Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2

No abstract is available for this paper.

• Publication year

  1981

• Venue

  European Journal of Immunology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.1830110812PMID 6456149
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.

  1980cited by this paper
• The functional relationship of the interleukins

  1980cited by this paper
• T‐T Cell Interactions during Cytotoxic T Lymphocyte (CTL) Responses: T Cell Derived Helper Factor (Interleukin 2) as a Probe to Analyze CTL Responsiveness and Thymic Maturation of CTL Progenitors

  1980cited by this paper
• Macrophages and T cells control distinct phases of B cell differentiation in the humoral immune response in vitro.

  1980cited by this paper
• Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.

  1980cited by this paper
• Participation of lymphocyte activating factor (Interleukin 1) in the induction of cytotoxic T cell responses.

  1980cited by this paper
• Studies on the mechanism of action of cyclosporin A.

  1980cited by this paper
• Two distinct factors are required for induction of T-cell growth

  1980cited by this paper
• Suppression of in vitro lymphocyte reactivity by cyclosporin A: existence of a population of drug-resistant cytotoxic lymphocytes

  1980cited by this paper
• Cyclosporin A: in vivo and in vitro suppression of rat T-lymphocyte function.

  1979cited by this paper
• Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P388D.

  1978cited by this paper
• T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity

  1978cited by this paper
• Long term culture of tumour-specific cytotoxic T cells

  1977cited by this paper
• Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

  1977cited by this paper
• A rapid method for the isolation of functional thymus‐derived murine lymphocytes

  1973cited by this paper

• Fulminant Cardiac Sarcoidosis Successfully Treated With Aggressive Immunosuppressive Therapy

  2025cites this paper
• Understanding Immunological insights of Liver Transplantation: A practice for attaining Operational Tolerance.

  2025cites this paper
• Consider systemic therapy alongside supportive care in the early phases of Stevens–Johnson syndrome/toxic epidermal necrolysis

  2025influential citation
• Animal models for transplant immunology: bridging bench to bedside

  2024cites this paper
• In memoriam Martin Röllinghoff (1941-2022).

  2024cites this paper
• Systemic Inflammatory Disorders, Immunosuppressive Treatment and Increase Risk of Head and Neck Cancers—A Narrative Review of Potential Physiopathological and Biological Mechanisms

  2023cites this paper
• Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells

  2022cites this paper
• Polymeric Micelles for the Enhanced Deposition of Hydrophobic Drugs into Ocular Tissues, without Plasma Exposure

  2021cites this paper
• Approaches for Controlling Antibody-Mediated Allograft Rejection Through Targeting B Cells

  2021cites this paper
• Neurologic Toxicities Associated with Tumor Necrosis Factor Inhibitors and Calcineurin Inhibitors.

  2020cites this paper
• Approaches to Medical Therapy

  2020cites this paper
• Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells

  2019cites this paper
• Kaposi’s varicelliform eruption due to cytomegalovirus infection in a six-month-old infant

  2019cites this paper
• What's New in Psoriasis.

  2019cites this paper
• Long Term Remission of Hyper IgE Syndrome after Treatment with Cyclosporine-A: Clinic and Immunological Correlations

  2019cites this paper
• Effects of burns on gut motor and mucosa functions.

  2018cites this paper
• Multicomponent High-throughput Drug Screening via Inkjet Printing to Verify the Effect of Immunosuppressive Drugs on Immune T Lymphocytes

  2017cites this paper
• Evaluation of Antigen-Specific IgM and IgG Production during an In Vitro Peripheral Blood Mononuclear Cell Culture Assay

  2017cites this paper
• Unraveling the Role of Allo-Antibodies and Transplant Injury

  2016cites this paper
• TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

  2016cites this paper
• Targeting the latent reservoir to achieve functional HIV cure

  2016cites this paper
• Cyclosporine in toxic epidermal necrolysis: a brief review of the emerging therapeutic modality.

  2016cites this paper
• Rejection After Transplantation

  2015cites this paper
• [Topical cyclosporine for the treatment of ocular surface changes in contact lens wearers].

  2015cites this paper
• Cyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content

  2015cites this paper
• Signals and pathways controlling regulatory T cells

  2014cites this paper
• Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.

  2013cites this paper
• graft-versus-host disease mediated control of - Graft-versus-leukemia effect after suicide-gene

  2013cites this paper
• The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell Infection

  2013cites this paper
• Cyclosporin A Enhances Callus Formation in Rabbit Tibia Fractures

  2013influential citation
• Differential effects of cyclosporin and etanercept treatment on various pathologic parameters in a murine model of irradiation-induced mucositis.

  2012cites this paper
• Effectiveness and safety of cyclosporin A therapy in steroid dependent nephrotic syndrome in childhood

  2012cites this paper
• Livedo reticularis as an initial clinical manifestation of gemcitabine‐induced hemolytic uremic syndrome

  2012cites this paper
• Role of the Actin Cytoskeleton in Pro-fibrotic Signaling

  2012cites this paper
• Successful combination therapy with dapsone and cyclosporine for erythema elevatum diutinum with unusual appearance

  2012cites this paper
• Sıçanlarda siklosporin ve takrolimus uygulamasının periodontal dokular üzerine etkileri

  2011cites this paper
• precursor frequencies allogeneic bone marrow recipients at the level of cytotoxic T-cell Studies on the mechanism of tolerance or graft-versus-host disease in

  2011cites this paper
• In vivo effects of immunomodulators in a murine model of Fluorouracil-induced mucositis.

  2011cites this paper
• PHARMACOLOGY AND DRUG THERAPY

  2011cites this paper
• Consecutive Low Doses of Cyclosporine A Induce Pro-Inflammatory Cytokines and Accelerate Allograft Skin Rejection

  2011cites this paper
• marrow transplantation graft-versus-host disease after allogeneic HLA-identical sibling bone secreting T-helper cell precursors in patients with and without acute Quantitative assessment of posttransplant host-specific interleukin-2-

  2011cites this paper
• Avaliação longitudinal do crescimento gengival induzido por Ciclosporina A (CsA) e Tacrolimus, na ausência de bloqueadores de canal de cálcio, em indivíduos transplantados renais

  2010cites this paper
• Cyclosporin A and atherosclerosis--cellular pathways in atherogenesis.

  2010cites this paper
• J-LEAPS VACCINES ARE SUFFICIENT TO ACTIVATE AND DIRECT AN IMMUNE RESPONSE THROUGH DENDRITIC CELLS

  2010cites this paper
• 7 – Philosophy, Goals, and Approaches to Medical Therapy

  2010cites this paper
• Treatment of therapy-resistant Sézary syndrome with Cyclosporin-A: suppression of pruritus, leukaemic T cell activation markers and tumour mass.

  2009cites this paper
• Long-term follow-up of cancer risk in patients treated with short-term cyclosporine.

  2008cites this paper
• The effect of two novel C-type lectins, Ba100 and Ba25, isolated from the venom of the puff adder, Bitis arietans on T lymphocyte proliferative responses

  2008cites this paper
• [Risk of infection during treatment with cyclosporin A].

  2008cites this paper
• The influence of HLA-A,B and -DR matching on leucocyte infiltration in renal allografts.

  2008cites this paper
• Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages

  2008cites this paper
• Cyclosporin A–Immunobiological Aspects

  2007cites this paper
• A randomized-controlled trial to compare topical cyclosporin with triamcinolone acetonide for the treatment of oral lichen planus.

  2007cites this paper
• Generalised Pustular Psoriasis (von Zumbusch type) following renal Transplantation. Report of a case and review of the literature

  2007cites this paper
• Cyclosporin inhibition of collagen remodeling is mediated by gelsolin.

  2007cites this paper
• Grundlagen der Autoimmunität

  2007cites this paper
• Susceptibility to Cyclosporine Therapy the Pattern of Acute Xenograft Rejection and Distinct Subsets of Dendritic Cells Regulate

  2006cites this paper
• The Effect of Cyclosporin A on Alveolar Bone in Rats Subjected to Experimental Periodontal Disease

  2006cites this paper
• Renal and macrophage aminopeptidase activities in cyclosporin-treated mice.

  2006cites this paper
• Liver and biliary In vitro effect of Cyclosporin A on immunoglobulin production and concanavalin A induced suppression in primary biliary cirrhosis

  2006cites this paper
• Distinct Subsets of Dendritic Cells Regulate the Pattern of Acute Xenograft Rejection and Susceptibility to Cyclosporine Therapy1

  2006cites this paper
• Kapitel 62 – Antiinflammatorische und immunmodulatorische Therapie

  2005cites this paper
• TRANSPLANTATION OF TIE HEART Immunosuppressive therapy with cyclosporine for cardiac transplantation

  2005cites this paper
• Immunosuppressive therapy for renal transplantation

  2005cites this paper
• Recreational exposure to freshwater cyanobacteria : epidemiology, dermal toxicity and biological activity of cyanobacterial lipopolysaccharides

  2005cites this paper
• Die Rolle von Interleukin-2 bei der Aktivierung von zytotoxischen T-Lymphozyten

  2005influential citation
• Topical treatment of severe corneal ulcers with cyclosporin A

  2005cites this paper
• therapy with cyclosporine for cardiac transplantation

  2005cites this paper
• Interleukin-2 Production , and Responsiveness to IL-2 in T 4-Positive T Lymphocyte Populations From Malignant Cutaneous T Cell Lymphoma ( S # { 233 } zary ’ s Syndrome ) : The Effect of Cyclosporine A

  2005cites this paper
• Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection

  2005cites this paper
• Effect of anticancer drugs on the release of tumour necrosis factor in vitro

  2005cites this paper
• Heart transplantation: Cellular and humoral immunity

  2004cites this paper
• Effects of cyclosporin A on humoral immunity to ticks and on cutaneous immediate and delayed hypersensitivity reactions toIxodes ricinus L. salivary-gland antigens in re-infested rabbits

  2004cites this paper
• Therapeutic monitoring of cyclosporin — an update

  2004cites this paper
• Endothelial expression of MHC class II molecules in autoimmune disease.

  2004cites this paper
• Temperature-Dependent Bindingof Cyclosporineto an Erythrocyte Protein

  2004cites this paper
• Reversal of multidrug resistance by an immunosuppressive agent FK-506

  2004cites this paper
• Inhibition of cyclosporin A-induced gingival overgrowth by azithromycin through phagocytosis: an in vivo and in vitro study.

  2004cites this paper
• Influences of Immunosuppressive Agents, FK506 and Cyclosporin on Systemic Candida albicans Infection in Mice

  2004cites this paper
• Parathyroid function in cardiac transplant patients: evaluation during physical exercise

  2004cites this paper
• New aspects of cyclosporin a mode of action: from gene silencing to gene up-regulation.

  2003cites this paper
• Effects of low-dose cyclosporin on osteogenesis of human demineralized bone grafts in a surgically created mandibular defect in rats.

  2003cites this paper
• Suppression of Hepatic CYP3A1/2 and CYP2C11 by Cyclosporine Is Not Mediated by Altering Growth Hormone Levels

  2003cites this paper
• Collagen arthritis in rats is an animal model of polyarthritis that can be produced by an intradermal injection of homologous or heterologous native type II collagen emulsified in incomplete Freund's adjuvant (ICFA)

  2003cites this paper
• Cytokines Regulate the Pattern of Rejection and Susceptibility to Cyclosporine Therapy in Different Mouse Recipient Strains After Cardiac Allografting1

  2003cites this paper
• Pre- and posttransplant immunologic monitoring: why, when, and how?

  2002cites this paper
• Immunosuppressants and operation in ulcerative colitis1

  2002cites this paper
• Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis

  2002cites this paper
• Protein dephosphorylation and protein phosphorylation

  2002cites this paper
• Effect of combined cytostatic cyclosporin A and cytolytic suicide gene therapy on the prevention of experimental graft-versus-host disease

  2002cites this paper
• Immunosuppressants and operation in ulcerative colitis.

  2002cites this paper
• Medical immunology: a new journal for a new subspecialty

  2002cites this paper
• Behavioral conditioning of immunosuppression is possible in humans

  2002cites this paper
• Graft-versus-leukemia effect after suicide-gene-mediated control of graft-versus-host disease.

  2002cites this paper
• Identification of Novel Targets of Immunosuppressive Agents by cDNA-based Microarray Analysis*

  2002cites this paper
• Effect of cyclosporin A on immunological response in lungs of guinea pigs infected with Trichinella spiralis.

  2002cites this paper
• DIABETIC RATS TRANSPLANTED WITH ADULT PORCINE ISLETS AND IMMUNOSUPPRESSED WITH CYCLOSPORINE A, MYCOPHENOLATE MOFETIL, AND LEFLUNOMIDE REMAIN NORMOGLYCEMIC FOR UP TO 100 DAYS1

  2001cites this paper
• Cyclosporin-induced gingival overgrowth at the newly formed edentulous ridge in rats: a morphological and histometric evaluation.

  2001cites this paper
• Pentalenolactone I and Hygromycin A, Immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus

  2001cites this paper
• The 12th Annual Report of the North American Pediatric Renal Transplant Cooperative Study: Renal transplantation from 1987 through 1998

  2001cites this paper