Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration

ABSTRACT The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo. Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies. Summary: Inner ear organoids from pluripotent stem cells and tissue-specific progenitors provide new tools to validate drug-based therapies, gene-targeting approaches and cell replacement strategies for hearing loss.

• Publication year

  2019

• Venue

  Development

• Publication date

  2019-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.177188PMID 31477580PMCID PMC6765123
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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