Mdm-2 binding and TAFII31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Oncogene

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.onc.1205856PMID 12370832
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• p53 Antiproliferative Function Is Enhanced by Aspartate Substitution at Threonine 18 and Serine 20

  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000influential reference
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  2000cited by this paper
• Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*

  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53*

  1999cited by this paper
• Protein kinase CK1 is a p53‐threonine 18 kinase which requires prior phosphorylation of serine 15

  1999cited by this paper
• Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers.

  1999cited by this paper
• Comparative study of the p53-mdm2 and p53-MDMX interfaces

  1999cited by this paper
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  1999cited by this paper
• Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.

  1999cited by this paper
• Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

  1999cited by this paper
• GADD45 induction of a G2/M cell cycle checkpoint.

  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1999influential reference
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  1999cited by this paper
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  1999cited by this paper
• Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

  1999cited by this paper
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  1999cited by this paper
• Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

  1999influential reference
• p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998influential reference
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• DNA damage induces phosphorylation of the amino terminus of p53.

  1997influential reference
• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

  1996influential reference
• p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1 (*)

  1995cited by this paper
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  1995influential reference
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Erratum: Cooperative DNA binding of p53 with TFIID (TBP): A possible mechanism for transcriptional activation (Genes and Development 7 (1837- 1849))

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992influential reference
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  2019cites this paper
• The 9aaTAD Transactivation Domains: From Gal4 to p53

  2016cites this paper
• Phosphorylation-Induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen*

  2015cites this paper
• Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen*

  2015cites this paper
• Overexpression of microRNA‑125a‑3p effectively inhibits the cell growth and invasion of lung cancer cells by regulating the mouse double minute 2 homolog/p53 signaling pathway.

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  2014cites this paper
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• Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

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• Identification of New p53 Acetylation Sites in COS-1 Cells*

  2009cites this paper
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• Digital Commons @ University of Digital Commons @ University of South Florida South Florida

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