Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

No abstract is available for this paper.

• Publication year

  1999

• Venue

  EMBO Journal

• Publication date

  1999-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/18.7.1805PMID 10202144PMCID PMC1171266
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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• p53 Is Phosphorylated in Vitro and in Vivo by an Ultraviolet Radiation-induced Protein Kinase Characteristic of the c-Jun Kinase, JNK1 (*)

  1995cited by this paper
• Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

  1995cited by this paper
• A functional p53-responsive intronic promoter is contained within the human mdm2 gene.

  1995cited by this paper
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  1995cited by this paper
• Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Induction of the growth inhibitor IGF-binding protein 3 by p53

  1995cited by this paper
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  1994cited by this paper
• The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities.

  1994cited by this paper
• Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

  1994influential reference
• Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

  1993cited by this paper
• Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

  1990cited by this paper

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