cardiac Troponin T Predicts Mortality in Patients With End-Stage Renal Disease

  2000cites this paper
• Increased methyl esterification of altered aspartyl residues in erythrocyte membrane proteins in response to oxidative stress.

  2000cites this paper
• Deimination of myelin basic protein. 2. Effect of methylation of MBP on its deimination by peptidylarginine deiminase.

  2000cites this paper
• Increased erythrocyte phosphatidylserine exposure in chronic renal failure.

  1999cites this paper
• Homocysteine, a New Crucial Element in the Pathogenesis of Uremic Cardiovascular Complications

  1999cites this paper
• Homocysteine and methionine metabolism in ESRD: A stable isotope study.

  1999cites this paper
• Homocysteine, a new cardiovascular risk factor, is also a powerful uremic toxin.

  1999cites this paper