Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cancer immunology research

• Publication date

  2017-09-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/2326-6066.CIR-17-0131PMID 28947544PMCID PMC5668144
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic Intervention

  2016cited by this paper
• Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers

  2016cited by this paper
• Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

  2015cited by this paper
• Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

  2015cited by this paper
• Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

  2015cited by this paper
• High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression

  2015cited by this paper
• A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+ T cells in carcinogen-induced fibrosarcomas

  2015cited by this paper
• Effector lymphocyte-induced lymph node-like vasculature enables naïve T-cell entry into tumors and enhanced anti-tumor immunity

  2015influential reference
• Understanding high endothelial venules: Lessons for cancer immunology

  2015cited by this paper
• PD‐L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti‐PD‐1/PD‐L1 clinical trials

  2015cited by this paper
• Tumor Endothelium FasL Establishes a Selective Immune Barrier Promoting Tolerance in Tumors

  2014cited by this paper
• Follicular dendritic cells: dynamic antigen libraries

  2014cited by this paper
• Progression of carcinogen‐induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics

  2013cited by this paper
• High Endothelial Venule Blood Vessels for Tumor-Infiltrating Lymphocytes Are Associated with Lymphotoxin β–Producing Dendritic Cells in Human Breast Cancer

  2013cited by this paper
• Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation

  2013cited by this paper
• Regulation of tumor-associated high-endothelial venules by dendritic cells

  2013cited by this paper
• Abstract 5473: Integrative approach towards the functionality of CIAO1 gene

  2012cited by this paper
• T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.

  2012influential reference
• Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors.

  2011cited by this paper
• Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer.

  2011influential reference
• Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

  2011cited by this paper
• Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

  2010cited by this paper
• Targeted depletion of lymphotoxin-alpha-expressing Th1 and Th17 cells inhibits autoimmune disease (48.22)

  2009cited by this paper
• Stromal cell contributions to the homeostasis and functionality of the immune system

  2009cited by this paper
• Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

  2009cited by this paper
• The Inhibitory HVEM-BTLA Pathway Counter Regulates Lymphotoxin β Receptor Signaling to Achieve Homeostasis of Dendritic Cells1

  2008cited by this paper
• A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells

  2008influential reference
• Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function.

  2008cited by this paper
• Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

  2007influential reference
• Regulatory T cells and tumour immunity – observations in mice and men

  2007cited by this paper
• Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

  2006cited by this paper
• Interactions of Tumor Necrosis Factor (TNF) and TNF Receptor Family Members in the Mouse and Human*

  2006cited by this paper
• Lymphoid organ development: from ontogeny to neogenesis

  2006cited by this paper
• Synchrony of High Endothelial Venules and Lymphatic Vessels Revealed by Immunization1

  2006cited by this paper
• Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function.

  2005influential reference
• A Lymphotoxin-IFN-β Axis Essential for Lymphocyte Survival Revealed during Cytomegalovirus Infection1

  2005cited by this paper
• Network communications: lymphotoxins, LIGHT, and TNF.

  2005cited by this paper
• Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

  2005cited by this paper
• Lymphotoxin-β Receptor Signaling Is Required for the Homeostatic Control of HEV Differentiation and Function

  2005cited by this paper
• Ligands for L-selectin: homing, inflammation, and beyond.

  2004cited by this paper
• Organogenesis of lymphoid tissues

  2003influential reference
• Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

  2002cited by this paper
• Faculty Opinions recommendation of IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity.

  2001cited by this paper
• Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente.

  2001cited by this paper
• IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

  2001cited by this paper
• Expression of lymphotoxins and their receptor-Fc fusion proteins by baculovirus.

  2000cited by this paper
• Development and maturation of secondary lymphoid tissues.

  1999cited by this paper
• CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.

  1998cited by this paper
• Lymph Node Genesis Is Induced by Signaling through the Lymphotoxin β Receptor

  1998cited by this paper
• Turning off follicular dendritic cells

  1998cited by this paper
• Lymph node genesis is induced by signaling through the lymphotoxin beta receptor.

  1998cited by this paper
• Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

  1997cited by this paper
• A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes.

  1996cited by this paper
• Induction of classical transplantation tolerance in the adult

  1989cited by this paper
• CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

  1987cited by this paper
• Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

  1984cited by this paper
• The route of re-circulation of lymphocytes in the rat

  1964cited by this paper
• Cáncer

  1939cited by this paper

• Optimizing anti-PI3Kδ and anti-LAG-3 immunotherapy dosing regimens in a mouse model of triple-negative breast cancer improves outcome by removing treatment-related adverse events

  2026cites this paper
• Antiangiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules.

  2025cites this paper
• The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment

  2025cites this paper
• Tumor-draining lymph nodes - friend or foe during immune checkpoint therapy?

  2025cites this paper
• Immune microenvironment of tumor-draining lymph nodes: insights for immunotherapy

  2025cites this paper
• The role of immunotherapy in targeting tumor microenvironment in genitourinary cancers

  2025cites this paper
• Pipelines for lymphocyte homeostasis maintenance during cancer immunotherapy

  2025cites this paper
• Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer

  2025cites this paper
• Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside.

  2025cites this paper
• Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg cell-dependent CD8+ T-cell exclusion.

  2025cites this paper
• Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma

  2025cites this paper
• Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities.

  2025cites this paper
• Mouse Models Enable the Functional Investigation of Tertiary Lymphoid Structures in Cancer.

  2025cites this paper
• Tumor-associated high endothelial venules as therapeutic modulation targets in cancer immunotherapy.

  2025cites this paper
• Rewiring the Lymphatic Landscape: Disorders, Remodeling, and Cancer Progression

  2025cites this paper
• B cell-associated research in non-small cell lung cancer: a bibliometric analysis of current landscapes and future directions

  2025cites this paper
• Dynamic remodeling of tertiary lymphoid structures in response to cancer therapy: a recent review

  2025cites this paper
• Analysis of the distribution of HEV by immunohistochemistry using a mouse oral squamous cell carcinoma model.

  2025cites this paper
• Regulatory T cells poise the myeloid landscape after chemotherapy in lung tumors.

  2025cites this paper
• Tumour-associated vasculature in T cell homing and immunity: opportunities for cancer therapy

  2025cites this paper
• Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

  2024influential citation
• Recent clinical researches and technological development in TIL therapy

  2024cites this paper
• PD1-Targeted Transgene Delivery to Treg Cells

  2024cites this paper
• The discovery of high endothelial venules. A historical note

  2024cites this paper
• PNAd-expressing vessels characterize the dermis of CD3+ T cell-mediated cutaneous diseases.

  2024cites this paper
• Pan-cancer identified ARPC1B as a promising target for tumor immunotherapy and prognostic biomarker, particularly in READ.

  2024cites this paper
• Advances in the study of tertiary lymphoid structures in the immunotherapy of breast cancer

  2024cites this paper
• T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle

  2024cites this paper
• Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?

  2024cites this paper
• Targeting cytotoxic lymphocyte antigen 4 (CTLA-4) in breast cancer

  2024cites this paper
• Deciphering Regulatory T-Cell Dynamics in Cancer Immunotherapy: Mechanisms, Implications, and Therapeutic Innovations.

  2024cites this paper
• Lymphocyte homing and recirculation with tumor tertiary lymphoid structure formation: predictions for successful cancer immunotherapy

  2024cites this paper
• Tailoring biomaterials for monitoring and evoking tertiary lymphoid structures.

  2023cites this paper
• Immunotherapy Targeting CCR8+ Regulatory T Cells Induces Antitumor Effects via Dramatic Changes to the Intratumor CD8+ T Cell Profile.

  2023cites this paper
• High endothelial venule is a prognostic immune‐related biomarker in patients with resected intrahepatic cholangiocarcinoma

  2023cites this paper
• Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies

  2023cites this paper
• HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy

  2023cites this paper
• THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC

  2023cites this paper
• Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg-dependent CD8+ T cell exclusion

  2023cites this paper
• The link between T cell activation and development of functionally useful tumour-associated high endothelial venules

  2023influential citation
• ARPC1B is a novel prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune infiltration

  2023cites this paper
• Mechanisms of tertiary lymphoid structure formation: cooperation between inflammation and antigenicity

  2023cites this paper
• Reprogramming endothelial cells to empower cancer immunotherapy.

  2023cites this paper
• Tertiary lymphoid structures, a historical reappraisal.

  2023cites this paper
• Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response

  2023cites this paper
• High endothelial venules in cancer: Regulation, function, and therapeutic implication.

  2023cites this paper
• Lymphoid tissue inducer cells in cancer: a potential therapeutic target

  2023cites this paper
• Stromal and Immune Cell Dynamics in Tumor Associated Tertiary Lymphoid Structures and Anti-Tumor Immune Responses

  2022influential citation
• Sensory nerves impede the formation of tertiary lymphoid structures and development of protective anti-melanoma immune responses.

  2022cites this paper
• Tertiary Lymphoid Structures as Mediators of Immunotherapy Response

  2022cites this paper
• Lkb1 aggravates diffuse large B-cell lymphoma by promoting the function of Treg cells and immune escape

  2022cites this paper
• Tumor necrosis factor receptor regulation of peripheral node addressin biosynthetic components in tumor endothelial cells

  2022cites this paper
• Regulatory T-cells-related signature for identifying a prognostic subtype of hepatocellular carcinoma with an exhausted tumor microenvironment

  2022cites this paper
• Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

  2022cites this paper
• The soldiers needed to be awakened: Tumor-infiltrating immune cells

  2022cites this paper
• Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes

  2022influential citation
• Carboplatin enhances lymphocyte-endothelial interactions to promote CD8+ T cell trafficking into the ovarian tumor microenvironment.

  2022cites this paper
• Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop.

  2022cites this paper
• The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers

  2022cites this paper
• Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

  2022influential citation
• Tertiary lymphoid structures in cancer

  2022cites this paper
• Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy.

  2022cites this paper
• Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival

  2022cites this paper
• Immunological Tolerance

  2021cites this paper
• Using methylcholanthrene-induced fibrosarcomas to study tumor immunology.

  2021cites this paper
• Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

  2021cites this paper
• CTLA-4 in Regulatory T Cells for Cancer Immunotherapy

  2021cites this paper
• Single-Cell Sequencing Reveals the Transcriptome and TCR Characteristics of pTregs and in vitro Expanded iTregs

  2021cites this paper
• High endothelial venules (HEVs) in immunity, inflammation and cancer

  2021influential citation
• STINGing the Tumor Microenvironment to Promote Therapeutic Tertiary Lymphoid Structure Development

  2021cites this paper
• Therapeutic Induction of Tertiary Lymphoid Structures in Cancer Through Stromal Remodeling

  2021cites this paper
• Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment

  2021cites this paper
• Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

  2021cites this paper
• Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

  2021cites this paper
• High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer

  2021influential citation
• Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

  2021cites this paper
• Tumor-draining lymph nodes: At the crossroads of metastasis and immunity

  2021cites this paper
• Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis

  2021influential citation
• The Immune System of Mesothelioma Patients: A Window of Opportunity for Novel Immunotherapies

  2021cites this paper
• The relationship of the tertiary lymphoid structures with the tumor-infiltrating lymphocytes and its prognostic value in gastric cancer

  2021cites this paper
• Exploiting ECM remodelling to promote immune-mediated tumour destruction.

  2021cites this paper
• Tumor-Associated Tertiary Lymphoid Structures: A Cancer Biomarker and a Target for Next-generation Immunotherapy.

  2021cites this paper
• High endothelial venule is a surrogate biomarker for T-cell inflamed tumor microenvironment and prognosis in gastric cancer

  2021cites this paper
• Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer

  2021cites this paper
• Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation

  2020cites this paper
• Fully Human Antibodies for Malignant Pleural Mesothelioma Targeting

  2020cites this paper
• Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection

  2020influential citation
• The Dual Role of High Endothelial Venules in Cancer Progression versus Immunity

  2020influential citation
• Densities of decidual high endothelial venules correlate with T-cell influx in healthy pregnancies and idiopathic recurrent pregnancy losses.

  2020cites this paper
• Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3

  2020cites this paper
• Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives

  2020cites this paper
• Cell and tissue engineering in lymph nodes for cancer immunotherapy.

  2020cites this paper
• Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

  2020cites this paper
• L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

  2019cites this paper
• Regulation of regulatory T cells in cancer

  2019cites this paper
• Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

  2019cites this paper
• Host tissue determinants of tumour immunity

  2019cites this paper
• Tumor angiogenesis: causes, consequences, challenges and opportunities

  2019cites this paper
• Vascular regulation of antitumor immunity

  2019cites this paper
• Human regulatory T cells (Treg) and their response to cancer

  2019cites this paper