[Systemic sclerosis: pathophysiology of a multifaceted disease].

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Presse medicale

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 17159716
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Endothelial and fibroblastic activation in scleroderma. The myth of the "uninvolved skin".

  2010cited by this paper
• Anti-endothelial cell antibodies from patients with limited cutaneous systemic sclerosis bind to centromeric protein B (CENP-B).

  2006cited by this paper
• Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension

  2006cited by this paper
• DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti-topoisomerase I autoantibodies from systemic sclerosis patients.

  2006cited by this paper
• Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes.

  2006cited by this paper
• Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.

  2006cited by this paper
• Antibodies against Human Cytomegalovirus in the Pathogenesis of Systemic Sclerosis: A Gene Array Approach

  2005cited by this paper
• Platelet-derived Growth Factor and Reactive Oxygen Species (ROS) Regulate Ras Protein Levels in Primary Human Fibroblasts via ERK1/2

  2005cited by this paper
• Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.

  2004cited by this paper
• A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease.

  2004cited by this paper
• IgG reactivity with a 100-kDa tissue and endothelial cell antigen identified as topoisomerase 1 distinguishes between limited and diffuse systemic sclerosis patients.

  2004cited by this paper
• Parvoviral infection of endothelial cells and stromal fibroblasts: a possible pathogenetic role in scleroderma

  2004cited by this paper
• Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis.

  2004cited by this paper
• Reduced risk for extensive chronic graft-versus-host disease in patients receiving transplants with human leukocyte antigen-identical sibling donors given polymerase chain reaction-based preemptive therapy against cytomegalovirus

  2004cited by this paper
• Oxidative stress in Systemic Sclerosis

  2004cited by this paper
• Elevated vascular endothelial growth factor in systemic sclerosis.

  2003cited by this paper
• Connective Tissue Growth Factor Is a Mediator of Angiotensin II–Induced Fibrosis

  2003cited by this paper
• Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients.

  2003cited by this paper
• Constitutive Connective Tissue Growth Factor Expression in Scleroderma Fibroblasts Is Dependent on Sp1*

  2003cited by this paper
• The clinical relevance of autoantibodies in scleroderma

  2003cited by this paper
• Distinct immune profiles characterize patients with diffuse or limited systemic sclerosis.

  2003cited by this paper
• Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan.

  2003cited by this paper
• Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies.

  2003cited by this paper
• In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay.

  2003cited by this paper
• Endothelin and endothelin receptor antagonists in systemic rheumatic disease.

  2003cited by this paper
• Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma.

  2003cited by this paper
• Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

  2003cited by this paper
• Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts.

  2003cited by this paper
• Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis.

  2003cited by this paper
• Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma.

  2003cited by this paper
• Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha.

  2003cited by this paper
• Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibroblasts.

  2003cited by this paper
• Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis*

  2003cited by this paper
• Cellular microchimerism as a lifelong physiologic status in parous women: an immunologic basis for its amplification in patients with systemic sclerosis.

  2003cited by this paper
• Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts.

  2003cited by this paper
• Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.

  2003cited by this paper
• Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production.

  2002cited by this paper
• Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis.

  2002cited by this paper
• Systemic sclerosis and occupational risk factors: a case–control study

  2002cited by this paper
• Transforming growth factor beta induces fibroblast fibrillin-1 matrix formation.

  2002cited by this paper
• Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice.

  2002cited by this paper
• Genetic epidemiology: Systemic sclerosis

  2002cited by this paper
• Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway.

  2002cited by this paper
• Beauty and the beast. The nitric oxide paradox in systemic sclerosis.

  2002cited by this paper
• Parvovirus B19 infection of cultured skin fibroblasts from systemic sclerosis patients: comment on the article by Ray et al.

  2002cited by this paper
• Bosentan therapy for pulmonary arterial hypertension.

  2002cited by this paper
• Oligoclonal T Cell Expansion in the Skin of Patients with Systemic Sclerosis1

  2002cited by this paper
• Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers

  2002cited by this paper
• Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.

  2002cited by this paper
• Deficient Smad7 expression: A putative molecular defect in scleroderma

  2002cited by this paper
• Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

  2002cited by this paper
• CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.

  2002cited by this paper
• NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues

  2001cited by this paper
• Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes.

  2001cited by this paper
• The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis.

  2001cited by this paper
• Circulating gamma/delta T lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization.

  2001cited by this paper
• Criteria for the classification of early systemic sclerosis.

  2001cited by this paper
• Microchimerism and hla relationships of pregnancy: Implications for autoimmune diseases

  2001cited by this paper
• Induction of an invasive phenotype by human parvovirus B19 in normal human synovial fibroblasts.

  2001cited by this paper
• Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants.

  2001cited by this paper
• Peripheral Blood T Lymphocytes from Systemic Sclerosis Patients Show Both Th1 and Th2 Activation

  2001cited by this paper
• Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus1

  2001cited by this paper
• Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis.

  2001cited by this paper
• Up-regulated expression of transforming growth factor beta receptors in dermal fibroblasts in skin sections from patients with localized scleroderma.

  2001cited by this paper
• Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway.

  2001cited by this paper
• Effect of IL-12 encoding plasmid administration on tight-skin mouse.

  2001cited by this paper
• Blockade of CTLA-4 Signals Inhibits Th2-Mediated Murine Chronic Graft-Versus-Host Disease by an Enhanced Expansion of Regulatory CD8+ T Cells1

  2000cited by this paper
• Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells

  2000cited by this paper
• Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.

  2000cited by this paper
• Characterization of autoantibodies to endothelial cells in systemic sclerosis (SSc): association with pulmonary fibrosis

  2000cited by this paper
• Quantitative Genetic Variation in CD19 Expression Correlates with Autoimmunity1

  2000cited by this paper
• Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases.

  2000cited by this paper
• Chemokine release from activated human dermal microvascular endothelial cells – implications for the pathophysiology of scleroderma?

  2000cited by this paper
• Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis.

  2000cited by this paper
• Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95.

  2000cited by this paper
• Abnormalities of erythrocyte membrane fluidity, lipid composition, and lipid peroxidation in systemic sclerosis: evidence of free radical-mediated injury.

  2000cited by this paper
• Role of transforming growth factor beta in human disease.

  2000cited by this paper
• Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis.

  2000cited by this paper
• Increased Levels of Alternatively Spliced Interleukin 4 (IL-4δ2) Transcripts in Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis

  1999cited by this paper
• Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis.

  1999cited by this paper
• Microchimerism of maternal origin persists into adult life.

  1999cited by this paper
• Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin

  1999cited by this paper
• A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.

  1999cited by this paper
• Effect of superoxide dismutase on bleomycin-induced dermal sclerosis: implications for the treatment of systemic sclerosis.

  1999cited by this paper
• Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

  1999cited by this paper
• Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma.

  1999cited by this paper
• Animal model of sclerotic skin. II. Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1-W/W(V) mice.

  1999cited by this paper
• Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma.

  1999cited by this paper
• Gammadelta receptor bearing T cells in scleroderma: enhanced interaction with vascular endothelial cells in vitro.

  1999cited by this paper
• Monocytes of patients wiht systemic sclerosis (scleroderma spontaneously release in vitro increased amounts of superoxide anion.

  1999cited by this paper
• Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype.

  1998cited by this paper
• Anti‐IL‐4 treatment prevents dermal collagen deposition in the tight‐skin mouse model of scleroderma

  1998cited by this paper
• Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population.

  1998cited by this paper
• Microchimerism and HLA-compatible relationships of pregnancy in scleroderma.

  1998cited by this paper
• Scleroderma fibroblasts promote migration of mononuclear leucocytes across endothelial cell monolayers

  1998cited by this paper
• The binding of some human antiendothelial cell antibodies induces endothelial cell apoptosis.

  1998cited by this paper
• TGFβ—a role in systemic sclerosis?

  1998cited by this paper
• Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis.

  1998cited by this paper
• Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts.

  1998cited by this paper
• Role of metal-catalyzed oxidation reactions in the early pathogenesis of scleroderma.

  1997cited by this paper

• Research progress on mesenchymal stem cells and their exosomes in systemic sclerosis

  2023cites this paper
• MicroRNA-320a: an important regulator in the fibrotic process in interstitial lung disease of systemic sclerosis

  2021cites this paper
• The reliability and validity of the Arabic version of the Mouth Handicap in Systemic Sclerosis (MHISS) Questionnaire in Arabian systemic sclerosis patients

  2020cites this paper
• Translation, validation and cross‐cultural adaptation of the mouth handicap in systemic sclerosis questionnaire into the Turkish language

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• Fat Grafting for Treatment of Facial Scleroderma.

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• In Silico Detection and Characterization of microRNAs and Their Target Genes in microRNA Microarray Datasets from Patients with Systemic Sclerosis–Interstitial Lung Disease

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• iNOS Activity Is Required for the Therapeutic Effect of Mesenchymal Stem Cells in Experimental Systemic Sclerosis

  2018cites this paper
• Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients

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• Modern trends in lipomodeling

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• B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis

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• Pulmonary involvement in systemic sclerosis.

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• Regenerative Approach to Scleroderma with Fat Grafting.

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• Micronutrients, their potential effect on patients with systemic sclerosis

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• Management of cutaneous discomfort in patients with scleroderma: a clinical trial.

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• Recommendations for the care of oral involvement in patients with systemic sclerosis

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• Sensitivity to Change in Systemic Sclerosis of the McMaster-Toronto Arthritis Patient Preference Disability Questionnaire (MACTAR): Shift in Patient Priorities Over Time

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• Recherche d'une hypercoagulabilité au cours de l'hypertension artérielle pulmonaire

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• [Orofacial manifestations of systemic sclerosis: A study of 30 consecutive patients].

  2010cites this paper
• Low influenza vaccination rate among patients with systemic sclerosis.

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• Therapeutic options for systemic sclerosis related interstitial lung diseases.

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• Myopathies related to systemic sclerosis: a case–control study of associated clinical and immunological features

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• The proteasomal system.

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• Immunizations in Adult Patients with Systemic Sclerosis

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• Cerebral Vasculopathy Is Associated with Severe Vascular Manifestations in Systemic Sclerosis

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• Antifibroblast antibodies from systemic sclerosis patients bind to α-enolase and are associated with interstitial lung disease

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• IgG from patients with systemic sclerosis bind to DNA antitopoisomerase 1 in normal human fibroblasts extracts

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