Infant pain management: a developmental neurobiological approach

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Clinical Practice Neurology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/ncpneuro0984PMID 19129789
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Venepuncture versus heel lance for blood sampling in term neonates.

  2011cited by this paper
• Responses to pain in school‐aged children with experience in a neonatal intensive care unit: Cognitive aspects and maternal influences

  2009cited by this paper
• Long‐term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm

  2009cited by this paper
• Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs.

  2008cited by this paper
• Midazolam Potentiates Nociceptive Behavior, Sensitizes Cutaneous Reflexes, and Is Devoid of Sedative Action in Neonatal Rats

  2008cited by this paper
• Action-Based Body Maps in the Spinal Cord Emerge from a Transitory Floating Organization

  2008cited by this paper
• Pain in children: recent advances and ongoing challenges.

  2008cited by this paper
• Developmental changes in the fidelity and short-term plasticity of GABAergic synapses in the neonatal rat dorsal horn.

  2008cited by this paper
• The other side of the opioid story: modulation of cell growth and survival signaling.

  2008cited by this paper
• Epidemiology and treatment of painful procedures in neonates in intensive care units.

  2008cited by this paper
• How Well Do Clinical Pain Assessment Tools Reflect Pain in Infants?

  2008cited by this paper
• Postnatal tuning of cutaneous inhibitory receptive fields in the rat

  2008cited by this paper
• Development of hemodynamic responses and functional connectivity in rat somatosensory cortex

  2008cited by this paper
• Good practice in postoperative and procedural pain management. Background.

  2008cited by this paper
• Opioids for neonates receiving mechanical ventilation.

  2008cited by this paper
• Prematurity and neonatal noxious events exert lasting effects on infant pain behaviour.

  2008cited by this paper
• Loss of glycinergic and GABAergic inhibition in chronic pain--contributions of inflammation and microglia.

  2008cited by this paper
• Opioids for neonates receiving mechanical ventilation.

  2008cited by this paper
• Topical amethocaine gel 4% for intramuscular injection in term neonates: a double-blind, placebo-controlled, randomized trial.

  2008cited by this paper
• Prolonged sedation and/or analgesia and 5-year neurodevelopment outcome in very preterm infants: results from the EPIPAGE cohort.

  2008cited by this paper
• Covariates of tramadol disposition in the first months of life.

  2008cited by this paper
• Isoflurane-induced Neuroapoptosis in the Developing Brain of Nonhypoglycemic Mice

  2008cited by this paper
• RESEARCH ARTICLE: Clinical Anesthesia Causes Permanent Damage to the Fetal Guinea Pig Brain

  2008cited by this paper
• The cerebral signature for pain perception and its modulation.

  2007cited by this paper
• The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.

  2007cited by this paper
• Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms.

  2007cited by this paper
• Paracetamol (acetaminophen) pharmacodynamics: interpreting the plasma concentration

  2007cited by this paper
• Venepuncture versus heel lance for blood sampling in term neonates.

  2007cited by this paper
• Mechanical Pain Hypersensitivity after Incisional Surgery Is Enhanced in Rats Subjected to Neonatal Peripheral Inflammation: Effects of N-Methyl-d-aspartate Receptor Antagonists

  2007cited by this paper
• Central sensitization: uncovering the relation between pain and plasticity.

  2007cited by this paper
• Neonates have a spinal alpha receptor too, as do adults

  2007cited by this paper
• Development of Pain: Maturation of Spinal Inhibitory Networks

  2007cited by this paper
• Use of Anesthetic Agents in Neonates and Young Children

  2007cited by this paper
• Endogenous opiates and behavior: 2006.

  2007cited by this paper
• Neonatal Exposure to a Combination of N-Methyl-d-aspartate and &ggr;-Aminobutyric Acid Type A Receptor Anesthetic Agents Potentiates Apoptotic Neurodegeneration and Persistent Behavioral Deficits

  2007cited by this paper
• Signaling pathways in sensitization: toward a nociceptor cell biology.

  2007cited by this paper
• Spinal microglia and neuropathic pain in young rats

  2007cited by this paper
• Pain in neonates and infants

  2007cited by this paper
• Rectal acetaminophen does not reduce morphine consumption after major surgery in young infants.

  2007cited by this paper
• Web-based method for translating neurodevelopment from laboratory species to humans

  2007cited by this paper
• Age-related changes in the spinal cord microglial and astrocytic response profile to nerve injury.

  2007cited by this paper
• Opioid Analgesia in Neonates Following Cardiac Surgery

  2007cited by this paper
• Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup

  2007cited by this paper
• Long‐term consequences of early infant injury and trauma upon somatosensory processing

  2007cited by this paper
• Nociceptors--noxious stimulus detectors.

  2007cited by this paper
• Ketamine-induced neuronal cell death in the perinatal rhesus monkey.

  2007cited by this paper
• Understanding LTP in pain pathways

  2007cited by this paper
• Characterization of spinal α‐adrenergic modulation of nociceptive transmission and hyperalgesia throughout postnatal development in rats

  2007cited by this paper
• Neurodevelopmental outcomes of very low-birth-weight infants with necrotizing enterocolitis: a systematic review of observational studies.

  2007cited by this paper
• The development of cerebral connections during the first 20-45 weeks' gestation.

  2006cited by this paper
• Neonatal nociceptive somatic stimulation differentially modifies the activity of spinal neurons in rats and results in altered somatic and visceral sensation

  2006cited by this paper
• Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis

  2006cited by this paper
• Behavioral Responses to Pain Are Heightened After Clustered Care in Preterm Infants Born Between 30 and 32 Weeks Gestational Age

  2006cited by this paper
• Long term alterations in neuroimmune responses of female rats after neonatal exposure to lipopolysaccharide.

  2006cited by this paper
• Recent developments in the pharmacological management of pain in children

  2006cited by this paper
• Long‐term alteration of pain sensitivity in school‐aged children with early pain experiences

  2006cited by this paper
• Breastfeeding or breast milk for procedural pain in neonates.

  2006cited by this paper
• Cortical Pain Responses in Human Infants

  2006cited by this paper
• Aberrant dendritic branching and sensory inputs in the superficial dorsal horn of mice lacking CaMKIIalpha autophosphorylation.

  2006cited by this paper
• Developmental Differences in Spinal Cyclooxygenase 1 Expression after Surgical Incision

  2006cited by this paper
• Neonatal urinary bladder inflammation produces adult bladder hypersensitivity.

  2006cited by this paper
• A postnatal switch in GABAergic control of spinal cutaneous reflexes

  2006cited by this paper
• Age-dependent Responses to Nerve Injury– induced Mechanical Allodynia

  2006cited by this paper
• Ephrin‐A4 inhibits sensory neurite outgrowth and is regulated by neonatal skin wounding

  2005cited by this paper
• Differential Maturation of GABA Action and Anion Reversal Potential in Spinal Lamina I Neurons: Impact of Chloride Extrusion Capacity

  2005cited by this paper
• The Effects of Early Pain Experience in Neonates on Pain Responses in Infancy and Childhood

  2005cited by this paper
• The development of nociceptive circuits

  2005cited by this paper
• The ontogeny of neuropathic pain: Postnatal onset of mechanical allodynia in rat spared nerve injury (SNI) and chronic constriction injury (CCI) models

  2005cited by this paper
• Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain

  2005cited by this paper
• Morphine Does Not Provide Adequate Analgesia for Acute Procedural Pain Among Preterm Neonates

  2005cited by this paper
• Pediatric intravenous paracetamol (propacetamol) pharmacokinetics: a population analysis 1

  2005cited by this paper
• Anesthesia and analgesia during and after surgery in neonates.

  2005cited by this paper
• Long‐term effects of neonatal surgery on adulthood pain behavior

  2005cited by this paper
• Human brain mechanisms of pain perception and regulation in health and disease

  2005cited by this paper
• Developmental Age Influences the Effect of Epidural Dexmedetomidine on Inflammatory Hyperalgesia in Rat Pups

  2005cited by this paper
• Risk Factors Associated with Acute Pyelonephritis in Healthy Women

  2005cited by this paper
• Neonatal immune challenge alters nociception in the adult rat

  2005cited by this paper
• Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways.

  2005cited by this paper
• Morphine, Hypotension, and Adverse Outcomes Among Preterm Neonates: Who’s to Blame? Secondary Results From the NEOPAIN Trial

  2005cited by this paper
• Pain management in the neonatal intensive care unit: a national survey in Italy

  2005cited by this paper
• Opioid analgesia in the newborn

  2005cited by this paper
• Of mice and men: should we extrapolate rodent experimental data to the care of human neonates?

  2005cited by this paper
• Does neonatal surgery lead to increased pain sensitivity in later childhood?

  2005cited by this paper
• The pharmacological treatment of neonatal pain.

  2005cited by this paper
• Activity of adenylyl cyclase and protein kinase A contributes to morphine-induced spinal apoptosis.

  2005cited by this paper
• Cellular signalling pathways of spinal pain neuroplasticity as targets for analgesic development.

  2005cited by this paper
• Development of GABAergic and Glycinergic Transmission in the Neonatal Rat Dorsal Horn

  2004cited by this paper
• Patient Safety Is Not Enough: Targeting Quality Improvements To Optimize the Health of the Population

  2004cited by this paper
• Do pediatric drugs cause developing neurons to commit suicide?

  2004cited by this paper
• Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial.

  2004cited by this paper
• Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates

  2004cited by this paper
• Psychosocial and Academic Characteristics of Extremely Low Birth Weight (≤800 g) Adolescents Who Are Free of Major Impairment Compared With Term-Born Control Subjects

  2004cited by this paper
• Descending modulation of pain.

  2004cited by this paper
• Pain relief for neonatal circumcision.

  2004cited by this paper
• Self‐mutilation in young children following brachial plexus birth injury

  2004cited by this paper
• Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

  2004cited by this paper
• The functional expression of mu opioid receptors on sensory neurons is developmentally regulated; morphine analgesia is less selective in the neonate

  2004cited by this paper
• Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABAA Miniature IPSCs in Lamina II of the Spinal Cord

  2004cited by this paper
• Characterization of basal and re‐inflammation‐associated long‐term alteration in pain responsivity following short‐lasting neonatal local inflamatory insult

  2004cited by this paper
• Sucrose for analgesia in newborn infants undergoing painful procedures.

  2004cited by this paper

• Sex differences in the transition to chronic pain

  2025cites this paper
• Extraction and quantitation of fentanyl in exhaled breath condensate using a magnetic dispersive solid phase based on graphene oxide and covalent organic framework composite and LC-MS/MS analysis.

  2025cites this paper
• Knowledge and attitudes toward pediatric pain management among final-year medical students in Italy: a multicenter observational study

  2025cites this paper
• Pain in very preterm infants-prevalence, causes, assessment, and treatment. A nationwide cohort study.

  2025cites this paper
• On the relation of injury to pain-an infant perspective.

  2024cites this paper
• Brain health in preterm infants: importance of early-life pain and analgesia exposure

  2024cites this paper
• Neonatal amygdala volumes, procedural pain and the association with social-emotional development in children born very preterm

  2024cites this paper
• Effective regional anesthesia for pediatric surgical care.

  2024cites this paper
• Effects of pain, sedation and analgesia on neonatal brain injury and brain development.

  2024cites this paper
• Pain Exposure and Brain Connectivity in Preterm Infants

  2024cites this paper
• Development of an Experimental Animal Screening Model for Induction of type-3 Diabetes Mellitus using High-fat Diet, Streptozotocin, and Nicotinamide

  2024cites this paper
• Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System

  2024cites this paper
• Pain and development: interacting phenomena.

  2024cites this paper
• A developmental shift in habituation to pain in human neonates.

  2023cites this paper
• Early life iron deficiency persistently alters nociception in developing mice.

  2023cites this paper
• Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants

  2023cites this paper
• The Importance of Managing Acute Pain in the Neonatal Intensive Care Unit Context

  2023cites this paper
• Intravenous dexamethasone does not prolong the duration of pudendal nerve block in infants and children undergoing hypospadias surgery: A randomized clinical trial

  2023cites this paper
• Skin-to-skin contact—An effective intervention on pain and stress reduction in preterm infants

  2023cites this paper
• Developmental impact of peripheral injury on neuroimmune signaling.

  2023cites this paper
• Utilizing umbilical cord blood - Minimizing blood sampling and pain in healthy infants at risk for polycythemia.

  2022cites this paper
• Evolving approaches in neonatal postoperative pain management.

  2022cites this paper
• Immunological contributions to age-dependent variations in behavioural responses to cutaneous inflammation

  2022cites this paper
• The neurobiology of childhood trauma, from early physical pain onwards: as relevant as ever in today's fractured world

  2022cites this paper
• Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks- American Pain Society-American Academy of Pain Medicine Pain Taxonomy Diagnostic Criteria for Acute Needle Pain.

  2022cites this paper
• Assessment and Management of Pain in Preterm Infants: A Practice Update

  2022cites this paper
• Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence

  2022influential citation
• Childhood trauma: a major risk factor in the military recruitment of young people

  2022cites this paper
• Bridging the gap: Identifying diverse stakeholder needs and barriers to accessing evidence and resources for children’s pain

  2022cites this paper
• New blocks on the kids: core basic nerve blocks in paediatric anaesthesia

  2022cites this paper
• Early life events in functional abdominal pain disorders in children

  2022cites this paper
• A Randomized Comparative Effectiveness Study of Reflexology, Sucrose, and Other Treatments for Needle Procedures in Newborns.

  2022cites this paper
• Mother-Infant Dyadic Synchrony in the NICU Context.

  2021cites this paper
• Delivering transformative change in paediatric pain: A Lancet Child & Adolescent Health Commission Christopher Eccleston (Ph.D.)1,2,3, Emma Fisher (Ph.D.)1,2, Richard F. Howard (FFPMRCA)4,

  2021cites this paper
• Psychosocial and Neurobiological Vulnerabilities of the Hospitalized Preterm Infant and Relevant Non-pharmacological Pain Mitigation Strategies

  2021cites this paper
• Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations

  2021cites this paper
• Validity and reliability of the Neonatal Infant Acute Pain Assessment Scale (NIAPAS) in Turkish: prospective study

  2021cites this paper
• Microglial activation in the trigeminal spinal subnucleus interpolaris/caudalis modulates orofacial incisional mechanical pain hypersensitivity associated with orofacial injury in infancy.

  2021cites this paper
• Tapentadol for the Treatment of Moderate-to-Severe Acute Pain in Children Under the Age of Two Years

  2021cites this paper
• Recommendations for a Pediatric Pain Education Curriculum for Physical and Occupational Therapists: Scoping Review and Survey

  2021cites this paper
• Using sensor-fusion and machine-learning algorithms to assess acute pain in non-verbal infants: a study protocol

  2021cites this paper
• Oxidative Stress in Preterm Newborns

  2021cites this paper
• Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability

  2021cites this paper
• Evaluation of the Premature Infant Pain Profile-Revised (PIPP-R) e-Learning Module

  2021cites this paper
• Fetal Pain: What is the Scientific Evidence?

  2021cites this paper
• Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction

  2020cites this paper
• Delivering transformative change in paediatric pain: A Lancet Child & Adolescent Health Commission

  2020cites this paper
• The Problem of Pain: Acute Pain and Procedures

  2020cites this paper
• Pain profile of premature infants during routine procedures in neonatal intensive care: An observational study

  2020cites this paper
• Evaluation of the Reliability and Validity of the Behavioral Indicators of Infant Pain Scale in Chinese Neonates.

  2020cites this paper
• Paracetamol (acetaminophen) for prevention or treatment of pain in newborns.

  2020cites this paper
• Mechanisms of Timing, Timbre, Repertoire, and Entrainment in Neuroplasticity: Mutual Interplay in Neonatal Development

  2020cites this paper
• Breastfeeding Support Team: When to Add a Chiropractor

  2020cites this paper
• Early Neonatal Pain—A Review of Clinical and Experimental Implications on Painful Conditions Later in Life

  2020cites this paper
• Cumulative procedural pain and brain development in very preterm infants: a systematic review of clinical and preclinical studies.

  2020cites this paper
• Grundlagen der Pharmakologie und Arzneimitteltherapie

  2020cites this paper
• Qualitative review on N‐methyl‐D‐aspartate receptor expression in rat spinal cord during the postnatal development: Implications for central sensitization and pain

  2020cites this paper
• OBSOLETE: The Development of the Nociceptive System and Childhood Pain

  2020cites this paper
• The Development of the Nociceptive System and Childhood Pain

  2020cites this paper
• Feasibility and clinical utility of the Finnish version of the FLACC pain scale in PICU.

  2020cites this paper
• Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

  2020cites this paper
• Pain response to vaccination in newborn infants of diabetic mothers.

  2020cites this paper
• Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation

  2020cites this paper
• Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

  2020cites this paper
• Reproducible, Generalizable Brain Models of Affective Processes

  2019cites this paper
• Systemic growth hormone deficiency causes mechanical and thermal hypersensitivity during early postnatal development

  2019cites this paper
• A Systematic Review of Behavioral and Environmental Interventions for Procedural Pain Management in Preterm Infants★

  2019cites this paper
• Does epigenetic ‘memory’ of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5

  2019cites this paper
• Betwixt Simplicity and Complexity : A Middle Road Representations

  2019cites this paper
• Does Repeated Painful Stimuli Change Cerebral Near-Infrared Spectroscopy Response in Healthy, Term, Large for Gestational Age Newborns?

  2019cites this paper
• The challenge of developing pain medications for children: therapeutic needs and future perspectives

  2019cites this paper
• Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats

  2019cites this paper
• Sensorialité fœtale

  2019cites this paper
• Individual variations in fentanyl pharmacokinetics and pharmacodynamics in preterm infants

  2019cites this paper
• Factors Associated With Early Deaths Following Neonatal Male Circumcision in the United States, 2001 to 2010

  2018cites this paper
• Do you see my pain? Aspects of pain assessment in hospitalized preverbal children

  2018cites this paper
• Development of a Clinical Pain Scale for Preterm Neonates

  2018influential citation
• Essentials of Anesthesia for Infants and Neonates

  2018cites this paper
• Neonatal Pain and Stress: Assessment and Management

  2018cites this paper
• Pain Control Interventions in Preterm Neonates: A Randomized Controlled Trial

  2018cites this paper
• Small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia.

  2018cites this paper
• Douleur et stress aigus en période néonatale : effets de l'utilisation des sucres et intérêts d'une évaluation multimodale de la douleur

  2018cites this paper
• The Impact of Blood Sampling Site on Pain Score in Preterm Infants: A Crossover Randomized Clinical Trial

  2018cites this paper
• Developmental Dimensions in Understanding Interpersonal Features of Pain

  2018cites this paper
• Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat

  2018cites this paper
• Neonatal Pain: Perceptions and Current Practice.

  2018cites this paper
• Oxidative Stress as a Physiological Pain Response in Full-Term Newborns

  2017cites this paper
• The New Rome IV Criteria for Functional Gastrointestinal Disorders in Infants and Toddlers

  2017cites this paper
• Early Procedural Pain Is Associated with Regionally-Specific Alterations in Thalamic Development in Preterm Neonates

  2017cites this paper
• Neuroimaging of Paediatric Pain

  2017cites this paper
• The Power of a Parent's Touch: Evaluation of Reach and Impact of a Targeted Evidence-Based YouTube Video

  2017cites this paper
• EDIN Scale Implemented by Gestational Age for Pain Assessment in Preterms: A Prospective Study

  2017cites this paper
• Pain: From genes and proteins to cells in the living organism

  2017cites this paper
• Translational studies identify long-term impact of prior neonatal pain experience

  2017cites this paper
• A Discourse about Autism Spectrum Disorders from the Aspect of Gender Relevancies of Biopsychology and Brain Research

  2017cites this paper
• Acupuncture in the neonatal intensive care unit—using ancient medicine to help today’s babies: a review

  2017cites this paper
• 137 – Developmental Aspects of Pain

  2017cites this paper
• Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats.

  2017cites this paper
• Upregulation of P2Y1 in neonatal nociceptors regulates heat and mechanical sensitization during cutaneous inflammation

  2017cites this paper
• Down-Regulation of Cough during Exercise Is Less Frequent in Healthy Children than Adults. Role of the Development and/or Atopy?

  2017cites this paper