Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Molecular Medicine

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF03401562PMID 8529093PMCID PMC2229942
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.

  1994cited by this paper
• Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

  1994cited by this paper
• Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

  1994cited by this paper
• Sequence-specific transcriptional activation is essential for growth suppression by p53.

  1994cited by this paper
• Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

  1994cited by this paper
• WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Gain of function mutations in p53

  1993cited by this paper
• The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

  1993cited by this paper
• Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• Mapping of the p53 and mdm-2 interaction domains.

  1993cited by this paper
• The p53-mdm-2 autoregulatory feedback loop.

  1993cited by this paper
• Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

  1993cited by this paper
• Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53.

  1993cited by this paper
• p21 is a universal inhibitor of cyclin kinases

  1993cited by this paper
• Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

  1993cited by this paper
• The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

  1993cited by this paper
• Oncogenic forms of p53 inhibit p53-regulated gene expression

  1992cited by this paper
• Amplification of a gene encoding a p53-associated protein in human sarcomas

  1992cited by this paper
• Wild-type p53 binds to the TATA-binding protein and represses transcription.

  1992cited by this paper
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.

  1992cited by this paper
• Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

  1992cited by this paper
• Oncogenic forms of p53 inhibit p53-regulated gene expression.

  1992cited by this paper
• Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53‐mediated growth arrest.

  1992cited by this paper
• Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

  1992cited by this paper
• Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

  1992cited by this paper
• Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

  1992cited by this paper
• Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

  1992cited by this paper
• p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

  1992cited by this paper
• Identification of p53 as a sequence-specific DNA-binding protein

  1991cited by this paper
• Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

  1991cited by this paper
• Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

  1991cited by this paper
• Analysis of p53 mutants for transcriptional activity

  1991cited by this paper
• Wild-type p53 can down-modulate the activity of various promoters.

  1991cited by this paper
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

  1991cited by this paper
• Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

  1991cited by this paper
• Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.

  1990cited by this paper
• Presence of a potent transcription activating sequence in the p53 protein.

  1990cited by this paper
• Structural aspects of the p53 protein in relation to gene evolution.

  1990cited by this paper
• Suppression of human colorectal carcinoma cell growth by wild-type p53.

  1990cited by this paper
• Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

  1990cited by this paper
• Rearrangement of the p53 gene in human osteogenic sarcomas.

  1987cited by this paper
• Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

  1984cited by this paper
• The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

  1982cited by this paper

• Monitoring Changes in the Levels of Newly Synthesized Proteins in Response to Nutlin‐3 Treatment

  2025cites this paper
• A testis-specific lncRNA functions as a post-transcriptional regulator of MDM2 and stimulates apoptosis of testicular germ cell tumor cells

  2024cites this paper
• The Ubiquitination of Arrestin3 within the Nucleus Triggers the Nuclear Export of Mdm2, Which, in Turn, Mediates the Ubiquitination of GRK2 in the Cytosol

  2024cites this paper
• Phospholipase A and acyltransferase 4/retinoic acid receptor responder 3 at the intersection of tumor suppression and pathogen restriction

  2023cites this paper
• Modeling Transport Regulation in Gene Regulatory Networks

  2022cites this paper
• Inorganic arsenic induces MDM2, p53, and their phosphorylation and affects the MDM2/p53 complex in vitro

  2022cites this paper
• p53 Isoforms as Cancer Biomarkers and Therapeutic Targets

  2022cites this paper
• Advances in the Structural and Physiological Functions of SHARPIN

  2022cites this paper
• p53 regulation by MDM2 contributes to self‐renewal and differentiation of basal stem cells in mouse and human airway epithelium

  2021cites this paper
• SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw

  2021cites this paper
• The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression

  2021cites this paper
• Shank-associated RH domain interactor signaling in tumorigenesis

  2020cites this paper
• Mdm2-mediated ubiquitination of β-arrestin2 in the nucleus occurs in a Gβγ- and clathrin-dependent manner.

  2020cites this paper
• Targeting Therapies for the p53 Protein in Cancer Treatments

  2019cites this paper
• Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity.

  2019cites this paper
• A study of the role of microRNAs in gastric cancer : the effect of miR-140-5p dysregulation in the expression of MDM2 in p53-dependent gastric cancer subtypes

  2019cites this paper
• MicroRNA-26a targets the mdm2/p53 loop directly in response to liver regeneration.

  2019cites this paper
• Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function

  2018cites this paper
• A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

  2018cites this paper
• Synthesis and characterization of novel chromone Schiff base complexes as p53 activators

  2018cites this paper
• 331 436 482 491 1 19 102 215 255 290 332 437 483 490 p 53 BD ACIDIC ZINC RING p 53 BD ACIDIC ZINC RING HDM 2

  2018cites this paper
• p16 Immunohistochemistry is Less Useful Than MDM2 and CDK4 to Distinguish Dedifferentiated Liposarcomas From Other Retroperitoneal Mimics

  2017cites this paper
• The p53 Independent Functions of Estrogen-Activated MDM2 in Cell Signaling and Mammary Architecture

  2017cites this paper
• Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity

  2017cites this paper
• Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2–p53 signaling

  2016cites this paper
• The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation

  2016cites this paper
• histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2–p53 signaling

  2016cites this paper
• Modulation of p53 signalling and response to MDM2-p53 binding antagonists

  2016influential citation
• Gene expression profiling analysis of the role of miR-22 in clear cell ovarian cancer.

  2016cites this paper
• Synthesis of androstanopyridine and pyrimidine compounds as novel activators of the tumor suppressor protein p53

  2015cites this paper
• Switching Mechanism in the p53 Regulatory Network

  2015cites this paper
• Signaling Pathways Involved in Megakaryocyte‐Mediated Proliferation of Osteoblast Lineage Cells

  2015cites this paper
• Structural and Functional Characterization of the Human Mdm2 and MdmX RING Domains

  2014influential citation
• ARF tumor suppression in the nucleolus.

  2014cites this paper
• Dynamics of stress p53: Nitric oxide induced transition of states and synchronization

  2014cites this paper
• Nitric Oxide as stress inducer and synchronizer of p53 dynamics

  2014cites this paper
• Raman Spectroscopic Study of Radioresistant Oral Cancer Sublines Established by Fractionated Ionizing Radiation

  2014cites this paper
• Stochastic and Deterministic Models of Cellular p53 Regulation

  2013cites this paper
• Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity

  2013cites this paper
• p53 in DNA Damage, Repair and Cancer Therapeutics

  2013cites this paper
• Switching p53 states by calcium: dynamics and interaction of stress systems.

  2013cites this paper
• p53 Tumor Suppressor Protein Stability and Transcriptional Activity Are Targeted by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factor 3

  2013cites this paper
• SUMO and Parkinson’s Disease

  2013cites this paper
• Critical role for Ser 20 of human p 53 in the negative regulation of p 53 by Mdm 2

  2013cites this paper
• Diagnostic Utility of p16, CDK4, and MDM2 as an Immunohistochemical Panel in Distinguishing Well-differentiated and Dedifferentiated Liposarcomas From Other Adipocytic Tumors

  2012cites this paper
• Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

  2012cites this paper
• ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice.

  2012cites this paper
• Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation

  2012cites this paper
• Small molecules that bind the Mdm2 RING stabilize and activate p53.

  2012cites this paper
• Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis.

  2012cites this paper
• DNA Damage and Oxidative Stress Induced-p53 Activity In Astrocytes causes Growth Arrest

  2012cites this paper
• Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics

  2012cites this paper
• MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells.

  2012cites this paper
• Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability

  2012cites this paper
• MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

  2011cites this paper
• Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.

  2011cites this paper
• Regulation of p53 stability and function by the deubiquitinating enzyme USP42

  2011cites this paper
• The role of ATR mediated p 53 phosphorylatio n at Serine 15 in Homologous

  2011cites this paper
• Redox modulation of p53: Mechanisms and functional significance

  2011cites this paper
• A Theoretical Exploration of Birhythmicity in the p53-Mdm2 Network

  2011cites this paper
• Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles.

  2011cites this paper
• Inhibition of HIF prolyl 4-hydroxylases protect endothelial cells from apoptosis INAUGURAL

  2010cites this paper
• Regulation of the p53 tumor suppressor pathway: the problems and promises of studying Mdm2's E3 ligase function.

  2010cites this paper
• Cooperation between MDM2 and MDMX in the Regulation of p53

  2010cites this paper
• Allosteric regulation of MDM2 protein

  2010cites this paper
• A Novel E1B-55kD-Deleted Oncolytic Adenovirus Carrying Mutant KRAS-Regulated hdm2 Transgene Exerts Specific Antitumor Efficacy on Colorectal Cancer Cells

  2010cites this paper
• Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53

  2010cites this paper
• From structure to dynamics: frequency tuning in the p53-Mdm2 network. II Differential and stochastic approaches.

  2010cites this paper
• Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53

  2009cites this paper
• MI-63: A novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53

  2009cites this paper
• The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos

  2009cites this paper
• Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma.

  2009cites this paper
• From structure to dynamics: frequency tuning in the p53-Mdm2 network I. Logical approach.

  2009cites this paper
• Veränderungen am Protoonkogen MDM2 bei Urothelkarzinomen in Bezug auf bekannte Risikofaktoren - Relation von Umweltfaktoren und intrazellulärem Signalweg?

  2009cites this paper
• Protein methylation : a new regulator of the p 53 tumor suppressor

  2009cites this paper
• PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

  2009cites this paper
• MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation*

  2009cites this paper
• Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2

  2008cites this paper
• MdmX regulates transformation and chromosomal stability in p53-deficient cells

  2008cites this paper
• Protein methylation: a new mechanism of p53 tumor suppressor regulation.

  2008cites this paper
• Life or cell death: identifying c-Myc regulated genes in two distinct tissues

  2008cites this paper
• CHARACTERIZATION OF THE DWNN DOMAIN AND RING FINGER-LIKE MOTIF WITHIN THE DCM OF THE Drosophila melanogaster SNAMA PROTEIN

  2008cites this paper
• An investigation of p53’s differential activation of cell cycle arrest and apoptosis

  2008cites this paper
• Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7

  2008cites this paper
• Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.

  2008cites this paper
• Unlocking the Mdm2-p53 loop: Ubiquitin is the key

  2008cites this paper
• Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen

  2008cites this paper
• Contribution of the DNA binding domain of p53 to regulation of its stability

  2008cites this paper
• Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

  2008cites this paper
• An essential function of the extreme C‐terminus of MDM2 can be provided by MDMX

  2007cites this paper
• Ubiquitination and Degradation of Mutant p53

  2007cites this paper
• The role of Drosophila sumo conjugating enzyme lesswright in larval hematopoiesis : effects on cactus, dorsal and dorsal-related immunity factor (DIF).

  2007influential citation
• Regulation of FOXO stability and activity by MDM2 E3 ligase

  2007cites this paper
• THE FUNCTIONAL SIGNIFICANCE OF AN ALTERNATELY SPLICED PRODUCT OF THE HDM2 GENE

  2007cites this paper
• Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop.

  2007cites this paper
• Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells.

  2007cites this paper
• The p53 network: p53 and its downstream genes.

  2007cites this paper
• Expression of the regulatory cell cycle proteins p21, p27, p14, p16, p53, mdm2, and cyclin E in bone marrow biopsies with acute myeloid leukemia. Correlation with patients' survival.

  2007cites this paper
• Minireview Mdm 2 : The Ups and Downs

  2007cites this paper
• A SURVEY OF NOVEL MOLECULAR TARGETS FOR ANTICANCER DRUG DISCOVERY

  2006cites this paper