Circulating gamma/delta T lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Clinical and Experimental Immunology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 11529924PMCID PMC1906121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients.

  1998cited by this paper
• Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis.

  1998cited by this paper
• Innate T-cell immunity to nonpeptidic antigens.

  1998cited by this paper
• Patterns of lymphokine secretion amongst mouse gamma delta T cell clones.

  1997cited by this paper
• Gamma delta T cells of human early pregnancy decidua: evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation.

  1997cited by this paper
• An innate view of gamma delta T cells.

  1997cited by this paper
• Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens.

  1997cited by this paper
• Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.

  1997cited by this paper
• Circulating levels of soluble CD30 are increased in patients with systemic sclerosis (SSc) and correlate with serological and clinical features of the disease

  1997cited by this paper
• Modulation of cytokine expression by CD4+ T cells during coxsackievirus B3 infections of BALB/c mice initiated by cells expressing the gamma delta + T-cell receptor

  1996cited by this paper
• Peripheral blood mononuclear cells of patients with systemic sclerosis produce increased amounts of interleukin 6, but not transforming growth factor beta 1.

  1996cited by this paper
• gamma/delta and other unconventional T lymphocytes: what do they see and what do they do?

  1996cited by this paper
• Th1 and Th2 cells in autoimmunity.

  1995cited by this paper
• CDR3-independent gamma delta V delta 1+ T cell expansion in the peripheral blood of HIV-infected persons.

  1995cited by this paper
• Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells.

  1995cited by this paper
• Natural killer cells and gamma delta T cells in scleroderma: relationship to disease duration and anti-Scl-70 antibodies.

  1995cited by this paper
• Immunologic aspects of scleroderma

  1994cited by this paper
• Expansion of selected V delta 1+ gamma delta T cells in systemic sclerosis patients.

  1994cited by this paper
• Different cytokine production profiles of gamma delta T cell clones: relation to inflammatory arthritis.

  1994cited by this paper
• Raynaud's phenomenon and the vascular disease in scleroderma

  1994cited by this paper
• Patterns of cytokine production by mycobacterium-reactive human T-cell clones

  1993cited by this paper
• IL-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells: relationship between vimentin and CD23.

  1993cited by this paper
• Reliability of skin involvement measures in scleroderma. The UK Scleroderma Study Group.

  1992cited by this paper
• Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4.

  1992cited by this paper
• Lymphokine-activated killer cell and natural killer cell activities in patients with systemic sclerosis.

  1992cited by this paper
• Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor alpha, and interferon-gamma levels in sera from patients with scleroderma.

  1992cited by this paper
• Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells

  1991cited by this paper
• Biology of the human gamma delta T-cell receptor.

  1991cited by this paper
• Fibrogenic cytokines: the role of immune mediators in the development of scar tissue.

  1991cited by this paper
• Natural killer activity and antibody‐dependent cellular cytotoxicity in progressive systemic sclerosis

  1990cited by this paper
• Soluble interleukin‐2 receptor, interleukin‐2 and interleukin‐4 in sera and supernatants from patients with progressive systemic sclerosis

  1990cited by this paper
• A new murine CD4+ T cell subset with an unrestricted cytokine profile.

  1989cited by this paper
• Polyclonal B lymphocyte activation in progressive systemic sclerosis.

  1989cited by this paper
• Molecular analysis of human gamma/delta+ clones from thymus and peripheral blood

  1989cited by this paper
• Scleroderma (systemic sclerosis): classification, subsets and pathogenesis.

  1988cited by this paper
• Inhibition of excessive scleroderma fibroblast collagen production by recombinant gamma-interferon. Association with a coordinate decrease in types I and III procollagen messenger RNA levels.

  1986cited by this paper
• Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee.

  1980cited by this paper
• A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma?

  1979cited by this paper

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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
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  2017cites this paper
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  2016cites this paper
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  2015cites this paper
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  2013cites this paper
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  2012cites this paper
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  2011cites this paper
• [Cytokines and T cell differentiation in systemic sclerosis].

  2011cites this paper
• Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis

  2011cites this paper
• The Pathogenesis of Systemic Sclerosis Revisited

  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• The immunobiology of systemic sclerosis.

  2008cites this paper
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  2008cites this paper
• Interferons and scleroderma-a new clue to understanding the pathogenesis of scleroderma?

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007influential citation
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  2007cites this paper
• The Journal of Rheumatology Increased serum interleukin 23 in patients with systemic sclerosis.

  2007cites this paper
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  2007cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
• [Systemic sclerosis: pathophysiology of a multifaceted disease].

  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper