RNA binding proteins in the control of autoimmune diseases

Abstract Autoimmune disease is induced by the breakdown of immune tolerance to self-antigens. This is brought about by an imbalance between the activation and the repression of immune responses. Dysregulation of the immune response is driven by the excess of proinflammatory cytokines such as IL-6 and TNF, which play a central role in the pathogenesis of a set of autoimmune diseases. The expression of proinflammatory mediator genes is tightly controlled by post-transcriptional regulation, which is mediated by a set of immune-related RNA binding proteins, such as tristetraprolin, Roquin, and Regnase-1. These proteins coordinately control the stability of proinflammatory mRNAs to regulate aberrant immune reactions. In this review, we discuss the roles of RNA binding proteins which are associated with the immune regulation and autoimmune pathogenesis.

• Publication year

  2019

• Venue

  Immunological Medicine

• Publication date

  2019-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/25785826.2019.1655192PMID 31449478
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeting Interleukin-6 Signaling in Clinic.

  2019cited by this paper
• ZC3H12B/MCPIP2, a new active member of the ZC3H12 family

  2019cited by this paper
• Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

  2019cited by this paper
• Anemia of inflammation.

  2019cited by this paper
• Aged Sanroque Mice Spontaneously Develop Sjögren's Syndrome-like Disease

  2019cited by this paper
• Terminal uridylyltransferases target RNA viruses as part of the innate immune system

  2018cited by this paper
• Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

  2018cited by this paper
• The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers

  2018cited by this paper
• Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem‐loop structure in its 3′UTR

  2018cited by this paper
• IL-17 integrates multiple self-reinforcing, feed-forward mechanisms through the RNA binding protein Arid5a

  2018cited by this paper
• ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

  2018cited by this paper
• RNA-binding protein Ptbp1 is essential for BCR-mediated antibody production

  2018cited by this paper
• Endonuclease Regnase‐1/Monocyte chemotactic protein‐1‐induced protein‐1 (MCPIP1) in controlling immune responses and beyond

  2018cited by this paper
• Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

  2018cited by this paper
• RNA-binding proteins control gene expression and cell fate in the immune system

  2018cited by this paper
• Regulation of inflammatory responses by dynamic subcellular localization of RNA-binding protein Arid5a

  2018cited by this paper
• Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.

  2017cited by this paper
• Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis

  2017cited by this paper
• MCPIP1/Regnase-1 Restricts IL-17A– and IL-17C–Dependent Skin Inflammation

  2017cited by this paper
• TNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein

  2017cited by this paper
• Maintenance of the marginal zone B cell compartment specifically requires the RNA-binding protein ZFP36L1

  2017cited by this paper
• Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway

  2017cited by this paper
• Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

  2017cited by this paper
• The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells

  2017cited by this paper
• The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.

  2017influential reference
• The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses

  2017cited by this paper
• A Red Carpet for Iron Metabolism.

  2017cited by this paper
• Identification of RNA-binding Proteins in Macrophages by Interactome Capture*

  2016influential reference
• MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A.

  2016cited by this paper
• The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression

  2016cited by this paper
• Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

  2016cited by this paper
• RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence

  2016cited by this paper
• RNA recognition by Roquin in posttranscriptional gene regulation

  2016cited by this paper
• Arid5a exacerbates IFN-γ–mediated septic shock by stabilizing T-bet mRNA

  2016cited by this paper
• RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins

  2016cited by this paper
• Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA

  2016cited by this paper
• Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40

  2016cited by this paper
• Mechanisms of human autoimmunity.

  2015cited by this paper
• The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response

  2015cited by this paper
• MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.

  2015cited by this paper
• RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

  2015cited by this paper
• Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.

  2015cited by this paper
• Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

  2014cited by this paper
• AT‐Rich–Interactive Domain–Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γt–Induced Th17 Cell Differentiation

  2014cited by this paper
• Post-transcriptional regulation of gene expression in innate immunity

  2014cited by this paper
• Posttranscriptional Modulation of Cytokine Production in T Cells for the Regulation of Excessive Inflammation by TFL

  2014influential reference
• Post-transcriptional coordination of immunological responses by RNA-binding proteins

  2014cited by this paper
• A census of human RNA-binding proteins

  2014cited by this paper
• Posttranscriptional Gene Regulation of IL-17 by the RNA-Binding Protein HuR Is Required for Initiation of Experimental Autoimmune Encephalomyelitis

  2013cited by this paper
• MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.

  2013cited by this paper
• Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

  2013influential reference
• Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

  2013cited by this paper
• Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

  2013cited by this paper
• Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

  2013cited by this paper
• Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.

  2013influential reference
• Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by Tristetraprolin

  2013cited by this paper
• Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.

  2013cited by this paper
• Myeloid-Specific Tristetraprolin Deficiency in Mice Results in Extreme Lipopolysaccharide Sensitivity in an Otherwise Minimal Phenotype

  2012cited by this paper
• Tristetraprolin down‐regulates IL‐17 through mRNA destabilization

  2012cited by this paper
• Identification of fifteen new psoriasis susceptibility loci highlights the role of innate immunity

  2012cited by this paper
• Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

  2012cited by this paper
• IL-10–induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

  2012cited by this paper
• The IκB Kinase Complex Regulates the Stability of Cytokine-Encoding mRNA Induced by TLR-IL-1R by Controlling Degradation of Regnase-1

  2012influential reference
• Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.

  2012cited by this paper
• Loss of Roquin induces early death and immune deregulation but not autoimmunity

  2011cited by this paper
• Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b

  2011cited by this paper
• Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality.

  2011cited by this paper
• New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes.

  2011cited by this paper
• The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

  2011cited by this paper
• miR-365, a Novel Negative Regulator of Interleukin-6 Gene Expression, Is Cooperatively Regulated by Sp1 and NF-κB*

  2011cited by this paper
• Tristetraprolin Regulates Interleukin-6 Expression Through p38 MAPK-Dependent Affinity Changes with mRNA 3′ Untranslated Region

  2011influential reference
• Faculty Opinions recommendation of An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.

  2010cited by this paper
• Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia (vol 11, pg 717, 2010)

  2010cited by this paper
• Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

  2010cited by this paper
• Post-transcriptional regulons coordinate the initiation and resolution of inflammation

  2010cited by this paper
• Pattern recognition receptors and inflammation.

  2010cited by this paper
• Physiological and pathological roles for microRNAs in the immune system

  2010cited by this paper
• Zcchc11-dependent uridylation of microRNA directs cytokine expression

  2009cited by this paper
• Tristetraprolin Mediates Interferon-γ mRNA Decay*

  2009cited by this paper
• The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

  2009cited by this paper
• Follicular helper T cells are required for systemic autoimmunity

  2009cited by this paper
• An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.

  2009cited by this paper
• Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

  2009cited by this paper
• Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals

  2008cited by this paper
• Tristetraprolin Regulates CXCL1 (KC) mRNA Stability1

  2008cited by this paper
• Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

  2007cited by this paper
• The highways and byways of mRNA decay

  2007cited by this paper
• A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

  2006cited by this paper
• Genetic variations in ZFP36 and their possible relationship to autoimmune diseases.

  2006cited by this paper
• Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.

  2005cited by this paper
• A Hairpin-like Structure within an AU-rich mRNA-destabilizing Element Regulates trans-Factor Binding Selectivity and mRNA Decay Kinetics*

  2005cited by this paper
• Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins

  2005cited by this paper
• A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

  2005cited by this paper
• mRNA Openers and Closers: Modulating AU‐Rich Element‐Controlled mRNA Stability by a Molecular Switch in mRNA Secondary Structure

  2004cited by this paper
• MK2‐induced tristetraprolin:14‐3‐3 complexes prevent stress granule association and ARE‐mRNA decay

  2004cited by this paper
• Targeted mRNA degradation by deadenylation-independent decapping.

  2004cited by this paper
• MAPKAP Kinase 2 Phosphorylates Tristetraprolin on in Vivo Sites Including Ser178, a Site Required for 14-3-3 Binding*

  2004cited by this paper
• Transcript-Selective Translational Silencing by Gamma Interferon Is Directed by a Novel Structural Element in the Ceruloplasmin mRNA 3′ Untranslated Region

  2003cited by this paper
• The selenocysteine incorporation machinery: interactions between the SECIS RNA and the SECIS-binding protein SBP2.

  2001cited by this paper
• Decreased Sensitivity of Tristetraprolin-deficient Cells to p38 Inhibitors Suggests the Involvement of Tristetraprolin in the p38 Signaling Pathway*

  2001cited by this paper

• Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis

  2026cites this paper
• Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis

  2025cites this paper
• Genome-wide identification of abnormal alternative splicing and RBP regulators in intestinal failure-associated liver disease.

  2025cites this paper
• Posttranscriptional Events Orchestrate Immune Homeostasis of CD8+ T Cells.

  2024cites this paper
• Regulation of inflammatory diseases via the control of mRNA decay

  2024cites this paper
• Arid5a uses disordered extensions of its core ARID domain for distinct DNA- and RNA-recognition and gene regulation

  2024cites this paper
• RNA Metabolism Governs Immune Function and Response.

  2024cites this paper
• Genome-wide identification of dysregulated alternative splicing and RNA-binding proteins involved in atopic dermatitis

  2024cites this paper
• Cysteine-rich zinc finger proteins and the nuclear factor kappa-B pathway

  2024cites this paper
• RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.

  2023cites this paper
• Identification of Potential HUB Genes and Associated Transcription Factors in Rheumatoid Arthritis

  2023cites this paper
• RNA‐binding proteins in autoimmunity: From genetics to molecular biology

  2023influential citation
• Deciphering the Neurosensory Olfactory Pathway and Associated Neo-Immunometabolic Vulnerabilities Implicated in COVID-Associated Mucormycosis (CAM) and COVID-19 in a Diabetes Backdrop—A Novel Perspective

  2022cites this paper
• Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins

  2022cites this paper
• Inherent conformational plasticity in dsRBDs enables interaction with topologically distinct RNAs.

  2022cites this paper
• NMR-derived secondary structure of the full-length Ox40 mRNA 3′UTR and its multivalent binding to the immunoregulatory RBP Roquin

  2022cites this paper
• Post-transcriptional control of T-cell development in the thymus.

  2022cites this paper
• Pb(II) coordination to the nonclassical zinc finger tristetraprolin: retained function with an altered fold

  2022cites this paper
• Role of Tristetraprolin in the Resolution of Inflammation

  2021cites this paper
• Targeting Zinc Finger Proteins with Exogenous Metals and Molecules: Lessons learned from Tristetraprolin, a CCCH type Zinc Finger.

  2021cites this paper
• TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation

  2021cites this paper
• Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review

  2021cites this paper
• Conceptual Advances in Control of Inflammation by the RNA-Binding Protein Tristetraprolin

  2021cites this paper
• Tristetraprolin Gene Single-Nucleotide Polymorphisms and mRNA Level in Patients With Rheumatoid Arthritis

  2021cites this paper
• Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells

  2021cites this paper
• Post‐transcriptional control of T‐cell cytokine production: Implications for cancer therapy

  2021cites this paper
• SARS-CoV-2 vaccines in patients with SLE

  2021cites this paper
• Ribonucleoprotein Immunoprecipitation (RIP) Analysis.

  2020cites this paper
• Exploring the factors underlying remyelination arrest by studying the post‐transcriptional regulatory mechanisms of cystatin F gene

  2020cites this paper
• The immunomodulatory role of Regnase family RNA-binding proteins

  2020cites this paper
• Differential modulation of Ahr and Arid5a: A promising therapeutic strategy for autoimmune encephalomyelitis

  2020cites this paper
• Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells

  2020influential citation
• Comprehensive Survey and Comparative Assessment of RNA-Binding Residue Predictions with Analysis by RNA Type

  2020cites this paper
• Mapping the Regulatory Programs of RNA Binding Protein Regulators in Rheumatoid Arthritis: Data from Single-Cell Transcriptome Analysis

  year unknowncites this paper