The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Bio/Technology

• Publication date

  1995-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NBT1295-1474PMID 9636306
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL)

  1995cited by this paper
• Regulation of the Adapter Molecule Grb2 by the FcR1 in the Mast Cell Line RBL2H3 (*)

  1995cited by this paper
• The α6Aβ1 and α6Bβ1 Integrin Variants Signal Differences in the Tyrosine Phosphorylation of Paxillin and Other Proteins (*)

  1995cited by this paper
• Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE(*)

  1995cited by this paper
• Different roles for the Fc epsilon RI gamma chain as a function of the receptor context

  1995cited by this paper
• Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells

  1995cited by this paper
• Regulation of the adapter molecule Grb2 by the Fc epsilon R1 in the mast cell line RBL2H3.

  1995cited by this paper
• Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

  1995cited by this paper
• Protein modules and signalling networks

  1995cited by this paper
• Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains

  1995cited by this paper
• Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI

  1995cited by this paper
• Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.

  1994cited by this paper
• Meiosis-dependent tyrosine phosphorylation of a yeast protein related to the mouse p51ferT

  1994cited by this paper
• The two-hybrid system: an assay for protein-protein interactions.

  1994cited by this paper
• Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

  1994cited by this paper
• Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

  1994cited by this paper
• Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

  1994cited by this paper
• Signal transduction by Fc receptors: the Fc epsilon RI case.

  1993cited by this paper
• Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine.

  1993cited by this paper
• T cell activation by clustered tyrosine kinases.

  1993cited by this paper
• Guide to yeast genetics and molecular biology

  1993cited by this paper
• Signal transduction by Fc receptors: the Fc&RI case

  1993cited by this paper
• Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element.

  1992cited by this paper
• Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

  1992cited by this paper
• Analysis of polypeptide transit through yeast secretory pathway.

  1991cited by this paper
• Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family.

  1990cited by this paper
• Methods in Yeast Genetics: A Laboratory Course Manual

  1990cited by this paper
• High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

  1989cited by this paper
• Structure and expression of Ick transcripts in human lymphoid cells

  1988cited by this paper
• Structure and expression of lck transcripts in human lymphoid cells.

  1988cited by this paper
• Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E.

  1988cited by this paper
• The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck

  1987cited by this paper
• Characterization of avian and viral p60src proteins expressed in yeast.

  1987cited by this paper
• DNA sequence of the herpes simplex virus type 1 gene whose product is responsible for transcriptional activation of immediate early promoters.

  1985cited by this paper
• Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

  1985cited by this paper
• Identification of phosphotyrosine in yeast proteins and of a protein tyrosine kinase associated with the plasma membrane.

  1985cited by this paper
• A short amino acid sequence able to specify nuclear location.

  1984cited by this paper
• Isolation and characterization of cDNAs coding for the j3 subunit of the high-affinity receptor for immunoglobulin E

  year unknowncited by this paper

• Expression analysis of the adaptor proteins Sh2b family during zebrafish embryonic development.

  2025cites this paper
• Control of germinal center B cell survival and IgE production by an adaptor molecule containing PH and SH2 domains, Aps/Sh2b2

  2024cites this paper
• 2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity.

  2023cites this paper
• New perspective on SH2B1: An accelerator of cancer progression.

  2019cites this paper
• Investigation of the Role of MERISTEM-DEFECTIVE (MDF) in Arabidopsis thaliana Root Development

  2019cites this paper
• Visualizing Post‐Translational Modifications in Protein Interaction Networks Using PTMOracle

  2019cites this paper
• Insight into the Brain-Specific Alpha Isoform of the Scaffold Protein SH2B1and its Rare Obesity-Associated Variants

  2017cites this paper
• Identification and first characterization of SmEps8, a potential interaction partner of SmTK3 and SER transcribed in the gonads of Schistosoma mansoni.

  2017cites this paper
• Yeast-based assays for detecting protein-protein/drug interactions and their inhibitors.

  2017cites this paper
• PTMOracle: A Cytoscape App for Covisualizing and Coanalyzing Post-Translational Modifications in Protein Interaction Networks.

  2017cites this paper
• Two-Hybrid and Related Systems

  2017cites this paper
• Growth hormone signaling pathways.

  2016cites this paper
• Decoding common and divergent cellular functions of the domains of forkhead transcription factors Fkh1 and Fkh2.

  2016cites this paper
• Lysine methylation modulates the protein–protein interactions of yeast cytochrome C Cyc1p

  2015cites this paper
• The split-ubiquitin system for the analysis of three-component interactions.

  2014cites this paper
• SH2B1 regulation of energy balance, body weight, and glucose metabolism.

  2014cites this paper
• This information is current as Can Inhibit T Cell Activation Homology and Src Homology 2 Domains that an Adaptor Protein with Pleckstrin Cloning and Characterization of Human Lnk

  2013cites this paper
• [Identification of therapeutic and diagnostic targets through yeast two hybrid system: molecular biology in medicine].

  2013cites this paper
• Effects of Human Obesity-associated Mutations on Cellular Actions of the Adapter Protein SH2B1.

  2013cites this paper
• [Expression of SH2B1 adaptor protein in oesophageal cancer and its clinical significance].

  2013influential citation
• Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System

  2012cites this paper
• Regulation of spindle assembly checkpoint (SAC) by phosphorylation and protein-protein interactions in Drosophila melanogaster

  2012cites this paper
• Negative Regulation of Haematopoiesis: Role of Inhibitory Adaptors

  2012cites this paper
• Clinical significance of SH2B1 adaptor protein expression in non-small cell lung cancer.

  2012influential citation
• The Lnk Adaptor Protein: A Key Regulator of Normal and Pathological Hematopoiesis

  2012cites this paper
• Regulation of insulin and type 1 insulin‐like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins

  2012cites this paper
• Clinical Significance of SH 2 B 1 Adaptor Protein Expression in Non-small Cell Lung Cancer

  2012influential citation
• Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)

  2012cites this paper
• A Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain Containing E3 Ubiquitin Ligase

  2011cites this paper
• The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling.

  2011cites this paper
• Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins

  2011cites this paper
• Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins.

  2010cites this paper
• Strategies and Methods in Monitoring and Targeting Protein–Protein Interactions

  2010cites this paper
• The Syk Kinase SmTK4 of Schistosoma mansoni Is Involved in the Regulation of Spermatogenesis and Oogenesis

  2010cites this paper
• Molecular Mechanisms of Growth Hormone-Induced Signal Transduction and SH2B1

  2010influential citation
• Identification of putative interactors of Fanconi anaemia proteins by yeast to hybrid system: characterization of two novel genes highly expressed during spermatogenesis

  2009cites this paper
• Clinical applications of immunomics

  2009cites this paper
• Identification of novel protein binding partners for the tumor suppressor DLC1

  2009cites this paper
• Deciphering soluble and membrane protein function using yeast systems (Review)

  2009cites this paper
• Immunomics: At the Forefront of Innate Immunity Research

  2009cites this paper
• Reverse two-hybrid screening to analyze protein-protein interaction of HIV-1 viral and cellular proteins.

  2009cites this paper
• PSM/SH2B1 splice variants: Critical role in src catalytic activation and the resulting STAT3s‐mediated mitogenic response

  2008cites this paper
• Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system.

  2008cites this paper
• Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins

  2008cites this paper
• Large-Scale Protein-Protein Interaction Detection Approaches: Past, Present and Future

  2008cites this paper
• Protein Engineering

  2008cites this paper
• Essential role of PSM/SH2‐B variants in insulin receptor catalytic activation and the resulting cellular responses

  2008cites this paper
• Advanced technologies for studies on protein interactomes.

  2008cites this paper
• [Sh2b3/Lnk family adaptor proteins in the regulation of lymphohematopoiesis].

  2008cites this paper
• SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.

  2008cites this paper
• SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other.

  2007cites this paper
• Neuronal SH 2 B 1 is essential for controlling energy and glucose homeostasis

  2007cites this paper
• PSM/SH2‐B distributes selected mitogenic receptor signals to distinct components in the PI3‐kinase and MAP kinase signaling pathways

  2007cites this paper
• 6 Yeast Hybrid Approaches

  2007cites this paper
• Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis

  2007cites this paper
• SH2B1β adaptor is a key enhancer of RET tyrosine kinase signaling

  2007cites this paper
• Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

  2007cites this paper
• Interaction of SH2-Bβ with RET is involved in signaling of GDNF-induced neurite outgrowth

  2006cites this paper
• Binding of SH2-B Family Members within a Potential Negative Regulatory Region Maintains JAK2 in an Active State

  2006influential citation
• Fluorescence‐Based Cloning of a Protein Tyrosine Kinase with a Yeast Tribrid System

  2005cites this paper
• Kinase Activation through Dimerization by Human SH2-B

  2005cites this paper
• APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation.

  2005cites this paper
• The interaction between the adaptor protein APS and Enigma is involved in actin organisation.

  2005cites this paper
• Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains

  2004cites this paper
• Application of the yeast two-hybrid system in molecular gerontology

  2004cites this paper
• Fcγ Receptors on Mast Cells: Activatory and Inhibitory Regulation of Mediator Release

  2004cites this paper
• Target discovery using the yeast two-hybrid system

  2004cites this paper
• Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly.

  2004cites this paper
• A tethered catalysis, two-hybrid system to identify protein-protein interactions requiring post-translational modifications

  2004cites this paper
• The role of the IL-15R[alpha] cytoplasmic domain in the IL-15 signal transduction pathway

  2004cites this paper
• SH2-B Is a Positive Regulator of Nerve Growth Factor-mediated Activation of the Akt/Forkhead Pathway in PC12 Cells*

  2004cites this paper
• A phenylalanine zipper mediates APS dimerization

  2004cites this paper
• Yeast Saccharomyces cerevisiae as a tool in cloning and analysis of fungal genes: Applications for biomass hydrolysis and utilisation: Dissertation

  2004cites this paper
• YXXL Motifs in SH2-Bβ Are Phosphorylated by JAK2, JAK1, and Platelet-derived Growth Factor Receptor and Are Required for Membrane Ruffling*

  2003cites this paper
• Forward and Reverse Proteomics: It Takes Two (or More) to Tango

  2003cites this paper
• Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells.

  2003cites this paper
• The formation and functions of the 21‐ and 23‐kDa tyrosine‐phosphorylated TCR ζ subunits

  2003cites this paper
• Impaired Lymphopoiesis and Altered B Cell Subpopulations in Mice Overexpressing Lnk Adaptor Protein

  2003cites this paper
• Systematic identification of regulatory proteins critical for T-cell activation

  2003cites this paper
• Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase

  2003cites this paper
• Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene.

  2003cites this paper
• Control of gene expression with small molecules: biotin-mediated acylation of targeted lysine residues in recombinant yeast.

  2003cites this paper
• Protein‐protein interactions as a target for drugs in proteomics

  2003cites this paper
• Enhanced Hematopoiesis by Hematopoietic Progenitor Cells Lacking Intracellular Adaptor Protein, Lnk

  2002cites this paper
• Rapid detection of protein tyrosine kinase activity in recombinant yeast expressing a universal substrate.

  2002cites this paper
• Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity

  2002cites this paper
• Subpopulations in Mice Overexpressing Lnk Impaired Lymphopoiesis and Altered B Cell

  2002cites this paper
• Screening for protein-protein interactions in the yeast two-hybrid system.

  2002cites this paper
• Discovery of protein—protein interaction using two-hybrid systems

  2002cites this paper
• Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice

  2002cites this paper
• MAPPIT: a cytokine receptor‐based two‐hybrid method in mammalian cells 1

  2002cites this paper
• Interaction of Fibroblast Growth Factor Receptor 3 and the Adapter Protein SH2-B

  2002cites this paper
• SH2-B Is Required for Both Male and Female Reproduction

  2002cites this paper
• SH2-B Family Members Differentially Regulate JAK Family Tyrosine Kinases*

  2002cites this paper
• Identification of receptor tyrosine kinase associating proteins using the yeast two-hybrid system.

  2001cites this paper
• Four PSM/SH2-B Alternative Splice Variants and Their Differential Roles in Mitogenesis*

  2001cites this paper
• SH2-B and APS Are Multimeric Adapters That Augment TrkA Signaling

  2001cites this paper
• Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins.

  2001cites this paper
• cDNA expression cloning and characterization of phosphorylation dependent protein interactors using the yeast tribrid system.

  2001cites this paper
• Using the yeast interaction trap and other two-hybrid-based approaches to study protein-protein interactions.

  2001cites this paper